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Genome‑scale analysis to identify potential prognostic microRNA biomarkers for predicting overall survival in patients with colon adenocarcinoma.

Abstract：

:The aim of the present study was to identify potential prognostic microRNA (miRNA) biomarkers for colon adenocarcinoma (COAD) prognostic prediction using the dataset of The Cancer Genome Atlas (TCGA). The genome‑wide miRNA sequencing dataset and corresponding COAD clinical information were downloaded from TCGA. Prognosis‑related miRNA screening was performed by genome‑wide multivariable Cox regression analysis and used for prognostic signature construction. Ten miRNAs (hsa‑mir‑891a, hsa‑mir‑6854, hsa‑mir‑216a, hsa‑mir‑378d‑1, hsa‑mir‑92a‑1, hsa‑mir‑4709, hsa‑mir‑92a‑2, hsa‑mir‑210, hsa‑mir‑940 and hsa‑mir‑887) were identified as prognostic miRNAs and used for further prognostic signature construction. The 10‑miRNA prognostic signature showed good performance in prognosis prediction (adjusted P<0.0001; adjusted hazard ratio, 4.580; 95% confidence interval, 2.783‑7.538). In the time‑dependent receiver operating characteristic analysis, the area under the curve was 0.735, 0.788, 0.806, 0.806, 0.775 and 0.900 for 1‑, 2‑, 3‑, 4‑, 5‑ and 10‑year COAD overall survival prediction, respectively. Comprehensive survival analysis suggested that the 10‑miRNA prognostic signature is an independent prognostic factor in COAD, with a better performance in COAD overall survival prediction than other traditional clinical parameters. Functional enrichment indicated that the corresponding target genes were significantly enriched in multiple biological processes and pathways, including regulation of cell proliferation, cell cycle, cell growth, and Wnt and transforming growth factor‑β signaling pathways. In conclusion, our present study identified a 10‑miRNA expression signature that may serve as a potential prognostic biomarker in COAD patients.

journal_name

Oncol Rep

journal_title

Oncology reports

authors

Wei HT,Guo EN,Liao XW,Chen LS,Wang JL,Ni M,Liang C

doi

10.3892/or.2018.6607

subject

Has Abstract

pub_date

2018-10-01 00:00:00

pages

1947-1958

issue

eissn

1021-335X

issn

1791-2431

journal_volume

pub_type

杂志文章

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Genome‑scale analysis to identify potential prognostic microRNA biomarkers for predicting overall survival in patients with colon adenocarcinoma.