Fatty acid metabolic enzyme acyl-CoA thioesterase 8 promotes the development of hepatocellular carcinoma.

abstract：:To determine whether immunohistochemistry can identify BRCA1 mutations, immunohistochemical (IH) analysis was undertaken on paraffin sections of paired ovarian cancer and normal tissue using antibodies against both terminal regions of the BRCA1 protein. Ten patients at risk for BRCA1 mutations were studied. The result...

journal_title：Oncology reports

authors： Byrne TJ,Reece MT,Adams LA,Lane MA,Cohn GM

更新日期：2000-09-01 00:00:00

abstract：:MA128, a novel herbal medicine, was previously identified and its effectiveness in the treatment of asthma and atopic dermatitis (AD) was demonstrated. In particular, post-inflammatory hyperpigmentation (PIH) in AD mice was improved by treatment with MA128. In addition, MA128 exhibited anti-melanogenic activity by inh...

journal_title：Oncology reports

authors： Kim A,Im M,Yim NH,Hwang YH,Yang HJ,Ma JY

更新日期：2015-08-01 00:00:00

abstract：:Triple-negative breast cancer is a highly aggressive type of mammalian carcinoma. It is defined by a rather weak expression of estrogen-, progesterone- and Her2-receptor, and is thus difficult to treat, resulting in low disease-free and overall survival rates of the affected patients. Hence it is important to find new...

journal_title：Oncology reports

authors： Andergassen U,Kölbl AC,Mumm JN,Mahner S,Jeschke U

更新日期：2017-05-01 00:00:00

abstract：:We radiographically evaluated the response of primary lesions to chemotherapy in 101 patients with inoperable advanced gastric cancer. The median survival time in the 50 responders (49.5%) was 379 days, as compared with only 210 days in the 51 non-responders (50.1%) (p<0. 001). Morphologic changes of the gastric mucos...

journal_title：Oncology reports

authors： Yamazaki I,Koizumi W,Kondo I,Saigenji K

更新日期：2000-11-01 00:00:00

abstract：:Chemokine (C-C motif) ligand 2 (CCL2) has been shown to play an important role in the regulation of tumor cell growth, metastasis and host immune response. CCL2 preferentially binds to the C-C chemokine receptor type 2 (CCR2), which is expressed in various tissues. However, the role of the CCL2/CCR2 axis in hepatocell...

journal_title：Oncology reports

authors： Zhuang H,Cao G,Kou C,Liu T

更新日期：2018-01-01 00:00:00

abstract：:Juvenile myelomonocytic leukemia (JMML) is a rare but severe primary hemopoietic system tumor of childhood, most frequent in children 4 years and younger. There are currently no specific anticancer therapies targeting JMML, and the underlying gene expression changes have not been revealed. To define molecular targets ...

journal_title：Oncology reports

authors： Zhao W,Wang L,Yu Y

更新日期：2018-12-01 00:00:00

abstract：:Immune responses are frequently depressed in patients with cancer. One of the reasons for a poor immune response is the presence of increased levels of immunosuppressive substances associated with tumor growth. Transforming growth factor-beta (TGF-beta), a representative immunosuppressive cytokine, plays various roles...

journal_title：Oncology reports

authors： Yamamoto Y,Ueda Y,Itoh T,Iwamoto A,Yamagishi H,Shimagaki M,Teramoto K

更新日期：2006-12-01 00:00:00

abstract：:Agaricus blazei is well known as a traditional medicinal mushroom and it has been shown to exhibit immunostimulatory and anti-cancer activity. However, the cellular and molecular mechanism of cell cycle arrest and apoptosis of cancer cells is poorly understood. In this study, we have investigated whether A. blazei ext...

journal_title：Oncology reports

authors： Jin CY,Choi YH,Moon DO,Park C,Park YM,Jeong SC,Heo MS,Lee TH,Lee JD,Kim GY

更新日期：2006-12-01 00:00:00

abstract：:Burkitt's lymphoma (BL) is a fast growing cancer of the human lymphatic system, and an extremely invasive B-cell non-Hodgkin's lymphoma. We explored the mechanism of apoptosis in Raji cells associated with the post-transcriptional regulation factors. To confirm that the predicted microRNA-520a (miR-520a) is matched wi...

journal_title：Oncology reports

authors： Wang X,Wang P,Zhu Y,Zhang Z,Zhang J,Wang H

更新日期：2016-09-01 00:00:00

abstract：:miR-367 is one of the most abundant miRNAs in human embryonic stem cells (hESCs) and is mainly involved in maintaining the pluripotency of stem cells. However, its role in cancer development remains poorly understood. In the present study, we explored the function and mechanism of the endogenous miR-367 in non-small c...

journal_title：Oncology reports

authors： Xiao G,Gao X,Sun X,Yang C,Zhang B,Sun R,Huang G,Li X,Liu J,Du N,Liu D,Liang R,Ren H,Qin S

更新日期：2017-08-01 00:00:00

abstract：:Adenoid cystic carcinoma (ACC) is a generally slow-growing but highly malignant salivary gland neoplasm with remarkable capacities for local invasion and lung metastasis. The precise characteristics of ACC are not fully understood because there was no suitable animal model. We have successfully established a new human...

journal_title：Oncology reports

authors： Hashitani S,Urade M,Zushi Y,Segawa E,Okui S,Sakurai K

更新日期：2007-01-01 00:00:00

abstract：:Eukaryotic elongation factor 2 (eEF2) is an essential factor for protein synthesis. Previous studies have shown that the eEF2 gene was overexpressed and plays an oncogenic role in various types of cancers and that eEF2 gene product elicited both humoral immune responses to produce eEF2-specific IgG autoantibody in can...

journal_title：Oncology reports

authors： Nakajima H,Murakami Y,Morii E,Akao T,Tatsumi N,Odajima S,Fukuda M,Machitani T,Iwai M,Kawata S,Hojo N,Oka Y,Sugiyama H,Oji Y

更新日期：2016-04-01 00:00:00

abstract：:Androgen receptor (AR) expression in prostate cancer (CaP) cells varies due to the multiple changes including epigenetic modifications such as DNA methylation and histone deacetylation. DNA methyltransferase and histone deacetylase inhibitors are promising for the treatment of CaP. The aim of our study was to analyze ...

journal_title：Oncology reports

authors： Fialova B,Smesny Trtkova K,Paskova L,Langova K,Kolar Z

更新日期：2013-05-01 00:00:00

abstract：:Matrine is a traditional Chinese herbal medicine that shows antitumor efficacy for many types of cancer. The present study evaluated the antitumor efficacy of matrine on cervical cancer and to investigate the underlying mechanisms. We performed MTT assays, and in vitro invasion and migration assays, and P1 L6 found th...

journal_title：Oncology reports

authors： Wu X,Zhou J,Cai D,Li M

更新日期：2017-08-01 00:00:00

abstract：:Epithelial to mesenchymal transition (EMT) is a process implicated in cancer progression in which the underlying cellular changes have been identified mainly using in vitro models. We determined the expression of some putative EMT biomarkers including E-cadherin, beta-catenin, zinc finger factor Snail (Snail), transfo...

journal_title：Oncology reports

authors： Logullo AF,Nonogaki S,Pasini FS,Osório CA,Soares FA,Brentani MM

更新日期：2010-02-01 00:00:00

abstract：:The phosphatase and tensin homolog (PTEN) gene, an important tumor-suppressor gene, has been demonstrated to have the potential for inhibiting proliferation, migration and invasion in various types of cancer cells. The aim of the present study was to investigate the effect of PTEN expression on osteosarcoma (OS) cells...

journal_title：Oncology reports

authors： Hu Y,Xu S,Jin W,Yi Q,Wei W

更新日期：2014-10-01 00:00:00

abstract：:The protein p27/kip1 is a cyclin-dependent kinase inhibitor that regulates cell-cycle progression. In the present study, p27/kip1 expression as well as tumor cell proliferation and apoptosis were investigated in 80 colorectal carcinomas, using anti-p27/kip1 antibodies, in situ apoptosis detection kits and anti-PCNA an...

journal_title：Oncology reports

authors： Noguchi T,Kikuchi R,Ono K,Takeno S,Moriyama H,Uchida Y

更新日期：2003-07-01 00:00:00

abstract：:Gentian violet (GV) is a cationic triphenylmethane dye, with potent antifungal and antibacterial activity. We recently reported that in vitro GV suppresses the differentiation of bone resorbing osteoclasts while stimulating the differentiation and activity of bone forming osteoblasts. Breast cancer is highly metastati...

journal_title：Oncology reports

authors： Yamaguchi M,Vikulina T,Weitzmann MN

更新日期：2015-10-01 00:00:00

abstract：:Long non‑coding RNAs (lncRNAs) can act as carcinogenic or cancer suppressive factors during the pathogenesis, invasion and metastasis of non‑small cell lung cancer (NSCLC). The current study explored the role of long intergenic non‑protein coding RNA 00887 (LINC00887) and competing endogenous RNAs (ceRNAs). It was rev...

journal_title：Oncology reports

authors： Tian Y,Yu M,Sun L,Liu L,Huo S,Shang W,Sheng S,Wang J,Sun J,Hu Q,Dou Y,Zhu J,Ren X,Yang S

更新日期：2019-09-01 00:00:00

abstract：:Pien Tze Huang (PZH) is a well-known traditional Chinese formula that was first prescribed by a royal physician in the Ming Dynasty. PZH has been used to treat various types of cancers including osteosarcoma. Previous studies have shown that PZH may effectively inhibit osteosarcoma cell growth in vivo and in vitro via...

journal_title：Oncology reports

authors： Zhang Y,Wang Q,Niu S,Liu J,Zhang L

更新日期：2014-02-01 00:00:00

abstract：:Neuroblastoma is an aggressive pediatric tumor that accounts for 15% of cancer-related deaths in children. More than half of high-risk neuroblastoma patients develop tumor relapse that is lethal in most cases. A small population of tumor-initiating cells (TICs), recently identified from high-risk neuroblastoma patient...

journal_title：Oncology reports

authors： Pham TV,Hartomo TB,Lee MJ,Hasegawa D,Ishida T,Kawasaki K,Kosaka Y,Yamamoto T,Morikawa S,Yamamoto N,Kubokawa I,Mori T,Yanai T,Hayakawa A,Takeshima Y,Iijima K,Matsuo M,Nishio H,Nishimura N

更新日期：2012-06-01 00:00:00

abstract：:It has been reported that granulocyte-colony stimulating factor (G-CSF) and granulocyte-macrophage-colony stimulating factor (GM-CSF) can mobilize endothelial progenitor cells (EPCs) in bone marrow cells (BMCs) into peripheral blood (PB) in vivo. Previously, we also reported that macrophage-colony stimulating factor (...

journal_title：Oncology reports

authors： Zhang Y,Adachi Y,Iwasaki M,Minamino K,Suzuki Y,Nakano K,Koike Y,Mukaide H,Shigematsu A,Kiriyama N,Li C,Ikehara S

更新日期：2006-06-01 00:00:00

abstract：:CD147, a multifunction glycoprotein of the immuno-globulin family, is associated with many types of tumors, and the overexpression of CD147 can enhance malignancy. However, the role of CD147 in cervical cancer remains unclear. In the present study, cervical cancer cells were found to express much more CD147 protein an...

journal_title：Oncology reports

authors： Wu Y,Zhou X,Zheng PS

更新日期：2011-09-01 00:00:00

abstract：:Oxymatrine, a traditional Chinese herb extracted from Sophora flavescens Ait., displays strong anti-inflammatory and anticancer activities, but how oxymatrine exhibits anticarcinogenic effects in human colorectal cancer (CRC) remains uncertain. The present study aimed to elucidate the exact mechanism by which oxymatri...

journal_title：Oncology reports

authors： Liang L,Huang J

更新日期：2016-09-01 00:00:00

abstract：:Cell cycle control is a promising target in cancer treatments, and some small-molecule cyclin-dependent kinase (CDK) inhibitors have exhibited clinical effectiveness. However, no biomarkers predictive of efficacy have been developed. Recent studies have revealed that CDK inhibitor (CKI) proteins, such as p27 and p16, ...

journal_title：Oncology reports

authors： Okada Y,Kato S,Sakamoto Y,Oishi T,Ishioka C

更新日期：2017-07-01 00:00:00

abstract：:Histamine receptor H3 (HRH3) is mainly expressed in the central nervous system, where it is involved in the regulation of the release of various neurotransmitters in the brain. Recent studies have demonstrated that the expression of HRH3 is upregulated in several types of cancer. However, the functional effect of HRH3...

journal_title：Oncology reports

authors： Yu D,Zhao J,Wang Y,Hu J,Zhao Q,Li J,Zhu J

更新日期：2019-06-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is highly resistant to chemotherapy, leading to a poor prognosis of advanced disease. Inhibitors of histone deacetylase (HDACi) induce re-differentiation in tumor cells and thereby re-establish sensitivity towards apoptotic stimuli. HDACi are entering the clinical stage of tumor treatmen...

journal_title：Oncology reports

authors： Schuchmann M,Schulze-Bergkamen H,Fleischer B,Schattenberg JM,Siebler J,Weinmann A,Teufel A,Wörns M,Fischer T,Strand S,Lohse AW,Galle PR

更新日期：2006-01-01 00:00:00

abstract：:The t(8;21) translocation is one of the most frequent chromosome abnormalities associated with acute myeloid leukaemia (AML). This abberation deregulates numerous molecular pathways including the ERK signalling pathway among others. Therefore, the aim of the present study was to investigate the gene expression pattern...

journal_title：Oncology reports

authors： Bashanfer SAA,Saleem M,Heidenreich O,Moses EJ,Yusoff NM

更新日期：2019-03-01 00:00:00

abstract：:We have recently noticed an accidental error in part of a figure which appeared in the above‑mentioned article. In Fig. 3A, the image for the HGC27‑pEF, 15 h panel was mistakenly replicated as the HGC27‑KD, 0 h panel in the same figure, and the AGS‑pEF, 15 h and AGS KD, 0 h panels were mistakenly switched with each ot...

journal_title：Oncology reports

authors： Gao XY,Li L,Wang XH,Wen XZ,Ji K,Ye L,Cai J,Jiang WG,Ji JF

更新日期：2018-04-01 00:00:00

abstract：:Mice are particularly susceptible to carcinogens when exposure starts early in life. We evaluated the expression of stem cell antigen-1 (Sca-1) gene in the lung of variously aged CD-1 mice, either untreated or exposed to environmental cigarette smoke (ECS) and/or to a light source. Sca-1 expression progressively decre...

journal_title：Oncology reports

authors： Izzotti A,D'Agostini F,Larghero P,Cartiglia C,Travaini G,Balansky R,Steele VE,De Flora S

更新日期：2009-09-01 00:00:00