The chemokine receptor 7 regulates cell adhesion and migration via beta1 integrin in metastatic squamous cell carcinoma of the head and neck.

abstract：:WNT signaling pathway networks with Hedgehog, Notch and FGF signaling pathways during carcinogenesis and embryogenesis. FZD8 is up-regulated in HeLa S3 and A549 cells. Here we identified and characterized rat Fzd8 gene by using bioinformatics. Rat Fzd8 gene was identified within AC131883.2 genome sequence. Rat Fzd8 (6...

journal_title：Oncology reports

authors： Katoh Y,Katoh M

更新日期：2005-05-01 00:00:00

abstract：:EVL belongs to the Ena/VASP (Enabled/vasodilator-stimulated phosphoprotein) family of proteins [Mena (mammalian Ena), VASP and EVL], which have a range of roles in regulating the actin cytoskeleton. Growing evidence suggests that Mena and VASP are involved in carcinogenesis, though little is known about the significan...

journal_title：Oncology reports

authors： Hu LD,Zou HF,Zhan SX,Cao KM

更新日期：2008-04-01 00:00:00

abstract：:Expression of Src homology phosphotyrosine phosphatase 2 (SHP2) has been observed in human breast cancer. SHP2 is known to promote cell migration and invasiveness. However, the pathophysiologic role of SHP2 and its relevance to tumorigenesis are still largely unknown. In the present study, we aimed to evaluate the eff...

journal_title：Oncology reports

authors： Hu Z,Fang H,Wang X,Chen D,Chen Z,Wang S

更新日期：2014-07-01 00:00:00

abstract：:microRNAs (miRNAs), small non-coding RNAs, have emerged as key regulators of a large number of genes. The present study aimed to explore novel biological functions of miR-330 in the human prostate cancer cell lines DU145 and PC3. We confirmed that miR-330 was downregulated and inversely correlated with specificity pro...

journal_title：Oncology reports

authors： Mao Y,Chen H,Lin Y,Xu X,Hu Z,Zhu Y,Wu J,Xu X,Zheng X,Xie L

更新日期：2013-07-01 00:00:00

abstract：:Dendritic cells (DCs) as 'professional' antigen-presenting cells (APCs) initiate and regulate immune responses to various antigens. DC-based vaccines have become a promising modality in cancer immunotherapy. Cytokeratin 19 (CK19) protein is expressed at high levels in lung cancer and many other tumor cells, suggesting...

journal_title：Oncology reports

authors： Sun QF,Zhao XN,Peng CL,Hao YT,Zhao YP,Jiang N,Xue H,Guo JZ,Yun CH,Cong B,Zhao XG

更新日期：2015-11-01 00:00:00

abstract：:Mammary small cell carcinoma (SmCC) is a very rare neoplasm with a poor prognosis compared with other invasive carcinomas. We studied the histological and immunohistochemical profiles of two cases of mammary SmCC, and compared them with those of five cases of carcinoma with endocrine features (CEF) and five cases of i...

journal_title：Oncology reports

authors： Yamamoto J,Ohshima K,Nabeshima K,Ikeda S,Iwasaki H,Kikuchi M

更新日期：2004-04-01 00:00:00

abstract：:Forkhead box F2 transcription factor (FoxF2) has been described to promote organ development, extracellular matrix (ECM) synthesis and epithelial-mesenchymal interaction. Although recent studies reported decreased FoxF2 expression in several types of cancers, indicating its potential role in carcinogenesis, the mechan...

journal_title：Oncology reports

authors： Zhang Y,Wang X,Wang Z,Tang H,Fan H,Guo Q

更新日期：2015-05-01 00:00:00

abstract：:MicroRNAs (miRNAs), as gene expression regulators, have been identified to be closely associated with tumorigenesis. Thus a loss-of-function study is more likely to reveal the biological roles of endogenous miRNAs. Genetic knockout, antisense oligonucleotide inhibitors, and miRNA sponge (miR‑SP) are usually performed ...

journal_title：Oncology reports

authors： Ma J,Wu Q,Zhang Y,Li J,Yu Y,Pan Q,Sun F

更新日期：2014-12-01 00:00:00

abstract：:Serenoa repens, a palm species native to the Southeastern United States, is one of the widely used phytotherapeutic agents in benign prostatic hyperplasia. In this study, we found for the first time that Serenoa repens induced growth arrest of a variety of human leukemia cells including U266 and RPMI 8226 multiple mye...

journal_title：Oncology reports

authors： Che Y,Hou S,Kang Z,Lin Q

更新日期：2009-08-01 00:00:00

abstract：:Thymidine kinase-1 (TK-1) and thymidylate synthase (TS) are key enzymes for salvage and de novo pyrimidine synthesis, respectively. Numerous studies have suggested that increased TS levels are associated closely with resistance to fluoropyrimidine-based chemotherapy. TAS-102 is a novel drug containing trifluorothymidi...

journal_title：Oncology reports

authors： Shintani M,Urano M,Takakuwa Y,Kuroda M,Kamoshida S

更新日期：2010-05-01 00:00:00

abstract：:Metastasis is the main cause of death in osteosarcoma. Targeting the process of metastasis is a main strategy for osteosarcoma therapy. As a traditional Chinese medicine, Zanthoxylum nitidum (Roxb) has been applied to treat various diseases, including cancer. However, no evidence has been shown on the anti-metastasis ...

journal_title：Oncology reports

authors： Cheng Z,Guo Y,Yang Y,Kan J,Dai S,Helian M,Li B,Xu J,Liu C

更新日期：2016-08-01 00:00:00

abstract：:The adenovirus vector-based cancer gene therapy is controversial. Low transduction efficacy is believed to be one of the main barriers for the decreased expression of coxsackie and adenovirus receptor (CAR) on tumor cells. However, the expression of CAR on primary tumor tissue and tumor tissue survived from treatment ...

journal_title：Oncology reports

authors： Zhang NH,Peng RQ,Ding Y,Zhang XS

更新日期：2016-08-01 00:00:00

abstract：:Progesterone has a potential protective effect against ovarian carcinoma induced by estrogen. Progesterone is also known to cause apoptosis while tamoxifen induces growth arrest. Therefore, we attempted to determine whether combined treatment with progesterone and tamoxifen has a sy...

journal_title：Oncology reports

authors： Lee JY,Shin JY,Kim HS,Heo JI,Kho YJ,Kang HJ,Park SH,Lee JY

更新日期：2012-01-01 00:00:00

abstract：:Tubulin is a major component of microtubules. Class III beta-tubulin (beta III) is a neuron-associated beta-tubulin isotype and expressed in the normal central and peripheral nervous systems. According to a previous study, beta III is not expressed in normal skin and squamous cell carcinoma. However, its expression ha...

journal_title：Oncology reports

authors： Ishida M,Kushima R,Okabe H

更新日期：2009-10-01 00:00:00

abstract：:Tumor angiogenesis, growth and metastasis are three closely related processes. We therefore explored the effects of (-)-oleocanthal (OC) on the three processes in melanoma and investigated underlying mechanisms. In vitro, OC suppressed proliferation, migration, invasion and induced apoptosis in melanoma cells. In addi...

journal_title：Oncology reports

authors： Gu Y,Wang J,Peng L

更新日期：2017-01-01 00:00:00

abstract：:Temozolomide (TMZ), as a kind of alkylating agent, is widely utilized for the treatment of glioblastoma (GBM). However, temozolomide resistance (TR) often develops quickly and results in tumor recurrence and poor outcome. Recent advances have demonstrated that miRNAs exert critical roles in chemoresistance. Downregula...

journal_title：Oncology reports

authors： Qian Z,Zhou S,Zhou Z,Yang X,Que S,Lan J,Qiu Y,Lin Y

更新日期：2017-11-01 00:00:00

abstract：:In this work we studied the effect of v-raf and different form RAF on up regulation of VEGF gene expression and angiogenesis. In the experiments the truncated forms of RAF1 gene were transfected into the cells of the established human urothelial line HCV-29, otherwise non-angiogenic. The plasmids coding for mitochondr...

journal_title：Oncology reports

authors： Malecki M,Seneta M,Miloszewska J,Trembacz H,Przybyszewska M,Janik P

更新日期：2004-01-01 00:00:00

abstract：:Neuropilin-1 (NRP-1), a co-receptor for VEGF165, is overexpressed in various prostate cancer cell lines and in advanced prostate tumors. However, distribution of the NRP-1 in prostate tumors has not yet been evaluated. Using immunohistochemical analysis, we evaluated 21 archival prostate tumors and 5 benign glands for...

journal_title：Oncology reports

authors： Vanveldhuizen PJ,Zulfiqar M,Banerjee S,Cherian R,Saxena NK,Rabe A,Thrasher JB,Banerjee SK

更新日期：2003-09-01 00:00:00

abstract：:B-cell-specific Moloney murine leukemia virus insertion site 1 (Bmi1) is directly involved in cell growth, proliferation and self-renewal of cancer stem cells (CSCs). The aim of the present study was to assess the role of Bmi1 in the maintenance of stemness properties and tumorigenicity of human bladder CSC-like side ...

journal_title：Oncology reports

authors： Zhu D,Wan X,Huang H,Chen X,Liang W,Zhao F,Lin T,Han J,Xie W

更新日期：2014-02-01 00:00:00

abstract：:Chemotherapeutic drug resistance is correlated with treatment failure and poor prognosis among lung cancer patients. Numerous studies indicate the relevance of miRNAs in inducing certain drug resistance. In the course of the study, we unexpectedly found that miR‑144‑3p could regulate the cisplatin resistance of lung c...

journal_title：Oncology reports

authors： Yin Y,Liu H,Xu J,Shi D,Zhai L,Liu B,Wang L,Liu G,Qin J

更新日期：2018-12-01 00:00:00

abstract：:Non‑small cell lung cancer (NSCLC) is the most common type of lung cancer, and numerous oncogenes are associated with this disease. Oxysterol‑binding protein‑related protein 8 (ORP8) is essential for cell growth, migration and the modulation of mitochondrial respiration and morphology. However, the underlying role of ...

journal_title：Oncology reports

authors： Li J,Cui J,Li Z,Fu X,Li J,Li H,Wang S,Zhang M

更新日期：2020-05-01 00:00:00

abstract：:The overexpression of EGFR and/or HER-2 is associated with tumor cell resistance to chemotherapy, radiotherapy, disease progression and poor prognosis in patients with a variety of malignant tumors. Treatment combining the EGFR-targeting drug, gefitinib (ZD1839, Iressa) with the HER-2-targeting drug, trastuzumab (Herc...

journal_title：Oncology reports

authors： Kondo N,Ishiguro Y,Kimura M,Sano D,Fujita K,Sakakibara A,Taguchi T,Toth G,Matsuda H,Tsukuda M

更新日期：2008-08-01 00:00:00

abstract：:Thrombospondin-1 (TSP1) is known to possess tumor suppressor functions. In contradiction, TSP1 enhances the stromal vascularization and growth of certain cancers. A cell adhesion receptor, CD36, has been shown to interact with a ligand TSP1. We studied how CD36 affects the growth of the osteosarcoma cell line (HOS) ex...

journal_title：Oncology reports

authors： Yamazaki H,Handa A,Nishi M,Tokunaga T,Tomisawa M,Hatanaka H,Abe Y,Kijima H,Ueyama Y,Nakamura M

更新日期：2004-02-01 00:00:00

abstract：:The identification of the specific molecular targets, which underlie liver carcinogenesis is essential for the establishment of an effective strategy for the prevention and/or treatment of hepatocellular carcinomas (HCCs). We previously found that a malfunction of RXRalpha due to its aberrant phosphorylation was assoc...

journal_title：Oncology reports

authors： Ando N,Shimizu M,Okuno M,Matsushima-Nishiwaki R,Tsurumi H,Tanaka T,Moriwaki H

更新日期：2007-10-01 00:00:00

abstract：:Investigations into extracellular vesicles (EVs) have significantly increased since their role in physiological and pathological processes has become more clearly understood. Furthermore, it has become increasingly clear that several subpopulations of EVs exist, such as exosomes (EXOs) and microvesicles (MVs). Various...

journal_title：Oncology reports

authors： Giusti I,Di Francesco M,Cantone L,D'Ascenzo S,Bollati V,Carta G,Dolo V

更新日期：2015-11-01 00:00:00

abstract：:Several investigators have demonstrated that TGF-beta stimulated clone-22 (TSC-22) regulates cell growth and differentiation, and cell death. TSC-22 is a putative transcriptional regulator containing a leucine zipper-like structure and a nuclear export signal. We previously showed the cytoplasmic localization of TSC-2...

journal_title：Oncology reports

authors： Hino S,Kawamata H,Omotehara F,Uchida D,Begum NM,Yoshida H,Sato M,Fujimori T

更新日期：2002-03-01 00:00:00

abstract：:Breast cancer is the most common type of cancer among women worldwide. Research using breast cancer cell lines derived from primary tumors may provide valuable additional knowledge regarding this type of cancer. Therefore, the aim of this study was to investigate the phenotypic prof...

journal_title：Oncology reports

authors： Corrêa NC,Kuasne H,Faria JA,Seixas CC,Santos IG,Abreu FB,Nonogaki S,Rocha RM,Aparecida Borges Silva G,Gobbi H,Rogatto SR,Goes AM,Gomes DA

更新日期：2013-04-01 00:00:00

abstract：:Anti-cytotoxic T lymphocyte antigen-4 (CTLA-4) treatment is effective for the treatment of primary tumors, but not sufficient for the treatment of metastatic tumors, likely owing to the effects of the tumor microenvironment. In this study, we aimed to determine the therapeutic effects of combined treatment with a matr...

journal_title：Oncology reports

authors： Li M,Xing S,Zhang H,Shang S,Li X,Ren B,Li G,Chang X,Li Y,Li W

更新日期：2016-03-01 00:00:00

abstract：:Resolvins, an endogenous lipid mediator derived from eicosapentaenoic acid (EPA) or docosahexaenoic acid (DHA) of fish oil, has been reported to have anti-inflammatory and antitumor effect in various pathogenic processes. However, there are no studies about the effects of resolvin D1 and E1 on concanavalin A-induced h...

journal_title：Oncology reports

authors： Kuang H,Hua X,Zhou J,Yang R

更新日期：2016-01-01 00:00:00

abstract：:To evaluate the efficacy of long-term postoperative adjuvant chemotherapy with low-dose cisplatin (CDDP) plus 5-fluorouracil (5-FU) (CDDP/5-FU), we retrospectively examined 167 patients with squamous cell carcinoma of the esophagus who received the treatment after curative surgery (R0 resection). We classified the pat...

journal_title：Oncology reports

authors： Shiozaki A,Yamagishi H,Itoi H,Fujiwara H,Kikuchi S,Okamoto K,Ichikawa D,Fuji N,Ochiai T,Sonoyama T,Ueda Y

更新日期：2005-04-01 00:00:00