Abstract:
:The effectiveness of granulocyte colony-stimulating factor (G-CSF) for granulocytopenia has been widely recognized. However, although granulocyte counts rapidly increase after a few injection of G-CSF, a large proportion of the increased granulocytes disappear from peripheral blood within a few days following G-CSF withdrawal. Where do they go? In this report, the answer can be seen at a glance. Using MitoCapture and a CCD camera-equipped fluorescence microscope, we succeeded in demonstrating that G-CSF withdrawal induced loss of mitochondrial membrane potential, i.e., an early stage of apoptosis, in human peripheral granulocytes increased by G-CSF.
journal_name
Oncol Repjournal_title
Oncology reportsauthors
Ogawa Y,Kobayashi T,Nishioka A,Kariya S,Garcia Del Saz E,Seguchi H,Yoshida Sdoi
10.3892/or.8.5.1027keywords:
subject
Has Abstractpub_date
2001-09-01 00:00:00pages
1027-9issue
5eissn
1021-335Xissn
1791-2431journal_volume
8pub_type
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