Abstract:
:Ubiquitin specific protease 22 (USP22) is an oncogene that is upregulated in many cancer types, and aberrant expression of USP22 correlates with clinical outcome. However, its potential functional impact in epithelial ovarian cancer (EOC) has not been determined. Here, we report that USP22 was upregulated in EOC specimens and EOC cell lines with important functional consequences. A high level of USP22 in EOC tissues was associated with advanced clinical FIGO stage, lymph node metastasis and worse prognosis. Patients with higher USP22 expression had shorter relapse-free and overall survival. Depletion of USP22 suppressed cell proliferation in vitro and tumor growth in vivo. We found that inhibition of USP22 suppressed cell proliferation by inducing G1 phase cell cycle arrest through synergy with oncogenic transforming growth factor-β1 (TGFB1). Our results indicate that USP22 functions as an oncogene in EOC, and thus USP22 may serve as a potential therapeutic target for individualized EOC treatment.
journal_name
Oncol Repjournal_title
Oncology reportsauthors
Ji M,Shi H,Xie Y,Zhao Z,Li S,Chang C,Cheng X,Li Ydoi
10.3892/or.2014.3580subject
Has Abstractpub_date
2015-01-01 00:00:00pages
133-40issue
1eissn
1021-335Xissn
1791-2431journal_volume
33pub_type
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