Cell motility and spreading promoted by CEACAM6 through cyclin D1/CDK4 in human pancreatic carcinoma.

abstract：:Insulin resistance (IR) is reportedly involved in the progression of hepatocellular carcinoma (HCC). Since neovascularization plays an important role in hepatocarcinogenesis and IR, an angiostatic therapy may be considered as one of the promising approaches for chemoprevention again...

journal_title：Oncology reports

authors： Yoshiji H,Noguchi R,Ikenaka Y,Kaji K,Aihara Y,Yamazaki M,Yamao J,Toyohara M,Mitoro A,Sawai M,Yoshida M,Morioka C,Fujimoto M,Uemura M,Fukui H

更新日期：2011-12-01 00:00:00

abstract：:Chemokines are small chemotactic cytokines that can induce the migration of leukocytes, activate inflammatory/immune responses and have recently been implicated in the regulation of tumor growth and organ-specific spread. In this setting, the macrophage inflammatory protein-1alpha (CCL3) chemokine displays a diversity...

journal_title：Oncology reports

authors： Silva TA,Ribeiro FL,Oliveira-Neto HH,Watanabe S,Alencar Rde C,Fukada SY,Cunha FQ,Leles CR,Mendonça EF,Batista AC

更新日期：2007-11-01 00:00:00

abstract：:Anti-cytotoxic T lymphocyte antigen-4 (CTLA-4) treatment is effective for the treatment of primary tumors, but not sufficient for the treatment of metastatic tumors, likely owing to the effects of the tumor microenvironment. In this study, we aimed to determine the therapeutic effects of combined treatment with a matr...

journal_title：Oncology reports

authors： Li M,Xing S,Zhang H,Shang S,Li X,Ren B,Li G,Chang X,Li Y,Li W

更新日期：2016-03-01 00:00:00

abstract：:Zinc finger protein 403 (ZFP403), located on human chromosome 17q12‑21, is closely associated with the development of cancer. However, to date, there are a limited number of studies on the biological functions of this gene, particularly in prostate cancer (PCa). The results of the present study demonstrated that compa...

journal_title：Oncology reports

authors： Xu X,Zhu Z,Xu Y,Tian S,Jiang Y,Zhao H

更新日期：2020-12-01 00:00:00

abstract：:Tumor growth is accelerated by induction of angiogenesis regulated by many cytokines and growth factors. In a tumor mass, various angiogenic factors and their receptors are simultaneously expressed and the overlapped expressions of various factors may contribute to the aggressive growth of tumor. However, the possible...

journal_title：Oncology reports

authors： Lee YM,Bae MH,Lee OH,Moon EJ,Moon CK,Kim WH,Kim KW

更新日期：2004-10-01 00:00:00

abstract：:The growth inhibitory effects of bufadienolide compounds were investigated in two intractable cancer cells, a human glioblastoma cell line U-87 and a pancreatic cancer cell line SW1990. Among four bufadienolide compounds, a dose-dependent cytotoxicity was observed in these cancer cells after treatment with gamabufotal...

journal_title：Oncology reports

authors： Yuan B,He J,Kisoh K,Hayashi H,Tanaka S,Si N,Zhao HY,Hirano T,Bian B,Takagi N

更新日期：2016-09-01 00:00:00

abstract：:Human leukocyte antigen B (HLA-B), a novel member of the NF-kappaB signal pathway in laryngeal squamous cell carcinoma (LSCC), mediates immunological surveillance of tumor cells by presenting peptides to cytotoxic T-lymphocytes (CTLs) together with S100 calcium binding protein A8 (S100A8). The objective of this study ...

journal_title：Oncology reports

authors： Guo Y,Liu J,Xu Z,Sun K,Fu W

更新日期：2008-06-01 00:00:00

abstract：:It is well known that low-dose metronomic chemotherapy has antiangiogenic activity. The aim of the present trial was to investigate the antiangiogenic properties of weekly docetaxel in patients with metastatic breast cancer. In total, 157 metastatic breast cancer patients received 3...

journal_title：Oncology reports

authors： Pectasides D,Papaxoinis G,Kotoula V,Fountzilas H,Korantzis I,Koutras A,Dimopoulos AM,Papakostas P,Aravantinos G,Varthalitis I,Kosmidis P,Skarlos D,Bournakis E,Bafaloukos D,Kalofonos HP,Kalogeras KT,Fountzilas G

更新日期：2012-01-01 00:00:00

abstract：:We investigated the role of mitochondrial function in the invasiveness of human colorectal cancer (CRC) cell lines, using paired primary SW480 and metastatic SW620 cells, and appraised the clinical relevance of the alteration of mtDNA copy number in 33 pairs of CRC specimens after surgical resection. Suppression of mi...

journal_title：Oncology reports

authors： Lin CS,Liu LT,Ou LH,Pan SC,Lin CI,Wei YH

更新日期：2018-01-01 00:00:00

abstract：:Ultraviolet (UV) radiation is the primary risk factor underlying photoaging and photocarcinogenesis. Mounting research has focused on the role of DNA damage response pathways in UV-induced double-strand break (DSB) repair. In the present study, we hypothesized that UVA-induced aberrant progerin upregulation may advers...

journal_title：Oncology reports

authors： Huang X,Pan Y,Cao D,Fang S,Huang K,Chen J,Chen A

更新日期：2017-06-01 00:00:00

abstract：:We aimed to examine the relationship between the preoperative GSA index [uptake ratio of the liver to the liver plus heart at 15 min (LHL15) to uptake ratio of the heart at 15 min to that at 3 min (HH15) ratio] calculated from 99mTc‑labeled diethylene triamine pentaacetate-galactosyl human serum albumin (99mTc-GSA) sc...

journal_title：Oncology reports

authors： Nishikawa H,Osaki Y,Komekado H,Sakamoto A,Saito S,Nishijima N,Nasu A,Arimoto A,Kita R,Kimura T

更新日期：2015-03-01 00:00:00

abstract：:In preclinical studies, antagonists of growth hormone-releasing hormone (GHRH) have demonstrated inhibitory effects on the growth of various types of cancers expressing the pituitary type of GHRH receptors (pGHRH-R) and/or its active splice variant 1 (SV1). In this study, we investigated the effectiveness of the treat...

journal_title：Oncology reports

authors： Seitz S,Rick FG,Schally AV,Treszl A,Hohla F,Szalontay L,Zarandi M,Ortmann O,Engel JB,Buchholz S

更新日期：2013-07-01 00:00:00

abstract：:Four tumour suppressor genes (Chk1, Chk2, Apaf1 and Rb1) in nine human malignant melanoma cell lines were screened for a loss of gene expression, point mutations and small deletions/insertions by cDNA-based DGGE/SCCP analysis. In two cell lines alterations of the investigated genes could be demonstrated. This result c...

journal_title：Oncology reports

authors： Papp T,Niemetz A,Dosdahl N,Kumar K,Schiffmann D

更新日期：2007-01-01 00:00:00

abstract：:Prostate and breast cancer overexpressed 1 (PBOV1) is significantly upregulated in prostate, breast and bladder cancer, while its expression status in ovarian cancer and its clinical significance are unclear. We examined the expression levels of PBOV1 mRNA and protein in ovarian cancer cell lines and primary tissues u...

journal_title：Oncology reports

authors： Wang L,Niu CH,Wu S,Wu HM,Ouyang F,He M,He SY

更新日期：2016-01-01 00:00:00

abstract：:Serenoa repens, a palm species native to the Southeastern United States, is one of the widely used phytotherapeutic agents in benign prostatic hyperplasia. In this study, we found for the first time that Serenoa repens induced growth arrest of a variety of human leukemia cells including U266 and RPMI 8226 multiple mye...

journal_title：Oncology reports

authors： Che Y,Hou S,Kang Z,Lin Q

更新日期：2009-08-01 00:00:00

abstract：:We have recently shown that covalent attachment of the nitric oxide (NO) moiety to the HIV protease inhibitor Saquinavir (Saq) produced a qualitatively new chemical entity, named Saquinavir-NO (Saq-NO), with enhanced anticancer properties and reduced toxicity both in vitro and in vi...

journal_title：Oncology reports

authors： Donia M,Mangano K,Fagone P,De Pasquale R,Dinotta F,Coco M,Padron J,Al-Abed Y,Giovanni Lombardo GA,Maksimovic-Ivanic D,Mijatovic S,Zocca MB,Perciavalle V,Stosic-Grujicic S,Nicoletti F

更新日期：2012-08-01 00:00:00

abstract：:WNT5B is a member of the WNT family that has been reported to be overexpressed in a variety of cancer cell lines and tissues, including colorectal cancer (CRC). However, the potential roles of WNT5B in tumorigenesis have not been reported. In the present study, the WNT5B gene was transfected into CRC cells and generat...

journal_title：Oncology reports

authors： Zhang Y,Lin L,Jin Y,Lin Y,Cao Y,Zheng C

更新日期：2016-07-01 00:00:00

abstract：:More than 80% of hepatocellular carcinoma (HCC) arises in HBV based liver cirrhotic patients, suggesting that patients with cirrhosis form the main risk group of HCC. α fetoprotein (AFP) has poor sensitivity for the detection of AFP-negative and/or small tumors in HCC patients. Screening serum markers, along with HCC ...

journal_title：Oncology reports

authors： Shu H,Kang X,Guo K,Li S,Li M,Sun L,Gan L,Liu Y,Qin X

更新日期：2010-11-01 00:00:00

abstract：:Neuropilin-1 (NRP-1), a co-receptor for VEGF165, is overexpressed in various prostate cancer cell lines and in advanced prostate tumors. However, distribution of the NRP-1 in prostate tumors has not yet been evaluated. Using immunohistochemical analysis, we evaluated 21 archival prostate tumors and 5 benign glands for...

journal_title：Oncology reports

authors： Vanveldhuizen PJ,Zulfiqar M,Banerjee S,Cherian R,Saxena NK,Rabe A,Thrasher JB,Banerjee SK

更新日期：2003-09-01 00:00:00

abstract：:Aquaporins (AQPs) are a family of small, integral membrane proteins that have been shown to play an important role in tumor development and metastasis. Several studies have demonstrated that expression of AQP3 contributes to the enhanced migration of epithelial cells and is related to differentiation, metastasis and v...

journal_title：Oncology reports

authors： Li A,Lu D,Zhang Y,Li J,Fang Y,Li F,Sun J

更新日期：2013-02-01 00:00:00

abstract：:It is known that the TGF-β superfamily receptors act as master regulators of cancer progression. However, alteration and role of type III TGF-β receptor (TβRIII, or betaglycan) as the most abundant of the TGF-β receptor has not been explored in salivary gland adenoid cystic carcinoma (ACC). Here, we reported that tumo...

journal_title：Oncology reports

authors： Xu D,Li D,Lu Z,Dong X,Wang X

更新日期：2016-01-01 00:00:00

abstract：:In 72 patients without occult neoplastic cells (ONCs) in their lymph node sinuses, the 5-year relapse-free survival (RFS) rate and overall survival (OS) rate were 71.3% and 69.2%, respectively. In 33 patients with ONCs, the 5-year RFS rate and OS rate were 33.9% and 31.3%, respectively. There was a marked difference o...

journal_title：Oncology reports

authors： Mukai M,Sato S,Ninomiya H,Wakui K,Komatsu N,Tsuchiya K,Nakasaki H,Makuuchi H

更新日期：2005-11-01 00:00:00

abstract：:Epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase and mutations in this gene are major drivers of lung cancer development. EGFR tyrosine kinase inhibitors (TKIs) are standard first‑line therapies for patients with advanced non‑small cell lung cancer (NSCLC) with activating EGFR mutations, but are n...

journal_title：Oncology reports

authors： Ota K,Okuma T,Lorenzo A,Yokota A,Hino H,Kazama H,Moriya S,Takano N,Hiramoto M,Miyazawa K

更新日期：2019-07-01 00:00:00

abstract：:Tanshinone IIA (Tan‑IIA; C19H18O3) is derived from Danshen (the roots of Salvia miltiorrhiza), and has been reported to possess anti‑inflammatory and antioxidant activities. Tan‑IIA can inhibit BxPC‑3 human pancreatic cancer cells in vitro through inducing endoplasmic reticulum stress and apoptosis via mitochondrial p...

journal_title：Oncology reports

authors： Su CC

更新日期：2018-11-01 00:00:00

abstract：:The aim of this study was to verify whether histopathological features of extratumoral and of primary tumor breast tissue could play a role in identifying patients with familial characteristics. We examined the clinicopathological features of 504 patients with sporadic or familial breast cancer stratified for risk of ...

journal_title：Oncology reports

authors： Mangia A,Tommasi S,Bruno M,Malfettone A,D'Amico C,Zito FA,Paradiso A,Simone G

更新日期：2010-06-01 00:00:00

abstract：:Pancreatic cancer is one of the most lethal cancers, with an incidence equaling mortality. It is a heterogeneous group of neoplasms in which pancreatic ductal adenocarcinoma is most common. Pancreatic cancer cannot be cured even if detected early. When treatment is initiated, a suit...

journal_title：Oncology reports

authors： Takata T,Ishigaki Y,Shimasaki T,Tsuchida H,Motoo Y,Hayashi A,Tomosugi N

更新日期：2012-12-01 00:00:00

abstract：:Metastasis‑associated lung adenocarcinoma transcript 1 (MALAT1) is a long non‑coding RNA (lncRNA) that has an oncogenic role in some types of cancers, uncluding breast cancer (BC). To investigate the role of MALAT1 in human BC progression, we detected MALAT1 expression levels based on tissue samples from 20 BC cases a...

journal_title：Oncology reports

authors： Huang XJ,Xia Y,He GF,Zheng LL,Cai YP,Yin Y,Wu Q

更新日期：2018-11-01 00:00:00

abstract：:Histone deacetylase inhibitors are currently being evaluated for their therapeutic potential and have shown considerable promise as adjuvant therapies for a number of cancers. This study compared the effects of 2 hydroxamic acid based inhibitors, CG-1521 and SAHA, on gene expression...

journal_title：Oncology reports

authors： Knutson AK,Welsh J,Taylor T,Roy S,Wang WL,Tenniswood M

更新日期：2012-03-01 00:00:00

abstract：:The antitumor effect of the human umbilical vein endothelial cell (HUVEC) vaccine has been well documented; however, its anti‑angiogenic effects on human esophageal squamous cell carcinoma (ESCC) have yet to be studied. In the present study, a 'humanized' mouse model was established by transplanting NOD/SCID mice with...

journal_title：Oncology reports

authors： Liu H,Zhao J,Yang Y,Jin G,Zhang X,Wang D,Xie C,Liu K,Chen X,Li X,Tian F,Dong Z,Lu J

更新日期：2018-11-01 00:00:00

abstract：:Lapatinib, an inhibitor of human epidermal growth factor receptor 2 (HER2) phosphorylation, has been reported to inhibit several types of tumors such as HER2-overexpressing breast cancer. However, the effect of lapatinib on the malignant phenotype of human osteosarcoma (OS) cells and the potential molecular mechanisms...

journal_title：Oncology reports

authors： Long XH,Zhang GM,Peng AF,Luo QF,Zhang L,Wen HC,Zhou RP,Gao S,Zhou Y,Liu ZL

更新日期：2014-01-01 00:00:00