Abstract:
:Long non‑coding RNAs (lncRNAs) can act as carcinogenic or cancer suppressive factors during the pathogenesis, invasion and metastasis of non‑small cell lung cancer (NSCLC). The current study explored the role of long intergenic non‑protein coding RNA 00887 (LINC00887) and competing endogenous RNAs (ceRNAs). It was revealed that LINC00887 interacts with several microRNAs (miRs), which regulates downstream genes such as fibronectin 1, MET proto‑oncogene, receptor tyrosine kinase and mothers against decapentaplegic homolog 4, which are associated with the spread of lung cancer. The experimental results also suggested that LINC00887 can stimulate miR‑613, miR‑206 and miR‑1‑2 to become competing endogenous RNAs, which may regulate the epithelial‑mesenchymal transition of NSCLC cells through the transforming growth factor‑â signal transduction pathway, and therefore promote the migration of cells and the acquisition of stem cell characteristics. Therefore, it can be concluded that high levels of LINC00887 can accelerate the malignant transformation ability of NSCLC cells.
journal_name
Oncol Repjournal_title
Oncology reportsauthors
Tian Y,Yu M,Sun L,Liu L,Huo S,Shang W,Sheng S,Wang J,Sun J,Hu Q,Dou Y,Zhu J,Ren X,Yang Sdoi
10.3892/or.2019.7228subject
Has Abstractpub_date
2019-09-01 00:00:00pages
1173-1182issue
3eissn
1021-335Xissn
1791-2431journal_volume
42pub_type
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