Primary pulmonary hypertension and cor pulmonale.

Abstract:

:Primary pulmonary hypertension and cor pulmonale represent forms of precapillary pulmonary hypertension due to intrinsic lung disease. In the case of primary pulmonary hypertension, this is due to disease of the pulmonary vasculature while cor pulmonale is related to diseases of the pulmonary vasculature, airways, or interstitium. Patients present with signs and symptoms of right ventricular dysfunction and low cardiac output including dyspnea, chest pain and peripheral edema. Therapy is directed at the underlying disease and may include supplemental oxygen for diseases causing chronic hypoxemia and anticoagulation for thrombotic disease. Vasodilator therapy has variable efficacy for pulmonary vascular disorders. Postacyclin by continuous infusion has been a major advance in the therapy of primary pulmonary hypertension and has prolonged survival and delayed the need for lung transplantation. Bosentan, an endothelin receptor blocking agent is the first oral medication approved for the therapy of pulmonary hypertension.

journal_name

Cardiol Rev

journal_title

Cardiology in review

authors

Lehrman S,Romano P,Frishman W,Rashid A,Dobkin J,Reichel J

doi

10.1097/00045415-200209000-00003

keywords:

subject

Has Abstract

pub_date

2002-09-01 00:00:00

pages

265-78

issue

5

eissn

1061-5377

issn

1538-4683

pii

01.CRD.0000026722.29852.3E

journal_volume

10

pub_type

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