Development of a rapid genotyping method for single nucleotide polymorphisms and its application in cancer studies.

abstract：:MicroRNAs (miRNAs) play an important role in the genesis and development of gastric cancer. In the present study, we determined whether miRNA-135a-5p expression was increased in gastric cancer compared with adjacent non-tumor tissues using 20 pairs of gastric cancer and para-carcinoma tissue samples which were assesse...

journal_title：Oncology reports

authors： Pan Y,Ren F,Zhang W,Liu G,Yang D,Hu J,Feng K,Feng Y

更新日期：2014-12-01 00:00:00

abstract：:The interface between malignant melanoma and patient immunity has long been recognised and efforts to treat this most lethal form of skin cancer by activating immune responses with cytokine, vaccine and also antibody immunotherapies have demonstrated promise in limited subsets of patients. In the present study, we dis...

journal_title：Oncology reports

authors： Malas S,Harrasser M,Lacy KE,Karagiannis SN

更新日期：2014-09-01 00:00:00

abstract：:Although antiestrogens significantly improve the survival of patients with ER-positive breast cancer, therapeutic resistance remains a major limitation. The combinatorial use of antiestrogen with other therapies was proposed to increase their efficiency and more importantly, to prevent or delay the resistance phenomen...

journal_title：Oncology reports

authors： Maynadier M,Basile I,Gallud A,Gary-Bobo M,Garcia M

更新日期：2016-08-01 00:00:00

abstract：:Oncolytic vaccinia virus is currently undergoing evaluation as a biological anticancer agent in clinical trials. This treatment exploits the lytic nature of a viral infection to eradicate the tumor mass in a cancer cell‑specific manner. So far, various vaccinia strains have been used as backbones in the design of onco...

journal_title：Oncology reports

authors： Deng L,Fan J,Ding Y,Zhang J,Zhou B,Zhang Y,Huang B,Hu Z

更新日期：2019-01-01 00:00:00

abstract：:The anaphylatoxin C5a is a chemoattractant that can induce various inflammatory responses in vivo via the C5a receptor (C5aR). There is emerging evidence that C5a is generated in the cancer microenvironment. However, the role of C5a in human nasopharyngeal carcinoma (NPC) remains largely unclear. Thus, the present stu...

journal_title：Oncology reports

authors： Cai K,Wan Y,Wang Z,Wang Y,Zhao X,Bao X

更新日期：2014-11-01 00:00:00

abstract：:p73 is a member of p53 tumor suppressor protein family. In spite of similarities of three meaningful domains between p53 and p73, the exact function of p73 protein is not established. To approach the relevance of p73 expression to a pathological parameter in human breast cancer, the apoptotic index (AI) and the mitoti...

journal_title：Oncology reports

authors： Yamamoto T,Oda K,Kubota T,Miyazaki K,Takenouti Y,Nimura Y,Hamaguchi M,Matsuda S

更新日期：2002-07-01 00:00:00

abstract：:Licochalcone A (LicA) is a chalcone extracted from liquorice which has been used as a traditional Chinese medicine for many generations. Increased glucose consumption and glycolytic activity are important hallmarks of cancer cells, and hexokinase 2 (HK2) upregulation is a major contributor to the elevation of glycolys...

journal_title：Oncology reports

authors： Wu J,Zhang X,Wang Y,Sun Q,Chen M,Liu S,Zou X

更新日期：2018-03-01 00:00:00

abstract：:The aim of this study was to evaluate HSP27 expression in fetal, normal and inflamed oral mucosal epithelium and in oral premalignant epithelial lesions and in their ensuing invasive cancers. In developing human oral epithelia, immunoreactions for HSP27 were moderately observed in suprabasal keratinocytes of palate an...

journal_title：Oncology reports

authors： Leonardi R,Pannone G,Magro G,Kudo Y,Takata T,Lo Muzio L

更新日期：2002-03-01 00:00:00

abstract：:Solid tumors are abnormal tissues containing tumor and non-tumor cells, also known as tumor stromal cells. However, the malignant potential of tumor stromal cells remains largely unknown. The aim of the present study was to investigate the malignant potential of host bone marrow‑derived stroma cells in transplanted su...

journal_title：Oncology reports

authors： Dai X,Chen H,Chen Y,Wu J,Wang H,Shi J,Fei X,Wang Z,Wang A,Dong J,Lan Q,Huang Q

更新日期：2015-12-01 00:00:00

abstract：:Epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase and mutations in this gene are major drivers of lung cancer development. EGFR tyrosine kinase inhibitors (TKIs) are standard first‑line therapies for patients with advanced non‑small cell lung cancer (NSCLC) with activating EGFR mutations, but are n...

journal_title：Oncology reports

authors： Ota K,Okuma T,Lorenzo A,Yokota A,Hino H,Kazama H,Moriya S,Takano N,Hiramoto M,Miyazawa K

更新日期：2019-07-01 00:00:00

abstract：:Honokiol (HNK), a potential antitumor compound, has been widely studied in recent years. It induces apoptosis and affects autophagy in cancer cells, yet the mechanism of its antitumor efficacy remains obscure. Chloroquine (CQ), an autophagy inhibitor, is often applied to sensitize antitumor drugs in clinical trials. H...

journal_title：Oncology reports

authors： Lv X,Liu F,Shang Y,Chen SZ

更新日期：2015-09-01 00:00:00

abstract：:The aim of the present study was to investigate the efficacy of using human umbilical cord blood-derived mesenchymal stem cells (hUCB-MSCs) as gene delivery vectors in the treatment of ovarian cancer. Lentivectors overexpressing cytosine deaminase (CD) and herpes simplex virus thymidine kinase (HSV-tk) (pGC-FU-CD-TK) ...

journal_title：Oncology reports

authors： Jiang J,Wei D,Sun L,Wang Y,Wu X,Li Y,Fang Z,Shang H,Wei Z

更新日期：2014-02-01 00:00:00

abstract：:It has been revealed by our previous proteomic study that the expression profile is different between well‑differentiated and poorly differentiated hepatocellular carcinoma (HCC). Among those differently expressed proteins, peroxiredoxin2 (PRDX2) was our protein of interest. The present study aimed to further investig...

journal_title：Oncology reports

authors： Bai B,Lin Y,Hu J,Wang H,Li L,Zhao S,Zhang J,Meng W,Yue P,Bai Z,Li X

更新日期：2019-03-01 00:00:00

abstract：:The long-term effort in investigating chemical methods to eliminate only cancer cells has improved our knowledge and has led to the development of new drugs. The targets for cancer treatment may be large polymeric molecules such as DNA or microtubules as well as regulatory pathways for tumor development and cell survi...

journal_title：Oncology reports

authors： Stathopoulos GP

更新日期：2002-11-01 00:00:00

abstract：:We investigated the microsatellite alterations in mitochondrial DNA (mtDNA) and in TP53 in thoracic esophageal squamous cell carcinomas (TESCC). Using laser microdissection, 66 paired non-cancerous esophageal muscles, non-cancerous esophageal mucosa, cancerous TESCC nests plus 35 metastatic lymph nodes harvested from ...

journal_title：Oncology reports

authors： Lin CS,Wang LS,Chang SC,Chou TY,Hsu WH,Liu CS,Lee MH,Chung MY,Wei YH

更新日期：2012-07-01 00:00:00

abstract：:Signal transducer and activator of transcription 3 (STAT3) is an oncogene that promotes cell survival, proliferation, and motility. In the present study, we explored the mechanism involved in the inhibition by epigallocatechin-3-gallate (EGCG) of STAT3 signaling as detected by surface plasmon resonance (SPR)-binding a...

journal_title：Oncology reports

authors： Wang Y,Ren X,Deng C,Yang L,Yan E,Guo T,Li Y,Xu MX

更新日期：2013-12-01 00:00:00

abstract：:The usefulness of diagnostic ultrasound in gene transfer was investigated. The hepatocellular carcinoma cell lines PRL/PRF/5 and Hep3B, and the pancreatic carcinoma Panc-1 cells were transfected with lipofectin or irradiated with a linear probe with a frequency of 8 MHz at a mechani...

journal_title：Oncology reports

authors： Tomizawa M,Shinozaki F,Sugiyama T,Yamamoto S,Sueishi M,Yoshida T

更新日期：2012-05-01 00:00:00

abstract：:T cell-mediated cell immunity is the main anti-tumor immunity in which the effector T cells need specific antigen and costimulatory signals. One of the vaccines applied in tumor immunotherapy is the gene-modified tumor cell vaccine. One potential method to increase cell epitope density is to link the antigen with the ...

journal_title：Oncology reports

authors： Fang L,Wang K,Liu X,Zhang L,Zhang X,Qian L,Lu J,Qian G,Ge S

更新日期：2008-06-01 00:00:00

abstract：:Human telomerase reverse transcriptase (hTERT) is an attractive target for cancer gene therapy. However, the poor inhibition of telomerase and a time lag between the inhibition and arrest of cell proliferation limits its use in cancer gene therapy. RNA interference (RNAi) has been proposed as a potential technique for...

journal_title：Oncology reports

authors： Qian X,Cheng J,Chen A,Wang Y,Tao Y,Cao J,Feng Z

更新日期：2008-02-01 00:00:00

abstract：:Medulloblastoma is the most common malignant tumor of the central nervous system in children. The insulin-like growth factor-I receptor (IGF-IR) is an important growth factor for medulloblastoma. The novel IGF-I receptor (IGF-IR) kinase inhibitor NVP-ADW742 has in vitro activity against tumors. Daoy cells were treated...

journal_title：Oncology reports

authors： Zhou H,Rao J,Lin J,Yin B,Sheng H,Lin F,Zhang N,Yang L

更新日期：2011-06-01 00:00:00

abstract：:Peroxisome proliferator-activated receptor-gamma (PPAR-gamma), a member of the nuclear hormone receptor superfamily, is involved in suppressing the growth of several tumors. We showed that PPAR-gamma is expressed in Barrett's adenocarcinoma cell lines and inhibited the growth of these lines through the induction of G1...

journal_title：Oncology reports

authors： Takashima T,Fujiwara Y,Hamaguchi M,Sasaki E,Tominaga K,Watanabe T,Oshitani N,Higuchi K,Arakawa T

更新日期：2005-04-01 00:00:00

abstract：:A-kinase can inhibit RhoA activation through phosphorylating ser188 of RhoA. AKAP is a novel protein that can target PKA to different subcellular compartment. Evidence has been presented that PKA anchorage by AKAP is important for the kinase to exert its function. This study analyzed the role of PKA anchorage in PKA-i...

journal_title：Oncology reports

authors： Wang Y,Chen Y,Chen M,Xu W

更新日期：2006-10-01 00:00:00

abstract：:B-cell-specific Moloney murine leukemia virus insertion site 1 (Bmi1) is directly involved in cell growth, proliferation and self-renewal of cancer stem cells (CSCs). The aim of the present study was to assess the role of Bmi1 in the maintenance of stemness properties and tumorigenicity of human bladder CSC-like side ...

journal_title：Oncology reports

authors： Zhu D,Wan X,Huang H,Chen X,Liang W,Zhao F,Lin T,Han J,Xie W

更新日期：2014-02-01 00:00:00

abstract：:Genetically modified tumour cells producing cytokines such as interleukin 12 (IL-12) are potent activators of the antitumour immune responses and represent a promising therapeutic modality when combined with chemotherapy. The objective of this study was to examine whether IL-12-producing cellular vaccines can augment ...

journal_title：Oncology reports

authors： Mikyšková R,Indrová M,Símová J,Bieblová J,Bubeník J,Reiniš M

更新日期：2011-06-01 00:00:00

abstract：:Semaphorin 3A (SEMA3A), a secretory protein, is a founding member of the semaphorin family and functions in both the biological behavior of tumor cells and the modulation of tumor-associated macrophages. However, the role of SEMA3A in hepatocellular carcinoma (HCC) is still not well established. In the present study, ...

journal_title：Oncology reports

authors： Li X,Chen Q,Yin D,Shi S,Yu L,Zhou S,Chen E,Zhou Z,Shi Y,Fan J,Zhou J,Dai Z

更新日期：2017-06-01 00:00:00

abstract：:Colorectal cancer (CRC) is still one of the most important neoplasias causing human death. Multidisciplinary therapy has won consensus in the management of CRC, of which, radiotherapy occupies an important position. However, radioresistance is still a major obstacle in local control of CRC. Overexpression of long non-...

journal_title：Oncology reports

authors： Yang XD,Xu HT,Xu XH,Ru G,Liu W,Zhu JJ,Wu YY,Zhao K,Wu Y,Xing CG,Zhang SY,Cao JP,Li M

更新日期：2016-01-01 00:00:00

abstract：:Androgen receptor (AR) expression in prostate cancer (CaP) cells varies due to the multiple changes including epigenetic modifications such as DNA methylation and histone deacetylation. DNA methyltransferase and histone deacetylase inhibitors are promising for the treatment of CaP. The aim of our study was to analyze ...

journal_title：Oncology reports

authors： Fialova B,Smesny Trtkova K,Paskova L,Langova K,Kolar Z

更新日期：2013-05-01 00:00:00

abstract：:Breast cancer mortality is strongly related to the invasive and metastatic potential of tumor cells. We previously showed that an active mutant of H-Ras induced invasive phenotype of MCF10A human breast epithelial cells. Membrane anchoring of Ras requires isoprenylation which involves the activity of 3-hydroxy 3-methy...

journal_title：Oncology reports

authors： Kang S,Kim ES,Moon A

更新日期：2009-05-01 00:00:00

abstract：:As part of the efforts to drug repurposing, some HIV drugs have recently been identified to exert anticancer effects. Selected nucleoside analogues of nucleosidic reverse-transcriptase inhibitors (NRTIs) have been shown to interfere with RNA transcription of HI viruses as well as with the replication of DNA in cancer ...

journal_title：Oncology reports

authors： Brüning A,Jückstock J,Kost B,Tsikouras P,Weissenbacher T,Mahner S,Mylonas I

更新日期：2017-01-01 00:00:00

abstract：:It is reported that patients with Huntington's disease (HD) have a low incidence of cancer. In this study, we investigated the expression of huntingtin-associated protein 1 (HAP1), the ligand of HD's production, in breast tumor and normal tissues. We found that HAP1 expression was significantly lower in tumor compared...

journal_title：Oncology reports

authors： Zhu L,Song X,Tang J,Wu J,Ma R,Cao H,Ji M,Jing C,Wang Z

更新日期：2013-05-01 00:00:00