Abstract:
:Doubts exist as to whether afferent nerve fibers exert a neurotrophic effect on the differentiation of sensory cells in the developing vestibular neuroepithelium. To determine whether innervation of hair cells precedes their differentiation, we have used the L1 adhesion molecule as a marker for axons. The detection of L1 on afferent axons in the otic vesicle of mouse embryos on gestation day 11 shows that nerve fibers penetrate the neuroepithelium before the sensory cells differentiate. L1-immunoreactivity of nerve endings also reveals the considerable fiber ramification on gestation days 14 and 15, i.e., corresponding to the first stages of sensory cell differentiation. The expression of L1 at successive stages of nerve fiber growth in the neuroepithelium, such as fasciculation and ramification, is not consistent with the previous role proposed for L1 as a fascicule-promoting factor and raises the possibility that other mechanisms are involved in L1 mediated adhesion.
journal_name
Cell Tissue Resjournal_title
Cell and tissue researchauthors
Mbiene JP,Dechesne CJ,Schachner M,Sans Adoi
10.1007/BF00229069subject
Has Abstractpub_date
1989-01-01 00:00:00pages
81-8issue
1eissn
0302-766Xissn
1432-0878journal_volume
255pub_type
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