Pax-2 in the chiasm.

Abstract:

:Pax genes are expressed in specific patterns in the nervous system during development and in the adult. Recent findings suggest a link between the expression of Pax-2 and axonal guidance. Mice with a targeted deletion of Pax-2 are an excellent tool for studying axonal pathfinding at the molecular level, especially with respect to the optic chiasm. The date reviewed here suggest that Pax-2 regulates the expression of surface molecules involved in contact attraction and that the mutual regulation of the expression of Pax-2 and the Sonic hedgehog gene is of importance in the formation of the chiasm region.

journal_name

Cell Tissue Res

journal_title

Cell and tissue research

authors

Alvarez-Bolado G,Schwarz M,Gruss P

doi

10.1007/s004410050923

subject

Has Abstract

pub_date

1997-11-01 00:00:00

pages

197-200

issue

2

eissn

0302-766X

issn

1432-0878

journal_volume

290

pub_type

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