Saphenous vein graft disease: review of pathophysiology, prevention, and treatment.

Abstract:

:Saphenous vein graft (SVG) disease after coronary artery bypass grafting (CABG) occurs in three phases: thrombosis, intimal hyperplasia, and atherosclerosis. Within the first month, thrombosis plays a major role. From month 1 to month 12, intimal hyperplasia occurs. Beyond 12 months, atherosclerosis becomes the primary cause for late graft failure. Endothelial damage has been shown to be the major underlying pathophysiology of SVG disease. Many factors contribute to endothelial damage from the moment the vein is harvested to when the vein is grafted into an arterial environment. To address this disease process, various therapeutic modalities, from surgical methods to medical treatment, have been evaluated. Surgically, the technical method of harvesting the vein has been shown to affect SVG patency. From a pharmacologic perspective, only two guideline class I recommended medications, aspirin and statins, have been shown to improve short- and long-term SVG patency after CABG. Despite these surgical and medical advances, SVG disease remains a significant problem with 1-year patency rates of 89% dropping to 61% after 10 years. This review discusses the pathogenesis of SVG disease, predictors of SVG failure, and current surgical and pharmacologic therapies to address SVG disease, including possible future treatment.

journal_name

Cardiol Rev

journal_title

Cardiology in review

authors

Kim FY,Marhefka G,Ruggiero NJ,Adams S,Whellan DJ

doi

10.1097/CRD.0b013e3182736190

subject

Has Abstract

pub_date

2013-03-01 00:00:00

pages

101-9

issue

2

eissn

1061-5377

issn

1538-4683

journal_volume

21

pub_type

杂志文章,评审
  • Towards a Saphenous Vein Graft Moratorium.

    abstract::Atherosclerosis develops and rapidly progresses in saphenous veins grafts after coronary bypass surgery. In contrast to native coronary artery, percutaneous revascularization does not impede the progression of saphenous vein atherosclerosis and saphenous vein graft failure commonly ensues. The protracted patency of ar...

    journal_title:Cardiology in review

    pub_type: 杂志文章

    doi:10.1097/CRD.0000000000000277

    authors: Motwani A,Ayinapudi K,Singh T,Maini R,Hendel R,Le Jemtel TH

    更新日期:2020-09-01 00:00:00

  • Gender differences in treatment of heart failure and acute myocardial infarction: a question of quality or epidemiology?

    abstract::Recent articles have inquired about the quality of care for women presenting with cardiovascular disease. The Cooperative Cardiovascular Project and the National Heart Failure Project, 2 Medicare databases, provide national data to address concerns that women receive poorer quality care than men. In these databases, s...

    journal_title:Cardiology in review

    pub_type: 杂志文章,评审

    doi:10.1097/01.crd.0000194093.53005.f0

    authors: Gold LD,Krumholz HM

    更新日期:2006-07-01 00:00:00

  • Primary pulmonary hypertension and cor pulmonale.

    abstract::Primary pulmonary hypertension and cor pulmonale represent forms of precapillary pulmonary hypertension due to intrinsic lung disease. In the case of primary pulmonary hypertension, this is due to disease of the pulmonary vasculature while cor pulmonale is related to diseases of the pulmonary vasculature, airways, or ...

    journal_title:Cardiology in review

    pub_type: 杂志文章,评审

    doi:10.1097/00045415-200209000-00003

    authors: Lehrman S,Romano P,Frishman W,Rashid A,Dobkin J,Reichel J

    更新日期:2002-09-01 00:00:00

  • GUT MICROBIOTA AND CARDIOVASCULAR DISEASES: A CRITICAL REVIEW.

    abstract::The human intestine contains the largest and most diverse ecosystem of microbes. The main function of the intestinal bacterial flora is to limit the growth of potentially pathogenic microorganisms. However, the intestinal microbiota is increasingly emerging as a risk factor for the development of cardiovascular diseas...

    journal_title:Cardiology in review

    pub_type: 杂志文章

    doi:10.1097/CRD.0000000000000327

    authors: Anselmi G,Gagliardi L,Egidi G,Leone S,Gasbarrini A,Miggiano GAD,Galiuto L

    更新日期:2020-06-18 00:00:00

  • The Prognostic Implications of Two-Dimensional Speckle Tracking Echocardiography in Hypertrophic Cardiomyopathy: Current and Future Perspectives.

    abstract::Two-dimensional speckle tracking echocardiography represents a novel, simple, and reproducible technique for the estimation of left ventricular myocardial deformation (strain) and the evaluation of left ventricular twist mechanics. During the last few years, its clinical and prognostic implications in cardiomyopathies...

    journal_title:Cardiology in review

    pub_type: 杂志文章,评审

    doi:10.1097/CRD.0000000000000172

    authors: Zegkos T,Parcharidou D,Ntelios D,Efthimiadis G,Karvounis H

    更新日期:2018-05-01 00:00:00

  • Chagas heart disease: report on recent developments.

    abstract::Chagas disease, caused by the parasite Trypanosoma cruzi, is an important cause of cardiac disease in endemic areas of Latin America. It is now being diagnosed in nonendemic areas because of immigration. Typical cardiac manifestations of Chagas disease include dilated cardiomyopathy, congestive heart failure, arrhythm...

    journal_title:Cardiology in review

    pub_type: 杂志文章,评审

    doi:10.1097/CRD.0b013e31823efde2

    authors: Machado FS,Jelicks LA,Kirchhoff LV,Shirani J,Nagajyothi F,Mukherjee S,Nelson R,Coyle CM,Spray DC,de Carvalho AC,Guan F,Prado CM,Lisanti MP,Weiss LM,Montgomery SP,Tanowitz HB

    更新日期:2012-03-01 00:00:00

  • Resting measures and physiological responses to exercise for the determination of prognosis in patients with chronic heart failure: useful tools for clinical decision-making.

    abstract::Despite recent advances in the management of chronic heart failure (CHF), the prognosis of many of these patients remains dire. The need for an accurate prognosis in these patients has led to the identification of several indicators purported to represent the impact of the disease. Such indicators often are obtained a...

    journal_title:Cardiology in review

    pub_type: 杂志文章,评审

    doi:10.1097/CRD.0b013e3181c4ae0c

    authors: Jorge Alves A,Ribeiro F,Sagiv M,Eynon N,Yamin C,Sagiv M,Oliveira J

    更新日期:2010-07-01 00:00:00

  • Glucose-insulin-potassium therapy in the era of coronary revascularization.

    abstract::Glucose-insulin-potassium (GIK) utilization in the treatment of acute myocardial infarction (AMI) has been studied since the early 1960s with varying results. It is well established that ischemic myocardial cells convert from aerobic metabolism of glucose to toxic anaerobic free fatty acid (FFA) metabolism for the pro...

    journal_title:Cardiology in review

    pub_type: 杂志文章,评审

    doi:10.1097/01.crd.0000175287.38905.14

    authors: Leos CL,Griego JE,Anderson JR

    更新日期:2005-09-01 00:00:00

  • What a physician needs to know about cost-effectiveness.

    abstract::The cost of medical care in the United States continues to spiral upward, partly as a result of new technological breakthroughs that promise improved length of life and quality of life for patients. But how good are these treatments in everyday practice? How do we make policies for adopting innovations that improve ou...

    journal_title:Cardiology in review

    pub_type: 杂志文章,评审

    doi:10.1097/00045415-200008020-00006

    authors: Heidenreich PA,Lee TT

    更新日期:2000-03-01 00:00:00

  • Successful thrombolysis of st. Jude medical aortic prosthesis with tissue-type plasminogen activator in a pregnant woman: a case report.

    abstract::Mechanical valve thrombosis is a life-threatening event. Pregnancy is associated with a hypercoagulable state that further emphasizes the importance of adequate anticoagulation. This is associated with a therapeutic dilemma. Continued anticoagulation with warfarin throughout the first trimester can result in fetopathi...

    journal_title:Cardiology in review

    pub_type: 杂志文章

    doi:10.1097/00045415-200211000-00007

    authors: Behrendt P,Schwartzkopff B,Perings S,Gerhardt A,Zotz RB,Strauer BE

    更新日期:2002-11-01 00:00:00

  • Short QT Syndrome in Current Clinical Practice.

    abstract::Short QT syndrome is a rare inherited autosomal dominant cardiac channelopathy associated with malignant ventricular and atrial arrhythmias. A shortened corrected QT interval is a marker for risk of malignant arrhythmias, which are secondary to increased transmural dispersion of repolarization. The underlying gain of ...

    journal_title:Cardiology in review

    pub_type: 杂志文章,评审

    doi:10.1097/CRD.0000000000000091

    authors: Khera S,Jacobson JT

    更新日期:2016-07-01 00:00:00

  • Is Anacetrapib Better Than Its CETP Inhibitor Counterparts?

    abstract::Cholesterol metabolism and transport has been a major focus in cardiovascular disease risk modification over the past several decades. Hydroxymethylglutaryl-CoA reductase inhibitors (statins) have been the most commonly used agents, with the greatest benefit in reducing both the primary and secondary risks of cardiova...

    journal_title:Cardiology in review

    pub_type: 杂志文章,评审

    doi:10.1097/CRD.0000000000000245

    authors: Grabie M,Tai CH,Frishman WH

    更新日期:2019-09-01 00:00:00

  • Valvular aortic stenosis in the elderly.

    abstract::Elderly patients with valvular aortic stenosis have an increased prevalence of coronary risk factors, of coronary artery disease, and evidence of other atherosclerotic vascular diseases. Statins may reduce the progression of aortic stenosis (AS). Angina pectoris, syncope or near syncope, and congestive heart failure a...

    journal_title:Cardiology in review

    pub_type: 杂志文章,评审

    doi:10.1097/CRD.0b013e31805f6796

    authors: Aronow WS

    更新日期:2007-09-01 00:00:00

  • Brown adipose tissue thermogenesis: β3-adrenoreceptors as a potential target for the treatment of obesity in humans.

    abstract::It has been shown in rodents and newborn babies that brown adipose tissue (BAT) plays an important role in the generation of heat for maintenance of core body temperature. BAT is responsible for the process of adaptive thermogenesis, which involves heat generation in response to a drop in the environment's temperature...

    journal_title:Cardiology in review

    pub_type: 杂志文章,评审

    doi:10.1097/CRD.0b013e31829cabff

    authors: Mund RA,Frishman WH

    更新日期:2013-11-01 00:00:00

  • Assessment of the Patient With Intracerebral Hemorrhage: A Review of the Literature.

    abstract::Spontaneous nontraumatic intracerebral hemorrhage is associated with high morbidity and mortality. Given the risk of rapid neurological deterioration, early identification with rapid neuroimaging is vital. Predictors of outcome, such as spot sign and intracerebral hemorrhage score, can help guide management goals. Man...

    journal_title:Cardiology in review

    pub_type: 杂志文章

    doi:10.1097/CRD.0000000000000332

    authors: Kurian C,Kaur K,Kaur G,Sahni R

    更新日期:2021-01-01 00:00:00

  • Heat shock proteins in cardiovascular disease a new therapeutic target.

    abstract::Cells have the capability of defending themselves from various stressors by activating a genetic program with the production of substances known as heat shock proteins and their regulatory partners, the heat shock transcription factors. In this article, heat shock proteins are discussed, including their roles in patho...

    journal_title:Cardiology in review

    pub_type: 杂志文章,评审

    doi:10.1097/01.crd.0000090894.70619.fa

    authors: Gupta M,Vavasis C,Frishman WH

    更新日期:2004-01-01 00:00:00

  • Sudden Cardiac Death in Hypertrophic Cardiomyopathy.

    abstract::Hypertrophic cardiomyopathy (HCM) is a heart disease characterized by hypertrophy of the left ventricular myocardium and is most often caused by mutations in sarcomere genes. The structural and functional abnormalities are not explained by flow-limiting coronary artery disease or loading conditions. The disease affect...

    journal_title:Cardiology in review

    pub_type: 杂志文章,评审

    doi:10.1097/CRD.0000000000000184

    authors: Adamczak DM,Oko-Sarnowska Z

    更新日期:2018-05-01 00:00:00

  • Clinical application of rest thallium-201/Stress technetium-99m sestamibi dual isotope myocardial perfusion single-photon emission computed tomography.

    abstract::Stress radionuclide myocardial perfusion imaging is a commonly used modality to evaluate patients with known or suspected coronary artery disease. The dual isotope rest thallium-201/stress technetium-99m sestamibi gated single-photon emission computed tomography protocol has gained increasing popularity for these appl...

    journal_title:Cardiology in review

    pub_type: 杂志文章,评审

    doi:10.1097/00045415-199903000-00011

    authors: Hachamovitch R

    更新日期:1999-03-01 00:00:00

  • Evacetrapib: Another CETP Inhibitor for Dyslipidemia With No Clinical Benefit.

    abstract::Evacetrapib is a cholesteryl ester transfer protein (CETP) inhibitor that has been recently studied as a cholesterol modifying agent to reduce cardiovascular risk and mortality in high risk cardiovascular disease patients. Evacetrapib acts to decrease lipid exchange through CETP inhibition. CETP acts to transfer chole...

    journal_title:Cardiology in review

    pub_type: 杂志文章,评审

    doi:10.1097/CRD.0000000000000137

    authors: Eyvazian VA,Frishman WH

    更新日期:2017-03-01 00:00:00

  • Lipid-altering therapy and atrial fibrillation.

    abstract::Atrial fibrillation (AF) is a common cardiac arrhythmia with significant morbidity and public health cost. Because of limitations of efficacy and safety of conventional antiarrhythmic agents, alternative therapies for AF are needed. The potential antiarrhythmic properties of lipid-altering therapy, including the 3-hyd...

    journal_title:Cardiology in review

    pub_type: 杂志文章,评审

    doi:10.1097/CRD.0b013e318177271d

    authors: Bachmann JM,Majmudar M,Tompkins C,Blumenthal RS,Marine JE

    更新日期:2008-07-01 00:00:00

  • Pulmonary artery hypertension: caveolin-1 and eNOS interrelationship: a new perspective.

    abstract::Pulmonary artery hypertension (PAH) is a sequela of a number of disparate diseases, often with a fatal consequence. Endothelial dysfunction is considered to be an early event during the development of PAH. Impaired availability of bioactive nitric oxide (NO) is a key underlying feature in most forms of clinical and ex...

    journal_title:Cardiology in review

    pub_type: 杂志文章,评审

    doi:10.1097/01.crd.0000249381.49138.b9

    authors: Mathew R,Huang J,Gewitz MH

    更新日期:2007-05-01 00:00:00

  • Sauna as a therapeutic option for cardiovascular disease.

    abstract::The physiologic effect of the sauna in human beings has been studied extensively, but only recently have there been studies to suggest sauna can be an effective therapeutic modality for patients with cardiovascular disease, especially for those with congestive heart failure. The data reported to date have been promisi...

    journal_title:Cardiology in review

    pub_type: 杂志文章

    doi:10.1097/01.crd.0000124844.56479.05

    authors: Nguyen Y,Naseer N,Frishman WH

    更新日期:2004-11-01 00:00:00

  • Severe Hypoglycemia and Risk of Subsequent Cardiovascular Events: Systematic Review and Meta-Analysis of Randomized Controlled Trials.

    abstract::Intensive glycemic control significantly increases the risk of hypoglycemia in patients with diabetes mellitus. Recent data have shown that hypoglycemia may also be a marker of cardiovascular disease in these patients. We performed a systemic review and a meta-analysis to evaluate the relationship between severe hypog...

    journal_title:Cardiology in review

    pub_type: 杂志文章

    doi:10.1097/CRD.0000000000000276

    authors: Malik AH,Yandrapalli S,Aronow WS,Jain D,Frishman WH,Panza JA,Cooper HA

    更新日期:2020-09-01 00:00:00

  • Antiretroviral and statin drug-drug interactions.

    abstract::Patients living with the human immunodeficiency virus (HIV) are at risk for dyslipidemia as a result of the disease itself and from certain classes of antiretroviral therapy. The protease inhibitors and non-nucleoside reverse transcription inhibitors have been associated with elevated triglycerides, total, and low-den...

    journal_title:Cardiology in review

    pub_type: 杂志文章,评审

    doi:10.1097/CRD.0b013e3181903b7f

    authors: Ray GM

    更新日期:2009-01-01 00:00:00

  • Role of infection in atherosclerosis and coronary artery disease: a new therapeutic target?

    abstract::There is growing evidence that inflammatory processes may be involved in the development of atherosclerosis and its complications. Viral and bacterial pathogens have been implicated as possible causative factors in the pathogenesis of coronary artery disease and postangioplasty restenosis. Antibiotic trials have been ...

    journal_title:Cardiology in review

    pub_type: 杂志文章,评审

    doi:10.1097/00045415-200207000-00004

    authors: Frishman WH,Ismail AA

    更新日期:2002-07-01 00:00:00

  • Use of long-term combined therapy with inhaled iloprost and oral sildenafil in an adult patient with eisenmenger syndrome.

    abstract::Eisenmenger syndrome is characterized by elevated pulmonary vascular resistance and right-to-left shunting of blood through a systemic to pulmonary circulation connection. Treatment requires either lung transplantation with intracardiac repair or heart-lung transplantation. There are inadequate data regarding treatmen...

    journal_title:Cardiology in review

    pub_type: 杂志文章

    doi:10.1097/01.crd.0000181618.29506.1e

    authors: Okyay K,Cemri M,Boyac B,Yalcn R,Cengel A

    更新日期:2005-11-01 00:00:00

  • The prognostic impact of myocardial late gadolinium enhancement.

    abstract::Cardiovascular magnetic resonance using late gadolinium enhancement (LGE) provides a unique opportunity to assess myocardial tissue in vivo. LGE enables tissue characterization in ischemic and nonischemic cardiomyopathies and other cardiac diseases. LGE is associated with adverse clinical outcomes across a range of di...

    journal_title:Cardiology in review

    pub_type: 杂志文章,评审

    doi:10.1097/CRD.0000000000000002

    authors: Panovsky R,Pleva M,Feitova V,Kruzliak P,Meluzin J,Kincl V

    更新日期:2014-05-01 00:00:00

  • The cost-effectiveness of argatroban treatment in heparin-induced thrombocytopenia: the effect of early versus delayed treatment.

    abstract::A decision-tree analysis was used to estimate the average cost per patient using the direct thrombin inhibitor argatroban for early treatment (<48 hours after thrombocytopenia onset) compared with delayed treatment (> or =48 hours after thrombocytopenia onset) of immune-mediated heparin-induced thrombocytopenia (HIT) ...

    journal_title:Cardiology in review

    pub_type: 杂志文章

    doi:10.1097/01.crd.0000164011.17381.6f

    authors: Arnold RJ,Kim R,Tang B

    更新日期:2006-01-01 00:00:00

  • Effect of an ongoing educational program on the use of antiplatelet drugs, beta-blockers, angiotensin-converting enzyme inhibitors, and lipid-lowering drugs in patients with coronary artery disease seen in an academic cardiology clinic.

    abstract::The effect of an ongoing educational program on the use of cardiovascular drugs in patients with coronary artery disease without contraindications to these drugs seen in an academic cardiology clinic was assessed in 100 patients seen during the 6-month period prior to the educational program and in 200 patients seen 9...

    journal_title:Cardiology in review

    pub_type: 杂志文章

    doi:10.1097/01.crd.0000131191.57664.e7

    authors: Nayak D,Aronow WS

    更新日期:2005-03-01 00:00:00

  • Work-related psychosocial factors and the development of ischemic heart disease: a systematic review.

    abstract::The literature on the relationship between work-related psychosocial factors and the development of ischemic heart disease (IHD) was systematically reviewed: 33 articles presented 51 analyses of studies involving male participants, 18 analyses involving female participants, and 8 analyses with both genders. Twenty of ...

    journal_title:Cardiology in review

    pub_type: 杂志文章,评审

    doi:10.1097/CRD.0b013e318198c8e9

    authors: Eller NH,Netterstrøm B,Gyntelberg F,Kristensen TS,Nielsen F,Steptoe A,Theorell T

    更新日期:2009-03-01 00:00:00