Abstract:
:The antiarrhythmic effect of carbocromene (Intensain) was studied in 17 anaesthetized dogs. Ventricular tachycardia was induced by infusion of K-strophanthin (mean dose: 154 mug/kg i.v.). In 25 out of 26 experiments carbocromene (4 mg/kg i.v.) was effective. Ventricular tachycardia was converted to sinus rhythm in 16 experiments, to atrial tachycardia in 6 experiments and to junctional tachycardia in 3 experiments. The favourable effect started 8 to 50 seconds after the injection with lower doses of carbocromene (3 and 2 mg/kg i.v.) in time intervals of 5 minutes resulted in similar positive effects leading after 2 or 3 injections finally to a second phase of drug effect where ventricular tachycardia was strongly modified for about 30 minutes. The results favour the therapeutic use of this drug in patients with arrhythmia especially with arrhythmias caused by digitalis.
journal_name
Basic Res Cardioljournal_title
Basic research in cardiologyauthors
Carp CI,Scholtholt J,Nitz REdoi
10.1007/BF01914339keywords:
subject
Has Abstractpub_date
1975-07-01 00:00:00pages
434-45issue
4eissn
0300-8428issn
1435-1803journal_volume
70pub_type
杂志文章abstract::A methodological approach based on Frank's pressure-volume (P-V) diagram and model calculations for analyzing the determinants of stroke volume (SV) under conditions of altered ventricular geometrical configuration is discussed with respect to the underlying geometrical models. The approach is generalized in the sense...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF02190551
更新日期:1991-03-01 00:00:00
abstract::The effects of a c-myc antisense phosphorothioate DNA oligonucleotide were assessed on the proliferation rate of human arterial smooth muscle cells (HSMCs). Compared to a control oligonucleotide the antisense oligonucleotide suppressed the proliferation of HSMCs in a concentration-dependent manner without a major cyto...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF00788668
更新日期:1992-11-01 00:00:00
abstract::A study of substrate selection in the isolated heart was made using 13C NMR isotopomer analysis, a method that unequivocally identifies relative substrate utilization. This technique has several advantages over conventional approaches used to study this problem. It detects the labeling of metabolic end-products presen...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF00788500
更新日期:1995-09-01 00:00:00
abstract::In the chronically volume-overloaded canine heart due to AV-block evaluations of cardiac function were performed during the development of hypertrophy and at stable hypertrophy. In an early stage (1 and 2 weeks of AV-block) when no or only a slight increase of cardiac muscle occurred, contractility measured from dP/dt...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF01906357
更新日期:1977-03-01 00:00:00
abstract::Mobilization of triacylglycerol stored in heart cells is accomplished by the combined action of lysosomal (acid) lipase and microsomal monoacylglycerol lipase or carboxylesterase. Non(heparin)-releasable neutral or alkaline lipase is similar to non(readily)-releasable lipoprotein lipase (LPL). The enzyme is mainly loc...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF01908026
更新日期:1984-05-01 00:00:00
abstract::We tested the hypothesis that in isolated cardiac myocytes, the negative functional effects of cyclic GMP would be blunted when the level of cyclic AMP was increased and that this interaction would be altered in renal hypertensive (One-Kidney-One-Clip, 1K1C) cardiac hypertrophic rabbits. Using isolated control and 1K1...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/s003950170075
更新日期:2001-02-01 00:00:00
abstract::An adult rat heart myocyte preparation was used to study the uptake and metabolism of the 1-14C-labelled fatty acids decanoate, laurate, myristate, and palmitate. Metabolism was saturable, but free fatty acid accumulation was not. Use of metabolic inhibitors indicated that metabolism and not uptake was rate limiting a...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:
更新日期:1985-01-01 00:00:00
abstract::Therapeutic angiogenesis improves tissue ischemia by supplementing and supporting the intrinsic process of angiogenesis. Besides direct administration of angiogenic growth factor proteins, injection of naked DNA, non-viral vectors and viral vector constructs carrying angiogenic genes have been used. A novel approach i...
journal_title:Basic research in cardiology
pub_type: 杂志文章,评审
doi:10.1007/s00395-004-0447-x
更新日期:2004-03-01 00:00:00
abstract::Transformation of structural, functional, metabolic and molecular characteristics is induced by stimulating fast-twitch muscles with the frequency pattern of a motoneuron normally innervating a slow-twitch muscle. These changes correspond to a transition of a "fast-white" into a "slow-red" muscle. Intermittent stimula...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF01906369
更新日期:1977-03-01 00:00:00
abstract::8 mm long sections of common carotid arteries of conscious, freely moving rabbits were electrically stimulated with DC-impulses by chronically implanted gold-electrodes daily for 1/2 h or two times 1/2 h per day for 4--6 weeks. The electrodes were arranged in such a way that the wall was stimulated transmurally, In th...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF01907681
更新日期:1979-01-01 00:00:00
abstract::A previous study indicated that 5 mg/kg aspirin can reverse the cardioprotective effects of thromboxane A2 synthetase inhibitors. We determined in the present study if this dose of aspirin can also reverse the protective effects of the thromboxane A2/PGH2 receptor antagonist SQ 30,741 in the same model of coronary occ...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF02190542
更新日期:1991-03-01 00:00:00
abstract::Increased activity of the sympathetic system is an important feature contributing to the pathogenesis and progression of chronic heart failure. While the mechanisms and consequences of enhanced norepinephrine release from sympathetic nerves have been intensely studied, the role of the adrenal gland in the development ...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/s00395-011-0166-z
更新日期:2011-06-01 00:00:00
abstract::In the human heart several isoforms of the sodium pump (Na,K-ATPase, the cardiac glycoside receptor) are expressed (alpha1beta1, alpha2beta1, and alpha3beta1). Their expression is regulated in a highly specific manner, so that there are region specific differences in the expression pattern. The isoform expression patt...
journal_title:Basic research in cardiology
pub_type: 杂志文章,评审
doi:10.1007/s003950200025
更新日期:2002-01-01 00:00:00
abstract::Persistent inflammatory responses participate in the pathogenesis of adverse ventricular remodeling after myocardial infarction (MI). We hypothesized that regulatory T (Treg) cells modulate inflammatory responses, attenuate ventricular remodeling and subsequently improve cardiac function after MI. Acute MI was induced...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/s00395-011-0232-6
更新日期:2012-01-01 00:00:00
abstract::The influence of decapitation, ketamine and thiopental anesthesia on some properties of rat heart mitochondria was compared. Polarographic analysis were performed, oxygen consumption rates, respiratory control index, ADP : O ratio and oxidation of exogenous NADH were determined. Electronmicroscopic and gasometric exam...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF01907952
更新日期:1981-03-01 00:00:00
abstract::Total global ischaemia of the normothermic working rat heart caused an initial positive inotropic response characterized by vigorous contractions. After +/- 15 s this response reached a peak whereafter the isotonic contraction amplitude started to decline. After +/- 3.5 min the heart ceased to beat. The low level of h...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF01906862
更新日期:1987-05-01 00:00:00
abstract::This study was designed to evaluate whether the decreased early survival rate of diabetic rats submitted to acute experimental myocardial infarction can be improved by pretreatment with lidocaine. Male Wistar rats (+/- 210 g) were rendered diabetic with i.v. injection of streptozotocin (50 mg/kg), and only those prese...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF01907132
更新日期:1990-07-01 00:00:00
abstract::The concentration of fibroblast growth factor 23 (FGF23) rises progressively in renal failure (RF). High FGF23 concentrations have been consistently associated with adverse cardiovascular outcomes or death, in chronic kidney disease (CKD), heart failure or liver cirrhosis. We identified the mechanisms whereby high con...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/s00395-020-0810-6
更新日期:2020-07-22 00:00:00
abstract::We compared the effects of linagliptin (Lina, a DPP4 inhibitor) and GLP-1 receptor activation by exenatide followed by exendin-4 in an infusion pump (EX) on infarct size (IS), post-infarction activation of the inflammasome and remodeling in wild-type (WT) and db/db diabetic mice. Mice underwent 30 min ischemia followe...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/s00395-019-0743-0
更新日期:2019-08-06 00:00:00
abstract::The cardiac organ manifestation of arterial hypertension comprises the myocardium itself with left-ventricular hypertrophy, the interstitium with perivascular and interstitial fibrosis, and the coronary circulation with disease of large and small coronary arteries. The consequences of the sum and interactions of these...
journal_title:Basic research in cardiology
pub_type: 杂志文章,评审
doi:10.1007/978-3-662-30769-4_22
更新日期:1991-01-01 00:00:00
abstract::An orifice equation for the non-invasive measurement of mitral-valve area is demonstrated. It is shown that by combining this expression with the assumption of mitral-valve area invariance an orifice equation for the non-invasive assessment of cardiac output in conditions of mitral stenosis using simple echographicall...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF01923191
更新日期:1983-01-01 00:00:00
abstract::Epidemiological studies have repeatedly demonstrated a beneficial effect of moderate alcohol consumption on the incidence of coronary heart disease, myocardial infarction and overall mortality. The latter increases with excessive alcohol consumption. Although most epidemiological studies demonstrate a beneficial effec...
journal_title:Basic research in cardiology
pub_type: 杂志文章,评审
doi:10.1007/s003950170062
更新日期:2001-04-01 00:00:00
abstract::Cardiac alpha- and beta-adrenoceptors and the positive inotropic effects of several adenylate cyclase dependent and independent agents have been measured in papillary muscle strips from patients without, as well as with moderate and severe heart failure. The number of beta-adrenoceptors was found to be decreased depen...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF02650352
更新日期:1989-01-01 00:00:00
abstract::Although it has long been recognized that thyroid hormone is an effective positive inotrope, its efficacy in supporting hemodynamics in the acute setting of ischaemia and reperfusion (R) without worsening reperfusion injury remains largely unknown. Thus, we investigated the effects of triiodothyronine (T3) on reperfus...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/s00395-008-0758-4
更新日期:2009-01-01 00:00:00
abstract::We investigated whether preconditioning could protect several cultured cell lines, to determine whether the protection is specific for cells derived from different myogenic and non-myogenic sources. Ischemia was simulated by centrifugation of cells into a pellet, and cell viability was determined by hypotonic trypan b...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF00788726
更新日期:1996-11-01 00:00:00
abstract::Recent findings on the induction of anti-apoptotic gene expression in ischemic/reperfused hearts encouraged us to investigate whether ischemic/reperfused hearts may be protected against apoptosis induction. To analyze this hypothesis we performed studies on isolated perfused hearts of rat. For apoptosis induction, hea...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/s003950200053
更新日期:2002-11-01 00:00:00
abstract::Using isolated canine small (right coronary branch, left coronary branch; o. d. 0.4-0.8 mm) and large (left coronary, circumflex; o. d. 1-2 mm) coronary arteries, the beta-adrenergic antagonist dl-propranolol (5 X 10(-7) to 5 X 10(-5) m/l) was found to produce concentration-dependent contractions. Interestingly, most ...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF01908132
更新日期:1982-01-01 00:00:00
abstract::We measured the amount of 1,2-diacylglycerol (DAG) and its fatty acid composition in hamster hearts of various ages because 1,2-DAG has been recognized to be one of the intracellular second messengers. The highest level in 1,2-DAG was detected in 30-day-old hamster hearts. The heart weight increased about 2.5 times be...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF01906969
更新日期:1990-03-01 00:00:00
abstract::Short repeated cycles of peripheral ischemia/reperfusion (I/R) can protect distant organs from subsequent prolonged I/R injury; a phenomenon known as remote ischemic preconditioning (RIPC). A RIPC-mediated release of humoral factors might play a key role in this protection and vascular endothelial cells are potential ...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/s00395-015-0474-9
更新日期:2015-03-01 00:00:00
abstract::Age-related changes in the myocardial energy metabolism were studied in spontaneously hypertensive (SHR) rats of 5-15 weeks of age. Systolic blood pressure increased rapidly during 5 to 10 weeks of age (developing phase) and attained a plateau level at 10 to 15 weeks (sustained phase). Even during the developing phase...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF02005337
更新日期:1982-07-01 00:00:00