TFAM is directly regulated by miR-23b in glioma.

abstract：:Mitogenic actions of estrogens are mediated by two distinct estrogen receptors (ERs), which are critical in the progression and therapeutic response of breast cancer. ER expression is a dynamic phenomenon that is regulated by numerous factors, including cytokines, in the tumor microenvironment. Recently, studies have ...

journal_title：Oncology reports

authors： Niu XL,Wang Y,Yao Z,Duan H,Li Z,Liu W,Zhang H,Deng WM

更新日期：2015-12-01 00:00:00

abstract：:Previous studies have suggested that certain genetic polymorphisms, specifically the Xeroderma pigmentosum group D (XPD) gene codon 751 and the X-ray repair cross-complementing group 1 (XRCC1) gene codon 399 polymorphisms, were associated with an increased risk of lung cancer, and, in some studies, with a greater risk...

journal_title：Oncology reports

authors： Gao W,Romkes M,Zhong S,Nukui T,Persad RA,Smith PJ,Branch R,Keohavong P

更新日期：2010-07-01 00:00:00

abstract：:Epidemiologic studies indicate the use of either statins or aspirin have beneficial effects in prostate cancer patients. The present study was undertaken to evaluate the effects and mechanisms of atorvastatin and aspirin alone or in combination in human prostate cancer cells cultured in vitro and grown as xenograft tu...

journal_title：Oncology reports

authors： He Y,Huang H,Farischon C,Li D,Du Z,Zhang K,Zheng X,Goodin S

更新日期：2017-02-01 00:00:00

abstract：:Tumor metastasis is one of the causes for the high mortality rate of prostate cancer (PCa) patients, yet the molecular mechanisms of PCa metastasis are not fully understood. In our previous studies, we found that PSMA suppresses the metastasis of PCa, yet the underlying mechanism remains unknown. To identify the genes...

journal_title：Oncology reports

authors： Xu L,Wang Z,Li XF,He X,Guan LL,Tuo JL,Wang Y,Luo Y,Zhong HL,Qiu SP,Cao KY

更新日期：2013-10-01 00:00:00

abstract：:Osteosarcoma is the most common type of malignant bone tumor in children and adolescents and approximately 30% of patients develop lung metastasis, which is the leading cause of mortality. In this study, we investigated the role of miR-34a in the invasion and metastasis of osteosarc...

journal_title：Oncology reports

authors： Zhao H,Ma B,Wang Y,Han T,Zheng L,Sun C,Liu T,Zhang Y,Qiu X,Fan Q

更新日期：2013-03-01 00:00:00

abstract：:Immature colon carcinoma transcript-1 (ICT1) is a newly identified oncogene, which regulates proliferation, cell cycle progression and apoptosis of cancer cells. However, the clinical significance, biological function and underlying mechanisms of ICT1 in hepatocellular carcinoma (HCC) remain poorly known. In the prese...

journal_title：Oncology reports

authors： Chang W,Yu Z,Tian M,Lin X

更新日期：2017-12-01 00:00:00

abstract：:Mast cell-derived chymase promotes inflammatory responses and tissue fibrosis. Although previous studies have reported changes in the number of mucosal mast cells in inflammatory bowel disease (IBD), the behaviour of chymase immunopositive mast cells has not been studied. In this study, we immunohistochemically invest...

journal_title：Oncology reports

authors： Andoh A,Deguchi Y,Inatomi O,Yagi Y,Bamba S,Tsujikawa T,Fujiyama Y

更新日期：2006-07-01 00:00:00

abstract：:To elucidate the mechanism of resistance to 5-fluorouracil (5-FU) in human gastric cancer cells, we established a cell line MKN45/F2R, which acquired 5-FU resistance as a result of continuous exposure to increasing dosages of 5-FU over a year. The cell line showed 157-fold elevated 5-FU resistance compared to the MKN4...

journal_title：Oncology reports

authors： Tsutani Y,Yoshida K,Sanada Y,Wada Y,Konishi K,Fukushima M,Okada M

更新日期：2008-12-01 00:00:00

abstract：:MAP kinase signaling proteins have major implications in the molecular oncogenesis of breast cancers and have been extensively investigated as putative targets for therapy. This study reports the investigation of the expression of P38 MAPK and its phosphorylated form (p-P38 MAPK) in clinical specimens of invasive brea...

journal_title：Oncology reports

authors： Merlin JL,Harlé A,Lion M,Ramacci C,Leroux A

更新日期：2013-10-01 00:00:00

abstract：:Anaplastic thyroid cancer is one of the most aggressive human malignancies and is resistant to multimodal treatments. The expression of h-prune, the human homologue of Drosophila prune, has been reported to be correlated with progression and aggressiveness in various cancers including breast, colorectal and pancreatic...

journal_title：Oncology reports

authors： Nambu J,Kobayashi T,Hashimoto M,Tashiro H,Sugino K,Shimamoto F,Kikuchi A,Ohdan H

更新日期：2016-06-01 00:00:00

abstract：:Honokiol (HNK), a potential antitumor compound, has been widely studied in recent years. It induces apoptosis and affects autophagy in cancer cells, yet the mechanism of its antitumor efficacy remains obscure. Chloroquine (CQ), an autophagy inhibitor, is often applied to sensitize antitumor drugs in clinical trials. H...

journal_title：Oncology reports

authors： Lv X,Liu F,Shang Y,Chen SZ

更新日期：2015-09-01 00:00:00

abstract：:In the present study, we investigated the role of lysyl oxidase‑like 2 (LOXL2), the correlation between LOXL2 and epithelial to mesenchymal transition (EMT) and the effects of using β‑aminopropionitrile (BAPN) to inhibit LOXL2 with the aim of reducing tumor progression in hepatocellular carcinoma (HCC). The expression...

journal_title：Oncology reports

authors： Ninomiya G,Yamada S,Hayashi M,Takeda S,Suenaga M,Takami H,Kanda M,Iwata N,Niwa Y,Tanaka C,Kobayashi D,Fujii T,Nakayama G,Sugimoto H,Koike M,Fujiwara M,Kodera Y

更新日期：2018-06-01 00:00:00

abstract：:The phosphatase and tensin homolog (PTEN) gene, an important tumor-suppressor gene, has been demonstrated to have the potential for inhibiting proliferation, migration and invasion in various types of cancer cells. The aim of the present study was to investigate the effect of PTEN expression on osteosarcoma (OS) cells...

journal_title：Oncology reports

authors： Hu Y,Xu S,Jin W,Yi Q,Wei W

更新日期：2014-10-01 00:00:00

abstract：:Minimal residual disease (MRD) is derived from tumor-initiating cells (TICs) and is responsible for tumor relapse. Neuroblastoma is characterized by extreme tumor heterogeneity, and more than half of high-risk patients experience tumor relapse. To overcome tumor heterogeneity and ac...

journal_title：Oncology reports

authors： Hartomo TB,Kozaki A,Hasegawa D,Van Huyen Pham T,Yamamoto N,Saitoh A,Ishida T,Kawasaki K,Kosaka Y,Ohashi H,Yamamoto T,Morikawa S,Hirase S,Kubokawa I,Mori T,Yanai T,Hayakawa A,Takeshima Y,Iijima K,Matsuo M,Nishio H

更新日期：2013-04-01 00:00:00

abstract：:WNT signaling pathway networks with Hedgehog, Notch and FGF signaling pathways during carcinogenesis and embryogenesis. FZD8 is up-regulated in HeLa S3 and A549 cells. Here we identified and characterized rat Fzd8 gene by using bioinformatics. Rat Fzd8 gene was identified within AC131883.2 genome sequence. Rat Fzd8 (6...

journal_title：Oncology reports

authors： Katoh Y,Katoh M

更新日期：2005-05-01 00:00:00

abstract：:microRNAs are an abundant class of short endogenous non-coding RNAs that function as important regulators of multiple target genes and participate in diverse biological roles in carcinogenesis. However, the role of miR-7 in lung cancer remains unclear and requires further elucidation. In the present study, we found a ...

journal_title：Oncology reports

authors： Li J,Zheng Y,Sun G,Xiong S

更新日期：2014-12-01 00:00:00

abstract：:Emodin (EMO) has been shown to possess pleiotropic anticancer capabilities in many types of cancer, including epithelial ovarian cancer (EOC). Inhibitory efficacy of EMO on EOC invasion and migration was previously observed, however, the underlying mechanisms have not been completely elucidated. The present study is a...

journal_title：Oncology reports

authors： Hu C,Dong T,Li R,Lu J,Wei X,Liu P

更新日期：2016-04-01 00:00:00

abstract：:Dendritic cell-mediated cancer immunotherapy employs several ways to engage tumor antigens. We have demonstrated in both pre-clinical animal studies and early clinical trials that dendritomas, highly purified hybrids between dendritic cells (DC) and tumor cells, are superior activators of anti-tumor immunity. It has b...

journal_title：Oncology reports

authors： Branham-O'Connor M,Li J,Kotturi HS,Yu X,Wagner TE,Wei Y

更新日期：2010-02-01 00:00:00

abstract：:Osteosarcoma (OS) is a common primary malignancy in children and adolescents with relative high survival rate after chemotherapy. While the toxicity of chemotherapy and personalized different response to chemotherapy makes it difficult for the selection of therapeutics and improvement of diagnosis. In this study, we c...

journal_title：Oncology reports

authors： Zhang W,Han S,Sun K

更新日期：2017-02-01 00:00:00

abstract：:Recent studies have shown that miRNAs have potent abilities to activate gene expression by targeting promoter elements, a phenomenon known as RNA activation (RNAa). In the present study, we identified a new endogenous miR-3619-5p which was decreased in prostate cancer tissues and cells compared to corresponding normal...

journal_title：Oncology reports

authors： Li S,Wang C,Yu X,Wu H,Hu J,Wang S,Ye Z

更新日期：2017-01-01 00:00:00

abstract：:Lung cancer remains the leading cause of cancer-related mortality worldwide and non-small cell lung cancer (NSCLC) accounts for approximately 80-85% of all cases of lung cancer. Cisplatin plays a significant role in the management of human lung cancer. Translesion DNA synthesis (TLS) is involved in DNA damage repair. ...

journal_title：Oncology reports

authors： Wang W,Sheng W,Yu C,Cao J,Zhou J,Wu J,Zhang H,Zhang S

更新日期：2015-09-01 00:00:00

abstract：:Engrailed 2 (EN2) is a member of the homeobox gene family. Many studies suggest that overexpression of EN2 protein may be associated with tumor development, including bladder cancer (BC). However, to date, the mechanisms of how EN2 functions to promote BC progression remain elusive. The present study introduced RNAi t...

journal_title：Oncology reports

authors： Li Y,Liu H,Lai C,Su Z,Heng B,Gao S

更新日期：2015-05-01 00:00:00

abstract：:Tumor angiogenesis, growth and metastasis are three closely related processes. We therefore explored the effects of (-)-oleocanthal (OC) on the three processes in melanoma and investigated underlying mechanisms. In vitro, OC suppressed proliferation, migration, invasion and induced apoptosis in melanoma cells. In addi...

journal_title：Oncology reports

authors： Gu Y,Wang J,Peng L

更新日期：2017-01-01 00:00:00

abstract：:The aim of this study was to assess the use of human papillomavirus (HPV) E6/E7 mRNA testing in the follow-up of women treated for cervical intraepithelial neoplasia (CIN) by conization and to compare the prognostic value of HPV E6/E7 mRNA to HPV L1 DNA and cytology. One hundred and...

journal_title：Oncology reports

authors： Persson M,Brismar Wendel S,Ljungblad L,Johansson B,Weiderpass E,Andersson S

更新日期：2012-07-01 00:00:00

abstract：:Peroxiredoxin 1 (Prdx1) is an antioxidant and plays an important role in H2O2-mediated cell signaling. We previously found that the expression level of Prdx1 was elevated in esophagus squamous cell carcinoma (ESCC) tissue using a proteomics approach. Since overexpressed protein can induce an autoimmune response, to fu...

journal_title：Oncology reports

authors： Ren P,Ye H,Dai L,Liu M,Liu X,Chai Y,Shao Q,Li Y,Lei N,Peng B,Yao W,Zhang J

更新日期：2013-11-01 00:00:00

abstract：:Many prostate cancer (PCa) patients die of recurrent disease due to the emergence of hormone-independent cancer cells of which the mechanism is not fully understood. Our previous studies demonstrated that most castration- resistant prostate cancers (CRPC) overexpress the HOXB13 transcription factor to confer positive ...

journal_title：Oncology reports

authors： Kim YR,Kang TW,To PK,Xuan Nguyen NT,Cho YS,Jung C,Kim MS

更新日期：2016-04-01 00:00:00

abstract：:In this study 10(7) peripheral blood mononuclear cells including on average 78.56% CD19+/CD5+ lymphocytes were irradiated, and then administered intradermally as an anti-cancer vaccine to seventeen patients with B-cell chronic lymphocytic leukemia (B-CLL) at early stages (twelve injections, four at a weekly interval f...

journal_title：Oncology reports

authors： Hus I,Kawiak J,Tabarkiewicz J,Radej S,Hoser G,Bojarska-Junak A,Schmitt M,Giannopoulos K,Dmoszynska A,Rolinski J

更新日期：2008-08-01 00:00:00

abstract：:While Taxol has been reported to improve the clinical survival of breast cancer patients, subsequently developed drug-resistance of the cancer cells limits its final efficacy and applications. Previous studies suggested that Aurora A is involved in the development of the Taxol-resistance of breast cancer. We establish...

journal_title：Oncology reports

authors： Li Y,Zhou W,Tang K,Chen X,Feng Z,Chen J

更新日期：2017-10-01 00:00:00

abstract：:Neuroblastoma is the most common inheritable, solid neoplasm in children found under the age of 7 and accounts for approximately 7% of childhood cancers. A common treatment that has been prescribed for over a decade is retinoid therapy [using all‑trans retinoic acid (RA)]. Treatment with this differentiating agent has...

journal_title：Oncology reports

authors： Illendula A,Fultang N,Peethambaran B

更新日期：2020-09-01 00:00:00

abstract：:There is increasing evidence of an angiogenic response of irradiated tumors resulting in decreased radiation sensitivity. However, little is known about the contribution of tumor vascular endothelial growth factor (VEGF) or basic fibroblast growth factor (bFGF)-release induced by irradiation to the individual level of...

journal_title：Oncology reports

authors： Brieger J,Kattwinkel J,Berres M,Gosepath J,Mann WJ

更新日期：2007-12-01 00:00:00