Inhibition of contractility during the early phase of total ischaemia in the working heart. Recovery during reperfusion.

Abstract:

:Total global ischaemia of the normothermic working rat heart caused an initial positive inotropic response characterized by vigorous contractions. After +/- 15 s this response reached a peak whereafter the isotonic contraction amplitude started to decline. After +/- 3.5 min the heart ceased to beat. The low level of high energy phosphates (HEP), determined 3 min after the onset of ischaemia, indicated that these phases of contractility during ischaemia might play a significant role in depleting HEP. This was substantiated by the observation that inhibition of the contractions during ischaemia by low calcium or high potassium solutions resulted in conservation of myocardial adenosine triphosphate (ATP) and creatine phosphate (CP) stores. It also resulted in the prevention of contracture development during ischaemia and improved mechanical recovery during reperfusion. It was therefore concluded that inhibition of contractility immediately after the onset of total global ischaemia of the normothermic working rat heart is of prime importance in mechanical recovery during reperfusion.

journal_name

Basic Res Cardiol

authors

Steinmann CM,Lochner A,Niesler RA

doi

10.1007/BF01906862

subject

Has Abstract

pub_date

1987-05-01 00:00:00

pages

297-303

issue

3

eissn

0300-8428

issn

1435-1803

journal_volume

82

pub_type

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