Abstract:
:It is a well-established fact that the sympathetic, parasympathetic and enteric nervous systems are affected at early stages in Parkinson's disease (PD). However, it is not yet clarified whether the earliest pathological events preferentially occur in any of these three divisions of the autonomic nervous system (ANS). Significant involvement of the peripheral autonomic nervous system of the heart and gastrointestinal tract has been documented in PD. Accumulating evidence suggests that the PD pathology spreads centripetally from the peripheral to central nervous system through autonomic nerve fibers, implicating the ANS as a major culprit in PD pathogenesis and a potential target for therapy. This study begins with a brief overview of the structures of the central and peripheral autonomic nervous system and then outlines the major clinicopathological manifestations of cardiovascular and gastrointestinal disturbances in PD.
journal_name
Cell Tissue Resjournal_title
Cell and tissue researchauthors
Orimo S,Ghebremedhin E,Gelpi Edoi
10.1007/s00441-018-2851-9subject
Has Abstractpub_date
2018-07-01 00:00:00pages
267-286issue
1eissn
0302-766Xissn
1432-0878pii
10.1007/s00441-018-2851-9journal_volume
373pub_type
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journal_title:Cell and tissue research
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journal_title:Cell and tissue research
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journal_title:Cell and tissue research
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journal_title:Cell and tissue research
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