Abstract:
:A recently developed immunohistochemical technique for serotonin (Steinbusch et al. 1978) was used in the present investigation to study the occurrence of this indoleamine in the granulated epithelial cells of neuro-epithelial bodies (NEB). Lungs from neonatal rabbits and pigs exhibit immunoreactive cell groups identical in morphology and their preferential location (i.e., at bronchiolar bifurcations) to the recently described intrapulmonary NEB. Moreover, in the trachea and lung of rabbits isolated immunoreactive cells, presumably of Kultschitsky type, were found in the lining respiratory mucosa. Such single cells were also frequently observed in the bronchial epithelium of pig lungs. It is concluded that the corpuscular cells, being modulated by the central nervous system, probably represent intrapulmonary neuro(chemo-)receptors with local secretory activities, one of the substances released being serotonin and reacting to the oxygen composition of the inhaled air. It is proposed that the cells of Kultschitsky type exert a more local effect upon the airways.
journal_name
Cell Tissue Resjournal_title
Cell and tissue researchauthors
Lauweryns JM,de Bock V,Verhofstad AA,Steinbusch HWdoi
10.1007/BF00217095subject
Has Abstractpub_date
1982-01-01 00:00:00pages
215-23issue
1eissn
0302-766Xissn
1432-0878journal_volume
226pub_type
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