Induction and mechanism of HeLa cell apoptosis by 9-oxo‑10, 11-dehydroageraphorone from Eupatorium adenophorum.

abstract：:Triple-negative breast cancer is a highly aggressive type of mammalian carcinoma. It is defined by a rather weak expression of estrogen-, progesterone- and Her2-receptor, and is thus difficult to treat, resulting in low disease-free and overall survival rates of the affected patients. Hence it is important to find new...

journal_title：Oncology reports

authors： Andergassen U,Kölbl AC,Mumm JN,Mahner S,Jeschke U

更新日期：2017-05-01 00:00:00

abstract：:Colorectal carcinoma (CRC) is a major type of malignancy worldwide. Ellagic acid (EA), a natural phenolic constituent, has been shown to exhibit anticancer effects. In our previous study, it was shown that EA inhibited proliferation of CRC cells. Additionally, microarray analysis revealed 4,738 differentially expresse...

journal_title：Oncology reports

authors： Zhao J,Li G,Wei J,Dang S,Yu X,Ding L,Shang C,Zhang H,Zhang Z,Chen H,Liu M

更新日期：2020-08-01 00:00:00

abstract：:Colorectal cancer (CRC) is a common malignancy globally. The aim of the present study was to explore the role and the working mechanism of circular RNA NADPH oxidase 4 (circNOX4; circBase ID, hsa_circ_0023990) in CRC. Reverse transcription‑quantitative (RT‑q)PCR was used to examine the expression of circNOX4, NOX4 mRN...

journal_title：Oncology reports

authors： Wang X,Tao G,Huang D,Liang S,Zheng D

更新日期：2020-11-01 00:00:00

abstract：:Hepatocellular carcinoma is the most common type of liver cancer. The risk of hepatocellular carcinoma for type 2 diabetic patients is greater than that for non-diabetic individuals although the mechanism is unclear. The cancer suppressor resveratrol inhibits cancer cell proliferation partly through the STAT3 signalin...

journal_title：Oncology reports

authors： Li Y,Zhu W,Li J,Liu M,Wei M

更新日期：2013-12-01 00:00:00

abstract：:Notch signaling plays a critical role in embryonic vascular development and tumor angiogenesis. The present study was conducted to investigate the prognostic role of the angiogenesis-related Notch ligand and the receptor in acute myeloid leukemia (AML) and assess whether their expre...

journal_title：Oncology reports

authors： Zhang J,Ma D,Ye J,Zang S,Lu F,Yang M,Qu X,Sun X,Ji C

更新日期：2012-10-01 00:00:00

abstract：:This study was designed to investigate the effect of pseudo-G-Rh2, a novel metabolite of ginsenoside Rh2, on the apoptosis of SGC-7901 human gastric cancer cells. Pseudo-G-Rh2 demonstrated antitumor activity and significantly inhibited the proliferation of SGC-7901 cells in a concen...

journal_title：Oncology reports

authors： Qu X,Qu S,Yu X,Xu H,Chen Y,Ma X,Sui D

更新日期：2011-12-01 00:00:00

abstract：:A phase I study of S-1 and biweekly docetaxel (DOC) combination therapy was conducted to determine the maximum tolerated dose (MTD) and pharmacokinetic parameters. Fourteen patients with advanced or recurrent gastric cancer were analyzed. The treatment consisted of S-1 [body surface area (BSA) <1.25 m2:80 mg/day, 1.25...

journal_title：Oncology reports

authors： Takahashi I,Emi Y,Kakeji Y,Tokunaga E,Ushiro S,Oki E,Watanabe M,Baba H,Maehara Y

更新日期：2006-04-01 00:00:00

abstract：:RNA‑binding motif 3 (RBM3) is a cold‑shock protein that has been previously shown to attenuate cancer stem cell‑like features in prostate cancer (PCa) cells. However, the mechanism underlying RBM3 regulation in PCa cells is largely unknown. The present study investigated the impact of RBM3 expression on the whole tran...

journal_title：Oncology reports

authors： Dong Q,Lv C,Zhang G,Yu Z,Kong C,Fu C,Zeng Y

更新日期：2018-10-01 00:00:00

abstract：:Signal transducer and activator of transcription 3 (STAT3) plays a key role in the transformation of normal cells to cancerous cells. Although inhibitors of STAT3 have been shown to suppress the growth of multiple cancer types in vitro and in vivo, such agents are of particular interest for the prevention of breast ca...

journal_title：Oncology reports

authors： Shoemaker RH,Fox JT,Juliana MM,Moeinpour FL,Grubbs CJ

更新日期：2019-09-01 00:00:00

abstract：:Tongue cancer is one of the most common types of cancer, but its molecular etiology and pathogenesis remain unclear. The aim of the present study was to elucidate the pathogenesis of tongue cancer and investigate novel potential diagnostic and therapeutic targets. Four matched pairs of tongue cancer and paracancerous ...

journal_title：Oncology reports

authors： Tang M,Dai W,Wu H,Xu X,Jiang B,Wei Y,Qian H,Han L

更新日期：2020-06-01 00:00:00

abstract：:Zoledronic acid (Zometa, ZOL) is increasingly used to treat tumour-induced bone disease, and is also reported to have antiangiogenic properties in vivo. In this study, we have investigated the correlations between changes in the proangiogenic cytokine, vascular endothelial growth factor (VEGF), and markers of bone res...

journal_title：Oncology reports

authors： Santini D,Vincenzi B,Hannon RA,Brown JE,Dicuonzo G,Angeletti S,La Cesa A,Coleman RE,Tonini G,Budillon A,Caraglia M,Holen I

更新日期：2006-05-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is a leading cause of cancer‑related morbidity and mortality globally. Despite the remarkable improvements in comprehensive HCC treatment, the underlying mechanistic details of HCC remain elusive. We screened HCC patients for differentially expressed genes (DEGs) using the Gene Expressio...

journal_title：Oncology reports

authors： Li L,Huang K,Lu Z,Zhao H,Li H,Ye Q,Peng G

更新日期：2020-11-01 00:00:00

abstract：:We have studied the effects of Saiboku-to, a traditional Chinese medicine having suppressive activities for leukotriene production and release, on the proliferation of the estrogen-responsive mouse Leydig tumor cell line B-1F. In our previous reports, it is shown that Saiboku-to promotes, but Scutellaria baicalensis, ...

journal_title：Oncology reports

authors： Murashima T,Katayama H,Shojiro K,Nishizawa Y

更新日期：2011-05-01 00:00:00

abstract：:The aim of this study was to investigate the effect of temozolomide (TZM) in combination with X-rays on proliferation and migration in human glioma spheroids. Multicellular spheroids were derived from GaMg and U87 cell lines. Spheroids were treated with various concentrations of TZM (5 micromol, 0.025 mmol, 0.05 mmol)...

journal_title：Oncology reports

authors： Fehlauer F,Muench M,Richter E,Rades D

更新日期：2007-04-01 00:00:00

abstract：:Caspases play an essential role in the initiation/regulation of apoptosis. Aberrant apoptotic regulation has been associated with carcinogenesis and therapeutic resistance. To explore the possible involvement of altered caspase expression in breast cancer, we have systematically examined the expression of both protein...

journal_title：Oncology reports

authors： Yang S,Liu J,Thor AD,Yang X

更新日期：2007-05-01 00:00:00

abstract：:Cyclin Y (CCNY) is a newly identified PFTK1 interacting protein and has been found to be associated with the proliferation and tumorigenesis of human non-small cell lung cancer. In the present study, we analyzed the expression levels of CCNY in 65 cases of breast cancer (BC) tissues and in four BC cell lines, BT-474, ...

journal_title：Oncology reports

authors： Yan F,Wang X,Zhu M,Hu X

更新日期：2016-11-01 00:00:00

abstract：:S-1 is an oral antitumor agent that contains tegafur, which is converted to fluorouracil (5-FU) in the human body. Cytochrome P450 2A6 (CYP2A6) is the principal enzyme responsible for bioconversion of tegafur to 5-FU. A number of CYP2A6 polymorphisms have been associated with variat...

journal_title：Oncology reports

authors： Fang WJ,Mou HB,Jin DZ,Zheng YL,Zhao P,Mao CY,Peng L,Huang MZ,Xu N

更新日期：2012-05-01 00:00:00

abstract：:The aim of this study is to evaluate characteristics in lung cancer patients with chronic obstructive pulmonary disease (COPD). Among 966 lung cancer patients admitted to our division over a period of 24 years, 73 patients were diagnosed as having COPD. There were 68 (93.2%) men and 5 women; of the tumors 43 (58.9%) w...

journal_title：Oncology reports

authors： Kurishima K,Satoh H,Ishikawa H,Yamashita YT,Homma T,Ohtsuka M,Sekizawa K

更新日期：2001-01-01 00:00:00

abstract：:The aim of the present study was to investigate the role of miR‑203a‑3p in colorectal cancer (CRC) and identify the target gene of microRNA (miR)‑203a‑3p. A total of 59 sets of cancer tissues and corresponding adjacent non‑tumor tissues were collected from CRC patients (aged 31‑78 years) between October 2016 and May 2...

journal_title：Oncology reports

authors： Qian Z,Gong L,Mou Y,Han Y,Zheng S

更新日期：2019-11-01 00:00:00

abstract：:Esculetin, a phenolic compound, has been shown to inhibit the growth of colon tumors in animal studies. However, the roles of signaling pathways and cell cycle regulation in the esculetin-induced inhibition of cancer cell growth, remain to be elucidated. The present study suggests a novel mechanism for the Ras/ERK1/2 ...

journal_title：Oncology reports

authors： Park SS,Park SK,Lim JH,Choi YH,Kim WJ,Moon SK

更新日期：2011-01-01 00:00:00

abstract：:Ultraviolet (UV) radiation is the primary risk factor underlying photoaging and photocarcinogenesis. Mounting research has focused on the role of DNA damage response pathways in UV-induced double-strand break (DSB) repair. In the present study, we hypothesized that UVA-induced aberrant progerin upregulation may advers...

journal_title：Oncology reports

authors： Huang X,Pan Y,Cao D,Fang S,Huang K,Chen J,Chen A

更新日期：2017-06-01 00:00:00

abstract：:Solid tumors are abnormal tissues containing tumor and non-tumor cells, also known as tumor stromal cells. However, the malignant potential of tumor stromal cells remains largely unknown. The aim of the present study was to investigate the malignant potential of host bone marrow‑derived stroma cells in transplanted su...

journal_title：Oncology reports

authors： Dai X,Chen H,Chen Y,Wu J,Wang H,Shi J,Fei X,Wang Z,Wang A,Dong J,Lan Q,Huang Q

更新日期：2015-12-01 00:00:00

abstract：:Arginine and nitric oxide (NO) are important mediators of tumorigenesis in various types of cancer. Dysregulation of NO content by argininosuccinate lyase (ASL) has been previously demonstrated to inhibit the proliferation of liver and breast cancer cells. However, the function of ASL in colon cancer is not well defin...

journal_title：Oncology reports

authors： Huang HL,Chen WC,Hsu HP,Cho CY,Hung YH,Wang CY,Lai MD

更新日期：2017-01-01 00:00:00

abstract：:This study was conducted to assess protective effect of an antioxidant protein, sericin, on tumor promotion in the 7,12-dimethylbenz (alpha) anthracene (DMBA)-initiated and 12-O-tetradecanoylphorbol 13-acetate (TPA)-promoted mouse skin tumorigenesis model. In experiment 1, sericin was applied topically to DMBA-initiat...

journal_title：Oncology reports

authors： Zhaorigetu S,Yanaka N,Sasaki M,Watanabe H,Kato N

更新日期：2003-05-01 00:00:00

abstract：:Dendritic cells (DCs) as 'professional' antigen-presenting cells (APCs) initiate and regulate immune responses to various antigens. DC-based vaccines have become a promising modality in cancer immunotherapy. Cytokeratin 19 (CK19) protein is expressed at high levels in lung cancer and many other tumor cells, suggesting...

journal_title：Oncology reports

authors： Sun QF,Zhao XN,Peng CL,Hao YT,Zhao YP,Jiang N,Xue H,Guo JZ,Yun CH,Cong B,Zhao XG

更新日期：2015-11-01 00:00:00

abstract：:Modulation of the activity of tumor suppressor p53 is a key event in the replication of many viruses. They could manipulate p53 function through modification of phosphorylation for their own purpose. However, there are scarce data on the relationship between high risk human papillomavirus (HPV) E6 protein and p53 phos...

journal_title：Oncology reports

authors： Zhang G,Sun L,Li Z,Si L,Song T,Huang C,Zhang W

更新日期：2009-02-01 00:00:00

abstract：:This study evaluates and compares the accuracy of positron emission tomography with 18F-fluoro-2-deoxyglucose (FDG-PET) and gallium-67 citrate (Ga-67) scintigraphy in identifying disease sites in patients with malignant lymphoma at initial diagnosis or relapse. Histology subgroups included low (n=5), intermediate (n=6...

journal_title：Oncology reports

authors： Shen YY,Kao A,Yen RF

更新日期：2002-03-01 00:00:00

abstract：:Anaplastic thyroid carcinoma (ATC) is a rare type of thyroid carcinoma with a poor prognosis. Thus, suitable preclinical tumor models are required for the development of new ATC therapies. In the present study, orthotopic tumor xenograft models were established using ATC cell lines and SCID mice, and tumor invasion an...

journal_title：Oncology reports

authors： Aoyama M,Takizawa H,Otani T,Inoue S,Kawakita N,Tsuboi M,Bando Y,Uehara H,Kondo K,Tangoku A

更新日期：2020-10-01 00:00:00

abstract：:Fluoroquinolones affect the proliferation and apoptotic cell death of several human malignancies. Therefore, we investigated whether new 6-aminoquinolone derivatives, initially synthesized as anti-HIV agents, could affect the proliferation and apoptotic cell death of human prostate cancer cell lines. PC3 and LNCaP cel...

journal_title：Oncology reports

authors： Minelli A,Bellezza I,Siciliano E,Liguori L,Tabarrini O,Cecchetti V,Fravolini A

更新日期：2005-06-01 00:00:00

abstract：:The aim of the present study was to evaluate human epididymis protein 4 (HE4) as a marker of epithelial ovarian cancer (EOC) relapse and the combination of this biomarker with contrast-enhanced high-resolution multidetector row computed tomography CE CT imaging to impove the monitoring of EOC patients. Twenty-one pati...

journal_title：Oncology reports

authors： Manganaro L,Michienzi S,Vinci V,Falzarano R,Saldari M,Granato T,Viggiani V,Frati L,Anastasi E

更新日期：2013-11-01 00:00:00