Abstract:
:Polysaccharides derived from Inonotus obliquus (PIO) are known to possess multiple pharmacological activities including antitumor activity. However, the possible molecular mechanisms of these activities are unknown. In the present study, we determined the anti-metastatic potential and signaling pathways of PIO in the highly metastatic B16-F10 mouse melanoma cell line in vitro. We found that PIO suppressed the migration and invasive ability of B16-F10 cells and decreased the expression levels and activities of matrix metalloproteinase (MMP)-2 and MMP-9. In addition, PIO decreased the phosphorylation levels of extracellular signal-regulated protein kinase (ERK), c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (MAPK); PIO also decreased the expression level of cyclooxygenase (COX)‑2 and inhibited the nuclear translocation of nuclear factor κB (NF-κB) in B16-F10 melanoma cells. These results suggest that PIO could suppress the invasion and migration of B16-F10 melanoma cells by reducing the expression levels and activities of MMP-2 and MMP-9 through suppressing MAPK, COX-2 and NF-κB signaling pathways.
journal_name
Oncol Repjournal_title
Oncology reportsauthors
Lee KR,Lee JS,Kim YR,Song IG,Hong EKdoi
10.3892/or.2014.3103subject
Has Abstractpub_date
2014-05-01 00:00:00pages
2447-53issue
5eissn
1021-335Xissn
1791-2431journal_volume
31pub_type
杂志文章相关文献
ONCOLOGY REPORTS文献大全abstract::Glucocorticoids such as dexamethasone are widely used as comedication in the treatment of head and neck cancer, e.g., to improve appetite and decrease weight loss and fatigue in patients with advanced disease or as antiallergic and antiemetic prophylaxis during anti-EGFR therapy. However, the literature suggests that ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or_00000421
更新日期:2009-07-01 00:00:00
abstract::High mobility group N (HMGNs) are members of the high mobility group protein family, and are involved in the development and progression of several tumors. HMGN1 and HMGN5 were previously shown to be associated with the bioactivities of osteosarcoma. However, the effects and molecular mechanisms of HMGN2 on osteosarco...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2014.3689
更新日期:2015-03-01 00:00:00
abstract::Tumor metastasis is considered the main cause of mortality in cancer patients, thus it is important to investigate the differences between high- and low-metastatic cancer cells. Our previous study showed that the highly metastatic breast cancer cell line MDA-MB-231 released higher levels of ATP and exhibited higher P2...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.3972
更新日期:2015-07-01 00:00:00
abstract::Signal transducer and activator of transcription 3 (STAT3) regulates the expression of genes mediating cell survival, proliferation and angiogenesis and is aberrantly activated in various types of malignancies, including bladder cancer. We examined whether it could be a novel therapeutic target for bladder cancer usin...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2017.5902
更新日期:2017-10-01 00:00:00
abstract::Expression of Src homology phosphotyrosine phosphatase 2 (SHP2) has been observed in human breast cancer. SHP2 is known to promote cell migration and invasiveness. However, the pathophysiologic role of SHP2 and its relevance to tumorigenesis are still largely unknown. In the present study, we aimed to evaluate the eff...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2014.3201
更新日期:2014-07-01 00:00:00
abstract::Modified actin dynamics are a unique feature of transformed cancer cells and thereby promising targets for cancer chemotherapy. While latrunculin B (LB) and pectenotoxin-2 (PTX-2), both derived from natural sources, inhibit actin polymerization, jasplakinolide (JSP) prevents actin depolymerization. The purpose of this...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2011.1214
更新日期:2011-05-01 00:00:00
abstract::The carcinogenic role of hepatitis B virus x protein (HBx) in hepatocellular carcinoma (HCC) remains largely unknown. Centromere protein A (CENP-A) has been found to be frequently overexpressed in HCC. In the present study, we aimed to investigate the role of HBx in regulating CENP-...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2011.1478
更新日期:2012-01-01 00:00:00
abstract::Juvenile myelomonocytic leukemia (JMML) is a rare but severe primary hemopoietic system tumor of childhood, most frequent in children 4 years and younger. There are currently no specific anticancer therapies targeting JMML, and the underlying gene expression changes have not been revealed. To define molecular targets ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2018.6709
更新日期:2018-12-01 00:00:00
abstract::Mechanisms of synergistic effect of thermotherapy and chemotherapy on human lung adenocarcinoma cell growth are unclear. The purpose of this study was to investigate these effects and explore the function of ROS, Akt and caspase-3 in relation to these. A549 cells were subjected to different thermochemotherapy treatmen...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2012.1954
更新日期:2012-10-01 00:00:00
abstract::Anaplastic thyroid cancer is one of the most aggressive human malignancies and is resistant to multimodal treatments. The expression of h-prune, the human homologue of Drosophila prune, has been reported to be correlated with progression and aggressiveness in various cancers including breast, colorectal and pancreatic...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.4759
更新日期:2016-06-01 00:00:00
abstract::The characteristics of ovarian cancers that showed low activation of glycolysis were investigated. Using medical records of patients with ovarian cancers who had undergone fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) prior to their primary surgery at the University of Tokyo Hospital...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2017.5398
更新日期:2017-03-01 00:00:00
abstract::The adenovirus vector-based cancer gene therapy is controversial. Low transduction efficacy is believed to be one of the main barriers for the decreased expression of coxsackie and adenovirus receptor (CAR) on tumor cells. However, the expression of CAR on primary tumor tissue and tumor tissue survived from treatment ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.4870
更新日期:2016-08-01 00:00:00
abstract::PSMB4, proteasome subunit β4, is a member of the ubiquitin-proteasome family, and is elevated in a variety of malignancies. However, the expression level and related mechanism of PSMB4 in breast cancer remains unclear. Therefore, the present study investigated the expression level of PSMB4 in eight pairs of breast can...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2018.6588
更新日期:2018-10-01 00:00:00
abstract::Although many studies have been conducted on the role of alternative medicine in the treatment of cancer, only a few reports have been published regarding the total regression of malignant tumors. At the PBH Research Foundation (PBHRF), two of the authors have used homoeopathic therapy to treat many patients with vari...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2008-07-01 00:00:00
abstract::We present a case of resected hepatocellular carcinoma (HCC) which invaded the gallbladder with a metastasis to a lymph node. It was extremely difficult to make a differential diagnosis between HCC and gallbladder cancer preoperatively. A 68-year old man was admitted to hospital with complaint of a fever. Ultrasonogra...
journal_title:Oncology reports
pub_type: 杂志文章,评审
doi:10.3892/or.8.2.331
更新日期:2001-03-01 00:00:00
abstract::Despite the established importance of angiogenesis in the pathogenesis of solid tumours, there is still no consensus on how this is best measured or which method is the most appropriate in the determination of prognosis. Here we review the pros and cons of current methods of assessing angiogenesis, both clinical and i...
journal_title:Oncology reports
pub_type: 杂志文章,评审
doi:10.3892/or.13.5.931
更新日期:2005-05-01 00:00:00
abstract::Primary and metastatic cancers that affect bones are frequently associated with severe and intractable pain. The mechanisms underlying the development of bone cancer pain are largely unknown. In the present study, we investigated whether inhibition of KCNQ/M (Kv7) potassium channels in the spinal cord contributes to t...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.3718
更新日期:2015-03-01 00:00:00
abstract::ZNF703, a member of the NET/Nlz family of zinc finger transcription factors, contributes to aspects of developmental growth and patterning across evolutionarily diverse species. ZNF703 has been identified as a novel oncogene in human breast cancer. In the present study, we investigated the expression of ZNF703 in gast...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2014.2997
更新日期:2014-04-01 00:00:00
abstract::Large‑scale projects, such as The Cancer Genome Atlas (TCGA), Human Epigenome Project (HEP) and Human Epigenome Atlas (HEA), provide an insight into DNA methylation and histone modification markers. Changes in the epigenome significantly contribute to the initiation and progression of cancer. The goal of the present s...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2019.7159
更新日期:2019-07-01 00:00:00
abstract::Prostate cancer (PCa) is the second most common type of male malignancy worldwide. The transcription factor zinc finger E‑box binding homeobox 1 (ZEB1) is associated with epithelial‑mesenchymal transition and is also involved in regulation of androgen receptor (AR) expression, the main ligands of which are testosteron...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2018.6885
更新日期:2019-02-01 00:00:00
abstract::Graft-versus-host disease (GVHD) is a devastating complication of hematopoietic stem cell transplantation (HSCT), and is characterized by systemic inflammation and tissue damage in multiple organs, such as the liver and small intestine. Interleukin-18 (IL-18), an important pro-inflammatory cytokine, is elevated during...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.4176
更新日期:2015-10-01 00:00:00
abstract::We radiographically evaluated the response of primary lesions to chemotherapy in 101 patients with inoperable advanced gastric cancer. The median survival time in the 50 responders (49.5%) was 379 days, as compared with only 210 days in the 51 non-responders (50.1%) (p<0. 001). Morphologic changes of the gastric mucos...
journal_title:Oncology reports
pub_type: 临床试验,杂志文章
doi:10.3892/or.7.6.1279
更新日期:2000-11-01 00:00:00
abstract::Investigations into extracellular vesicles (EVs) have significantly increased since their role in physiological and pathological processes has become more clearly understood. Furthermore, it has become increasingly clear that several subpopulations of EVs exist, such as exosomes (EXOs) and microvesicles (MVs). Various...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.4199
更新日期:2015-11-01 00:00:00
abstract::To clarify hepatocarcinogenesis by the heterocyclic amine, 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx), we investigated the global expression of genes in rat liver. Rats were continuously fed MeIQx 100 ppm in their diet, and were sacrificed at weeks 4 and 16 for early time points, and week 104 for tumor samp...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2007-04-01 00:00:00
abstract::Tobacco smoke is one of the serious risk factors of gastric cancer. Epithelial‑mesenchymal transition (EMT) has been shown to be associated with the initiation and carcinogenesis of gastric cancer. The role of Notch pathway in regulating tobacco smoke-induced EMT has not been investigated. β‑carotene, a carotenoid pre...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2018.6246
更新日期:2018-04-01 00:00:00
abstract::Pancreatic cancer (PC) is one of the leading causes of cancer-related deaths worldwide. Frequent metastasis and recurrence are the main reasons for the poor prognosis of PC patients. Thus, the discovery of new biomarkers and wider insights into the mechanisms involved in pancreatic tumorigenesis and metastasis is cruc...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.4865
更新日期:2016-08-01 00:00:00
abstract::The development and characterization of effective anticancer drugs against colorectal cancer (CRC) is of urgent need since it is the second most common cause of cancer death. The study was designed to evaluate the effects of two IGF-1R antagonists, MK-0646, a recombinant fully humanized monoclonal antibody and OSI-906...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2013.2819
更新日期:2014-01-01 00:00:00
abstract::Immunotherapy with autologous dendritic cells (DCs) loaded with tumor lysate(s) from allogeneic tumor cell lines is a novel strategy to induce immune responses in cancer patients. We report on a pilot trial of autologous DCs pulsed with tumor cell lysate derived from allogeneic medullary thyroid carcinoma (MTC) cell l...
journal_title:Oncology reports
pub_type: 临床试验,杂志文章
doi:10.3892/or_00000391
更新日期:2009-06-01 00:00:00
abstract::Esculetin, a phenolic compound, has been shown to inhibit the growth of colon tumors in animal studies. However, the roles of signaling pathways and cell cycle regulation in the esculetin-induced inhibition of cancer cell growth, remain to be elucidated. The present study suggests a novel mechanism for the Ras/ERK1/2 ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2011-01-01 00:00:00
abstract::Non‑small cell lung cancer (NSCLC) is the most common type of lung cancer, and numerous oncogenes are associated with this disease. Oxysterol‑binding protein‑related protein 8 (ORP8) is essential for cell growth, migration and the modulation of mitochondrial respiration and morphology. However, the underlying role of ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2020.7517
更新日期:2020-05-01 00:00:00