Heat shock proteins in cardiovascular disease a new therapeutic target.

Abstract:

:Cells have the capability of defending themselves from various stressors by activating a genetic program with the production of substances known as heat shock proteins and their regulatory partners, the heat shock transcription factors. In this article, heat shock proteins are discussed, including their roles in pathophysiology and as possible pharmacologic targets to treat disease. Multiple investigations have demonstrated an elevation in heat shock proteins in patients with systemic hypertension, coronary artery disease, carotid atherosclerosis, and myocardial infarction and ischemia. As we further understand how to manipulate their expression, we can explore pharmacologic interventions and gene transfection techniques that can safely be used in humans.

journal_name

Cardiol Rev

journal_title

Cardiology in review

authors

Gupta M,Vavasis C,Frishman WH

doi

10.1097/01.crd.0000090894.70619.fa

keywords:

subject

Has Abstract

pub_date

2004-01-01 00:00:00

pages

26-30

issue

1

eissn

1061-5377

issn

1538-4683

pii

01.crd.0000090894.70619.fa

journal_volume

12

pub_type

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