Chemokines mediate mesenchymal stem cell migration toward gliomas in vitro.

abstract：:Human colon cancer cells were implanted s.c. in nude mice. After 6 days, the mice were divided into four groups, 10 in each. During the first 5 days, the first and second groups were injected i.p. with leucovorin (LV)/5-fluorouracil (FU), and the third and fourth groups with sterile saline solution. During the subsequ...

journal_title：Oncology reports

authors： El-Salhy M

更新日期：2004-06-01 00:00:00

abstract：:Accumulation of an excess amount of reactive oxygen species (ROS) can cause hepatotoxicity that may result in liver damage. Therefore, development of anti-oxidative agents is needed for reducing liver toxicity. This study investigated the anti-oxidative and hepatoprotective activity of lithospermic acid, a plant-deriv...

journal_title：Oncology reports

authors： Chan KW,Ho WS

更新日期：2015-08-01 00:00:00

abstract：:Chronic lymphocytic leukemia (CLL) is the most common leukemia in Western countries, and mainly originates from an accumulation of abnormal B cells caused by the dysregulation of cell proliferation and apoptosis rates. The aberration of apoptosis-related genes in CLL cells results in defective apoptosis of CLL cells i...

journal_title：Oncology reports

authors： Fu C,Gong Y,Shi X,Sun Z,Niu M,Sang W,Xu L,Zhu F,Wang Y,Xu K

更新日期：2016-09-01 00:00:00

abstract：:PFN2 is an invasion promoter in several cancers including lung cancer. However, the probable effects and underlying mechanisms of PFN2 in tumor cell epithelial-mesenchymal-transition (EMT) of non-small cell lung cancer (NSCLC) remain poorly understood. The protein and mRNA levels of PFN2 in human bronchial epithelial ...

journal_title：Oncology reports

authors： Yan J,Ma C,Gao Y

更新日期：2017-05-01 00:00:00

abstract：:Increased production of reactive oxygen species (ROS) is a distinct feature of various types of cancer. ROS drive tumor progression and render cancer cells vulnerable to additional oxidative insult. The various natural herb compounds have been shown to induce additional production of ROS in cancer cells, although the ...

journal_title：Oncology reports

authors： Chen X,Song L,Hou Y,Li F

更新日期：2019-02-01 00:00:00

abstract：:Apoptosis is a process associated with development and progression of breast cancer. The association between connexins and programmed cell death has only been demonstrated in a few studies. The aim of the present study was the evaluation of Cx26 and Cx43 expression in breast cancer in correlation with Bcl-2 and Bak pr...

journal_title：Oncology reports

authors： Kanczuga-Koda L,Sulkowski S,Tomaszewski J,Koda M,Sulkowska M,Przystupa W,Golaszewska J,Baltaziak M

更新日期：2005-08-01 00:00:00

abstract：:We investigated whether 18F-fluorothymidine-positron-emission tomography/computed tomography (18F-FLT-PET/CT) is useful for the evaluation of the very early response to anti-epidermal growth factor receptor (EGFR) antibody cetuximab therapy in human lung cancer xenografts. A human tumor xenograft model was established...

journal_title：Oncology reports

authors： Takeuchi S,Zhao S,Kuge Y,Zhao Y,Nishijima K,Hatano T,Shimizu Y,Kinoshita I,Tamaki N,Dosaka-Akita H

更新日期：2011-09-01 00:00:00

abstract：:Long non‑coding RNA (lncRNA) forkhead box P4 antisense RNA 1 (FOXP4‑AS1) has been determined to function as an oncogene in various types of cancer. However, the biological function and the underlying mechanisms of FOXP4‑AS1 in mantle cell lymphoma (MCL) remain to be uncovered. The expression and the associated clinico...

journal_title：Oncology reports

authors： Tao HF,Shen JX,Hou ZW,Chen SY,Su YZ,Fang JL

更新日期：2020-12-11 00:00:00

abstract：:Cell cycle-related molecules play crucial roles in maintaining genomic stability, and can also serve as biomarkers of cell cycle phase distribution at the same time. In this study, we used multiparameter analysis of various biomarkers to investigate their utility for the evaluation ...

journal_title：Oncology reports

authors： Haruki T,Shomori K,Shiomi T,Taniguchi Y,Nakamura H,Ito H

更新日期：2012-09-01 00:00:00

abstract：:Chromatin assembly factor 1 subunit B (CHAF1B) participates in DNA synthesis and repair. High CHAF1B expression has been associated with a poor prognosis in several types of cancers. However, no study has evaluated the clinical significance and biological function of CHAF1B in non‑small cell lung cancer (NSCLC). In th...

journal_title：Oncology reports

authors： Duan Y,Liu T,Li S,Huang M,Li X,Zhao H,Li J

更新日期：2019-04-01 00:00:00

abstract：:Esophageal cancer (EC) has a globally increasing incidence with poor curative treatment options and survival rates. Crucial risk factors are exposure to toxins or carcinogens. Microsomal epoxide hydrolase (mEH) is a biotransformation enzyme essential for the detoxification of xenobiotics. Polymorphisms in exon 3 and e...

journal_title：Oncology reports

authors： Dura P,Bregitha CV,Te Morsche RH,Roelofs HM,Kristinsson JO,Wobbes T,Witteman BJ,Tan AC,Drenth JP,Peters WH

更新日期：2012-06-01 00:00:00

abstract：:In order to investigate the involvement of the IER3/PP2A-B56γ/ERK-positive feedback loop, which leads to sustained phosphorylation/activation of ERK in carcinogenesis, we immunohistochemically examined the expression of IER3 and phosphorylated ERK in lung tumor tissues. IER3 was overexpressed in all cases of adenocarc...

journal_title：Oncology reports

authors： Ito T,Ozaki S,Chanasong R,Mizutani Y,Oyama T,Sakurai H,Matsumoto I,Takemura H,Kawahara E

更新日期：2016-05-01 00:00:00

abstract：:The protein p27/kip1 is a cyclin-dependent kinase inhibitor that regulates cell-cycle progression. In the present study, p27/kip1 expression as well as tumor cell proliferation and apoptosis were investigated in 80 colorectal carcinomas, using anti-p27/kip1 antibodies, in situ apoptosis detection kits and anti-PCNA an...

journal_title：Oncology reports

authors： Noguchi T,Kikuchi R,Ono K,Takeno S,Moriyama H,Uchida Y

更新日期：2003-07-01 00:00:00

abstract：:We radiographically evaluated the response of primary lesions to chemotherapy in 101 patients with inoperable advanced gastric cancer. The median survival time in the 50 responders (49.5%) was 379 days, as compared with only 210 days in the 51 non-responders (50.1%) (p<0. 001). Morphologic changes of the gastric mucos...

journal_title：Oncology reports

authors： Yamazaki I,Koizumi W,Kondo I,Saigenji K

更新日期：2000-11-01 00:00:00

abstract：:The present study was performed to investigate the protective effects of tannic acid (TA) on liver injury induced by arsenic trioxide (ATO) and to elucidate the mechanism involved as related to the Kelch‑like ECH‑associated protein 1 (Keap1)‑nuclear factor erythroid 2‑related factor 2 (Nrf2)/antioxidant response eleme...

journal_title：Oncology reports

authors： Li M,Liu P,Xue Y,Liang Y,Shi J,Han X,Zhang J,Chu X,Chu L

更新日期：2020-11-01 00:00:00

abstract：:ZNF703, a member of the NET/Nlz family of zinc finger transcription factors, contributes to aspects of developmental growth and patterning across evolutionarily diverse species. ZNF703 has been identified as a novel oncogene in human breast cancer. In the present study, we investigated the expression of ZNF703 in gast...

journal_title：Oncology reports

authors： Yang G,Ma F,Zhong M,Fang L,Peng Y,Xin X,Zhong J,Yuan F,Gu H,Zhu W,Zhang Y

更新日期：2014-04-01 00:00:00

abstract：:Secalonic acid F (SAF) has been previously identified, however, little is known about its cytotoxic activity and related cytotoxic mechanism. The aim of this study was to evaluate the cytotoxic activity of SAF isolated from a deep sea originated fungus Penicillium sp. F11 in HL60 ce...

journal_title：Oncology reports

authors： Li N,Yi Z,Wang Y,Zhang Q,Zhong T,Qiu Y,Wu Z,Tang X

更新日期：2012-12-01 00:00:00

abstract：:B-cell-specific Moloney murine leukemia virus insertion site 1 (Bmi1) is directly involved in cell growth, proliferation and self-renewal of cancer stem cells (CSCs). The aim of the present study was to assess the role of Bmi1 in the maintenance of stemness properties and tumorigenicity of human bladder CSC-like side ...

journal_title：Oncology reports

authors： Zhu D,Wan X,Huang H,Chen X,Liang W,Zhao F,Lin T,Han J,Xie W

更新日期：2014-02-01 00:00:00

abstract：:The aim of this study is to assess, in squamous cell carcinoma of the cervix, the expression of pan-ras, c-myc and tp53 at protein level using an immunohistochemical (IHC) staining method. One hundred and seven patients with squamous cell carcinoma of the cervix were recruited. Fifty-four patients were of stage 1B/2A ...

journal_title：Oncology reports

authors： Ngan HY,Cheung AN,Liu SS,Cheng DK,Ng TY,Wong LC

更新日期：2001-05-01 00:00:00

abstract：:A growing body of evidence suggests that microRNA-365 (miR-365) played crucial role in the initiation and development of many types of cancers. However, the biological role of miR-365 in human glioma remains unclear. Herein, the aims of this study were to investigate the role and underlying mechanisms of miR-365 in gl...

journal_title：Oncology reports

authors： Zhu Y,Zhao H,Rao M,Xu S

更新日期：2017-04-01 00:00:00

abstract：:Tongue cancer is one of the most common types of cancer, but its molecular etiology and pathogenesis remain unclear. The aim of the present study was to elucidate the pathogenesis of tongue cancer and investigate novel potential diagnostic and therapeutic targets. Four matched pairs of tongue cancer and paracancerous ...

journal_title：Oncology reports

authors： Tang M,Dai W,Wu H,Xu X,Jiang B,Wei Y,Qian H,Han L

更新日期：2020-06-01 00:00:00

abstract：:Ginsenoside is known to have potential cancer-preventive activities. The major active components in red ginseng consist of a variety of ginsenosides including Rg3, Rg5 and Rk1, each of which has different pharmacological activities. Among these, Rg3 has been reported to exert anticancer activities through inhibition o...

journal_title：Oncology reports

authors： Choi YJ,Lee HJ,Kang DW,Han IH,Choi BK,Cho WH

更新日期：2013-09-01 00:00:00

abstract：:The aim of the present study was to search for an effective regimen among existing chemotherapies for head and neck squamous cell carcinoma (HNSCC). Among the tested drugs, we focused on combined SN-38, which is the active metabolite produced from irinotecan hydrochloride - a type I DNA topoisomerase inhibitor - after...

journal_title：Oncology reports

authors： Nanbu T,Umemura N,Ohkoshi E,Nanbu K,Sakagami H,Shimada J

更新日期：2018-01-01 00:00:00

abstract：:We evaluated the efficacy of anti-human VEGF antibody (bevacizumab) with or without irinotecan (CPT-11) against lung metastases in which neovascularization was already induced, as a postoperative adjuvant therapy using orthotopically implanted colon cancer in rat. The high VEGF productive KM12SM human colon cancer cel...

journal_title：Oncology reports

authors： Mizobe T,Ogata Y,Murakami H,Akagi Y,Ishibashi N,Mori S,Sasatomi T,Shirouzu K

更新日期：2008-09-01 00:00:00

abstract：:To investigate the antitumor action of arsenic trioxide (As2O3) by intratumoral injection into solid tumors, tumor growth inhibition (TGI) and angiogenesis of heterotransplanted esophageal carcinoma in mice was carried out. The cultured human esophageal carcinoma cells were inoculated into both laterals of the abdomin...

journal_title：Oncology reports

authors： Shen ZY,Shen J,Chen MH,Wu XY,Wu MH,Zeng Y

更新日期：2003-11-01 00:00:00

abstract：:The aim of this study was to better understand the mechanisms of tumor development and disease progression in human epithelial ovarian cancer. Fifty genes were screened for gene signature; 20 expressed genes were assessed in tumor and normal samples of EOC patients by RT-PCR. Expres...

journal_title：Oncology reports

authors： Guo Y,Fu P,Zhu H,Reed E,Remick SC,Petros W,Mueller MD,Yu JJ

更新日期：2012-01-01 00:00:00

abstract：:Dysregulated metabolism is an emerging hallmark of cancer development, and upregulated lipid synthesis is one of the important tumor metabolic features. However, lipolysis may also contribute to cancer pathogenesis by altering free fatty acid (FFA) metabolism. In the present study, we investigated the importance of th...

journal_title：Oncology reports

authors： Hung YH,Chan YS,Chang YS,Lee KT,Hsu HP,Yen MC,Chen WC,Wang CY,Lai MD

更新日期：2014-06-01 00:00:00

abstract：:In breast cancer, neuregulin-1 (NRG1) is known as a ligand for the HER3 receptor, which has no intrinsic tyrosine kinase activity. When activated by NRG1 binding, the HER3 receptor forms a heterodimer with other HER family receptors and mediates downstream signaling pathways, leading to multiple effects including grow...

journal_title：Oncology reports

authors： Jeong H,Kim J,Lee Y,Seo JH,Hong SR,Kim A

更新日期：2014-09-01 00:00:00

abstract：:The present study aimed to investigate the effects of cold atmospheric plasma (CAP)‑activated Ringer's solution on osteosarcoma cell lines MG63 and U2OS, and to identify the molecular mechanism underlying these effects. CAP‑activated Ringer's solution was used to treat osteosarcoma cell lines MG63 and U2OS for 30 min....

journal_title：Oncology reports

authors： Xu S,Wang Y,Que Y,Ma C,Cai S,Wang H,Yang X,Yang C,Cheng C,Zhao G,Hu Y

更新日期：2020-05-01 00:00:00

abstract：:The components of the Wnt-signaling pathway are mutated in tumors, but the relationship between these components and cervical cancer has not been elucidated. In this study, we used immunohistochemistry, single strand confirmation polymorphism (SSCP) and direct sequencing methods to analyze the mutation and protein exp...

journal_title：Oncology reports

authors： Su TH,Chang JG,Yeh KT,Lin TH,Lee TP,Chen JC,Lin CC

更新日期：2003-09-01 00:00:00