GUT MICROBIOTA AND CARDIOVASCULAR DISEASES: A CRITICAL REVIEW.

Abstract:

:The human intestine contains the largest and most diverse ecosystem of microbes. The main function of the intestinal bacterial flora is to limit the growth of potentially pathogenic microorganisms. However, the intestinal microbiota is increasingly emerging as a risk factor for the development of cardiovascular disease (CVD). The gut microbiota-derived metabolites, such as short chain fatty acids (SCFA), trimethylamine-N-oxide (TMAO), bile acids and polyphenols play a pivotal role in maintaining healthy cardiovascular function, and when dysregulated, can potentially lead to CVD. In particular, changes in the composition and diversity of gut microbiota, known as dysbiosis, have been associated with atherosclerosis, hypertension, and heart failure. Nonetheless, the underlying mechanisms remain yet to be fully understood. Therefore, the microbiota and its metabolites have become a new therapeutic target for the prevention and treatment of CVD. In addition to a varied and balanced diet, the use of prebiotic and probiotic treatments or selective TMAO inhibitors could play a pivotal role in the prevention of CVD, especially in patients with a high metabolic risk.

journal_name

Cardiol Rev

journal_title

Cardiology in review

authors

Anselmi G,Gagliardi L,Egidi G,Leone S,Gasbarrini A,Miggiano GAD,Galiuto L

doi

10.1097/CRD.0000000000000327

subject

Has Abstract

pub_date

2020-06-18 00:00:00

eissn

1061-5377

issn

1538-4683

pub_type

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