Role of v-Raf and truncated form RAF1 in the induction of vascular endothelial growth factor and vascularization.

abstract：:Recent studies suggest that latexin (Lxn) expression is involved in stem cell regulation and that it plays significant roles in tumor cell migration and invasion. The clinicopathological significance of Lxn expression and its possible correlation with CD133 expression in pancreatic ductal adenocarcinoma (PDAC) is curr...

journal_title：Oncology reports

authors： Xue Z,Zhou Y,Wang C,Zheng J,Zhang P,Zhou L,Wu L,Shan Y,Ye M,He Y,Cai Z

更新日期：2016-01-01 00:00:00

abstract：:Although many studies have been conducted on the role of alternative medicine in the treatment of cancer, only a few reports have been published regarding the total regression of malignant tumors. At the PBH Research Foundation (PBHRF), two of the authors have used homoeopathic therapy to treat many patients with vari...

journal_title：Oncology reports

authors： Banerji P,Campbell DR,Banerji P

更新日期：2008-07-01 00:00:00

abstract：:Colon cancer is the main cause of cancer mortality worldwide. Its poor prognosis is mainly ascribed to high recurrence rates. Identifying novel prognostic biomarkers and therapeutic key points for management is crucial and important. Long non-coding RNAs (lncRNAs) are a class of RNAs, which have various roles in carci...

journal_title：Oncology reports

authors： Yang H,Wang S,Kang YJ,Wang C,Xu Y,Zhang Y,Jiang Z

更新日期：2018-07-01 00:00:00

abstract：:CYP1A1 expression in various tissues of 43 gastric cancer cases was analyzed with frozen tissue array-based immunohistochemical staining (IHC), RT-PCR, Western blot analysis and EROD (7-ethoxyresourfin-O-deethylase) assay. CYP1A1 was detected immunohistochemically in 86% (37/43) of gastric cancers, in both 57% (4/7) o...

journal_title：Oncology reports

authors： Zhang KL,Ma JX,Chen XY,Sun Y,Kong QY,Liu J,Li H

更新日期：2004-12-01 00:00:00

abstract：:Thymidine phosphorylase (TP) and dihydropyrimidine dehydrogenase (DPD) are considered to be key enzymes affecting the prognosis for patients with various cancers. We tried to prove the correlation of TP and DPD expression in hepatocellular carcinoma (HCC) and liver metastasis. We quantified TP and DPD levels by an enz...

journal_title：Oncology reports

authors： Hotta T,Kobayashi Y,Taniguchi K,Johata K,Sahara M,Watanabe T,Ochiai M,Tanimura H,Tsubota YT

更新日期：2004-08-01 00:00:00

abstract：:The multi-target kinase inhibitor sorafenib has been approved for the treatment of patients with advanced differentiated thyroid cancer. However, different sensitivities to sorafenib have been observed, and few patients have benefited from sorafenib treatment in the long term. In the event of acquired resistance to so...

journal_title：Oncology reports

authors： Yi H,Ye T,Ge M,Yang M,Zhang L,Jin S,Ye X,Long B,Li L

更新日期：2018-02-01 00:00:00

abstract：:EGFR, p27kip1 and Skp2, have been implicated in human cancer development. We have studied these molecules in a search for molecular markers that may have prognostic value in head and neck squamous cell carcinomas (HNSCC). Tissue samples of 62 patients were collected and immunohistochemical analysis was carried out for...

journal_title：Oncology reports

authors： Carracedo DG,Astudillo A,Rodrigo JP,Suarez C,Gonzalez MV

更新日期：2008-09-01 00:00:00

abstract：:Zinc finger protein 703 (ZNF703), identified as an oncogene in luminal B breast cancer, is a member of the NET/NlZ family of zinc finger transcription factors. However, the role of ZNF703 in colorectal cancer (CRC) is unknown. We investigated the expression of ZNF703 in paired tumor and corresponding normal tissues us...

journal_title：Oncology reports

authors： Ma F,Bi L,Yang G,Zhang M,Liu C,Zhao Y,Wang Y,Wang J,Bai Y,Zhang Y

更新日期：2014-09-01 00:00:00

abstract：:Polysaccharides derived from Inonotus obliquus (PIO) are known to possess multiple pharmacological activities including antitumor activity. However, the possible molecular mechanisms of these activities are unknown. In the present study, we determined the anti-metastatic potential and signaling pathways of PIO in the ...

journal_title：Oncology reports

authors： Lee KR,Lee JS,Kim YR,Song IG,Hong EK

更新日期：2014-05-01 00:00:00

abstract：:Melanoma is the seventh most common malignancy in females and the fifth most common cancer in males worldwide. An increasing number of studies have reported that microRNA (miRNA) dysregulation is frequently observed in various types of human cancers, including melanoma. Abnormally expressed miRNAs play an important ro...

journal_title：Oncology reports

authors： Kang K,Zhang J,Zhang X,Chen Z

更新日期：2018-01-01 00:00:00

abstract：:Different members of the Ets-family of transcription factors are involved in TMPRSS-2-Ets translocations frequently found in human prostate cancers. We previously reported that Ets-1, which is the prototype of Ets-family members, promotes both migration and invasion of melanoma, Hela and glioma cells. Here, we examine...

journal_title：Oncology reports

authors： Shaikhibrahim Z,Langer B,Lindstrot A,Florin A,Bosserhoff A,Buettner R,Wernert N

更新日期：2011-04-01 00:00:00

abstract：:Neoadjuvant chemotherapy is often used in the treatment of advanced esophageal cancer. In this study, we determined the impact of chemotherapy on microRNA (miRNA) expression in esophageal cancer cells, and whether identified changes might have biological relevance. Two esophageal carcinoma cell lines (one adenocarcino...

journal_title：Oncology reports

authors： Hummel R,Wang T,Watson DI,Michael MZ,Van der Hoek M,Haier J,Hussey DJ

更新日期：2011-10-01 00:00:00

abstract：:Agaricus blazei is well known as a traditional medicinal mushroom and it has been shown to exhibit immunostimulatory and anti-cancer activity. However, the cellular and molecular mechanism of cell cycle arrest and apoptosis of cancer cells is poorly understood. In this study, we have investigated whether A. blazei ext...

journal_title：Oncology reports

authors： Jin CY,Choi YH,Moon DO,Park C,Park YM,Jeong SC,Heo MS,Lee TH,Lee JD,Kim GY

更新日期：2006-12-01 00:00:00

abstract：:Thymidine kinase-1 (TK-1) and thymidylate synthase (TS) are key enzymes for salvage and de novo pyrimidine synthesis, respectively. Numerous studies have suggested that increased TS levels are associated closely with resistance to fluoropyrimidine-based chemotherapy. TAS-102 is a novel drug containing trifluorothymidi...

journal_title：Oncology reports

authors： Shintani M,Urano M,Takakuwa Y,Kuroda M,Kamoshida S

更新日期：2010-05-01 00:00:00

abstract：:Deregulation of c-Jun NH2-terminal kinase (JNK) signaling is now increasingly reported in a variety of human malignancies. Non-small cell lung cancer (NSCLC) is among such human malignancies with aberrant JNK activation; yet the exact role(s) of JNK deregulation in NSCLC biology, in particular in vivo, remains unclear...

journal_title：Oncology reports

authors： Okada M,Shibuya K,Sato A,Seino S,Watanabe E,Suzuki S,Seino M,Kitanaka C

更新日期：2013-10-01 00:00:00

abstract：:MicroRNAs (miRNAs) are a group of important regulators in human types of cancer including non-small cell lung cancer (NSCLC). miR-616 has been found to be a novel cancer-related miRNA. However, the expression and biological function of miR-616 in NSCLC have not been investigated. In this study, qRT-PCR was performed t...

journal_title：Oncology reports

authors： Wang D,Cao Q,Qu M,Xiao Z,Zhang M,Di S

更新日期：2017-10-01 00:00:00

abstract：:This study investigated the prognostic significance of thymidine phosphorylase (TP) and p53 expression in 96 surgically resected primary esophageal squamous cell carcinomas. Expression was assessed using immunohistochemical staining methods. Prognostic values were determined by multivariate analysis using Cox's propor...

journal_title：Oncology reports

authors： Makoto O,Takeda A,Ting-Leig L,Shinnichi O,Hisahiro M,Yutaka F,Yoshihiro N,Kobayashi S,Gunji Y,Suzuki T,Takenori O,Hideaki S

更新日期：2002-01-01 00:00:00

abstract：:Osteosarcoma is the most common type of malignant bone tumor in children and adolescents and approximately 30% of patients develop lung metastasis, which is the leading cause of mortality. In this study, we investigated the role of miR-34a in the invasion and metastasis of osteosarc...

journal_title：Oncology reports

authors： Zhao H,Ma B,Wang Y,Han T,Zheng L,Sun C,Liu T,Zhang Y,Qiu X,Fan Q

更新日期：2013-03-01 00:00:00

abstract：:Breast cancer is one of the most malignant diseases world-wide and it ranks the first among female cancers. Masses of intrinsic and extrinsic factors, especially the inflammatory factors can lead to breast cancer. Aberrant activation and accumulation of key molecules can lead to inflammation associated carcinogenesis....

journal_title：Oncology reports

authors： Wang N,Wei L,Huang Y,Wu Y,Su M,Pang X,Wang N,Ji F,Zhong C,Chen T,Li B

更新日期：2017-03-01 00:00:00

abstract：:Paternally expressed imprinted gene 1/mesoderm-specific transcript (PEG1/MEST) is an imprinted gene expressed from the paternal allele. Recently, frequent loss of imprinting (LOI) of PEG1/MEST has been reported in lung adenocarcinomas. It is suggested that the LOI may be involved in pathogenesis of lung adenocarcinoma...

journal_title：Oncology reports

authors： Nakanishi H,Suda T,Katoh M,Watanabe A,Igishi T,Kodani M,Matsumoto S,Nakamoto M,Shigeoka Y,Okabe T,Oshimura M,Shimizu E

更新日期：2004-12-01 00:00:00

abstract：:Epigenetic mechanisms of histone acetylation/deacetylation play an important role in the regulation of gene expression associated with the cell cycle and apoptosis. Recently, sodium butyrate, a histone deacetylase (HDAC) inhibitor, has been shown to exhibit anticancer effects via di...

journal_title：Oncology reports

authors： Shin H,Lee YS,Lee YC

更新日期：2012-04-01 00:00:00

abstract：:Cell cycle-related molecules play crucial roles in maintaining genomic stability, and can also serve as biomarkers of cell cycle phase distribution at the same time. In this study, we used multiparameter analysis of various biomarkers to investigate their utility for the evaluation ...

journal_title：Oncology reports

authors： Haruki T,Shomori K,Shiomi T,Taniguchi Y,Nakamura H,Ito H

更新日期：2012-09-01 00:00:00

abstract：:Selenium has been associated with anticancer activity by affecting multiple cellular processes. We reasoned that the simultaneous modulation of multiple radioresponse regulators by selenium should increase radiosensitivity if selenium is combined with radiation in cancer therapy. Therefore, we explored the possibility...

journal_title：Oncology reports

authors： Shin SH,Yoon MJ,Kim M,Kim JI,Lee SJ,Lee YS,Bae S

更新日期：2007-01-01 00:00:00

abstract：:Urokinase plasminogen activator (uPA) and metalloproteinases (MMP) play key roles in invasion and metastasis, degrading extracellular matrix compounds and modulating tumor cell motility. Their regulation is an attractive therapeutic target for controlling tumor metastasis. Previously we have demonstrated that urokinas...

journal_title：Oncology reports

authors： Todaro LB,Ladeda V,Bal de Kier Joffé E,Farías EF

更新日期：2003-05-01 00:00:00

abstract：:Pin-1 has been shown to regulate several phases of the cell cycle and is strikingly overexpressed in many human cancers. Vascular endothelial growth factor (VEGF)-C is a potent lymphangiogenic factor produced by tumor and stromal cells. However, little is known about the roles of Pin-1 and VEGF-C in breast carcinoma. ...

journal_title：Oncology reports

authors： Kim BC,Han SI,Lim SC

更新日期：2009-12-01 00:00:00

abstract：:Tumour cell proliferation is an important biological prognostic parameter to be considered alongside clinical and histopathological parameters. It has been evaluated by immunohistochemistry using proliferative markers (PCNA, Ki67, etc.) and by flow cytometry considering DNA content, growth fraction (S + G2M) and S-pha...

journal_title：Oncology reports

authors： Tirelli G,Sidari L,Giacomarra V,Papanikolla L,Sasso F,Russolo M,Melato M

更新日期：2002-05-01 00:00:00

abstract：:Berbamine is an herbal compound derived from Berberis amurensis, which is used in Chinese traditional medicine. However, few studies have investigated this anti-tumor effect or the underlying mechanisms of berbamine on lymphoma cells. We investigate the effect, as well as the mechanism of action, of 4-chlorobenzoyl be...

journal_title：Oncology reports

authors： Du HP,Shen JK,Yang M,Wang YQ,Yuan XQ,Ma QL,Jin J

更新日期：2010-03-01 00:00:00

abstract：:A growing body of evidence suggests that microRNA-365 (miR-365) played crucial role in the initiation and development of many types of cancers. However, the biological role of miR-365 in human glioma remains unclear. Herein, the aims of this study were to investigate the role and underlying mechanisms of miR-365 in gl...

journal_title：Oncology reports

authors： Zhu Y,Zhao H,Rao M,Xu S

更新日期：2017-04-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) and pancreatic cancer are at the forefront of chemotherapy-resistant tumors with poor prognosis. Even with innovative treatment regimens, response rates remain low and the duration of response is short. We examined whether the suppression of DNA methylation was capable of enhancing the s...

journal_title：Oncology reports

authors： Kanda T,Tada M,Imazeki F,Yokosuka O,Nagao K,Saisho H

更新日期：2005-10-01 00:00:00

abstract：:Monoclonal antibody therapy for immune checkpoint blockade has achieved promising results for several types of malignant tumors. For the future treatment of gastrointestinal stromal tumors (GISTs) by immune checkpoint blockade, expression of immune checkpoint-related molecules that suppress antitumor immunity in GISTs...

journal_title：Oncology reports

authors： Komita H,Koido S,Hayashi K,Kan S,Ito M,Kamata Y,Suzuki M,Homma S

更新日期：2015-10-01 00:00:00