Abstract:
:Anti-cytotoxic T lymphocyte antigen-4 (CTLA-4) treatment is effective for the treatment of primary tumors, but not sufficient for the treatment of metastatic tumors, likely owing to the effects of the tumor microenvironment. In this study, we aimed to determine the therapeutic effects of combined treatment with a matrix metalloproteinase (MMP) inhibitor (MMPI) and anti-CTLA-4 antibody in a breast cancer model in mice. Interestingly, combined treatment with MMPI and anti-CTLA-4 antibody delayed tumor growth and reduced lung and liver metastases compared with anti-CTLA-4 alone or vehicle treatment. The functions of the liver and kidney in mice in the different groups did not differ significantly compared with that in normal mice. The CD8+/CD4+ ratio in T cells in the spleen and tumor were increased after monotherapy or combined anti-CTLA-4 antibody plus MMPI therapy compared with that in vehicle-treated mice. Anti-CTLA-4 antibody plus MMPI therapy reduced the percentage of regulatory T cells (Tregs) and myeloid-derived suppressor cells (MDSCs) and decreased the Treg/Th17 cell ratio in the spleen compared with those in the vehicle-treated group. Additionally, anti-CTLA-4 antibody plus MMPI therapy reduced the percentages of regulatory T cells (Tregs), myeloid-derived suppressor cells (MDSCs), and Th17 cells in tumors compared with that in the vehicle-treated group. Moreover, combined treatment with MMPI and anti-CTLA-4 antibody reduced the microvessel density (MVD) in tumors compared with that in vehicle or MMPI-treated mice. There was a negative correlation between MVD and the CD8+ T cell percentage, CD4+ T cell percentage, and CD8+/CD4+ T cell ratio, but a positive correlation with Tregs, Th17 cells, Treg/Th17 cell ratio, and MDSCs. Thus, these data demonstrated that addition of MMPI enhanced the effects of anti-CTLA-4 antibody treatment in a mouse model of breast cancer by delaying tumor growth and reducing metastases.
journal_name
Oncol Repjournal_title
Oncology reportsauthors
Li M,Xing S,Zhang H,Shang S,Li X,Ren B,Li G,Chang X,Li Y,Li Wdoi
10.3892/or.2016.4547subject
Has Abstractpub_date
2016-03-01 00:00:00pages
1329-39issue
3eissn
1021-335Xissn
1791-2431journal_volume
35pub_type
杂志文章相关文献
ONCOLOGY REPORTS文献大全abstract::Epigenetic mechanisms of histone acetylation/deacetylation play an important role in the regulation of gene expression associated with the cell cycle and apoptosis. Recently, sodium butyrate, a histone deacetylase (HDAC) inhibitor, has been shown to exhibit anticancer effects via di...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2011.1585
更新日期:2012-04-01 00:00:00
abstract::Signal transducer and activator of transcription 3 (STAT3) is an oncogene that promotes cell survival, proliferation, and motility. In the present study, we explored the mechanism involved in the inhibition by epigallocatechin-3-gallate (EGCG) of STAT3 signaling as detected by surface plasmon resonance (SPR)-binding a...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2013.2743
更新日期:2013-12-01 00:00:00
abstract::Cervical cancer is the second most common gynecological malignancy. The mechanisms of the genesis and progression of cervical cancer are complicated and not thoroughly understood. DEK is reported as an oncogene in various cancers, such as acute myeloid leukemia, bladder cancer, breast cancer and hepatocellular cancer....
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2017.5721
更新日期:2017-08-01 00:00:00
abstract::Bee venom (BV) therapy is a type of alternative medical treatment used to treat various diseases in oriental medicine. The mechanisms underlying the effects of BV remain poorly understood. In the present study, we evaluated the antiviral effect of BV on cervical carcinoma cell lines (CaSki, HeLa, C33A and TC-1). BV tr...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.3760
更新日期:2015-04-01 00:00:00
abstract::OCT4B1, a splice variant of OCT4, is a key regulator in maintaining the properties of pluripotency and self-renewal in embryonic stem (ES) cells. Recent results have shown that OCT4B1 is involved in tumorigenesis. However, the contribution of OCT4B1 in the tumorigenesis and drug resistance of colon cancer remains to b...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.4286
更新日期:2015-12-01 00:00:00
abstract::N-myc downstream regulated gene 1 (NDRG1)/Cap43 is a 43 kDa protein that is widely distributed in the body. Its expression is regulated by nickel, cobalt, hypoxic condition and others; it is reported to be weaker in tumors than normal tissues; and NDRG1/Cap43 is considered to act suppressively to tumor metastasis. Thi...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2008-12-01 00:00:00
abstract::Arginine and nitric oxide (NO) are important mediators of tumorigenesis in various types of cancer. Dysregulation of NO content by argininosuccinate lyase (ASL) has been previously demonstrated to inhibit the proliferation of liver and breast cancer cells. However, the function of ASL in colon cancer is not well defin...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.5221
更新日期:2017-01-01 00:00:00
abstract::Despite improvements in immunotherapy, little is known about dendritic cell (DC) subpopulations naturally occurring in the laryngeal cancer tissue (LCT) and peripheral blood (PB) of untreated laryngeal cancer (LC) patients. The purpose of the present study was to evaluate mature, im...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2012.1754
更新日期:2012-07-01 00:00:00
abstract::In the development and progression of cancer, tumor suppressor genes may be silenced by mechanisms such as methylation. Thus the discovery of new genes silenced by methylation may uncover new tumor suppressor genes, and improve our understanding of cancer biology. In this study we investigated the methylation of 19 ge...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or_00000325
更新日期:2009-04-01 00:00:00
abstract::Aberrant DNA methylation and histone deacetylation participate in cancer development and progression; hence, their reversal by inhibitors of DNA methylation and histone deacetylases is a promising cancer therapy. Experimental data demonstrate that these inhibitors in combination do not only show synergy in antitumor e...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2010.1086
更新日期:2011-02-01 00:00:00
abstract::The purpose of this study was to define gene expression profile changes in colorectal tumors in order to identify target genes involved in neoplastic progression. cDNA microarray analysis was used to detect differences in gene expression profiles between colon tumor samples obtained from 20 patients in different tumor...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2004-08-01 00:00:00
abstract::Tanshinone IIA is known to induce apoptosis in several types of cancer cells. However, little is known about its activity in chemoresistant cells. The aim of this study was to investigate the anticancer properties of tanshinone IIA in cisplatin-resistant human ovarian cancer COC1/DDP cells in vitro. We used a variety ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2010.1107
更新日期:2011-03-01 00:00:00
abstract::Human glioblastoma is a malignant and aggressive primary human brain solid tumor characterized by severe hypoxia. Hypoxia can induce autophagy, which may result in chemoresistance and malignant progression of cancer cells. MicroRNAs (miRNAs) have been reported to modulate hypoxia‑induced autophagy in various types of ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2018.6929
更新日期:2019-03-01 00:00:00
abstract::Regulator of G protein signaling 5 (RGS5) belongs to the R4 subfamily of RGS proteins, a family of GTPase activating proteins, which is dynamically regulated in various biological processes including blood pressure regulation, smooth muscle cell pathology, fat metabolism and tumor angiogenesis. Low-expression of RGS5 ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.3917
更新日期:2015-06-01 00:00:00
abstract::Taxol (paclitaxel) and vinblastine (VBL) are both efficacious chemotherapeutic agents that target the microtubules of tumor cells, but each functions in a mutual antagonistic manner. Op18/stathmin is a small molecular phosphoprotein which promotes depolymerization of microtubules. Non-small cell lung cancer (NSCLC) NC...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2017.5469
更新日期:2017-04-01 00:00:00
abstract::The aim of this study is to assess, in squamous cell carcinoma of the cervix, the expression of pan-ras, c-myc and tp53 at protein level using an immunohistochemical (IHC) staining method. One hundred and seven patients with squamous cell carcinoma of the cervix were recruited. Fifty-four patients were of stage 1B/2A ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2001-05-01 00:00:00
abstract::Human gonadotropin-releasing hormone receptor (GnRHR) and its natural ligand human gonadotropin-releasing hormone (GnRH) were initially described as signaling complexes that play a key role in reproductive functions. By binding to specific receptors present on pituitary gonadotropes, GnRH regulates the sperm and ovum ...
journal_title:Oncology reports
pub_type: 杂志文章,评审
doi:10.3892/or_00000525
更新日期:2009-11-01 00:00:00
abstract::Cell cycle control is a promising target in cancer treatments, and some small-molecule cyclin-dependent kinase (CDK) inhibitors have exhibited clinical effectiveness. However, no biomarkers predictive of efficacy have been developed. Recent studies have revealed that CDK inhibitor (CKI) proteins, such as p27 and p16, ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2017.5684
更新日期:2017-07-01 00:00:00
abstract::Correlation between inhibition of cell motility and anti-invasive activity by the water extract of HangAmDan-B (HAD-B), a crude extract of eight Korean medicinal animals and plants, in NCI-H460 human non-small cell lung cancer (NSCLC) cells was investigated. Within the concentration...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2011.1440
更新日期:2011-12-01 00:00:00
abstract::Telomere-associated proteins function as survival factors in telomere maintenance, which are major contributors to radiosensitivity in human cancers. The aim of this study was to investigate the association of telomere-associated gene expression and radiation resistance in human larynx squamous carcinoma. The changes ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or_00000381
更新日期:2009-06-01 00:00:00
abstract::The global rising incidence of hepatocellular carcinoma (HCC), which parallels the increase of hepatitis C virus (HCV) prevalence, has sparked a renewed interest in discovering additional HCC serum markers. In this study, we investigated the clinical use of serum E-cadherin, ICAM, MMP-2, VEGF, OPN and β-catenin as pot...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2011.1355
更新日期:2011-10-01 00:00:00
abstract::Prostate cancer (PCa) is a leading cause of death among men. The dysregulation of metabolism and autophagy contributes to the progression of PCa. The transcription factor specificity protein 1 (Sp1) is implicated in the regulation of metabolism and autophagy. We confirmed that Sp1 is overexpressed in castration-resist...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2017.5852
更新日期:2017-09-01 00:00:00
abstract::Emodin is an active ingredient derived from root and rhizome of Rheum palmatum L and many studies have reported that it exhibits anticancer effects in a number of human tumors. However, there is little information demonstrating the possible effects of emodin on the proliferation and apoptosis of hepatocellular carcino...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.4861
更新日期:2016-08-01 00:00:00
abstract::The usefulness of diagnostic ultrasound in gene transfer was investigated. The hepatocellular carcinoma cell lines PRL/PRF/5 and Hep3B, and the pancreatic carcinoma Panc-1 cells were transfected with lipofectin or irradiated with a linear probe with a frequency of 8 MHz at a mechani...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2012.1643
更新日期:2012-05-01 00:00:00
abstract::Four tumour suppressor genes (Chk1, Chk2, Apaf1 and Rb1) in nine human malignant melanoma cell lines were screened for a loss of gene expression, point mutations and small deletions/insertions by cDNA-based DGGE/SCCP analysis. In two cell lines alterations of the investigated genes could be demonstrated. This result c...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2007-01-01 00:00:00
abstract::Casein kinase 2 interacting protein-1 (CKIP-1; also known as PLEKHO1) is involved in regulating many processes such as cell proliferation, differentiation and apoptosis. CKIP-1 also plays an important role in many types of cancer, such as colon, breast cancer and human osteosarcoma. In the present study, we found that...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.5233
更新日期:2017-01-01 00:00:00
abstract::Perylenequinones that generate reactive oxygen species (ROS) when illuminated with visible light have been recommended as photodynamic chemotherapeutic agents. One of these is calphostin C (CalC), the action of the photo-activated derivative of which, CalCphiE, has been ascribed to its ability to selectively and irrev...
journal_title:Oncology reports
pub_type: 杂志文章,评审
doi:10.3892/or_00000711
更新日期:2010-04-01 00:00:00
abstract::Pancreatic cancer is one of the most deadly carcinomas worldwide. Although gemcitabine as the standard chemotherapy agent has been proven to be effective, the response rate remains at 5.4% and the 5-year survival rate is extremely poor. Ursolic acid (UA) is a small molecule compound...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2012.1827
更新日期:2012-08-01 00:00:00
abstract::We performed methylation specific PCR to explore the mechanism of inactivation of tumor suppressor genes P15, P16, P53 and VHL in 48 oral SCC. The frequencies of aberrant methylation on the promoter of the P15, the P16, the P53 and the VHL genes were 0.27 (13/48), 0.42 (20/48), 0.04 (2/48) and none, respectively. Alto...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2003-05-01 00:00:00
abstract::The present study investigated the expression and potential influence of SHC SH2 domain‑binding protein 1 (SHCBP1) in gastric cancer (GC) cells. SHCBP1 is closely related to cell proliferation and cell cycle progression, but its role in GC remains unclear. The TCGA database revealed that SHCBP1 is highly expressed in ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2018.6952
更新日期:2019-03-01 00:00:00