Abstract:
:Epigenetic changes as well as genetic changes are mechanisms of tumorigenesis. We aimed to identify novel genes that are silenced by DNA hypermethylation in hepatocellular carcinoma (HCC). We screened for genes with promoter DNA hypermethylation using a genome-wide methylation microarray analysis in primary HCC (the discovery set). The microarray analysis revealed that there were 2,670 CpG sites that significantly differed in regards to the methylation level between the tumor and non-tumor liver tissues; 875 were significantly hypermethylated and 1,795 were significantly hypomethylated in the HCC tumors compared to the non‑tumor tissues. Further analyses using methylation-specific PCR, combined with expression analysis, in the validation set of primary HCC showed that, in addition to three known tumor-suppressor genes (APC, CDKN2A, and GSTP1), eight genes (AKR1B1, GRASP, MAP9, NXPE3, RSPH9, SPINT2, STEAP4, and ZNF154) were significantly hypermethylated and downregulated in the HCC tumors compared to the non-tumor liver tissues. Our results suggest that epigenetic silencing of these genes may be associated with HCC.
journal_name
Oncol Repjournal_title
Oncology reportsauthors
Yamada N,Yasui K,Dohi O,Gen Y,Tomie A,Kitaichi T,Iwai N,Mitsuyoshi H,Sumida Y,Moriguchi M,Yamaguchi K,Nishikawa T,Umemura A,Naito Y,Tanaka S,Arii S,Itoh Ydoi
10.3892/or.2016.4619subject
Has Abstractpub_date
2016-04-01 00:00:00pages
2228-36issue
4eissn
1021-335Xissn
1791-2431journal_volume
35pub_type
杂志文章相关文献
ONCOLOGY REPORTS文献大全abstract::The present study exploited a versatile in vitro endothelial cell/fibroblast co-culture cell system to investigate the association between angiogenesis and breast cancer by comparing the capacity of plasma from women with breast cancer and age-matched controls, to influence tubule formation and modulate angiogenesis i...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2017.5803
更新日期:2017-09-01 00:00:00
abstract::Head and neck cancer is the sixth most common cancer worldwide and laryngeal cancer represents the largest subgroup. However, the molecular mechanism underlying its malignant behavior and progression is not clarified. Accumulating evidence has shown that Notch1 signaling pathway plays a central role in carcinogenesis,...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or_00000504
更新日期:2009-10-01 00:00:00
abstract::The aim of this study was to look for a new medicine in diagnosing and treating of glioblastoma. Radioiodine-labeled anti-epidermal growth factor receptor (EGFR) binding nanoparticles were constructed. In vitro cell-binding assays were confirmed by confocal microscopy and flow cytometry. Cell cytotoxicity assays were ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2017.5937
更新日期:2017-11-01 00:00:00
abstract::In this study the performance of various intelligent methodologies is compared in the task of pap-smear diagnosis. The selected intelligent methodologies are briefly described and explained, and then, the acquired results are presented and discussed for their comprehensibility and usefulness to medical staff, either f...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.15.4.1001
更新日期:2006-01-01 00:00:00
abstract::Colon cancer (CC) is one of the leading causes of cancer‑related mortality in China and western countries. Several studies have demonstrated that long non‑coding RNAs (lncRNAs) play critical roles in cancer development. However, the function of lncRNA RP11‑619L19.2 in colon cancer remains unclear. The aim of the prese...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2020.7794
更新日期:2020-12-01 00:00:00
abstract::Colorectal cancer is the second most deadly cancer in the United States. When diagnosed early, current treatments bring a limited success; however, once metastasis occurs, radiation and chemotherapy are generally ineffective. Structural changes in the ECM are necessary for cell migration during tissue remodeling. Matr...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2005-03-01 00:00:00
abstract::Vascular endothelial growth factor C (VEGF-C), a member of VEGF gene family, is considered to induce both lymph node metastasis and lymphatic involvement in various cancers related to lymphangiogenesis. We examined the relationship between VEGF-C expression and clinicopathological features in 112 Japanese patients wit...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.10.6.1747
更新日期:2003-11-01 00:00:00
abstract::Acute pancreatitis (AP) is an inflammatory disease with high morbidity and mortality rates. Pancreatic ductal cells are the most susceptible of all cell types that are exposed to the noxious stimuli of pancreatitis. Our previous studies demonstrated that emodin, a natural product extracted from Rheum palmatum L., prot...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2019.7270
更新日期:2019-08-08 00:00:00
abstract::Identification of safe, effective radiosensitizing agents is urgently needed to improve the outcome of radiotherapy in nasopharyngeal cancer (NPC). In this study, we assessed the ability of the polyphenol resveratrol to act as a radiosensitizer in vitro and in vivo. CNE-1 cells were treated with 50 µM resveratrol for ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2017.5413
更新日期:2017-03-01 00:00:00
abstract::To clarify hepatocarcinogenesis by the heterocyclic amine, 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx), we investigated the global expression of genes in rat liver. Rats were continuously fed MeIQx 100 ppm in their diet, and were sacrificed at weeks 4 and 16 for early time points, and week 104 for tumor samp...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2007-04-01 00:00:00
abstract::Burkitt's lymphoma (BL) is a fast growing cancer of the human lymphatic system, and an extremely invasive B-cell non-Hodgkin's lymphoma. We explored the mechanism of apoptosis in Raji cells associated with the post-transcriptional regulation factors. To confirm that the predicted microRNA-520a (miR-520a) is matched wi...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.4975
更新日期:2016-09-01 00:00:00
abstract::Oncolytic vaccinia virus is currently undergoing evaluation as a biological anticancer agent in clinical trials. This treatment exploits the lytic nature of a viral infection to eradicate the tumor mass in a cancer cell‑specific manner. So far, various vaccinia strains have been used as backbones in the design of onco...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2018.6801
更新日期:2019-01-01 00:00:00
abstract::A-kinase can inhibit RhoA activation through phosphorylating ser188 of RhoA. AKAP is a novel protein that can target PKA to different subcellular compartment. Evidence has been presented that PKA anchorage by AKAP is important for the kinase to exert its function. This study analyzed the role of PKA anchorage in PKA-i...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2006-10-01 00:00:00
abstract::The objective of this study was to examine how splenectomy affects the immune response, particularly T cells, in chemically-induced mammary tumors. Female rats were splenectomized and then exposed to 9,10-dimethyl-1,2-benz(a)anthracene (DMBA) to induce mammary tumors. Splenectomy significantly decreased the rate of tu...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.9.1.185
更新日期:2002-01-01 00:00:00
abstract::Activation of C-C chemokine receptor type 7 (CCR7) has been demonstrated to mediate the occurrence and progression of non-small cell lung cancer (NSCLC). However, the potential therapeutic role of CCR7 inhibition in NSCLC is still obscure. Thus, the present study was conducted to investigate the molecular mechanism un...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2017.5524
更新日期:2017-05-01 00:00:00
abstract::Primarily through in vitro studies, the Rho-family of small GTPases and their effector proteins have been implicated in mediating oncogenic properties of cancer cells. We sought to determine if pharmacological inhibition of the RhoA effector proteins known as Rho-kinases (ROCK) with the small molecule inhibitor Y-2763...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2010-03-01 00:00:00
abstract::Esophageal carcinosarcoma (ECS) is a rare malignant neoplasm associated with a poor patient prognosis. It is characterized by the presence of both malignant epithelial and mesenchymal components. Molecular-targeted therapy of several receptor tyrosine kinases (RTKs) has been reported to be effective in the treatment o...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2013.2371
更新日期:2013-06-01 00:00:00
abstract::Renal cell carcinoma (RCC) is the most common type of kidney cancer in adults and has been described as one of the deadliest of cancers affecting the genitourinary tract. Tropomyosin is a two-stranded α-helical coiled coil protein found in cell cytoskeletons. One of its isoforms, tropomyosin-1 (TPM1) has been reported...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.3733
更新日期:2015-03-01 00:00:00
abstract::Colorectal cancer (CRC) is one of the most common cancers worldwide. Long non-coding RNAs (lncRNAs) have been confirmed to play a critical regulatory role in various biological processes including carcinogenesis, which indicates that lncRNAs are valuable biomarkers and therapeutic targets. The novel lncRNA prostate ca...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.4364
更新日期:2016-01-01 00:00:00
abstract::It is reported that patients with Huntington's disease (HD) have a low incidence of cancer. In this study, we investigated the expression of huntingtin-associated protein 1 (HAP1), the ligand of HD's production, in breast tumor and normal tissues. We found that HAP1 expression was significantly lower in tumor compared...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2013.2303
更新日期:2013-05-01 00:00:00
abstract::Owing to aggressiveness and chemoresistance, pancreatic ductal adenocarcinoma (PDAC) is characterised by a poor prognosis. To address this disease-spe-cific dilemma we aimed to establish animal models, which can be used for identifying new specific tumor markers, as well as serving ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2012.2049
更新日期:2012-12-01 00:00:00
abstract::WNT5B is a member of the WNT family that has been reported to be overexpressed in a variety of cancer cell lines and tissues, including colorectal cancer (CRC). However, the potential roles of WNT5B in tumorigenesis have not been reported. In the present study, the WNT5B gene was transfected into CRC cells and generat...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.4772
更新日期:2016-07-01 00:00:00
abstract::The incidence of malignant melanoma has increased greatly in recent decades presenting a high mortality rate despite intensive efforts in this area of research. Recent studies indicate that the chemokine receptor 4 (CXCR4) plays a critical role in cancer. Thus, it has been reported that CXCL12 binding to CXCR4 initiat...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.4620
更新日期:2016-04-01 00:00:00
abstract::MHC class I-related chain molecules A and B (MICA and B) expressed on the cell-surface of tumor cells are ligands for an activating receptor, NKG2D, expressed on natural killer (NK) cells and stimulate the NK cell-mediated cytotoxicity. On the other hand, the soluble form of MICA and B produced by proteolytic cleavage...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or_00001026
更新日期:2010-12-01 00:00:00
abstract::Frizzled2 (Fzd2) is a receptor for wingless-type MMTV integration site family members (Wnts), the aberrant overexpression of which has been noted to contribute to cancer metastasis. The present study was performed to characterize the role of Fzd2 in the migration and invasion of oral squamous cell carcinomas (OSCC) in...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.4285
更新日期:2015-12-01 00:00:00
abstract::EVL belongs to the Ena/VASP (Enabled/vasodilator-stimulated phosphoprotein) family of proteins [Mena (mammalian Ena), VASP and EVL], which have a range of roles in regulating the actin cytoskeleton. Growing evidence suggests that Mena and VASP are involved in carcinogenesis, though little is known about the significan...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2008-04-01 00:00:00
abstract::Regulator of G protein signaling 5 (RGS5) belongs to the R4 subfamily of RGS proteins, a family of GTPase activating proteins, which is dynamically regulated in various biological processes including blood pressure regulation, smooth muscle cell pathology, fat metabolism and tumor angiogenesis. Low-expression of RGS5 ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.3917
更新日期:2015-06-01 00:00:00
abstract::The androgen receptor (AR) plays an essential role in the development and progression of prostate cancer. Castration-resistant prostate cancer (CRPC) is a consequence of androgen deprivation therapy. Unchecked CRPC followed by metastasis is lethal. Some CRPCs show decreased AR gene expression due to epigenetic mechani...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.5000
更新日期:2016-10-01 00:00:00
abstract::Secalonic acid F (SAF) has been previously identified, however, little is known about its cytotoxic activity and related cytotoxic mechanism. The aim of this study was to evaluate the cytotoxic activity of SAF isolated from a deep sea originated fungus Penicillium sp. F11 in HL60 ce...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2012.2062
更新日期:2012-12-01 00:00:00
abstract::High activity 125I brachytherapy has efficacy in selected recurrent malignant brain tumors, but limited efficacy and risk of radiation necrosis have prompted investigation of additional adjunctive therapies. This study aims to assess the toxicity of interstitial conductive hyperthermia used concurrently with 125I brac...
journal_title:Oncology reports
pub_type: 临床试验,杂志文章
doi:
更新日期:2004-01-01 00:00:00