Gene module analysis of juvenile myelomonocytic leukemia and screening of anticancer drugs.


:Juvenile myelomonocytic leukemia (JMML) is a rare but severe primary hemopoietic system tumor of childhood, most frequent in children 4 years and younger. There are currently no specific anticancer therapies targeting JMML, and the underlying gene expression changes have not been revealed. To define molecular targets and possible biomarkers for early diagnosis, optimal treatment, and prognosis, we conducted microarray data analysis using the Gene Expression Omnibus, and constructed protein‑protein interaction networks of all differentially expressed genes. Modular bioinformatics analysis revealed four core functional modules for JMML. We analyzed the Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway functions associated with these modules. Using the CMap database, nine potential anticancer drugs were identified that modulate expression levels of many JMML‑associated genes. In addition, we identified possible miRNAs and transcription factors regulating these differentially expressed genes. This study defines a new research strategy for developing JMML‑targeted chemotherapies.


Oncol Rep


Oncology reports


Zhao W,Wang L,Yu Y




Has Abstract


2018-12-01 00:00:00












  • Characteristics of normal stromal components and their correlation with cancer occurrence in human prostate.

    abstract::Prostate cancer is one of the most common age-related malignancies. The occurrence frequency of prostate cancer is very different according to prostate zones. The prostate stroma is an important element in growth and differentiation of the normal prostate and also has a close relationship to the occurrence of benign p...

    journal_title:Oncology reports

    pub_type: 杂志文章


    authors: Zhang Y,Nojima S,Nakayama H,Jin Y,Enza H

    更新日期:2003-01-01 00:00:00

  • Analysis of T-helper type 1 and 2 cells and T-cytotoxic type 1 and 2 cells of sentinel lymph nodes in breast cancer.

    abstract::The immune suppression of sentinel lymph node (SN) is directly influenced by primary tumors. It has been reported that the T-helper type 1 (Th1) to T-helper type 2 (Th2) ratio or T-cytotoxic type 1 (Tc1) to T-cytotoxic type 2 (Tc2) ratio of lymph node lymphocytes could be used to evaluate direct immunological circumst...

    journal_title:Oncology reports

    pub_type: 杂志文章


    authors: Ehi K,Ishigami S,Masamoto I,Uenosono Y,Natsugoe S,Arigami T,Arima H,Kijima Y,Yoshinaka H,Yanagita S,Kozono T,Funasako Y,Maruyama I,Aikou T

    更新日期:2008-03-01 00:00:00

  • Abnormal expression of pan-ras, c-myc and tp53 in squamous cell carcinoma of cervix: correlation with HPV and prognosis.

    abstract::The aim of this study is to assess, in squamous cell carcinoma of the cervix, the expression of pan-ras, c-myc and tp53 at protein level using an immunohistochemical (IHC) staining method. One hundred and seven patients with squamous cell carcinoma of the cervix were recruited. Fifty-four patients were of stage 1B/2A ...

    journal_title:Oncology reports

    pub_type: 杂志文章


    authors: Ngan HY,Cheung AN,Liu SS,Cheng DK,Ng TY,Wong LC

    更新日期:2001-05-01 00:00:00

  • Mangiferin induces radiosensitization in glioblastoma cells by inhibiting nonhomologous end joining.

    abstract::Although surgery and high‑dose radiotherapy have been the standard treatments for glioblastoma multiforme (GBM), these therapies are palliative, due to the high risk of local relapse. Emerging evidence has demonstrated that DNA double‑strand break (DSB) repair serves a critical role in resistance to radiotherapy. Prev...

    journal_title:Oncology reports

    pub_type: 杂志文章


    authors: Mu F,Liu T,Zheng H,Xie X,Lei T,He X,Du S,Tong R,Wang Y

    更新日期:2018-12-01 00:00:00

  • Expression of circular RNA CDR1‑AS in colon cancer cells increases cell surface PD‑L1 protein levels.

    abstract::The expression of CDR1‑AS, a representative circular RNA, is closely linked with poor prognosis in gastrointestinal cancers, such as colon, liver, and pancreatic cancers. Although it is well known that CDR1‑AS antagonizes microRNA‑7 function through its sequence similarities in the brain, its biological function and l...

    journal_title:Oncology reports

    pub_type: 杂志文章


    authors: Tanaka E,Miyakawa Y,Kishikawa T,Seimiya T,Iwata T,Funato K,Odawara N,Sekiba K,Yamagami M,Suzuki T,Ishibashi R,Otsuka M,Koike K

    更新日期:2019-10-01 00:00:00

  • Nicotine enhances store‑operated calcium entry by upregulating HIF‑1α and SOCC components in non‑small cell lung cancer cells.

    abstract::Store‑operated calcium entry (SOCE) is critical for regulating the proliferation and metastasis of various cancer types. The present study aimed to investigate the role of SOCE on nicotine‑promoted proliferation of non‑small cell lung cancer (NSCLC) A549 cells. Cell proliferation was evaluated by BrdU incorporation as...

    journal_title:Oncology reports

    pub_type: 杂志文章


    authors: Wang Y,He J,Jiang H,Zhang Q,Yang H,Xu X,Zhang C,Xu C,Wang J,Lu W

    更新日期:2018-10-01 00:00:00

  • Association of FOSB exon 4 unmethylation with poor prognosis in patients with late‑stage non‑small cell lung cancer.

    abstract::Alterations in DNA methylation have a central role in the development and outcome of most human malignancies. Non‑small cell lung cancer (NSCLC), the most common lung cancer, leads to the largest number of cancer‑related deaths worldwide. FBJ murine osteosarcoma viral oncogene homolog B (FOSB) is a key component of th...

    journal_title:Oncology reports

    pub_type: 杂志文章


    authors: Kim DS,Lee WK,Park JY

    更新日期:2020-02-01 00:00:00

  • Hydrogen gas restores exhausted CD8+ T cells in patients with advanced colorectal cancer to improve prognosis.

    abstract::Exhausted cluster of differentiation (CD)8+ T cells lose immunological activity due to mitochondrial dysfunction caused by peroxisome proliferator‑activated receptor γ coactivator 1α (PGC‑1α) inactivation, resulting in a poor prognosis in patients with cancer. As hydrogen gas was recently reported to activate PGC‑1α, ...

    journal_title:Oncology reports

    pub_type: 杂志文章,随机对照试验


    authors: Akagi J,Baba H

    更新日期:2019-01-01 00:00:00

  • Licochalcone A suppresses hexokinase 2-mediated tumor glycolysis in gastric cancer via downregulation of the Akt signaling pathway.

    abstract::Licochalcone A (LicA) is a chalcone extracted from liquorice which has been used as a traditional Chinese medicine for many generations. Increased glucose consumption and glycolytic activity are important hallmarks of cancer cells, and hexokinase 2 (HK2) upregulation is a major contributor to the elevation of glycolys...

    journal_title:Oncology reports

    pub_type: 杂志文章


    authors: Wu J,Zhang X,Wang Y,Sun Q,Chen M,Liu S,Zou X

    更新日期:2018-03-01 00:00:00

  • miR-194 is a negative regulator of GEF-H1 pathway in melanoma.

    abstract::The incidence and associated mortality of melanoma continues to increase worldwide. At present, there is no curative therapy for advanced stage of melanoma. It is necessary to find new indicators of prognosis and therapeutic targets. Increasing evidence shows that miRNA can provide potential candidate biomarkers for m...

    journal_title:Oncology reports

    pub_type: 杂志文章


    authors: Guo B,Hui Q,Zhang Y,Chang P,Tao K

    更新日期:2016-10-01 00:00:00

  • Cellular processing in the SW1222 cell line of mAb A33 directly and indirectly radiohalogenated.

    abstract::Investigations into the cellular processing of radiolabeled monoclonal antibodies (mAbs) for their further use in radioimmunodiagnosis and cancer therapy are needed in order to understand the fate of internalized and catabolized mAbs. The anti-colorectal cancer mAb, A33, was labelled with 76Br and 125I using the direc...

    journal_title:Oncology reports

    pub_type: 杂志文章


    authors: Höglund J,Orlova A,Sundin A,Lundqvist H,Tolmachev V

    更新日期:2006-07-01 00:00:00

  • Arginine 482 to glycine mutation in ABCG2/BCRP increases etoposide transport and resistance to the drug in HEK-293 cells.

    abstract::Resistance to etoposide has been associated with the overexpression of P-glycoprotein and MRP1 in human tumor cells. However, the role of BCRP in resistance to etoposide has not been clearly established, especially the significance of arginine 482 mutations in drug transport (cellul...

    journal_title:Oncology reports

    pub_type: 杂志文章


    authors: Eddabra L,Wenner T,El Btaouri H,Baranek T,Madoulet C,Cornillet-Lefebvre P,Morjani H

    更新日期:2012-01-01 00:00:00

  • Microarray analysis reveals differentially expressed lncRNAs in benign epithelial ovarian cysts and normal ovaries.

    abstract::Recent studies suggest that long non-coding RNAs (lncRNAs) play crucial roles in many types of human malignant cancers. However, the function of lncRNAs in benign tumors remains poorly understood. In the present study, to explored the potential roles of lncRNAs in benign epithelial ovarian cysts (BEOCs) which commonly...

    journal_title:Oncology reports

    pub_type: 杂志文章


    authors: Liu X,Dai C,Jia G,Xu S,Fu Z,Xu J,Li Q,Ruan H,Xu P

    更新日期:2017-08-01 00:00:00

  • Synergistic effects of eukaryotic co-expression plasmid-based STAT3-specific siRNA and LKB1 on ovarian cancer in vitro and in vivo.

    abstract::The signal transducer and activator of transcription 3 (STAT3) are ideal targets for ovarian cancer. Previous studies showed that downregulation of STAT3 using specific short hairpin RNAs (shRNA) can significantly reduce ovarian tumor growth. However, RNA interference does not fully ablate target gene expression due t...

    journal_title:Oncology reports

    pub_type: 杂志文章


    authors: Pan Y,Zhang L,Zhang X,Liu R

    更新日期:2015-02-01 00:00:00

  • Association between exposure-relevant polymorphisms in CYP1B1, EPHX1, NQO1, GSTM1, GSTP1 and GSTT1 and risk of colorectal cancer in a Czech population.

    abstract::Associations of functional single nucleotide polymorphisms in cytochrome P450 1B1, epoxide hydrolase 1, NAD(P)H:quinone oxidoreductase 1, glutathione S-transferase Pi-1 and deletions of glutathione S-transferases Mu-1 and θ-1 with colorectal cancer risk were investigated in a hospital-based case-control study on 495 m...

    journal_title:Oncology reports

    pub_type: 杂志文章


    authors: Hlavata I,Vrana D,Smerhovsky Z,Pardini B,Naccarati A,Vodicka P,Novotny J,Mohelnikova-Duchonova B,Soucek P

    更新日期:2010-11-01 00:00:00

  • Silencing of argininosuccinate lyase inhibits colorectal cancer formation.

    abstract::Arginine and nitric oxide (NO) are important mediators of tumorigenesis in various types of cancer. Dysregulation of NO content by argininosuccinate lyase (ASL) has been previously demonstrated to inhibit the proliferation of liver and breast cancer cells. However, the function of ASL in colon cancer is not well defin...

    journal_title:Oncology reports

    pub_type: 杂志文章


    authors: Huang HL,Chen WC,Hsu HP,Cho CY,Hung YH,Wang CY,Lai MD

    更新日期:2017-01-01 00:00:00

  • Downregulation of survivin expression and elevation of caspase-3 activity involved in pitavastatin-induced HepG 2 cell apoptosis.

    abstract::The aim of the present study was to research the apoptosis of human hepatocellular carcinoma cell line HepG 2 induced by pitavastatin. HepG 2 cells were treated with increasing doses of pitavastatin or with mevalonic acid for 48 h. The proliferation of cells was detected with WST-8. The morphology of the nucleus was o...

    journal_title:Oncology reports

    pub_type: 杂志文章


    authors: Wang J,Xu Z,Zhang M

    更新日期:2007-08-01 00:00:00

  • Protein-bound polysaccharide-K reduces the proportion of regulatory T cells in vitro and in vivo.

    abstract::Regulatory T cells (Tregs) play an important role in maintaining immunological tolerance. However, this mechanism is one of the major obstacles to overcome when attempting to improve antitumor immunity. Protein-bound polysaccharide‑K (PSK) has been used clinically as an antitumor drug, and one of its antitumor mechani...

    journal_title:Oncology reports

    pub_type: 杂志文章


    authors: Aoki R,Iijima H,Kato M,Uchida M,Wada T,Murata M,Ogawa K,Naritaka Y,Yoshimatsu K

    更新日期:2014-01-01 00:00:00

  • Aberrant expression of class III beta-tubulin in basal cell carcinoma of the skin.

    abstract::Tubulin is a major component of microtubules. Class III beta-tubulin (beta III) is a neuron-associated beta-tubulin isotype and expressed in the normal central and peripheral nervous systems. According to a previous study, beta III is not expressed in normal skin and squamous cell carcinoma. However, its expression ha...

    journal_title:Oncology reports

    pub_type: 杂志文章


    authors: Ishida M,Kushima R,Okabe H

    更新日期:2009-10-01 00:00:00

  • Expression of retinoid X receptor alpha is decreased in 3'-methyl-4-dimethylaminoazobenzene-induced hepatocellular carcinoma in rats.

    abstract::The identification of the specific molecular targets, which underlie liver carcinogenesis is essential for the establishment of an effective strategy for the prevention and/or treatment of hepatocellular carcinomas (HCCs). We previously found that a malfunction of RXRalpha due to its aberrant phosphorylation was assoc...

    journal_title:Oncology reports

    pub_type: 杂志文章


    authors: Ando N,Shimizu M,Okuno M,Matsushima-Nishiwaki R,Tsurumi H,Tanaka T,Moriwaki H

    更新日期:2007-10-01 00:00:00

  • Actin disruption agents induce phosphorylation of histone H2AX in human breast adenocarcinoma MCF-7 cells.

    abstract::Modified actin dynamics are a unique feature of transformed cancer cells and thereby promising targets for cancer chemotherapy. While latrunculin B (LB) and pectenotoxin-2 (PTX-2), both derived from natural sources, inhibit actin polymerization, jasplakinolide (JSP) prevents actin depolymerization. The purpose of this...

    journal_title:Oncology reports

    pub_type: 杂志文章


    authors: Shin IJ,Ahn YT,Kim Y,Kim JM,An WG

    更新日期:2011-05-01 00:00:00

  • Neuregulin-1 induces cancer stem cell characteristics in breast cancer cell lines.

    abstract::In breast cancer, neuregulin-1 (NRG1) is known as a ligand for the HER3 receptor, which has no intrinsic tyrosine kinase activity. When activated by NRG1 binding, the HER3 receptor forms a heterodimer with other HER family receptors and mediates downstream signaling pathways, leading to multiple effects including grow...

    journal_title:Oncology reports

    pub_type: 杂志文章


    authors: Jeong H,Kim J,Lee Y,Seo JH,Hong SR,Kim A

    更新日期:2014-09-01 00:00:00

  • Nucleosome-binding protein HMGN2 exhibits antitumor activity in human SaO2 and U2-OS osteosarcoma cell lines.

    abstract::High mobility group N (HMGNs) are members of the high mobility group protein family, and are involved in the development and progression of several tumors. HMGN1 and HMGN5 were previously shown to be associated with the bioactivities of osteosarcoma. However, the effects and molecular mechanisms of HMGN2 on osteosarco...

    journal_title:Oncology reports

    pub_type: 杂志文章


    authors: Liang G,Xu E,Yang C,Zhang C,Sheng X,Zhou X

    更新日期:2015-03-01 00:00:00

  • miR-365 targets ADAM10 and suppresses the cell growth and metastasis of hepatocellular carcinoma.

    abstract::Expression of miR-365 has been reported to be downregulated in hepatocellular carcinoma (HCC). However, the biological function and underlying mechanism of miR-365 in HCC growth and metastasis remain unclear. The aim of the present study was to explore the role of miR-365 in HCC progression. We found that miR-365 expr...

    journal_title:Oncology reports

    pub_type: 杂志文章


    authors: Liu Y,Zhang W,Liu S,Liu K,Ji B,Wang Y

    更新日期:2017-03-01 00:00:00

  • Terrein inhibits migration of human breast cancer cells via inhibition of the Rho and Rac signaling pathways.

    abstract::Breast cancer is the most common cancer in women worldwide. Progression and aggressiveness of breast cancer is usually associated with its migration and invasion abilities. Recently, natural products with potential anticancer activity have become attractive candidates for alternative treatment of cancer. A fungal meta...

    journal_title:Oncology reports

    pub_type: 杂志文章


    authors: Kasorn A,Loison F,Kangsamaksin T,Jongrungruangchok S,Ponglikitmongkol M

    更新日期:2018-03-01 00:00:00

  • Expression analysis of the autosomal recessive primary microcephaly genes MCPH1 (microcephalin) and MCPH5 (ASPM, abnormal spindle-like, microcephaly associated) in human malignant gliomas.

    abstract::Patients with autosomal recessive primary microcephaly have a small but architecturally normal brain containing a reduced number of neurons. Microcephalin and ASPM are two of the genes causing this disease. Both are centrosomal proteins involved in cell cycle regulation. Whereas microcephalin is a component of the DNA...

    journal_title:Oncology reports

    pub_type: 杂志文章


    authors: Hagemann C,Anacker J,Gerngras S,Kühnel S,Said HM,Patel R,Kämmerer U,Vordermark D,Roosen K,Vince GH

    更新日期:2008-08-01 00:00:00

  • Mutation analysis of CTNNB1 (beta-catenin) and AXIN1, the components of Wnt pathway, in cervical carcinomas.

    abstract::The components of the Wnt-signaling pathway are mutated in tumors, but the relationship between these components and cervical cancer has not been elucidated. In this study, we used immunohistochemistry, single strand confirmation polymorphism (SSCP) and direct sequencing methods to analyze the mutation and protein exp...

    journal_title:Oncology reports

    pub_type: 杂志文章


    authors: Su TH,Chang JG,Yeh KT,Lin TH,Lee TP,Chen JC,Lin CC

    更新日期:2003-09-01 00:00:00

  • Investigating the relationship between serum thrombopoietin kinetics and the platelet-sparing effect: A clinical pharmacological evaluation of combined paclitaxel and carboplatin in patients with non-small cell lung cancer.

    abstract::We conducted a clinical pharmacological evaluation of paclitaxel/carboplatin combination in Japanese patients with non-small cell lung cancer. The purpose of this study was to identify the optimal dose of this combination and to investigate the relationships between the pharmacokinetic profiles of these 2 drugs, serum...

    journal_title:Oncology reports

    pub_type: 杂志文章


    authors: Daga H,Isobe T,Miyazaki M,Fujitaka K,Kondo K,Kohno N

    更新日期:2004-06-01 00:00:00

  • Cross-validation of genes potentially associated with overall survival and drug resistance in ovarian cancer.

    abstract::Ovarian cancer is the leading cause of death among malignancies of the female reproductive system. The 5-year survival rates of ovarian cancer (OC) patients are very poor as a result of recurrent disease and emergence of drug resistance; thus, studies to find predictive markers and factors for drug resistance are ongo...

    journal_title:Oncology reports

    pub_type: 杂志文章


    authors: Gao Y,Liu X,Li T,Wei L,Yang A,Lu Y,Zhang J,Li L,Wang S,Yin F

    更新日期:2017-05-01 00:00:00

  • Triptolide induced DNA damage in A375.S2 human malignant melanoma cells is mediated via reduction of DNA repair genes.

    abstract::Numerous studies have demonstrated that triptolide induces cell cycle arrest and apoptosis in human cancer cell lines. However, triptolide-induced DNA damage and inhibition of DNA repair gene expression in human skin cancer cells has not previously been reported. We sought the effects of triptolide on DNA damage and a...

    journal_title:Oncology reports

    pub_type: 杂志文章


    authors: Chueh FS,Chen YL,Hsu SC,Yang JS,Hsueh SC,Ji BC,Lu HF,Chung JG

    更新日期:2013-02-01 00:00:00