Inhibition of epithelial‑mesenchymal transition in gastric cancer cells by miR‑711‑mediated downregulation of CD44 expression.

abstract：:Identification of novel botanicals that can selectively induce apoptosis and arrest growth of cancer cells without producing cytotoxic effects is highly appreciable for cancer therapy. The present study aimed to investigate the possibility of acetylbritannilactone (ABL) derivative 5-(5-(ethylperoxy)pentan-2-yl)-6-meth...

journal_title：Oncology reports

authors： Zhang Y,Liu K,Zhang Y,Qi J,Lu B,Shi C,Yin Y,Cai W,Li W

更新日期：2015-12-01 00:00:00

abstract：:The usefulness of the in vitro chemosensitivity test, the collagen gel droplet embedded culture drug- sensitivity test (CD-DST, Int J Oncol 11: 449, 1997), in cisplatin-based combined chemotherapy for postoperative recurrent tumors in non-small cell lung cancer (NSCLC) patients was retrospectively analyzed. CD-DST dat...

journal_title：Oncology reports

authors： Higashiyama M,Kodama K,Yokouchi H,Takami K,Nakagawa H,Imamura F,Minamigawa K,Kobayashi H

更新日期：2001-03-01 00:00:00

abstract：:The development and characterization of effective anticancer drugs against colorectal cancer (CRC) is of urgent need since it is the second most common cause of cancer death. The study was designed to evaluate the effects of two IGF-1R antagonists, MK-0646, a recombinant fully humanized monoclonal antibody and OSI-906...

journal_title：Oncology reports

authors： Leiphrakpam PD,Agarwal E,Mathiesen M,Haferbier KL,Brattain MG,Chowdhury S

更新日期：2014-01-01 00:00:00

abstract：:Research has confirmed that abnormally expressed miRNAs are involved in the occurrence and development of hepatocellular carcinoma (HCC). In the present study, we confirmed that miR‑577 expression both in HCC tissues and cell lines was markedly downregulated. Clinically, downregulated expression of miR‑577 is notably ...

journal_title：Oncology reports

authors： Han S,Liu Z,Wang Y,Wang L,Yao B,Guo C,Song T,Tu K,Liu Q

更新日期：2018-06-01 00:00:00

abstract：:Gentian violet (GV) is a cationic triphenylmethane dye, with potent antifungal and antibacterial activity. We recently reported that in vitro GV suppresses the differentiation of bone resorbing osteoclasts while stimulating the differentiation and activity of bone forming osteoblasts. Breast cancer is highly metastati...

journal_title：Oncology reports

authors： Yamaguchi M,Vikulina T,Weitzmann MN

更新日期：2015-10-01 00:00:00

abstract：:Gastric cancer (GC) is one of the most lethal malignancies worldwide. To reduce its high mortality, sensitive and specific biomarkers for early detection are urgently needed. Recent studies have reported that tumor-specific long non-coding RNAs (lncRNAs) seem to be potential biomarkers for the early diagnosis and trea...

journal_title：Oncology reports

authors： Li C,Liang G,Yao W,Sui J,Shen X,Zhang Y,Ma S,Ye Y,Zhang Z,Zhang W,Yin L,Pu Y

更新日期：2016-03-01 00:00:00

abstract：:The present study was designed to investigate the effects of Bowman-Birk inhibitor (BBI) on up-regulation of connexin (Cx) expression to estimate BBI's tumor-suppressor effect in mice with M5076 ovarian sarcoma. The relative tumor weight (p<0.05, r(2)=0.301) and proliferating cell nuclear antigen (PCNA, p<0.01, r(2)=0...

journal_title：Oncology reports

authors： Suzuki K,Yano T,Sadzuka Y,Sugiyama T,Seki T,Asano R

更新日期：2005-06-01 00:00:00

abstract：:Gastric cancer is the second most common fatal malignancy in the world. Proteomics studies of clinical tumor samples have led to the identification of specific protein markers of gastric cancer detection and better understanding the carcinogenesis of gastric cancer. Gastric cancer tissue of epithelial origin and adjac...

journal_title：Oncology reports

authors： Wu C,Luo Z,Chen X,Wu C,Yao D,Zhao P,Liu L,Shi B,Zhu L

更新日期：2009-06-01 00:00:00

abstract：:Nuclear factor (NF)-κB is the key transcription factor involved in the inflammatory responses, and its activation aggravates tumors. Peptidoglycan (PGN), a main cell wall component of Gram-positive bacteria, stimulates Toll-like receptor 2 (TLR-2) and activates a number of inflammat...

journal_title：Oncology reports

authors： Echigo R,Sugimoto N,Yachie A,Ohno-Shosaku T

更新日期：2012-10-01 00:00:00

abstract：:Lack of effective therapy is a major problem in the treatment of pancreatic cancer. In the present study, we investigated a natural product, the extract of Pao Pereira (Pao), for its anti-pancreatic cancer effect in vitro and in vivo, either alone or in combination with the first-line chemotherapeutic drug gemcitabine...

journal_title：Oncology reports

authors： Yu J,Drisko J,Chen Q

更新日期：2013-07-01 00:00:00

abstract：:Signal transducer and activator of transcription 3 (STAT3) regulates the expression of genes mediating cell survival, proliferation and angiogenesis and is aberrantly activated in various types of malignancies, including bladder cancer. We examined whether it could be a novel therapeutic target for bladder cancer usin...

journal_title：Oncology reports

authors： Tsujita Y,Horiguchi A,Tasaki S,Isono M,Asano T,Ito K,Asano T,Mayumi Y,Kushibiki T

更新日期：2017-10-01 00:00:00

abstract：:The aim of this study was to determine genetic alterations in mucoepidermoid carcinomas of the salivary gland in association with clinical and histopathological parameters. Nineteen formalin-fixed, paraffin-embedded tumors were analysed by using comparative genomic hybridization (CGH), fluorescence in situ hybridizati...

journal_title：Oncology reports

authors： Verdorfer I,Fehr A,Bullerdiek J,Scholz N,Brunner A,Krugmann J,Hager M,Haufe H,Mikuz G,Scholtz A

更新日期：2009-08-01 00:00:00

abstract：:The main objective was to analyze the influence of social factors on the interval from diagnosis to treatment in a cohort of 217 patients with digestive tract cancer. From the clinical charts data were obtained for: date of the beginning of illness, dates of medical attendance, type and date of diagnostic tests, chara...

journal_title：Oncology reports

authors： Mariscal M,Llorca J,Prieto-Salceda D,Palma S,Delgado-Rodríguez M

更新日期：2003-03-01 00:00:00

abstract：:Analysis of HER-2/neu gene amplification by fluorescence in situ hybridization was performed in 40 patients with invasive bladder cancer in order to evaluate the potential for molecular targeted therapy of HER-2 as a tailor-made treatment for patients with invasive bladder cancer. This study included 40 patients seen ...

journal_title：Oncology reports

authors： Yamada Y,Naruse K,Nakamura K,Aoki S,Taki T,Tobiume M,Zennami K,Katsuda R,Hirano M,Hayashida K,Mizumukai E,Nanaura H,Honda N

更新日期：2007-11-01 00:00:00

abstract：:The present study aimed to evaluate a previously reported predictive formula of output-limiting symptoms induced by radiofrequency (RF) to determine the efficacy of this neoadjuvant chemoradiation (NACR) and concurrent RF thermal therapy. The present study included 81 consecutive patients with confirmed diagnoses of r...

journal_title：Oncology reports

authors： Shoji H,Motegi M,Takakusagi Y,Asao T,Kuwano H,Takahashi T,Ogoshi K

更新日期：2017-02-01 00:00:00

abstract：:The aim of the present study was to evaluate human epididymis protein 4 (HE4) as a marker of epithelial ovarian cancer (EOC) relapse and the combination of this biomarker with contrast-enhanced high-resolution multidetector row computed tomography CE CT imaging to impove the monitoring of EOC patients. Twenty-one pati...

journal_title：Oncology reports

authors： Manganaro L,Michienzi S,Vinci V,Falzarano R,Saldari M,Granato T,Viggiani V,Frati L,Anastasi E

更新日期：2013-11-01 00:00:00

abstract：:To better understand the molecular mechanisms of carcinogenesis induced in uterine endometrium by therapeutic anti-estrogenic Tamoxifen (TAM) exposure, 27 uterine tumors (4 benign endometrial polyps and 23 carcinomas) associated with TAM exposure were analyzed for the presence and spectrum of p53 and K-ras mutations. ...

journal_title：Oncology reports

authors： Fujiwara K,Enomoto T,Fujita M,Kanda T,Fujii S,Ito K,Wakasa K,Ishiko O,Ueda M,Yamaguchi S,Kimura T,Umesaki N

更新日期：2008-05-01 00:00:00

abstract：:Resistance to chemotherapeutic agents is a major problem for successful cancer treatment. P-glycoprotein (Pgp), a product of the multidrug resistance (MDR)1 gene expressed in cancer cells, is one of the mechanism of MDR. However, there are few reports regarding the effects of Pgp on prognosis of colorectal cancer (CRC...

journal_title：Oncology reports

authors： Tokunaga Y,Hosogi H,Hoppou T,Nakagami M,Tokuka A,Ohsumi K

更新日期：2001-07-01 00:00:00

abstract：:The progress of the application of adenovirus in cancer gene therapy is hindered by the lack of expression of native adenovirus receptor on a variety of cancer types. Hence, strategies are needed to retarget the adenoviral vector to non-native cellular surface receptors. In the present study, a new peptide SWDIAWPPLKV...

journal_title：Oncology reports

authors： Wang D,Li W,Zhang H,Mao Q,Xia H

更新日期：2014-05-01 00:00:00

abstract：:ETS‑domain containing protein (Elk1) is reported to be a member of the ETS oncogene family, and promotes tumorigenesis in cancer such as bladder, prostate and ovarian. Nevertheless, the role of Elk1 in thyroid cancer progression remains unclear. In the present study, we aimed to investigate the role and underlying mol...

journal_title：Oncology reports

authors： Kong Y,Yin J,Fu Y,Chen Y,Zhou Y,Geng X

更新日期：2018-09-01 00:00:00

abstract：:The interface between malignant melanoma and patient immunity has long been recognised and efforts to treat this most lethal form of skin cancer by activating immune responses with cytokine, vaccine and also antibody immunotherapies have demonstrated promise in limited subsets of patients. In the present study, we dis...

journal_title：Oncology reports

authors： Malas S,Harrasser M,Lacy KE,Karagiannis SN

更新日期：2014-09-01 00:00:00

abstract：:A phase I study of S-1 and biweekly docetaxel (DOC) combination therapy was conducted to determine the maximum tolerated dose (MTD) and pharmacokinetic parameters. Fourteen patients with advanced or recurrent gastric cancer were analyzed. The treatment consisted of S-1 [body surface area (BSA) <1.25 m2:80 mg/day, 1.25...

journal_title：Oncology reports

authors： Takahashi I,Emi Y,Kakeji Y,Tokunaga E,Ushiro S,Oki E,Watanabe M,Baba H,Maehara Y

更新日期：2006-04-01 00:00:00

abstract：:It has been demonstrated that homozygous mutations at the L(2)gl locus in Drosophila result in the development of tumor in the presumptive adult optic centers of the larval brain and of the imaginal discs. We previously cloned an L(2)gl homologue, Rgl-1, in the rat brain. In this study, we analyzed the capability of R...

journal_title：Oncology reports

authors： Kim YK,Kim YS,Chung HM,Baek KH

更新日期：2004-11-01 00:00:00

abstract：:In recent years, several antioxidant substances have been found to have an antiproliferative effect on various types of carcinomas. α-lipoic acid (ALA) induces apoptosis in several types of cancer cell lines, but it is difficult to apply α-lipoic acid in clinical use as it is easily oxidized and unstable. Recently, we...

journal_title：Oncology reports

authors： Hiratsuka T,Inomata M,Kono Y,Yokoyama S,Shiraishi N,Kitano S

更新日期：2013-06-01 00:00:00

abstract：:Tumor invasion and migration are major causes of mortality in patients with cervical carcinoma. Tumors under hypoxic conditions are more invasive and have a higher metastasic activity. Lysyl oxidase (LOX) is a hypoxia-responsive gene. LOX has been shown to be essential for hypoxia-induced metastasis in breast cancer. ...

journal_title：Oncology reports

authors： Yang X,Li S,Li W,Chen J,Xiao X,Wang Y,Yan G,Chen L

更新日期：2013-02-01 00:00:00

abstract：:Polysaccharides derived from Inonotus obliquus (PIO) are known to possess multiple pharmacological activities including antitumor activity. However, the possible molecular mechanisms of these activities are unknown. In the present study, we determined the anti-metastatic potential and signaling pathways of PIO in the ...

journal_title：Oncology reports

authors： Lee KR,Lee JS,Kim YR,Song IG,Hong EK

更新日期：2014-05-01 00:00:00

abstract：:Galectin-3 is a soluble endogenous lectin in vertebrates and is implicated in a variety of biological functions, including tumor cell adhesion, proliferation, differentiation, apoptosis, cancer progression and metastasis. In the present study, we analyzed the role of galectin-3 in apoptosis in human malignant lymphoma...

journal_title：Oncology reports

authors： Suzuki O,Abe M

更新日期：2008-03-01 00:00:00

abstract：:The abilities of 5,6-benzoflavone (5,6-BF, a synthetic flavonoid), indole-3-carbinol (I3C, a plant derived product) or diindolylmethane (DIM, a condensation product of I3C) to alter the induction of mammary cancers induced by the carcinogens 7,12-dimethylbenzanthracene (DMBA) or N-methyl-N-nitrosourea (MNU) were evalu...

journal_title：Oncology reports

authors： Lubet RA,Heckman BM,De Flora SL,Steele VE,Crowell JA,Juliana MM,Grubbs CJ

更新日期：2011-09-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is an aggressive disease with a poor outcome due to the high incidence of metastasis. Cancer stem cells (CSCs) have been identified to be responsible for tumor progression and may be generated by epithelial-mesenchymal transition (EMT) characteristics. CD133 is a specific surface marker ...

journal_title：Oncology reports

authors： Liu YM,Li XF,Liu H,Wu XL

更新日期：2015-12-01 00:00:00

abstract：:The classical pathway involving receptor activator of nuclear factor‑κB (RANK) and its ligand (RANKL) induces the activation of osteoclasts and the migration of a variety of tumor cells, including breast and lung cancer. In our previous study, the expression of RANK was identified on the surface of gastric cancer cell...

journal_title：Oncology reports

authors： Wang Y,Song Y,Che X,Zhang L,Wang Q,Zhang X,Qu J,Li Z,Xu L,Zhang Y,Fan Y,Hou K,Liu Y,Qu X

更新日期：2018-09-01 00:00:00