Peripheral and central autonomic nervous system: does the sympathetic or parasympathetic nervous system bear the brunt of the pathology during the course of sporadic PD?

Abstract:

:It is a well-established fact that the sympathetic, parasympathetic and enteric nervous systems are affected at early stages in Parkinson's disease (PD). However, it is not yet clarified whether the earliest pathological events preferentially occur in any of these three divisions of the autonomic nervous system (ANS). Significant involvement of the peripheral autonomic nervous system of the heart and gastrointestinal tract has been documented in PD. Accumulating evidence suggests that the PD pathology spreads centripetally from the peripheral to central nervous system through autonomic nerve fibers, implicating the ANS as a major culprit in PD pathogenesis and a potential target for therapy. This study begins with a brief overview of the structures of the central and peripheral autonomic nervous system and then outlines the major clinicopathological manifestations of cardiovascular and gastrointestinal disturbances in PD.

journal_name

Cell Tissue Res

journal_title

Cell and tissue research

authors

Orimo S,Ghebremedhin E,Gelpi E

doi

10.1007/s00441-018-2851-9

subject

Has Abstract

pub_date

2018-07-01 00:00:00

pages

267-286

issue

1

eissn

0302-766X

issn

1432-0878

pii

10.1007/s00441-018-2851-9

journal_volume

373

pub_type

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