Loss of the metastasis suppressor gene KiSS1 is associated with lymph node metastasis and poor prognosis in human colorectal cancer.

abstract：:Sirtuin 6 (SIRT6) is a member of the mammalian NAD+‑dependent deacetylase sirtuin family that acts to maintain genomic stability and to repress genes. SIRT6 has recently been reported to be a tumor suppressor that controls cancer metabolism, although this effect of SIRT6 is still in dispute. Moreover, the role of SIRT...

journal_title：Oncology reports

authors： Feng J,Yan PF,Zhao HY,Zhang FC,Zhao WH,Feng M

更新日期：2016-03-01 00:00:00

abstract：:Lapatinib, an inhibitor of human epidermal growth factor receptor 2 (HER2) phosphorylation, has been reported to inhibit several types of tumors such as HER2-overexpressing breast cancer. However, the effect of lapatinib on the malignant phenotype of human osteosarcoma (OS) cells and the potential molecular mechanisms...

journal_title：Oncology reports

authors： Long XH,Zhang GM,Peng AF,Luo QF,Zhang L,Wen HC,Zhou RP,Gao S,Zhou Y,Liu ZL

更新日期：2014-01-01 00:00:00

abstract：:The drug sensitivity of tumor cells is one of key issues to explore individualized therapy for cancer patients. One of such methods is in vitro anticancer drug sensitivity test which is generally based on one drug concentration and contact time. In this study, 5-fluorouracil (5-FU) sensitivity of cancer cells from col...

journal_title：Oncology reports

authors： Ochiai T,Nishimura K,Noguchi H,Kitajima M,Tsuruoka Y,Takahashi Y

更新日期：2005-07-01 00:00:00

abstract：:microRNAs (miRNAs), a class of small non-coding RNA molecules, can regulate gene expression by interacting with the 3'-untranslated regions (3'UTR) of target genes and influence various biological processes. We investigated the potential role of miR-24-3p in the development of bladder cancer by regulating DEDD, a memb...

journal_title：Oncology reports

authors： Yu G,Jia Z,Dou Z

更新日期：2017-02-01 00:00:00

abstract：:Oral cancer is one of the leading types of cancer and remains the most common cause of cancer‑related mortality in Asia. The pathogenesis of oral cancer is complicated and, due to lack of accurate diagnostic methods and efficient treatment strategies, oral cancer is responsible for a large number of deaths. Therefore,...

journal_title：Oncology reports

authors： Wang J,Lv N,Lu X,Yuan R,Chen Z,Yu J

更新日期：2021-01-01 00:00:00

abstract：:Few studies on sarcomas have examined the relationships between microsatellite alterations in particular loci, tumor prognosis and tumorigenesis, because sarcomas are uncommon and those prognoses can be confounded by coexisting factors, such as tumor site. We studied the relationship between microsatellite alterations...

journal_title：Oncology reports

authors： Iyoda A,Hiroshima K,Toyozaki T,Baba M,Fujisawa T,Yusa T,Ohwada H

更新日期：2001-07-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is sexually disparate in humans, with a significantly increased prevalence in males. The molecular mechanisms by which the inhibition or development of liver cancer are facilitated require further investigation with regard to sex factors affecting disease progression. In the present stud...

journal_title：Oncology reports

authors： Wu Y,Yao N,Feng Y,Tian Z,Yang Y,Zhao Y

更新日期：2019-09-01 00:00:00

abstract：:The present study aimed to explore the relationship between the efficacy of epidermal growth factor receptor tyrosine kinase inhibitors (EGFR‑TKIs) and the expression of the cancer stem cell (CSC)‑related markers. Specimens of 72 cases of lung adenocarcinoma with significantly different therapeutic effects of the firs...

journal_title：Oncology reports

authors： Hu F,Li C,Zheng X,Zhang H,Shen Y,Zhou L,Yang X,Han B,Zhang X

更新日期：2020-02-01 00:00:00

abstract：:Paired box 6 (PAX6) is a transcription factor that has oncogenic features. In breast cancer, PAX6 facilitates tumor progression; however, the underlying mechanism is largely unknown. The majority of breast cancer‑related mortalities are associated with metastasis of cancer cells. Therefore, the present study aimed to ...

journal_title：Oncology reports

authors： Jin M,Gao D,Wang R,Sik A,Liu K

更新日期：2020-08-01 00:00:00

abstract：:Head and neck squamous cell carcinoma (HNSCC) is the sixth most commonly diagnosed cancer worldwide. It has poor clinical outcome due to intrinsic or acquired drug resistance. Deregulation of both apoptosis and autophagy contributes to chemotherapy resistance and disease progression. A new member of the inhibitors of ...

journal_title：Oncology reports

authors： Frassanito MA,Saltarella I,Vinella A,Muzio LL,Pannone G,Fumarulo R,Vacca A,Mariggiò MA

更新日期：2019-05-01 00:00:00

abstract：:The interface between malignant melanoma and patient immunity has long been recognised and efforts to treat this most lethal form of skin cancer by activating immune responses with cytokine, vaccine and also antibody immunotherapies have demonstrated promise in limited subsets of patients. In the present study, we dis...

journal_title：Oncology reports

authors： Malas S,Harrasser M,Lacy KE,Karagiannis SN

更新日期：2014-09-01 00:00:00

abstract：:We performed methylation specific PCR to explore the mechanism of inactivation of tumor suppressor genes P15, P16, P53 and VHL in 48 oral SCC. The frequencies of aberrant methylation on the promoter of the P15, the P16, the P53 and the VHL genes were 0.27 (13/48), 0.42 (20/48), 0.04 (2/48) and none, respectively. Alto...

journal_title：Oncology reports

authors： Yeh KT,Chang JG,Lin TH,Wang YF,Tien N,Chang JY,Chen JC,Shih MC

更新日期：2003-05-01 00:00:00

abstract：:This study investigated the prognostic significance of thymidine phosphorylase (TP) and p53 expression in 96 surgically resected primary esophageal squamous cell carcinomas. Expression was assessed using immunohistochemical staining methods. Prognostic values were determined by multivariate analysis using Cox's propor...

journal_title：Oncology reports

authors： Makoto O,Takeda A,Ting-Leig L,Shinnichi O,Hisahiro M,Yutaka F,Yoshihiro N,Kobayashi S,Gunji Y,Suzuki T,Takenori O,Hideaki S

更新日期：2002-01-01 00:00:00

abstract：:Antineoplastons are naturally occurring peptides and amino acid derivatives found in human blood and urine. antineoplastons have been shown to control neoplastic growth. In the present study, we investigated demethylation effect of the antineoplaston AS2-1 (a mixture of phenylacetylglutamine and phenylacetate in the r...

journal_title：Oncology reports

authors： Ushijima M,Ogata Y,Tsuda H,Akagi Y,Matono K,Shirouzu K

更新日期：2014-01-01 00:00:00

abstract：:Secreted frizzled-related protein 1 (SFRP1) is a candidate tumor suppressor gene located at 8p11.2 and antagonizes the Wnt signaling pathway. Epigenetic inactivation of SFRP1 by methylation of its promoter CpG island has recently been reported in several types of cancers. In the present study, we examined the expressi...

journal_title：Oncology reports

authors： Awakura Y,Nakamura E,Ito N,Kamoto T,Ogawa O

更新日期：2008-11-01 00:00:00

abstract：:Irinotecan HCl (CPT-11) has frequently been used in chemotherapy or concurrent chemoradiotherapy for patients with advanced cervical cancer, although an effective protocol for chemoradiotherapy with CPT-11 has not yet been established. Using the radiosensitive human cervical squamous cell carcinoma cell line ME180 and...

journal_title：Oncology reports

authors： Tanaka T,Yukawa K,Umesaki N

更新日期：2005-11-01 00:00:00

abstract：:Immunotherapy with autologous dendritic cells (DCs) loaded with tumor lysate(s) from allogeneic tumor cell lines is a novel strategy to induce immune responses in cancer patients. We report on a pilot trial of autologous DCs pulsed with tumor cell lysate derived from allogeneic medullary thyroid carcinoma (MTC) cell l...

journal_title：Oncology reports

authors： Bachleitner-Hofmann T,Friedl J,Hassler M,Hayden H,Dubsky P,Sachet M,Rieder E,Pfragner R,Brostjan C,Riss S,Niederle B,Gnant M,Stift A

更新日期：2009-06-01 00:00:00

abstract：:Metastasis is the major process responsible for the death in cancer patients. In the search for more effective antineoplasic drugs, many substances are under investigation, among them lapachol. This study aims to examine the molecular and morphological alterations caused by lapachol treatment, as well as its effects o...

journal_title：Oncology reports

authors： Balassiano IT,De Paulo SA,Henriques Silva N,Cabral MC,da Gloria da Costa Carvalho M

更新日期：2005-02-01 00:00:00

abstract：:Activation of p53-independent pathways plays an important role in phytochemical-induced apoptosis and is considered to be a crucial factor in the invasion and metastasis of cancer. Previous studies have shown that combined effects of Stephania tetrandra with medicinal herbs exhibit beneficial effects in cancer patient...

journal_title：Oncology reports

authors： Yu VW,Ho WS

更新日期：2013-06-01 00:00:00

abstract：:Circulating microRNAs (miRNAs) exist stably in body fluids and are potential biomarkers for hepatocellular carcinoma (HCC). Twenty-five patients with cirrhosis that evolved into HCC, who were treated at The Third Hospital of Zhenjiang Affiliated to Jiangsu University between January 2005 and December 2012, were enroll...

journal_title：Oncology reports

authors： Tan Y,Lin B,Ye Y,Wen D,Chen L,Zhou X

更新日期：2015-06-01 00:00:00

abstract：:Breast cancer is the worldwide leading cause of cancer incidence among women. Night shift work exposure has been recently considered one of the significant breast cancer risk factors in industrialized countries. The mechanisms by which this work exposure may be responsible for cance...

journal_title：Oncology reports

authors： Leonardi GC,Rapisarda V,Marconi A,Scalisi A,Catalano F,Proietti L,Travali S,Libra M,Fenga C

更新日期：2012-08-01 00:00:00

abstract：:Rad52 encodes a protein which is required for recombinational repair of double-strand breaks. It is also associated with breast cancer predisposition genes BRCA1 and BRCA2. Mutations in the genes Rad51 or Rad52 result in severe defects in genetic recombination and the repair of double-strand DNA breaks. In order to ex...

journal_title：Oncology reports

authors： Tong D,Volm T,Eberhardt E,Krainer M,Leodolter S,Kreienberg R,Zeillinger R

更新日期：2003-09-01 00:00:00

abstract：:Although the impact of vascular endothelial growth factor (VEGF) is clearly established in advanced prostate cancer (PCa), its role in localized PCa remains to be determined. The aim of our study was to analyse the plasma levels of VEGF-A and the expression of VEGF-A in prostatic tissue in a population of patients wit...

journal_title：Oncology reports

authors： Peyromaure M,Badoual C,Camparo P,Grabar S,Goulvestre C,Fulla Y,Vieillefond A,Mao K,Dinh-Xuan AT

更新日期：2007-07-01 00:00:00

abstract：:The estrogen receptor (ER) expression and HER2 amplification are important factors in determining the prognosis and therapy of breast cancer. Interactions between the two signaling pathways for example resulted in ERalpha-dependent regulation of HER2 expression in breast cancer cells. In this study, we investigated to...

journal_title：Oncology reports

authors： Lattrich C,Juhasz-Boess I,Ortmann O,Treeck O

更新日期：2008-03-01 00:00:00

abstract：:The p16 protein is a cyclin-dependent kinase (CDK) inhibitor, which plays an important role in the regulation of the cell cycle by inactivating the cyclin-dependent kinase (CDK) that phosphorylates the retinoblastoma (Rb) protein. Overexpression of p16 protein has been found in many types of human malignancy. Autoanti...

journal_title：Oncology reports

authors： Looi K,Megliorino R,Shi FD,Peng XX,Chen Y,Zhang JY

更新日期：2006-11-01 00:00:00

abstract：:The novel gene human Biot2 (hBiot2) was first reported by our laboratory. Previously, we indicated its function of proliferation and carcinogenesis in human endometrial cancer. In the present study, we aimed to investigate whether hBiot2 played a similar role in human cervical cancer. We tested hBiot2 expression profi...

journal_title：Oncology reports

authors： Shen YM,He X,Deng HX,Xie YP,Wang CT,Wei YQ,Zhao X

更新日期：2011-01-01 00:00:00

abstract：:The changes of the microtubular network induced by microtubule destabilizing (Vinblastine, VBL) and stabilizing (Taxol, TAX) agents were studied in NIH/3T3 fibroblastic cells in conventional culture conditions (NIHb) and in a subpopulation (NIHs), obtained after serum deprivation and expressing different morphofunctio...

journal_title：Oncology reports

authors： Spano A,Monaco G,Barni S,Sciola L

更新日期：2008-12-01 00:00:00

abstract：:Carboxypeptidase X, M14 family member 2 (CPXM2), has been associated with several human disorders such as developmental diseases. However, whether CPXM2 is involved in oncogenesis or tumor progression remains unclear. In the present study, we used clinical samples from gastric cancer (GC) patients to investigate poten...

journal_title：Oncology reports

authors： Niu G,Yang Y,Ren J,Song T,Hu Z,Chen L,Hong R,Xia J,Ke C,Wang X

更新日期：2019-10-01 00:00:00

abstract：:Hypoxia always exists in the processes involved in the development of lung cancer and contributes to an acidic microenvironment. Despite that hypoxia in the tumor microenvironment is associated with the formation of chemotherapeutic resistance, the exact role of an acidic microenvironment in the development of hypoxia...

journal_title：Oncology reports

authors： Hu CF,Huang YY,Wang YJ,Gao FG

更新日期：2016-07-01 00:00:00

abstract：:Oral mucositis is a severe complication of radiotherapy. Hence, it may constitute a serious medical safety risk for astronauts during extended space flights, such as missions to Mars, during which they are exposed to heavy-ion irradiation. For risk assessment of developing radiation-induced mucositis, a three-dimensio...

journal_title：Oncology reports

authors： Tschachojan V,Schroer H,Averbeck N,Mueller-Klieser W

更新日期：2014-11-01 00:00:00