Antiretroviral and statin drug-drug interactions.

Abstract:

:Patients living with the human immunodeficiency virus (HIV) are at risk for dyslipidemia as a result of the disease itself and from certain classes of antiretroviral therapy. The protease inhibitors and non-nucleoside reverse transcription inhibitors have been associated with elevated triglycerides, total, and low-density lipoprotein cholesterol with decreased high-density lipoprotein. These classes of medications affect the cytochrome P450 (CYP) enzyme resulting in both induction and inhibition of numerous CYP enzymes. The statins are extensively metabolized by the CYP system and therefore drug-drug interactions between the statins and antiretroviral therapy must be considered when treating HIV or antiretroviral drug-induced dyslipidemia.

journal_name

Cardiol Rev

journal_title

Cardiology in review

authors

Ray GM

doi

10.1097/CRD.0b013e3181903b7f

subject

Has Abstract

pub_date

2009-01-01 00:00:00

pages

44-7

issue

1

eissn

1061-5377

issn

1538-4683

pii

00045415-200901000-00007

journal_volume

17

pub_type

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