Topical vidarabine or 5-fluorouracil treatment against persistent HPV in genital (pre)cancerous lesions.

Abstract:

:In the present study, effectiveness of topical vidarabine or subsequent 5-fluorouracil (5-FU) administration was examined against persistent genital human papillomavirus (HPV) infection after local surgery. Thirty patients underwent local eradication treatment of uterine cervical intra-epithelial neoplasia (CIN) and stage Ia1 uterine cervical cancers. HPV typing was performed by PCR-RFLP analysis. HPV infection was detected pre-operatively in 29 of 30 patients. Of these, HPV was still present in the 20 patients within two months after the therapy. Topical administration of vidarabine or subsequent 5-FU once a week for four weeks was performed to the post-operative persistent HPV-positive cases. HPV infection was abolished in 1 of 10 (10%) with topical vidarabine, and in 2 of 4 vidarabine-resistant cases (50%) with topical 5-FU. Topical vidarabine or 5-FU treatment is beneficial for HPV-positive cases after local surgical excision.

journal_name

Oncol Rep

journal_title

Oncology reports

authors

Niwa K,Tagami K,Lian Z,Gao J,Mori H,Tamaya T

keywords:

subject

Has Abstract

pub_date

2003-09-01 00:00:00

pages

1437-41

issue

5

eissn

1021-335X

issn

1791-2431

journal_volume

10

pub_type

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