Abstract:
:Progenitor stem cells have been identified, isolated and characterized in numerous tissues and organs. However, their therapeutic potential and the use of these stem cells remain elusive except for a few progenitor cells from bone marrow, umbilical cord blood, eyes and dental pulp. The use of bone marrow-derived hematopoietic stem cells (HSC) or mesenchymal stem cells (MSCs) is restricted due to their extreme invasive procedures, low differentiation potential with age and rejection. Thus, we need a clinical grade alternative to progenitor stem cells with a high potential to differentiate, naïve and is relatively easy in in vitro propagation. In this review, we summarize cell populations of adherent and floating spheres derived from different origins of skin, or correctly foreskin, by enzymatic digestion compared with established MSCs. The morphology, phenotype, differentiation capability and immunosuppressive property of the adherent cell populations are comparable with MSCs. Serum-free cultured floating spheres have limited mesodermal but higher neurogenic differentation potential, analogous to neural crest stem cells. Both the populations confirmed their plethora potential in in vitro. Together, it may be noted that the skin-derived adherent cell populations and floating cells can be good alternative sources of progenitor cells especially in cosmetic, plastic and sports regenerative medicine.
journal_name
Cell Tissue Resjournal_title
Cell and tissue researchauthors
Vishnubalaji R,Al-Nbaheen M,Kadalmani B,Aldahmash A,Ramesh Tdoi
10.1007/s00441-012-1471-zsubject
Has Abstractpub_date
2012-10-01 00:00:00pages
1-12issue
1eissn
0302-766Xissn
1432-0878journal_volume
350pub_type
杂志文章,评审abstract::We investigated the binding characteristics of two monoclonal antibodies, 4F3 and 3F8, which in the retina specifically stain Müller cells, both with protein blots and immunohistochemically in sections of various regions of the central nervous system of neonatal and adult cats and rats. Clear differences emerged betwe...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s004410050887
更新日期:1997-09-01 00:00:00
abstract::The presence, location and degree of immunoexpression of various microfilament (MF) and intermediate filament (IF) systems (actin, cytokeratins, desmin, vimentin) were studied in the excurrent ducts of the testis in sexually mature and active galliform (Japanese quail, domestic fowl, turkey) and anseriform (duck) bird...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-008-0631-7
更新日期:2008-08-01 00:00:00
abstract::Chemoreception in marine invertebrates mediates a variety of ecologically important behaviors including defense, reproduction, larval settlement and recruitment, and feeding. The sensory pathways that regulate deposit-feeding activity by polychaetes living in sedimentary habitats are of particular interest because suc...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-008-0660-2
更新日期:2008-09-01 00:00:00
abstract::The distribution of endocrine cells in the gastrointestinal tract of the house musk shrew, Suncus murinus (Family Soricidae, Order Insectivora) was studied immunohistochemically. The hormones investigated were gastrin, cholecystokinin (CCK), somatostatin, secretin, glucagon, gastric inhibitory polypeptide (GIP), motil...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00239456
更新日期:1989-11-01 00:00:00
abstract::The formation of secretory granules in chronically hypersecretory melanotrophs in the rat pituitary was studied. Hypersecretion was induced by treatment with the dopamine antagonist haloperidol (1.5 mg/kg daily for 7 days), which releases the normal neural dopaminergic inhibition of secretion from the melanotroph. Mor...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00319432
更新日期:1994-02-01 00:00:00
abstract::Generally, the CRF-like activity of vasopressin is studied in experiments involving adrenalectomy and corticosteroid replacement. In order to avoid this complex type of stress, male and female (diestrus, estrus) rats were exposed to 5 min to immobilization stress and sacrificed 5, 15, and 30 min thereafter. After a su...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00209276
更新日期:1978-05-29 00:00:00
abstract::The lymphatic organization and its relationship to the vascular system in the rat small intestine was studied by scanning electron microscopy of corrosion casts and freeze-fractured tissues, and by light microscopy of injected preparations. The villus possessed 3-10 or more central lacteals depending upon the villous ...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00218204
更新日期:1987-05-01 00:00:00
abstract::Large conductance calcium-activated potassium channels (BK(ca)) are crucial for the regulation of cerebral vascular basal tone and might be involved in cerebral vasodilation relevant to migraine and stroke. We studied the differential gene expression of mRNA transcript levels and protein expression of the BK(Ca) chann...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-008-0701-x
更新日期:2008-12-01 00:00:00
abstract::Mesenchymal stem cells (MSCs) are increasingly being reported as occurring in a variety of tissues. Although MSCs from human bone marrow are relatively easy to harvest, the isolation of rodent MSCs is more difficult, thereby limiting the number of experiments in vivo. To determine a suitable cell source, we isolated r...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-006-0308-z
更新日期:2007-03-01 00:00:00
abstract::In Syrian hamsters (Mesocricetus auratus), oxytocin (OXT) activity within the medial preoptic-anterior hypothalamus (MPOA-AH) and the ventromedial hypothalamus (VMH) plays an important role in the expression of sexual receptivity. Immunocytochemical analysis with OXT-specific antibodies was used to identify the distri...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s004410050993
更新日期:1998-02-01 00:00:00
abstract::A multilamellate body (MLB), bearing close resemblance to an array of annulate lamellae, has been observed in several adenohypophysial cell types of the teleost, Hemihaplochromis philander. In longitudinal section, each MLB comprises a ladder-like row of 12-50 sausage-shaped profiles, termed lamellae. A few lamellae i...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00221372
更新日期:1976-10-06 00:00:00
abstract::In adrenalectomized rats the influence of salt loading or salt deprivation on the vasopressin and oxytocin content of the median eminence (ME) and the neural lobe (NL) was studied by means of various methods: morphometric and microphotometric analysis of aldehyde fuchsin-stained sections of ME and NL; immunohistochemi...
journal_title:Cell and tissue research
pub_type: 杂志文章,评审
doi:10.1007/BF00215904
更新日期:1986-01-01 00:00:00
abstract::Enzymatic activities of calcium-magnesium dependent adenosine triphosphatase (Ca-ATPase) and nonspecific alkaline phosphatase (ALPase) were localized at the initial calcification sites of dentin and enamel of rat incisor teeth using electron-microscopic cytochemistry. Ca-ATPase was localized in the Golgi cisternae, cy...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00221856
更新日期:1986-01-01 00:00:00
abstract::In the stalk-eyed fly Cyrtodiopsis whitei (Diopsidae; Diptera), the relatively long optic nerve develops within the tight lumen of a very short eyestalk. Axonal growth is generally considered in terms of path finding, selective fasciculation, and towing. Physical forces that are necessary for axon lengthening are gene...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-005-1142-4
更新日期:2005-09-01 00:00:00
abstract::The electric organs of embryonic Torpedo marmorata have been reacted with three cationic stains to evaluate the appearance and distribution of anionic sites. Ruthenium red, alcian blue and lysozyme were used at different pHs and found to react in a time-related manner to anionic components within the interelectrocyte ...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00214662
更新日期:1987-10-01 00:00:00
abstract::Two-month-old female Swiss mice that had come into estrus were injected intravenously with L-3H-fucose and killed at 5, 15, 40 min, and 4 h after injection. Pieces of the isthmus and of the ampulla of the uterine tubes were processed for light- and electron-microscopic radioautography. Incorporation of 3H-fucose was m...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00220036
更新日期:1988-10-01 00:00:00
abstract::We demonstrate the existence of nerve fibers possessing substance P (SP) and calcitonin gene-related peptide (CGRP) immunoreactivity in the mouse cervical ventral roots. The distribution of the SP and CGRP fibers was similar, but CGRP fibers were generally more numerous. Both types entered the ventral pia mater or for...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00327774
更新日期:1994-08-01 00:00:00
abstract::In the pond snail Lymnaea stagnalis, the growth regulating system consists of (1) about 200 neuroendocrine light green cells, located in four clusters in the cerebral ganglia, and (2) the paired canopy cells, located in the lateral lobes. These cells express genes encoding the molluscan insulin-related peptides (MIPs)...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00384739
更新日期:1992-07-01 00:00:00
abstract::The distribution of Mg++-ATPase in osteoclasts along the endosteal surface of the chick tibia was investigated by neutral and alkaline pH cytochemical methods at the electron-microscopic level. Reaction product was observed in mitochondria, cytoplasmic vesicles, and ruffled-border membrane. Levamisole, ouabain, and va...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00218550
更新日期:1986-01-01 00:00:00
abstract::The juxtaglomerular apparatus (JGA) in the rabbit kidney was examined by transmission electron microscopy and by freeze fracturing. It was found, that the Goormaghtigh cells of the JGA are extensively coupled with the mesangial cells within the glomerular tuft by gap junctions. A broad band of gap junctions starting w...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00225537
更新日期:1978-01-17 00:00:00
abstract::Kidneys of 2 to 10 day-old rats of Wistar and Sprague-Dawley strains were fixed with glutaraldehyde by retrograde vascular perfusion and then prepared for observation in TEM and SEM. In addition methacrylate casts of differentiating glomerular capillaries were examined by SEM. Although the glomerular vascular pattern ...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00233959
更新日期:1980-01-01 00:00:00
abstract::CD4+CD25+(high) regulatory T cells (Tregs) play a pivotal role in the control of the immune response. A growing body of evidence suggests the reduced function of these cells in autoimmune diseases, including type 1 diabetes (T1D). Restoration of their function can potentially delay further disease development. In the ...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-009-0900-0
更新日期:2010-03-01 00:00:00
abstract::Growing numbers of translational genomics studies are based on the highly efficient and versatile zebrafish (Danio rerio) vertebrate model. The increasing types of zebrafish models have improved our understanding of inherited kidney diseases, since they not only display pathophysiological changes but also give us the ...
journal_title:Cell and tissue research
pub_type: 杂志文章,评审
doi:10.1007/s00441-017-2593-0
更新日期:2017-07-01 00:00:00
abstract::Colitis is associated with alterations in electrolyte and water transport. These changes give rise to some of the symptoms experienced by patients with colitis. Alterations in fluid flux may also contribute to increased susceptibility to mucosal injury. Recently, endogenous water channel proteins (aquaporins; AQPs), h...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-004-0932-4
更新日期:2004-11-01 00:00:00
abstract::An ultrastructural study of the rostral pars distalis of the pituitary of Aphanius dispar specimens taken from freshwater or hypersaline marshes revealed significant structural differences which indicate higher activity of the prolactin cells in the hypotonic medium. Prolactin cells from freshwater specimens had large...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00221103
更新日期:1977-04-20 00:00:00
abstract::This study explores the molecular composition of the tight junction (TJ) in human term placenta from normal women and from patients with preeclampsia, a hypertensive disorder of pregnancy. Maternal endothelial dysfunction is a critical characteristic of preeclampsia; hence, we have analyzed its impact on placental ves...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-005-0135-7
更新日期:2006-06-01 00:00:00
abstract::It is a well-established fact that the sympathetic, parasympathetic and enteric nervous systems are affected at early stages in Parkinson's disease (PD). However, it is not yet clarified whether the earliest pathological events preferentially occur in any of these three divisions of the autonomic nervous system (ANS)....
journal_title:Cell and tissue research
pub_type: 杂志文章,评审
doi:10.1007/s00441-018-2851-9
更新日期:2018-07-01 00:00:00
abstract::Olfactory marker protein (OMP) was first described as a protein expressed in olfactory receptor neurons (ORNs) in the nasal cavity. In particular, OMP, a small cytoplasmic protein, marks mature ORNs and is also expressed in the neurons of other nasal chemosensory systems: the vomeronasal organ, the septal organ of Mas...
journal_title:Cell and tissue research
pub_type: 杂志文章,评审
doi:10.1007/s00441-020-03349-9
更新日期:2021-01-15 00:00:00
abstract::Male germ cells of the greater bandicoot rat, Bandicota indica, have recently been categorized into 12 spermiogenic steps based upon the morphological appearance of the acrosome and nucleus and the cell shape. In the present study, we have found that, in the Golgi and cap phases, round spermatid nuclei contain 10-nm t...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-008-0668-7
更新日期:2008-10-01 00:00:00
abstract::Loss of wild-type p53 activity is thought to be a major predictor of failure to respond to radiotherapy and chemotherapy in various human cancers. This assumption is largely based on some cell-death studies in p53-knockout mice and on correlations of p53 status assessed by immunochemistry or single-strand conformation...
journal_title:Cell and tissue research
pub_type: 杂志文章,评审
doi:10.1007/s004410051072
更新日期:1998-06-01 00:00:00