Abstract:
:Total global ischaemia of the normothermic working rat heart caused an initial positive inotropic response characterized by vigorous contractions. After +/- 15 s this response reached a peak whereafter the isotonic contraction amplitude started to decline. After +/- 3.5 min the heart ceased to beat. The low level of high energy phosphates (HEP), determined 3 min after the onset of ischaemia, indicated that these phases of contractility during ischaemia might play a significant role in depleting HEP. This was substantiated by the observation that inhibition of the contractions during ischaemia by low calcium or high potassium solutions resulted in conservation of myocardial adenosine triphosphate (ATP) and creatine phosphate (CP) stores. It also resulted in the prevention of contracture development during ischaemia and improved mechanical recovery during reperfusion. It was therefore concluded that inhibition of contractility immediately after the onset of total global ischaemia of the normothermic working rat heart is of prime importance in mechanical recovery during reperfusion.
journal_name
Basic Res Cardioljournal_title
Basic research in cardiologyauthors
Steinmann CM,Lochner A,Niesler RAdoi
10.1007/BF01906862subject
Has Abstractpub_date
1987-05-01 00:00:00pages
297-303issue
3eissn
0300-8428issn
1435-1803journal_volume
82pub_type
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journal_title:Basic research in cardiology
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journal_title:Basic research in cardiology
pub_type: 杂志文章,评审
doi:
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更新日期:2006-07-01 00:00:00
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journal_title:Basic research in cardiology
pub_type: 杂志文章,评审
doi:
更新日期:1991-01-01 00:00:00
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journal_title:Basic research in cardiology
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更新日期:2012-11-01 00:00:00
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journal_title:Basic research in cardiology
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doi:
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pub_type: 杂志文章
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更新日期:2009-09-01 00:00:00
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journal_title:Basic research in cardiology
pub_type: 杂志文章,评审
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更新日期:1993-09-01 00:00:00
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journal_title:Basic research in cardiology
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更新日期:1987-09-01 00:00:00
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journal_title:Basic research in cardiology
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更新日期:1983-09-01 00:00:00
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journal_title:Basic research in cardiology
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journal_title:Basic research in cardiology
pub_type: 杂志文章
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更新日期:1988-05-01 00:00:00
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journal_title:Basic research in cardiology
pub_type: 杂志文章,评审
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更新日期:2017-05-01 00:00:00
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