Role of miR-21 in the pathogenesis of atrial fibrosis.

abstract：:Implicit in attempts to characterize and purify biologically active factors is the premise that the bioassay system employed will show a progressive increase in the response as the concentration of the responsible factor increases. We employed the hamster cheek pouch to assay the neovascularization potential of growth...

journal_title：Basic research in cardiology

authors： Orlandi C,Paskins-Hurlburt AJ,Hollenberg NK

更新日期：1986-05-01 00:00:00

abstract：:Receptor binding studies usually show heterogenic characteristics of the binding isotherm. Scatchard transformation for graphical linearization of the data presentation affects the data inhomogeneously with respect to the experimental error. Thus a non-linear fitting procedure should be preferred for data analysis. Fu...

journal_title：Basic research in cardiology

authors： Wellstein A,Palm D

更新日期：1984-01-01 00:00:00

abstract：:K201 has previously been shown to reduce diastolic contractions in vivo during β-adrenergic stimulation and elevated extracellular calcium concentration ([Ca(2+)](o)). The present study characterised the effect of K201 on electrically stimulated and spontaneous diastolic sarcoplasmic reticulum (SR)-mediated Ca(2+) rel...

journal_title：Basic research in cardiology

authors： Elliott EB,Hasumi H,Otani N,Matsuda T,Matsuda R,Kaneko N,Smith GL,Loughrey CM

更新日期：2011-11-01 00:00:00

abstract：:A method is theoretically described to test the accuracy of various lead system of the ecg. The priniciple of this method consists in the following procedure. The heart position is changed maximally in a proband by varying the position of the body and by deep inspiration and exspiration. If the lead field is parallel,...

journal_title：Basic research in cardiology

authors： Hiltmann WD,Schaefer H

更新日期：1975-01-01 00:00:00

abstract：:The relationship between ischemic contracture and no-reflow phenomenon was studied in 59 isolated rat hearts during global ischemia. The contracture was measured by a water-filled balloon catheter placed in the left ventricular lumen. The time of onset of contracture was changed by preischemic infusion with buffer con...

journal_title：Basic research in cardiology

authors： Lipasti JA,Nevalainen TJ,Alanen KA

更新日期：1982-07-01 00:00:00

abstract：:Ultrasonic techniques for the measurement of ventricular dimensions are widely used in acute and chronic experiments. Implantation of ultrasonic crystals is associated with reversible and irreversible myocardial damage which might limit the interpretation of the obtained results, in particular during acute experiments...

journal_title：Basic research in cardiology

authors： Schipke J,Heusch G,Schulz R,Thämer V

更新日期：1987-07-01 00:00:00

abstract：:Ventricular remodeling following nonfatal myocardial infarction includes an excentric hypertrophy of the surviving myocardium, associated with hemodynamic overload. Disseminated cardiomyocyte apoptosis and phenotype changes of the surviving myocardium, such as a labile calcium homeostasis of the hypertrophied cardiomy...

journal_title：Basic research in cardiology

authors： Holtz J

更新日期：1998-01-01 00:00:00

abstract：:Elevation of cardiac troponin I (cTnI) is a well-known complication after percutaneous coronary interventions (PCI). The aims of this study were to quantify the extent of coronary microembolization during elective PCI, to identify predisposing anatomical and procedural factors, and to evaluate its impact on long-term ...

journal_title：Basic research in cardiology

authors： Otto S,Seeber M,Fujita B,Kretzschmar D,Ferrari M,Goebel B,Figulla HR,Poerner TC

更新日期：2012-09-01 00:00:00

abstract：:In this report we review the replacement (i.e., scarring) and reactive (i.e., perivascular and interstitial fibrosis) fibrous tissue responses found in the myocardium in response to effector hormones of the renin-angiotensin-aldosterone system. Experimental data are presented to indicate: a) endogenous or exogenous el...

journal_title：Basic research in cardiology

authors： Weber KT,Brilla CG,Campbell SE,Guarda E,Zhou G,Sriram K

更新日期：1993-01-01 00:00:00

abstract：:In an attempt to clarify the mechanism of sarcoplasmic reticulum (SR) dysfunction during the genesis of irreversible damage in the ischemic-reperfused myocardium, the changes in SR Ca2(+)-pumping ATPase (Ca2(+)-activated, Mg2(+)-dependent ATPase; Ca2(+)-ATPase) activity were studied during ischemia and subsequent repe...

journal_title：Basic research in cardiology

authors： Yoshida Y,Shiga T,Imai S

更新日期：1990-09-01 00:00:00

abstract：:Over the past decade, hydrogen sulfide has emerged as an important cardioprotective molecule with potential for clinical applications. Although several pathways have been proposed to mediate the beneficial effects of H2S, the NO/cGMP axis has attracted significant attention. Recent evidence has suggested that cGMP-dep...

journal_title：Basic research in cardiology

authors： Andreadou I,Iliodromitis EK,Szabo C,Papapetropoulos A

更新日期：2015-09-01 00:00:00

abstract：:Increasing the frequency of steady state stimulation increases the rate of mechanical restitution in hypothermic (27 degrees C) guinea pig papillary muscles. In this paper we have investigated the influences of the calcium antagonist nifedipine and of reduced extracellular calcium concentration on this phenomenon. We ...

journal_title：Basic research in cardiology

authors： Spencer CI,Mörner SE,Noble MI,Seed WA

更新日期：1993-03-01 00:00:00

abstract：:Transient receptor potential melastatin-7 (TRPM7) channels have been recently reported in human atrial fibroblasts and are believed to mediate fibrogenesis in human atrial fibrillation. The present study investigates whether TRPM7 channels are expressed in human atrial myocytes using whole-cell patch voltage-clamp, RT...

journal_title：Basic research in cardiology

authors： Zhang YH,Sun HY,Chen KH,Du XL,Liu B,Cheng LC,Li X,Jin MW,Li GR

更新日期：2012-09-01 00:00:00

abstract：:Acute ischemia is a well-known inductor of extracellular matrix (ECM) remodeling, which leads to the development of congestive heart failure and is associated with left ventricular dilatation. Here we investigate the timecourse of ECM processing with release of endostatin (ES) and other low-molecular-weight fragments ...

journal_title：Basic research in cardiology

authors： Lauten A,Majos E,Mühlich A,Wahlers T,Weider S,Fischer JH,Figulla HR,Bloch W

更新日期：2009-09-01 00:00:00

abstract：:Age-related changes in the myocardial energy metabolism were studied in spontaneously hypertensive (SHR) rats of 5-15 weeks of age. Systolic blood pressure increased rapidly during 5 to 10 weeks of age (developing phase) and attained a plateau level at 10 to 15 weeks (sustained phase). Even during the developing phase...

journal_title：Basic research in cardiology

authors： Shimamoto N,Goto N,Tanabe M,Imamoto T,Fujiwara S,Hirata M

更新日期：1982-07-01 00:00:00

abstract：:Long QT syndrome is a potentially life-threatening disease characterized by delayed repolarization of cardiomyocytes, QT interval prolongation in the electrocardiogram, and a high risk for sudden cardiac death caused by ventricular arrhythmia. The genetic type 3 of this syndrome (LQT3) is caused by gain-of-function mu...

journal_title：Basic research in cardiology

authors： Malan D,Zhang M,Stallmeyer B,Müller J,Fleischmann BK,Schulze-Bahr E,Sasse P,Greber B

更新日期：2016-03-01 00:00:00

abstract：:Calcium transport functions of mitochondria and sarcoplasmic reticulum (SR) were studied without prior extraction using isolated rat heart myocytes permeabilized with saponin. Calcium uptake by SR was rapid and its affinity was high in comparison to calcium uptake by mitochondria, which had a higher capacity. The sens...

journal_title：Basic research in cardiology

authors： Kaminishi T,Kako KJ

更新日期：1989-05-01 00:00:00

abstract：:The renin angiotensin system and endothelium-derived vasoactive substances are both important regulators of vascular tone. Recent evidence suggests that the two systems may be tightly interconnected and drugs interfering with one system may also affect the other. Beside the circulating renin angiotensin system, a vasc...

journal_title：Basic research in cardiology

authors： Lüscher TF

更新日期：1993-01-01 00:00:00

abstract：:In dog myocardium, the changes in the levels of creatine phosphate, inorganic phosphate, ATP, ADP, AMP, adenosine and inosine with 8 min of ischemia and subsequent reperfusion for 2, 4, 8, 16 and 32 min have been followed. Creatine phosphate and inorganic phosphate recovered completely within a few minutes as did the ...

journal_title：Basic research in cardiology

authors： Van Belle H,Xhonneux R,Flameng W,Wynants J

更新日期：1986-07-01 00:00:00

abstract：:Recent publications shown mitochondrial localization of the enzyme nitric oxide synthase (NOS) in a number of tissues. However, conflicting results about mitochondrial NOS (mtNOS) immunoreactivity and enzymatic activity are available to date in the literature. In this study we purified mitochondria from rat hearts and...

journal_title：Basic research in cardiology

authors： Zanella B,Giordano E,Muscari C,Zini M,Guarnieri C

更新日期：2004-05-01 00:00:00

abstract：:Isolated cells obtained from adult myocardium are proving invaluable for a wide range of studies concerned with the mechanisms underlying many important cardiological processes. Although care must always be taken to ensure that the single myocyte is an appropriate model for the particular question to be researched, it...

journal_title：Basic research in cardiology

authors： Powell T

更新日期：1985-01-01 00:00:00

abstract：:PDE3 cyclic nucleotide phosphodiesterase inhibitors raise cAMP and cGMP content in cardiac and vascular myocytes. Their administration to patients with dilated cardiomyopathy leads to improvements in hemodynamic parameters in the short term but reduces survival with chronic administration. The reasons for this 'biphas...

journal_title：Basic research in cardiology

authors： Movsesian MA

更新日期：2002-01-01 00:00:00

abstract：:The effects of the potassium channel openers (KCO), cromakalim or pinacidil, were evaluated in an anesthetized porcine model of pacing- and ischemia-induced ventricular fibrillation (VF). Hearts were paced at 180 bpm and the left anterior descending coronary artery was occluded until VF was induced. Reproducible times...

journal_title：Basic research in cardiology

authors： D'Alonzo AJ,Hess TA,Darbenzio RB,Sewter JC,Conder ML,McCullough JR

更新日期：1994-03-01 00:00:00

abstract：:It is commonly thought that the optimal method for intracoronary administration of cells is to stop coronary flow during cell infusion, in order to prolong cell/vascular wall contact, enhance adhesion, and promote extravasation of cells into the interstitial space. However, occlusion of a coronary artery with a balloo...

journal_title：Basic research in cardiology

authors： Keith MC,Tokita Y,Tang XL,Ghafghazi S,Moore JB 4th,Hong KU,Elmore JB,Amraotkar AR,Guo H,Ganzel BL,Grubb KJ,Flaherty MP,Vajravelu BN,Wysoczynski M,Bolli R

更新日期：2015-09-01 00:00:00

abstract：:Rat hearts were exposed and injured locally by direct cryoapplication. The hearts were examined 2, 4, 20 and 48 hours, 7 and 12 days later. In the first 48 hours mast cell and polymorphonuclear (mainly eosinophilic) granulocyte infiltration was followed by proliferation of mononuclear phagocytic and fibroblastic cells...

journal_title：Basic research in cardiology

authors： Yarom R,Havivi Y,Heling I

更新日期：1979-05-01 00:00:00

abstract：:A previous study indicated that 5 mg/kg aspirin can reverse the cardioprotective effects of thromboxane A2 synthetase inhibitors. We determined in the present study if this dose of aspirin can also reverse the protective effects of the thromboxane A2/PGH2 receptor antagonist SQ 30,741 in the same model of coronary occ...

journal_title：Basic research in cardiology

authors： Grover GJ,Parham CS,Schumacher WA

更新日期：1991-03-01 00:00:00

abstract：OBJECTIVE:The clinical usefulness of class III antiarrhythmic drugs for the treatment of tachyarrhythmias is limited by their potential proarrhythmic effects, mainly torsades-depointes (TdP). The goal of this experimental study was to develop an isolated whole-heart model exhibiting typical characteristics of class III...

journal_title：Basic research in cardiology

authors： Johna R,Mertens H,Haverkamp W,Eckardt L,Niederbröker T,Borggrefe M,Breithardt G

更新日期：1998-04-01 00:00:00

abstract：:A survey was made of vagal afferents whose endings originated in cardiopulmonary areas of the Rhesus monkey. Recordings of action potentials from single fiber preparations of the left cervical vagus were made in both open and closed chest monkeys. A total of 425 receptors were identified in sixteen animals. These cons...

journal_title：Basic research in cardiology

authors： Zucker IH,Gilmore JP

更新日期：1977-07-01 00:00:00

abstract：:The antiarrhythmic effect of carbocromene (Intensain) was studied in 17 anaesthetized dogs. Ventricular tachycardia was induced by infusion of K-strophanthin (mean dose: 154 mug/kg i.v.). In 25 out of 26 experiments carbocromene (4 mg/kg i.v.) was effective. Ventricular tachycardia was converted to sinus rhythm in 16 ...

journal_title：Basic research in cardiology

authors： Carp CI,Scholtholt J,Nitz RE

更新日期：1975-07-01 00:00:00

abstract：:Although it has long been recognized that thyroid hormone is an effective positive inotrope, its efficacy in supporting hemodynamics in the acute setting of ischaemia and reperfusion (R) without worsening reperfusion injury remains largely unknown. Thus, we investigated the effects of triiodothyronine (T3) on reperfus...

journal_title：Basic research in cardiology

authors： Pantos C,Mourouzis I,Saranteas T,Clavé G,Ligeret H,Noack-Fraissignes P,Renard PY,Massonneau M,Perimenis P,Spanou D,Kostopanagiotou G,Cokkinos DV

更新日期：2009-01-01 00:00:00