Metabolism of irinotecan and its active metabolite SN-38 by intestinal microflora in rats.

abstract：:MicroRNAs (miRs) have emerged as prospective tools for human cancer therapy, including hepatocellular carcinoma (HCC) therapy. Previous studies have suggested that miR-381 functions as oncogenic or tumor-suppressive miRs in other cancer types. However, the role of miR-381 in HCC remains unknown. The present study inve...

journal_title：Oncology reports

authors： Zhang Q,Zhao S,Pang X,Chi B

更新日期：2016-03-01 00:00:00

abstract：:The phosphatase and tensin homolog (PTEN) gene, an important tumor-suppressor gene, has been demonstrated to have the potential for inhibiting proliferation, migration and invasion in various types of cancer cells. The aim of the present study was to investigate the effect of PTEN expression on osteosarcoma (OS) cells...

journal_title：Oncology reports

authors： Hu Y,Xu S,Jin W,Yi Q,Wei W

更新日期：2014-10-01 00:00:00

abstract：:Chemomicin (CHM), an angucyclinone antibiotic extracted from the fermentation broth of Nocardia Mediterranei subsp. Kanglensis 1747-64, shows immunosuppressive activity. However, whether it can inhibit growth of tumor cells remains elusive. In the present study, we show that CHM potently inhibited the proliferations o...

journal_title：Oncology reports

authors： Li Y,Han N,Gao N,Xu R,Sun C,Li D,He Q

更新日期：2010-02-01 00:00:00

abstract：:Patients with brain metastases in disseminated non-seminomatous germ cell cancer of the testis are treated by combined modality, e.g., cisplatin-containing chemotherapy, whole brain irradiation and/or surgical excision. However, cure rates of patients refractory to that standard treatment are low (5-year survival rate...

journal_title：Oncology reports

authors： Feyerabend T,Wiedemann GJ,Steeves R

更新日期：2001-03-01 00:00:00

abstract：:Single nucleotide polymorphisms (SNPs) in cancer-related genes can act as low risk genetic factors for the development of this disease. SNPs have also been shown to influence the efficacy and toxicity of various cytotoxic agents used in the treatment of cancer. Progress in these important areas of cancer research reli...

journal_title：Oncology reports

authors： Grieu F,Joseph D,Norman P,Iacopetta B

更新日期：2004-02-01 00:00:00

abstract：:E1A binding protein P300 (EP300), tumor protein P53 (TP53) and BCL2 associated X, apoptosis regulator (BAX) genes encode proteins which cooperate to regulate important cellular processes. The present study aimed to determine the expression levels of EP300, TP53 and BAX in colorectal cancer (CRC) and to investigate the...

journal_title：Oncology reports

authors： Kowalczyk AE,Krazinski BE,Godlewski J,Kiewisz J,Kwiatkowski P,Sliwinska-Jewsiewicka A,Kiezun J,Sulik M,Kmiec Z

更新日期：2017-07-01 00:00:00

abstract：:The precise mechanism through which the two estrogen receptor subtypes, ERα and ERβ, are linked to endometrial malignant progression is not fully understood. The aim of the present study was to examine their role in endometrial carcinoma cell migration, invasion and proliferation. We also explored the correlation betw...

journal_title：Oncology reports

authors： Hou X,Zhao M,Wang T,Zhang G

更新日期：2014-03-01 00:00:00

abstract：:The aim of the present study was to discover the signaling pathways associated with 2-(3-hydroxy-5-methoxy-phenyl)-6,7-methylenedioxyquinolin-4-one (YYK1)-induced apoptosis in HL-60 human leukemia cells. YYK1 induced cytotoxic effects, cell morphological changes, decreased the cell ...

journal_title：Oncology reports

authors： Cheng YY,Yang JS,Tsai SC,Liaw CC,Chung JG,Huang LJ,Lee KH,Lu CC,Chien HC,Tsuzuki M,Kuo SC

更新日期：2012-10-01 00:00:00

abstract：:Interleukin‑9 (IL‑9) can function as both a positive and negative regulator of immune response, however the role of IL‑9 in tumor immunity is poorly understood. Chronic lymphocytic leukemia (CLL) is the most common chronic lympho‑proliferative disorder. Twenty CLL patients from 2010 to 2011 were recruited in the study...

journal_title：Oncology reports

authors： Chen N,Feng L,Qu H,Lu K,Li P,Lv X,Wang X

更新日期：2018-06-01 00:00:00

abstract：:Epstein-Barr virus (EBV) is a ubiquitous pathogen that was first identified as a human cancer virus. Many human cancers are associated with EBV, and we demonstrated that EBV infects macrophages. Macrophages infected with EBV show a close correlation with many human cancers, and thus more attention must be given to the...

journal_title：Oncology reports

authors： Shimakage M

更新日期：2014-11-01 00:00:00

abstract：:Patients with autosomal recessive primary microcephaly have a small but architecturally normal brain containing a reduced number of neurons. Microcephalin and ASPM are two of the genes causing this disease. Both are centrosomal proteins involved in cell cycle regulation. Whereas microcephalin is a component of the DNA...

journal_title：Oncology reports

authors： Hagemann C,Anacker J,Gerngras S,Kühnel S,Said HM,Patel R,Kämmerer U,Vordermark D,Roosen K,Vince GH

更新日期：2008-08-01 00:00:00

abstract：:A previous study by our group suggested that testis expressed 10 (Tex10) contributes to tumor progression by promoting stem cell‑like features in hepatocellular carcinoma. However, the relevance of pluripotency factor Tex10 in esophageal squamous cell carcinoma (ESCC) has remained elusive. The objective of the present...

journal_title：Oncology reports

authors： Xiang X,Xiong R,Yu C,Deng L,Bie J,Xiao D,Chen Z,Zhou Y,Li X,Liu K,Feng G

更新日期：2019-12-01 00:00:00

abstract：:Epidemiologic studies indicate the use of either statins or aspirin have beneficial effects in prostate cancer patients. The present study was undertaken to evaluate the effects and mechanisms of atorvastatin and aspirin alone or in combination in human prostate cancer cells cultured in vitro and grown as xenograft tu...

journal_title：Oncology reports

authors： He Y,Huang H,Farischon C,Li D,Du Z,Zhang K,Zheng X,Goodin S

更新日期：2017-02-01 00:00:00

abstract：:This study analyzed microRNA (miRNA) and mRNA expression profiles and investigated the biological characteristics of ESCC by using invasion and cytotoxicity cell models. miRNA profiles were evaluated through miRNA microarray. Transwell chamber and nedaplatin (NDP) were used to construct invasion and cytotoxicity cell ...

journal_title：Oncology reports

authors： Lu M,Song Y,Fu W,Liu Y,Huai S,Cui X,Pang L,Yang L,Wei Y

更新日期：2017-08-01 00:00:00

abstract：:Secreted frizzled-related protein 1 (SFRP1) is a candidate tumor suppressor gene located at 8p11.2 and antagonizes the Wnt signaling pathway. Epigenetic inactivation of SFRP1 by methylation of its promoter CpG island has recently been reported in several types of cancers. In the present study, we examined the expressi...

journal_title：Oncology reports

authors： Awakura Y,Nakamura E,Ito N,Kamoto T,Ogawa O

更新日期：2008-11-01 00:00:00

abstract：:The present study aimed to investigate the effects of cold atmospheric plasma (CAP)‑activated Ringer's solution on osteosarcoma cell lines MG63 and U2OS, and to identify the molecular mechanism underlying these effects. CAP‑activated Ringer's solution was used to treat osteosarcoma cell lines MG63 and U2OS for 30 min....

journal_title：Oncology reports

authors： Xu S,Wang Y,Que Y,Ma C,Cai S,Wang H,Yang X,Yang C,Cheng C,Zhao G,Hu Y

更新日期：2020-05-01 00:00:00

abstract：:There has been increasing evidence that numerous bioactive dietary agents can hamper the process of carcinogenesis by targeting epigenetic alterations including DNA methylation. This therapeutic approach is considered as a significant goal for cancer therapy due to the reversible nature of epigenetic-mediated gene sil...

journal_title：Oncology reports

authors： Khan MA,Hussain A,Sundaram MK,Alalami U,Gunasekera D,Ramesh L,Hamza A,Quraishi U

更新日期：2015-04-01 00:00:00

abstract：:Although ascorbate (Vitamin C) has been shown to inhibit cell growth and induce cell death in variety of cancer cells, results reported in other studies are inconsistent with this conclusion. It was previously reported that ascorbate induces apoptosis in human breast cancer cells. However, the molecular mechanism for ...

journal_title：Oncology reports

authors： Hong SW,Jin DH,Hahm ES,Yim SH,Lim JS,Kim KI,Yang Y,Lee SS,Kang JS,Lee WJ,Lee WK,Lee MS

更新日期：2007-10-01 00:00:00

abstract：:The identification of large numbers of genetic mutations in immature myeloid cells has made it difficult to identify specific targets for acute myeloid leukemia (AML) therapy. Although current pharmacological targets for controlling cancer are focused on identifying genetic mutations, it is hard to develop the specifi...

journal_title：Oncology reports

authors： Ryu I,Ryu MJ,Han J,Kim SJ,Lee MJ,Ju X,Yoo BH,Lee YL,Jang Y,Song IC,Chung W,Oh E,Heo JY,Kweon GR

更新日期：2018-12-01 00:00:00

abstract：:Malignant peripheral nerve tumours (MPNT), e.g. malignant schwannoma, represent a relatively rare tumour entity which is usually regarded as a member of the group of soft-tissue sarcomas and treated accordingly. For chemotherapeutic approaches in metastasised disease, ifosfamide and doxorubicin have been identified as...

journal_title：Oncology reports

authors： Steins MB,Serve H,Zühlsdorf M,Senninger N,Semik M,Berdel WE

更新日期：2002-05-01 00:00:00

abstract：:The effects of a novel oral fluoropyrimidine derivative S-1 on peritoneal metastasis from gastric cancer were investigated. OCUM-2MD3 cells, a highly peritoneal-metastatic cell line, were injected intraperitoneally in nude mice. These mice were allocated to the following three groups (each group, n=10): the S-1 group,...

journal_title：Oncology reports

authors： Yamagata S,Nakata B,Hirakawa K

更新日期：2004-11-01 00:00:00

abstract：:Lapatinib, an inhibitor of human epidermal growth factor receptor 2 (HER2) phosphorylation, has been reported to inhibit several types of tumors such as HER2-overexpressing breast cancer. However, the effect of lapatinib on the malignant phenotype of human osteosarcoma (OS) cells and the potential molecular mechanisms...

journal_title：Oncology reports

authors： Long XH,Zhang GM,Peng AF,Luo QF,Zhang L,Wen HC,Zhou RP,Gao S,Zhou Y,Liu ZL

更新日期：2014-01-01 00:00:00

abstract：:The immune suppression of sentinel lymph node (SN) is directly influenced by primary tumors. It has been reported that the T-helper type 1 (Th1) to T-helper type 2 (Th2) ratio or T-cytotoxic type 1 (Tc1) to T-cytotoxic type 2 (Tc2) ratio of lymph node lymphocytes could be used to evaluate direct immunological circumst...

journal_title：Oncology reports

authors： Ehi K,Ishigami S,Masamoto I,Uenosono Y,Natsugoe S,Arigami T,Arima H,Kijima Y,Yoshinaka H,Yanagita S,Kozono T,Funasako Y,Maruyama I,Aikou T

更新日期：2008-03-01 00:00:00

abstract：:Recent studies have shown that miRNAs have potent abilities to activate gene expression by targeting promoter elements, a phenomenon known as RNA activation (RNAa). In the present study, we identified a new endogenous miR-3619-5p which was decreased in prostate cancer tissues and cells compared to corresponding normal...

journal_title：Oncology reports

authors： Li S,Wang C,Yu X,Wu H,Hu J,Wang S,Ye Z

更新日期：2017-01-01 00:00:00

abstract：:Angiogenesis is a key factor in the growth and dissemination of malignant diseases, including breast cancer, with significant implications for its clinical management. It is known that microRNAs (miRNAs) play important roles in regulating tumor properties in cancers. However, whether miR-497 contributes to breast canc...

journal_title：Oncology reports

authors： Wu Z,Cai X,Huang C,Xu J,Liu A

更新日期：2016-03-01 00:00:00

abstract：:The decision to repeat transcatheter arterial chemoembolization (TACE) for hepatocellular carcinoma (HCC) is based on correct evaluation of response to therapy. The purpose of this study was to investigate whether apparent diffusion coefficient (ADC), a quantitative parameter of diffusion-weighted imaging (DWI), can p...

journal_title：Oncology reports

authors： Kubota K,Yamanishi T,Itoh S,Murata Y,Miyatake K,Yasunami H,Morio K,Hamada N,Nishioka A,Ogawa Y

更新日期：2010-09-01 00:00:00

abstract：:TRIM58 (tripartite motif containing 58) has been reported as a novel methylated gene in hepatocellular carcinoma (HCC) by methylation microarrays. However, its associations with mRNA expression and clinicopathological characteristics have not been evaluated. In this study, we explored the potential clinical implicatio...

journal_title：Oncology reports

authors： Qiu X,Huang Y,Zhou Y,Zheng F

更新日期：2016-08-01 00:00:00

abstract：:Gastric cancer (GC) is one of the most lethal malignancies worldwide. To reduce its high mortality, sensitive and specific biomarkers for early detection are urgently needed. Recent studies have reported that tumor-specific long non-coding RNAs (lncRNAs) seem to be potential biomarkers for the early diagnosis and trea...

journal_title：Oncology reports

authors： Li C,Liang G,Yao W,Sui J,Shen X,Zhang Y,Ma S,Ye Y,Zhang Z,Zhang W,Yin L,Pu Y

更新日期：2016-03-01 00:00:00

abstract：:Sunitinib is a novel, multi-targeted receptor tyrosine kinase inhibitor, which has demonstrated evidence of improved survival when compared to interferon (IFN)-alpha in patients with metastatic renal cell carcinoma (RCC). Recently published National Institute for Health and Clinical Excellence guidance recommends suni...

journal_title：Oncology reports

authors： Ansari J,Fatima A,Fernando K,Collins S,James ND,Porfiri E

更新日期：2010-08-01 00:00:00

abstract：:Epigenetic changes as well as genetic changes are mechanisms of tumorigenesis. We aimed to identify novel genes that are silenced by DNA hypermethylation in hepatocellular carcinoma (HCC). We screened for genes with promoter DNA hypermethylation using a genome-wide methylation microarray analysis in primary HCC (the d...

journal_title：Oncology reports

authors： Yamada N,Yasui K,Dohi O,Gen Y,Tomie A,Kitaichi T,Iwai N,Mitsuyoshi H,Sumida Y,Moriguchi M,Yamaguchi K,Nishikawa T,Umemura A,Naito Y,Tanaka S,Arii S,Itoh Y

更新日期：2016-04-01 00:00:00