Abstract:
:It has been shown that overexpression of signal transducer and activator of transcription 3 (Stat3) contribute to the progression and metastasis of various solid tumors and that silencing Stat3 inhibits tumor growth in several types of cancer. Gene associated with retinoid-IFN-induced mortality 19 (GRIM-19), a Stat3-inhibitory protein, was identified as a potential tumor suppressor associated with growth inhibition and cell apoptosis by targeting the transcription factor Stat3 for inhibition. However, little is known about Stat3 and GRIM-19 roles in the tumor growth of thyroid carcinoma cells. In the present study, we developed a dual expression plasmid that co-expressed Stat3-specific siRNA and GRIM-19 (pSi-Stat3-GRIM-19) and transfected it into SW579 cells (thyroid carcinoma cell line) to evaluate its effects on cell proliferation, cell apoptosis, cell migration and cell invasion in vitro and tumor growth in vivo. Simultaneous expression of pSi-Stat3-GRIM-19 in SW579 cancer cells was found to significantly suppress the proliferation, migration and invasion in vitro and tumor growth in vivo, when compared to the controls either Stat3-specific siRNA or GRIM-19 alone. In conclusion, our data demonstrated that a combined strategy of co-expressed Stat3-specific siRNA and GRIM19 synergistically and more effectively suppressed thyroid tumor growth, and have therapeutic potential for the treatment of thyroid cancer.
journal_name
Oncol Repjournal_title
Oncology reportsauthors
Wang GM,Ren ZX,Wang PS,Su C,Zhang WX,Liu ZG,Zhang L,Zhao XJ,Chen Gdoi
10.3892/or.2014.3233subject
Has Abstractpub_date
2014-08-01 00:00:00pages
573-80issue
2eissn
1021-335Xissn
1791-2431journal_volume
32pub_type
杂志文章相关文献
ONCOLOGY REPORTS文献大全abstract::Arginine and nitric oxide (NO) are important mediators of tumorigenesis in various types of cancer. Dysregulation of NO content by argininosuccinate lyase (ASL) has been previously demonstrated to inhibit the proliferation of liver and breast cancer cells. However, the function of ASL in colon cancer is not well defin...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.5221
更新日期:2017-01-01 00:00:00
abstract::Esophageal squamous cell carcinoma (ESCC) is a common cancer with a very poor prognosis. New methods are needed to screen high-risk populations and identify curable tumors and precursor lesions early. Molecular markers may be useful in such screening efforts. This study was designed to determine the prevalence of p16,...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2006-06-01 00:00:00
abstract::The present study aimed to investigate the role of miR‑181a in multiple myeloma (MM) cell lines. Reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR) was used to detect the expression of microRNA (miR)‑181a. The MM cell line RPMI 8226 stably transduced with miR‑181a mimics or inhibitor was establishe...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2019.7160
更新日期:2019-07-01 00:00:00
abstract::Ubiquitin specific protease 22 (USP22) is an oncogene that is upregulated in many cancer types, and aberrant expression of USP22 correlates with clinical outcome. However, its potential functional impact in epithelial ovarian cancer (EOC) has not been determined. Here, we report that USP22 was upregulated in EOC speci...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2014.3580
更新日期:2015-01-01 00:00:00
abstract::Lung cancer is the most frequent and deadliest cancer in the world, especially in China. However, the molecular mechanisms involved in lung cancer remain unclear. Occludin (OCLN), one of the first identified tight junction proteins, has been revealed to be a necessary integral protein for tight junction structure and ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2018.6408
更新日期:2018-07-01 00:00:00
abstract::Extracellular matrix remodeling crucial to tumorigenesis involves proteolytic enzymes, primarily matrix metalloproteinases (MMPs). MMP production is stimulated by multiple factors, including the extracellular matrix metallo-proteinase inducer EMMPRIN/CD147. Overexpression of EMMPRIN...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2011.1474
更新日期:2012-01-01 00:00:00
abstract::One of the most important clinical problems in the treatment of human solid carcinoma is the intrinsic/acquired resistance. Cisplatin is a platinum compound that is one of the most effective agents in clinic. Copper-transporting P-type adenosine triphosphate (ATP7B) has been reported to be associated with cisplatin re...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.8.6.1285
更新日期:2001-11-01 00:00:00
abstract::It has been demonstrated that homozygous mutations at the L(2)gl locus in Drosophila result in the development of tumor in the presumptive adult optic centers of the larval brain and of the imaginal discs. We previously cloned an L(2)gl homologue, Rgl-1, in the rat brain. In this study, we analyzed the capability of R...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2004-11-01 00:00:00
abstract::Gallbladder cancer (GBC) is a rare disease associated with an extremely poor patient prognosis, and occasionally, aberrant expression of p53 is present. Considering that p53 is one of the most widely studied tumor‑suppressor genes, we used a cell-penetrating peptide, 11R, to enhance the transferring efficiency of the ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2013.2511
更新日期:2013-08-01 00:00:00
abstract::Neurofibromatosis type 1 (NF1) caused by NF1 gene mutation is a commonly inherited autosomal dominant disorder. Malignant peripheral nerve sheath tumors (MPNSTs), a type of aggressive sarcoma, are a major cause of mortality in NF1 patients. The malignant transformation of benign plexiform neurofibromas (PNs) to MPNSTs...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2014.3379
更新日期:2014-10-01 00:00:00
abstract::The abilities of 5,6-benzoflavone (5,6-BF, a synthetic flavonoid), indole-3-carbinol (I3C, a plant derived product) or diindolylmethane (DIM, a condensation product of I3C) to alter the induction of mammary cancers induced by the carcinogens 7,12-dimethylbenzanthracene (DMBA) or N-methyl-N-nitrosourea (MNU) were evalu...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2011.1316
更新日期:2011-09-01 00:00:00
abstract::CYP1A1 expression in various tissues of 43 gastric cancer cases was analyzed with frozen tissue array-based immunohistochemical staining (IHC), RT-PCR, Western blot analysis and EROD (7-ethoxyresourfin-O-deethylase) assay. CYP1A1 was detected immunohistochemically in 86% (37/43) of gastric cancers, in both 57% (4/7) o...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2004-12-01 00:00:00
abstract::MHC class I-related chain molecules A and B (MICA and B) expressed on the cell-surface of tumor cells are ligands for an activating receptor, NKG2D, expressed on natural killer (NK) cells and stimulate the NK cell-mediated cytotoxicity. On the other hand, the soluble form of MICA and B produced by proteolytic cleavage...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or_00001026
更新日期:2010-12-01 00:00:00
abstract::In the development and progression of cancer, tumor suppressor genes may be silenced by mechanisms such as methylation. Thus the discovery of new genes silenced by methylation may uncover new tumor suppressor genes, and improve our understanding of cancer biology. In this study we investigated the methylation of 19 ge...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or_00000325
更新日期:2009-04-01 00:00:00
abstract::The objective of our study was to define a neural network for predicting recurrence and progression-free probability in patients affected by recurrent pTaG3 urothelial bladder cancer to use in everyday clinical practice. Among all patients who had undergone transurethral resection for bladder tumors, 143 were finally ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2007-10-01 00:00:00
abstract::Several studies have shown that curcumin can induce apoptosis and inhibit growth in human A549 lung adenocarcinoma cells. However, the mechanism is not completely understood yet. The present study was designed to investigate the effects of curcumin on A549 cells to better understand its apoptosis and apoptosis-related...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2010-02-01 00:00:00
abstract::Long non‑coding RNAs (lncRNAs) have emerged as critical regulators of tumor progression. However, the function and mechanism of lncRNA NEAT1 in oral squamous cell carcinoma (OSCC) are unclear. In the present study, NEAT1 was significantly upregulated in OSCC cells and tissues. High expression of NEAT1 was correlated w...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2018.6283
更新日期:2018-04-01 00:00:00
abstract::Triple-negative breast cancer is a highly aggressive type of mammalian carcinoma. It is defined by a rather weak expression of estrogen-, progesterone- and Her2-receptor, and is thus difficult to treat, resulting in low disease-free and overall survival rates of the affected patients. Hence it is important to find new...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2017.5512
更新日期:2017-05-01 00:00:00
abstract::MicroRNAs (miRNAs) are small non-coding RNAs that are involved in tumor initiation and development by suppressing target gene expression. miRNA-154 has been shown to be important in tumorigenesis in many types of cancers. However, its role in osteosarcoma (OS) remains unknown. In the present study, we focused on the r...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.4495
更新日期:2016-03-01 00:00:00
abstract::We investigated whether 18F-fluorothymidine-positron-emission tomography/computed tomography (18F-FLT-PET/CT) is useful for the evaluation of the very early response to anti-epidermal growth factor receptor (EGFR) antibody cetuximab therapy in human lung cancer xenografts. A human tumor xenograft model was established...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2011.1338
更新日期:2011-09-01 00:00:00
abstract::Oncolytic vaccinia virus is currently undergoing evaluation as a biological anticancer agent in clinical trials. This treatment exploits the lytic nature of a viral infection to eradicate the tumor mass in a cancer cell‑specific manner. So far, various vaccinia strains have been used as backbones in the design of onco...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2018.6801
更新日期:2019-01-01 00:00:00
abstract::Anaplastic thyroid cancer is one of the most aggressive human malignancies and is resistant to multimodal treatments. The expression of h-prune, the human homologue of Drosophila prune, has been reported to be correlated with progression and aggressiveness in various cancers including breast, colorectal and pancreatic...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.4759
更新日期:2016-06-01 00:00:00
abstract::Flavonoids exhibit chemopreventive and chemotherapeutic effects. Butein, a bioactive flavonoid isolated from numerous native plants, has been shown to induce apoptosis in human cancer cells. In the current study, the molecular mechanisms of butein action on cell proliferation and apoptosis of neuroblastoma cells were ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2012.1632
更新日期:2012-04-01 00:00:00
abstract::Glioma is the most common primary brain malignant tumor. Receptor for activated C-kinase 1 (RACK1) is widely expressed in the central nervous system, and regulates multiple cellular processes including cell survival, proliferation, migration and metastasis. However, the role of RACK1 in glioma has never been revealed....
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2013.2723
更新日期:2013-11-01 00:00:00
abstract::The majority of patients with hormone receptor-positive metastatic breast cancer die from disease progression despite different types of anti-hormonal treatments. Preclinical studies have indicated that resistance to anti-hormonal therapies may be the result of an activated NF-κB si...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2011.1562
更新日期:2012-03-01 00:00:00
abstract::Colorectal cancer is the second most deadly cancer in the United States. When diagnosed early, current treatments bring a limited success; however, once metastasis occurs, radiation and chemotherapy are generally ineffective. Structural changes in the ECM are necessary for cell migration during tissue remodeling. Matr...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2005-03-01 00:00:00
abstract::Intratumoral regions of low extracellular pH and low nutrition are common features of solid tumors. Although cancer cells normally die when they are removed from their environment, a small population of cells survive. In the present study, the subline LNCaP-F10, of the prostate canc...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2012.2039
更新日期:2012-12-01 00:00:00
abstract::Colon cancer (CC) is one of the leading causes of cancer‑related mortality in China and western countries. Several studies have demonstrated that long non‑coding RNAs (lncRNAs) play critical roles in cancer development. However, the function of lncRNA RP11‑619L19.2 in colon cancer remains unclear. The aim of the prese...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2020.7794
更新日期:2020-12-01 00:00:00
abstract::Although the impact of vascular endothelial growth factor (VEGF) is clearly established in advanced prostate cancer (PCa), its role in localized PCa remains to be determined. The aim of our study was to analyse the plasma levels of VEGF-A and the expression of VEGF-A in prostatic tissue in a population of patients wit...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2007-07-01 00:00:00
abstract::The Nemo‑like kinase (NLK), a conserved serine/threonine kinase, plays a critical role in the regulation of a variety of transcription factors, with important roles in determining cell fate. Although recent studies have demonstrated decreased expression patterns of NLK in various types of human cancer, the functional ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2020.7557
更新日期:2020-06-01 00:00:00