Abstract:
:Aberrant nuclear factor-erythroid 2 (NRF2) expression correlates with tumor development. We investigated NRF2 expression in ovarian epithelial carcinoma (OEC), aiming to identify associations with clinicopathological factors, hormones and induced reactive oxygen species (ROS). Immunohistochemical staining for NRF2 expression was performed on 10 benign cystadenomas, 4 boderline tumors and 64 OECs. Western blotting was used to determine the effects of hormones on NRF2 expression in OEC. NRF2 protein was found to be overexpressed in OEC. Gonadotrophins and estrogen induced ROS production in OEC; these hormones also enhanced NRF2 expression. Therefore, aberrant expression may be induced by hormones through ROS signaling. Increased NRF2 expression may be a molecular event in OEC carcinogenesis.
journal_name
Oncol Repjournal_title
Oncology reportsauthors
Liao H,Zhou Q,Zhang Z,Wang Q,Sun Y,Yi X,Feng Ydoi
10.3892/or.2012.1700subject
Has Abstractpub_date
2012-06-01 00:00:00pages
1918-24issue
6eissn
1021-335Xissn
1791-2431journal_volume
27pub_type
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