Quintuple carcinomas with metachronous triple cancer of the esophagus, kidney, and colonic conduit following synchronous double cancer of the stomach and duodenum.

abstract：:Gastroenteropancreatic neuroendocrine tumors (GEP‑NETs) are relatively uncommon. Unfortunately, epidemiological studies on the incidence of GEP‑NETs worldwide have reported a marked increase in the detection of these tumors. Although they often exhibit relatively indolent clinical courses, GEP‑NETs have the potential ...

journal_title：Oncology reports

authors： Tang C,Gong L,Zou W,Zhang J,Zhou Y,Wu X,Lu F,Ouyang C,Liu X

更新日期：2016-12-01 00:00:00

abstract：:Histone deacetylase (HDAC) 4 is an emerging target in cancer therapeutics, but little is known about the function of HDAC4 in gynecologic malignancies. Therefore we investigated the mechanism of HDAC4 promoting the proliferation of epithelial ovarian cancer cells (OV). In this study, we observed that the proliferation...

journal_title：Oncology reports

authors： Shen YF,Wei AM,Kou Q,Zhu QY,Zhang L

更新日期：2016-02-01 00:00:00

abstract：:Angiogenesis is a key factor in the growth and dissemination of malignant diseases, including breast cancer, with significant implications for its clinical management. It is known that microRNAs (miRNAs) play important roles in regulating tumor properties in cancers. However, whether miR-497 contributes to breast canc...

journal_title：Oncology reports

authors： Wu Z,Cai X,Huang C,Xu J,Liu A

更新日期：2016-03-01 00:00:00

abstract：:Circulating microRNAs (miRNAs) exist stably in body fluids and are potential biomarkers for hepatocellular carcinoma (HCC). Twenty-five patients with cirrhosis that evolved into HCC, who were treated at The Third Hospital of Zhenjiang Affiliated to Jiangsu University between January 2005 and December 2012, were enroll...

journal_title：Oncology reports

authors： Tan Y,Lin B,Ye Y,Wen D,Chen L,Zhou X

更新日期：2015-06-01 00:00:00

abstract：:Aberrant DNA methylation and histone deacetylation participate in cancer development and progression; hence, their reversal by inhibitors of DNA methylation and histone deacetylases is a promising cancer therapy. Experimental data demonstrate that these inhibitors in combination do not only show synergy in antitumor e...

journal_title：Oncology reports

authors： De la Cruz-Hernández E,Perez-Plasencia C,Pérez-Cardenas E,Gonzalez-Fierro A,Trejo-Becerril C,Chávez-Blanco A,Taja-Chayeb L,Vidal S,Gutiérrez O,Dominguez GI,Trujillo JE,Duenas-González A

更新日期：2011-02-01 00:00:00

abstract：:Cyclin‑dependent kinase 5 regulatory subunit‑​associated protein 3 (CDK5RAP3 or C53) is involved in the development of various types of tumor, and alternative splicing of C53 results in numerous transcription variants that encode different isoforms. The present study aimed to clone human C53 isoform d (IC53d) and expl...

journal_title：Oncology reports

authors： Lin JX,Xie XS,Weng XF,Qiu SL,Xie JW,Wang JB,Lu J,Chen QY,Cao LL,Lin M,Tu RH,Li P,Huang CM,Zheng CH

更新日期：2019-05-01 00:00:00

abstract：:MicroRNAs (miRNAs) are small non-coding RNAs of 20-25 nucleotides in length that are capable of modulating gene expression post-transcriptionally. The potential roles of miRNAs in the tumorigenesis of glioblastoma (GBM) have been under intensive studies in the past few years. In the present study, we found a positive ...

journal_title：Oncology reports

authors： Jiang H,Hua D,Zhang J,Lan Q,Huang Q,Yoon JG,Han X,Li L,Foltz G,Zheng S,Lin B

更新日期：2014-05-01 00:00:00

abstract：:Peroxiredoxin 1 (Prdx1) is an antioxidant and plays an important role in H2O2-mediated cell signaling. We previously found that the expression level of Prdx1 was elevated in esophagus squamous cell carcinoma (ESCC) tissue using a proteomics approach. Since overexpressed protein can induce an autoimmune response, to fu...

journal_title：Oncology reports

authors： Ren P,Ye H,Dai L,Liu M,Liu X,Chai Y,Shao Q,Li Y,Lei N,Peng B,Yao W,Zhang J

更新日期：2013-11-01 00:00:00

abstract：:E1A binding protein P300 (EP300), tumor protein P53 (TP53) and BCL2 associated X, apoptosis regulator (BAX) genes encode proteins which cooperate to regulate important cellular processes. The present study aimed to determine the expression levels of EP300, TP53 and BAX in colorectal cancer (CRC) and to investigate the...

journal_title：Oncology reports

authors： Kowalczyk AE,Krazinski BE,Godlewski J,Kiewisz J,Kwiatkowski P,Sliwinska-Jewsiewicka A,Kiezun J,Sulik M,Kmiec Z

更新日期：2017-07-01 00:00:00

abstract：:Secreted protein acidic and rich in cysteine (SPARC) is a glycoprotein which plays multiple roles in different types of cancer. Our previous study showed that SPARC overexpression inhibited the growth and angiogenesis of tumors, and reduced expression of vascular endothelial growth factor (VEGF). However, the relation...

journal_title：Oncology reports

authors： Zhang J,Wang P,Zhu J,Wang W,Yin J,Zhang C,Chen Z,Sun L,Wan Y,Wang X,Chen G,Liu Y

更新日期：2014-05-01 00:00:00

abstract：:The expression of the DNA mismatch repair proteins hMSH2 and hMLH1 and p21(waf1) the cyclin G1 inhibitor, may determine response of adult cancers to anti-cancer drugs, that include alkylating agents and platinum-based drugs. The role of DNA mismatch repair proteins (hMSH2 and hMLH1) and p21(waf1) in pediatric tumor re...

journal_title：Oncology reports

authors： Idikio HA

更新日期：2001-09-01 00:00:00

abstract：:Extracellular matrix remodeling crucial to tumorigenesis involves proteolytic enzymes, primarily matrix metalloproteinases (MMPs). MMP production is stimulated by multiple factors, including the extracellular matrix metallo-proteinase inducer EMMPRIN/CD147. Overexpression of EMMPRIN...

journal_title：Oncology reports

authors： Takahashi M,Suzuki S,Ishikawa K

更新日期：2012-01-01 00:00:00

abstract：:ABCG2 is a multidrug cellular transport protein that is associated with resistance to certain treatments in patients, particularly anticancer treatment. The tumor-protective properties of ABCG2 expression are reported to be a feature of a subset of stem cell-like tumor cells. While protection against chemotherapy has ...

journal_title：Oncology reports

authors： Zoernig I,Ziegelmeier C,Lahrmann B,Grabe N,Jäger D,Halama N

更新日期：2013-05-01 00:00:00

abstract：:Depressed and flat surface lesions are not easy to identify with routine colonoscopies during screening for colorectal cancer (CRC). Identifying clinically relevant genes that influence tumor shape could be useful when screening for the presence of depressed lesions. Total RNA was extracted from tumor cells collected ...

journal_title：Oncology reports

authors： Kida H,Takano Y,Yamamoto K,Mori M,Yanaga K,Tanaka J,Kudo SE,Mimori K

更新日期：2014-08-01 00:00:00

abstract：:Death-associated protein kinase (DAPK) plays an important role in apoptosis regulation and has been shown to maintain antitumor and metastasis suppressor properties. In the present study, we investigated whether DAPK overexpression may mediate vascular endothelial growth factor (VEGF)/hypoxia-inducible factor-1α (HIF-...

journal_title：Oncology reports

authors： Park ST,Kim BR,Park SH,Lee JH,Lee EJ,Lee SH,Rho SB

更新日期：2014-02-01 00:00:00

abstract：:Lymph node metastasis is one of the most important prognostic factors in malignant tumors. In this study, we investigated vascular endothelial growth factor (VEGF)-C expression in human gastric cancer using immunohistochemical techniques and determined the number of microvessels in peritumoral tissue. VEGF-C expressio...

journal_title：Oncology reports

authors： Hachisuka T,Narikiyo M,Yamada Y,Ishikawa H,Ueno M,Uchida H,Yoriki R,Ohigashi Y,Miki K,Tamaki H,Mizuno T,Nakajima Y

更新日期：2005-04-01 00:00:00

abstract：:The overexpression of EGFR and/or HER-2 is associated with tumor cell resistance to chemotherapy, radiotherapy, disease progression and poor prognosis in patients with a variety of malignant tumors. Treatment combining the EGFR-targeting drug, gefitinib (ZD1839, Iressa) with the HER-2-targeting drug, trastuzumab (Herc...

journal_title：Oncology reports

authors： Kondo N,Ishiguro Y,Kimura M,Sano D,Fujita K,Sakakibara A,Taguchi T,Toth G,Matsuda H,Tsukuda M

更新日期：2008-08-01 00:00:00

abstract：:Hepatocyte growth factor (HGF) was suggested to play an important role in the regulation of mitogenesis, motogenesis, angiogenesis, migration and invasion for various types of cells, and acts through a specific membrane receptor encoded by c-met proto-oncogene. However, the mechanism of the effect of HGF on tumor inva...

journal_title：Oncology reports

authors： Fujiuchi Y,Nagakawa O,Murakami K,Fuse H,Saiki I

更新日期：2003-07-01 00:00:00

abstract：:The aim of the present study was to investigate the expression, function and underlying molecular mechanism of the long non‑coding (lnc) RNA RP1‑163G9.1 in patients with gastric adenocarcinoma (GA). The expression levels of lncRNA RP1‑163G9.1 were determined in 112 paired clinical GA tissues by reverse transcription‑q...

journal_title：Oncology reports

authors： Sun B,Dang Y,Zhang F,Li K,Ouyang X,Wang K,Huang Q

更新日期：2019-06-01 00:00:00

abstract：:Hydrogen sulfide (H2S) participates in multifarious physiological and pathophysiologic progresses of cancer both in vitro and in vivo. We have previously demonstrated that exogenous H2S promoted liver cancer cells proliferation/anti‑apoptosis/angiogenesis/migration effects via amplifying the activation of NF-κB pathwa...

journal_title：Oncology reports

authors： Zhen Y,Zhang W,Liu C,He J,Lu Y,Guo R,Feng J,Zhang Y,Chen J

更新日期：2015-11-01 00:00:00

abstract：:Increased production of reactive oxygen species (ROS) is a distinct feature of various types of cancer. ROS drive tumor progression and render cancer cells vulnerable to additional oxidative insult. The various natural herb compounds have been shown to induce additional production of ROS in cancer cells, although the ...

journal_title：Oncology reports

authors： Chen X,Song L,Hou Y,Li F

更新日期：2019-02-01 00:00:00

abstract：:Numerous studies have demonstrated that triptolide induces cell cycle arrest and apoptosis in human cancer cell lines. However, triptolide-induced DNA damage and inhibition of DNA repair gene expression in human skin cancer cells has not previously been reported. We sought the effects of triptolide on DNA damage and a...

journal_title：Oncology reports

authors： Chueh FS,Chen YL,Hsu SC,Yang JS,Hsueh SC,Ji BC,Lu HF,Chung JG

更新日期：2013-02-01 00:00:00

abstract：:Histone deacetylase (HDAC) inhibitors exert potent inhibitory effects on various types of human cancer. The pioneer drug suberoylanilide hydroxamic acid (SAHA) is currently used in the clinic for cancer treatment. However, the effect of SAHA on tumor lymphangiogenesis is unclear. We recently showed that SAHA suppresse...

journal_title：Oncology reports

authors： Cheng HT,Hung WC

更新日期：2013-08-01 00:00:00

abstract：:Non‑small cell lung cancer (NSCLC) is the leading cause of cancer‑related deaths worldwide. Cisplatin‑based chemotherapy currently represents the main treatment option for patients with NSCLC. The aim of the present study was to evaluate effect of single nucleotide polymorphisms (SNPs) within the excision repair cross...

journal_title：Oncology reports

authors： Li M,Chen R,Ji B,Fan C,Wang G,Yue C,Jin G

更新日期：2021-01-14 00:00:00

abstract：:RNA‑binding motif 3 (RBM3) is a cold‑shock protein that has been previously shown to attenuate cancer stem cell‑like features in prostate cancer (PCa) cells. However, the mechanism underlying RBM3 regulation in PCa cells is largely unknown. The present study investigated the impact of RBM3 expression on the whole tran...

journal_title：Oncology reports

authors： Dong Q,Lv C,Zhang G,Yu Z,Kong C,Fu C,Zeng Y

更新日期：2018-10-01 00:00:00

abstract：:Prostate cancer (PCa) is one of the most commonly diagnosed malignancies, and 90% of advanced prostate cancer patients relapse after therapy. Trophinin associated protein (TROAP) is essential for centrosome integrity and proper bipolar organisation of spindle assembly during mitosis and plays an essential role in prol...

journal_title：Oncology reports

authors： Ye J,Chu C,Chen M,Shi Z,Gan S,Qu F,Pan X,Yang Q,Tian Y,Wang L,Yang W,Cui X

更新日期：2019-02-01 00:00:00

abstract：:In the present study, to evaluate the role of Ku80 in thyroid carcinoma (TC), 86 thyroid tissue samples from patients with a spectrum of thyroid disorders were examined for protein levels of Ku80, nuclear factor‑κB (NF‑κB) and RET/TC by immunohistochemistry. Furthermore, in TC cells, Ku80 mRNA was detected by reverse ...

journal_title：Oncology reports

authors： Fan Y,Li J,Wei W,Fang H,Duan Y,Li N,Zhang Y,Yu J,Wang J

更新日期：2019-12-01 00:00:00

abstract：:To investigate the components of the prostaglandin biosynthetic pathway, the characteristics of cyclooxygenase (COX)-1, COX-2, hematopoietic prostaglandin D synthase (hPGDS), microsomal prostaglandin E synthase (mPGES), and thromboxane synthase (TXS) were examined for autopsied cases with small cell lung cancer (SCLC)...

journal_title：Oncology reports

authors： Yoshimoto A,Kasahara K,Kawashima A,Fujimura M,Nakao S

更新日期：2005-06-01 00:00:00

abstract：:Telomerase activation is prevalent in most epithelial tumors, and may be a critical step in cellular immortalization and carcinogenesis. However, telomerase activity in tumors of mesenchymal origin is not well understood. In the present study, we examined telomerase activity in clinical samples from osteosarcoma and s...

journal_title：Oncology reports

authors： Terasaki T,Kyo S,Takakura M,Maida Y,Tsuchiya H,Tomita K,Inoue M

更新日期：2004-06-01 00:00:00

abstract：:The objective of the present study was to explore the in vitro and in vivo anticancer effects of Platycodin D (PD), derived from Platycodin grandiflorum, on highly metastatic MDA-MB-231 breast cancer cells. Using the MTT assay, we found that PD inhibited MDA-MB-231 cell growth in a concentration-dependent manner, with...

journal_title：Oncology reports

authors： Kong Y,Lu ZL,Wang JJ,Zhou R,Guo J,Liu J,Sun HL,Wang H,Song W,Yang J,Xu HX

更新日期：2016-09-01 00:00:00