Expression of KLF9 in pancreatic cancer and its effects on the invasion, migration, apoptosis, cell cycle distribution, and proliferation of pancreatic cancer cell lines.

abstract：:Although radiotherapy is routinely administered to high-risk endometrial carcinoma and offer a significant disease-free survival advantage, the therapeutic effect is sometimes limited by the occurrence of radioresistance. To determine the patterns of gene expression responsible for the radioresistance and to search fo...

journal_title：Oncology reports

authors： Du XL,Jiang T,Wen ZQ,Li QS,Gao R,Wang F

更新日期：2009-03-01 00:00:00

abstract：:The epidermal growth factor receptor (EGFR) network has rich targets for prostate cancer killing. Herein we evaluated the effects of combining the EGFR inhibition and radiation on DU145 prostate cancer. We treated DU145 prostate cancer cells with various doses of anti-EGFR antibody (C225) and gamma-irradiation (RAD). ...

journal_title：Oncology reports

authors： Wagener M,Zhang X,Villarreal HG,Levy L,Allen P,Shentu S,Fang B,Krishnan S,Chang JY,Cheung MR

更新日期：2008-05-01 00:00:00

abstract：:Effective therapy for advanced hepatocellular carcinoma (HCC) is lacking. Conventional chemotherapy was judged to be ineffective. We previously demonstrated that the histone deacetylase inhibitor Trichostatin A (TSA) blocks growth of HCC cells in vitro. The anti-tumoral effect of a combination of more than 2 classes o...

journal_title：Oncology reports

authors： Ganslmayer M,Ocker M,Zopf S,Leitner S,Hahn EG,Schuppan D,Herold C

更新日期：2004-05-01 00:00:00

abstract：:Human colon cancer cells were implanted s.c. in nude mice. After 6 days, the mice were divided into four groups, 10 in each. During the first 5 days, the first and second groups were injected i.p. with leucovorin (LV)/5-fluorouracil (FU), and the third and fourth groups with sterile saline solution. During the subsequ...

journal_title：Oncology reports

authors： El-Salhy M

更新日期：2004-06-01 00:00:00

abstract：:Enolase-phosphatase 1 (ENOPH1), is an enzyme that is involved in polyamine biosynthesis and is associated with stress responses. However, little is known about its role in the pathophysiology of glioma. In the present study, we examined the expression and function of ENOPH1 in human glioma tissues and cell lines. West...

journal_title：Oncology reports

authors： Su L,Yang K,Li S,Liu C,Han J,Zhang Y,Xu G

更新日期：2018-10-01 00:00:00

abstract：:Inhibins are dimeric glycoproteins, composed of an α-subunit and one of two possible β-subunits (βA or βB), with substantial roles in human reproduction and in endocrine-responsive tumours. Recently a novel β subunit named βC was described, although it is still unclear if normal or cancerous cervical epithelial cells ...

journal_title：Oncology reports

authors： Blankenstein T,Jückstock J,Shabani N,Kunze S,Brüning A,Bergauer F,Mylonas I

更新日期：2011-01-01 00:00:00

abstract：:Burkitt's lymphoma (BL) is a fast growing cancer of the human lymphatic system, and an extremely invasive B-cell non-Hodgkin's lymphoma. We explored the mechanism of apoptosis in Raji cells associated with the post-transcriptional regulation factors. To confirm that the predicted microRNA-520a (miR-520a) is matched wi...

journal_title：Oncology reports

authors： Wang X,Wang P,Zhu Y,Zhang Z,Zhang J,Wang H

更新日期：2016-09-01 00:00:00

abstract：:Progesterone has a potential protective effect against ovarian carcinoma induced by estrogen. Progesterone is also known to cause apoptosis while tamoxifen induces growth arrest. Therefore, we attempted to determine whether combined treatment with progesterone and tamoxifen has a sy...

journal_title：Oncology reports

authors： Lee JY,Shin JY,Kim HS,Heo JI,Kho YJ,Kang HJ,Park SH,Lee JY

更新日期：2012-01-01 00:00:00

abstract：:To evaluate the prognostic values of different protein expression in the progression of squamous cell carcinoma of the head and neck (SCCHN) patients, we conducted immunohistochemical (IHC) analysis in tissue samples of different patients enrolled on SWOG protocol S0420. S0420 was a phase II trial to evaluate the effi...

journal_title：Oncology reports

authors： Mehta S,Moon J,Hashmi M,Leblanc M,Huang CH,Rinehart E,Wolf GT,Urba SG,Banerjee SK,Williamson S

更新日期：2013-06-01 00:00:00

abstract：:Gene expression patterns as well as gene interactions are under investigation for their involvement in tumour heterogeneity. The molecular classification of breast cancer based on hormone receptor expression, grade and HER2 receptor levels, is indicative but not adequate enough to c...

journal_title：Oncology reports

authors： Armakolas A,Stathopoulos GP,Nezos A,Theos A,Stathaki M,Koutsilieris M

更新日期：2012-12-01 00:00:00

abstract：:Breast cancer is the most common malignancy in women, and metastasis is the leading cause of death in breast cancer patients. Previous studies have shown that epithelial‑mesenchymal transition (EMT) is involved in the metastasis of breast cancer, but the metabolic reprogramming and regulation mechanisms involved in th...

journal_title：Oncology reports

authors： Liu QQ,Huo HY,Ao S,Liu T,Yang L,Fei ZY,Zhang ZQ,Ding L,Cui QH,Lin J,Yu M,Xiong W

更新日期：2020-09-01 00:00:00

abstract：:miR-95 has been revealed to be aberrantly expressed in multiple types of cancer and to regulate tumor development. Moreover, miR-95 has been revealed to be downregulated in gastric cancer. However, the detailed function of miR-95 in gastric cancer has remained largely unknown. In the present study, we found that miR-9...

journal_title：Oncology reports

authors： Zhang W,Sun J,Chen J,Xu C,Zhang L

更新日期：2019-02-01 00:00:00

abstract：:The decision to repeat transcatheter arterial chemoembolization (TACE) for hepatocellular carcinoma (HCC) is based on correct evaluation of response to therapy. The purpose of this study was to investigate whether apparent diffusion coefficient (ADC), a quantitative parameter of diffusion-weighted imaging (DWI), can p...

journal_title：Oncology reports

authors： Kubota K,Yamanishi T,Itoh S,Murata Y,Miyatake K,Yasunami H,Morio K,Hamada N,Nishioka A,Ogawa Y

更新日期：2010-09-01 00:00:00

abstract：:In the present study, we identified a gene termed Nbla10993 whose expression levels are higher in favorable neuroblastomas versus unfavorable ones. Structural analysis showed that Nbla10993 is a novel splicing variant of the ER-associated protein of 140 kDa (ERAP140), which lacks the central acidic as well as the COOH...

journal_title：Oncology reports

authors： Arai H,Ozaki T,Niizuma H,Nakamura Y,Ohira M,Takano K,Matsumoto M,Nakagawara A

更新日期：2008-06-01 00:00:00

abstract：:Gastric cancer rich in stromal tissue, such as diffuse-type disease, carries a poor prognosis. In some cancers, expression of vimentin, a mesenchymal maker, is associated with poor survival. The expression of mesenchymal markers such as vimentin is observed after epithelial-mesenchymal transition (EMT), an important i...

journal_title：Oncology reports

authors： Otsuki S,Inokuchi M,Enjoji M,Ishikawa T,Takagi Y,Kato K,Yamada H,Kojima K,Sugihara K

更新日期：2011-05-01 00:00:00

abstract：:Resistance to chemotherapeutic agents is a major problem for successful cancer treatment. P-glycoprotein (Pgp), a product of the multidrug resistance (MDR)1 gene expressed in cancer cells, is one of the mechanism of MDR. However, there are few reports regarding the effects of Pgp on prognosis of colorectal cancer (CRC...

journal_title：Oncology reports

authors： Tokunaga Y,Hosogi H,Hoppou T,Nakagami M,Tokuka A,Ohsumi K

更新日期：2001-07-01 00:00:00

abstract：:Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related death worldwide, and only 15% of lung cancer patients live more than 5 years. microRNAs (miRNAs) are endogenously expressed non-coding RNAs, and dysregulation of miRNAs is a common feature in human cancers including lung cancer. In this study, w...

journal_title：Oncology reports

authors： Chen Y,Min L,Zhang X,Hu S,Wang B,Liu W,Wang R,Gu X,Shen W,Lv H,Zou J,Chen Y,Xu X,Chen L

更新日期：2013-10-01 00:00:00

abstract：:Epigenetic changes as well as genetic changes are mechanisms of tumorigenesis. We aimed to identify novel genes that are silenced by DNA hypermethylation in hepatocellular carcinoma (HCC). We screened for genes with promoter DNA hypermethylation using a genome-wide methylation microarray analysis in primary HCC (the d...

journal_title：Oncology reports

authors： Yamada N,Yasui K,Dohi O,Gen Y,Tomie A,Kitaichi T,Iwai N,Mitsuyoshi H,Sumida Y,Moriguchi M,Yamaguchi K,Nishikawa T,Umemura A,Naito Y,Tanaka S,Arii S,Itoh Y

更新日期：2016-04-01 00:00:00

abstract：:Though patients with EGFR mutations are initially responsive to EGFR-tyrosine kinase inhibitors (TKIs), most tumors ultimately acquire resistance to EGFR-TKIs. The most frequently reported mechanism is EGFR T790M mutation. In this study, using a droplet digital PCR (ddPCR) system, we assessed optimal conditions for a ...

journal_title：Oncology reports

authors： Suzawa K,Yamamoto H,Ohashi K,Hashida S,Tomida S,Kubo T,Maki Y,Soh J,Tsukuda K,Kiura K,Miyoshi S,Toyooka S

更新日期：2017-05-01 00:00:00

abstract：:The present study aimed to investigate the effects of cold atmospheric plasma (CAP)‑activated Ringer's solution on osteosarcoma cell lines MG63 and U2OS, and to identify the molecular mechanism underlying these effects. CAP‑activated Ringer's solution was used to treat osteosarcoma cell lines MG63 and U2OS for 30 min....

journal_title：Oncology reports

authors： Xu S,Wang Y,Que Y,Ma C,Cai S,Wang H,Yang X,Yang C,Cheng C,Zhao G,Hu Y

更新日期：2020-05-01 00:00:00

abstract：:Livistona chinensis seeds have been used for centuries to clinically treat various types of cancer. Our published data suggest that Livistona chinensis seeds are able to inhibit hepatocellular carcinoma (HCC) growth in vitro and in vivo via promotion of mitochondrial-dependent apoptosis. To further elucidate the molec...

journal_title：Oncology reports

authors： Lin W,Zhao J,Cao Z,Zhuang Q,Zheng L,Zeng J,Hong Z,Peng J

更新日期：2014-04-01 00:00:00

abstract：:Colorectal cancer (CRC) is a common gastrointestinal malignancy worldwide and is a lethal and aggressive malignancy with a dismal prognosis. EphrinB2 is a membrane-bound ligand and has an intracellular domain that also possesses an intrinsic signaling capacity called 'reverse signaling'. In the present study, CRC cell...

journal_title：Oncology reports

authors： Li P,Chen W,Wang Y,Fu X,Wen K,Qian J,Huang C,Fu Z

更新日期：2015-02-01 00:00:00

abstract：:Soft tissue sarcomas comprise a heterogeneous group of mesenchymal tumors with varying biological behavior ranging from indolent tumors with no or minimal metastatic risk to aggressive and frequently metastasizing tumors. Among the more common aggressive adult soft tissue sarcomas are malignant fibrous histiocytoma, s...

journal_title：Oncology reports

authors： Alford SH,Vrana MS,Waite L,Heim-Hall J,Sylvia VL,Williams RP

更新日期：2007-12-01 00:00:00

abstract：:Correlation between inhibition of cell motility and anti-invasive activity by the water extract of HangAmDan-B (HAD-B), a crude extract of eight Korean medicinal animals and plants, in NCI-H460 human non-small cell lung cancer (NSCLC) cells was investigated. Within the concentration...

journal_title：Oncology reports

authors： Choi YJ,Shin DY,Lee YW,Cho CK,Kim GY,Kim WJ,Yoo HS,Choi YH

更新日期：2011-12-01 00:00:00

abstract：:Protocadherin-10 (PCDH10), a member of non-clustered protocadherin family which plays important roles in calcium-dependent cell-cell signal transduction and adhesion. PCDH10 functions as a tumor suppressor gene and its expression is downregulated by promoter methylation in many malignances. In the present study, we ex...

journal_title：Oncology reports

authors： Qiu C,Bu X,Jiang Z

更新日期：2016-07-01 00:00:00

abstract：:MicroRNAs (miRNAs) are reported to be involved in renal hypoxia/reoxygenation (H/R) damage. To investigate this further, human kidney (HK‑2) cells were cultured, subjected to H/R and the function of miR‑30a‑5p and glutamate dehydrogenase 1 (GLUD1) was evaluated. The results showed that, miR‑30‑5p was downregulated and...

journal_title：Oncology reports

authors： He Y,Lang X,Cheng D,Zhang T,Yang Z,Xiong R

更新日期：2020-10-01 00:00:00

abstract：:Tanshinone IIA (Tan‑IIA; C19H18O3) is derived from Danshen (the roots of Salvia miltiorrhiza), and has been reported to possess anti‑inflammatory and antioxidant activities. Tan‑IIA can inhibit BxPC‑3 human pancreatic cancer cells in vitro through inducing endoplasmic reticulum stress and apoptosis via mitochondrial p...

journal_title：Oncology reports

authors： Su CC

更新日期：2018-11-01 00:00:00

abstract：:The mechanisms leading to squamous cell carcinoma of head and neck (SCCHN) metastasis are not fully understood. Although evidence shows that the chemokine receptor 7 (CCR7) and its ligand CCL19 may regulate tumor dissemination, their role is not clearly defined in SCCHN. Matrix metalloproteinases break consisting of t...

journal_title：Oncology reports

authors： Guo N,Liu F,Yang L,Huang J,Ding X,Sun C

更新日期：2014-08-01 00:00:00

abstract：:Anti-cytotoxic T lymphocyte antigen-4 (CTLA-4) treatment is effective for the treatment of primary tumors, but not sufficient for the treatment of metastatic tumors, likely owing to the effects of the tumor microenvironment. In this study, we aimed to determine the therapeutic effects of combined treatment with a matr...

journal_title：Oncology reports

authors： Li M,Xing S,Zhang H,Shang S,Li X,Ren B,Li G,Chang X,Li Y,Li W

更新日期：2016-03-01 00:00:00

abstract：:Angiogenesis is crucial for the development and metastasis of human brain glioma. Based on our previous successful construction of a lentivirus-mediated alphastatin (an endogenous angiogenesis inhibitor) gene transfer system and our findings that alphastatin exhibited potent inhibit...

journal_title：Oncology reports

authors： Che H,Song J,Guo S,Wang W,Gao G

更新日期：2013-03-01 00:00:00