Abstract：
:Age-related changes in the myocardial energy metabolism were studied in spontaneously hypertensive (SHR) rats of 5-15 weeks of age. Systolic blood pressure increased rapidly during 5 to 10 weeks of age (developing phase) and attained a plateau level at 10 to 15 weeks (sustained phase). Even during the developing phase, the heart was hypertrophic, as assessed by an increase in the ratio of the ventricular weight to body weight. However, myocardial contents of glycolytic intermediates and high energy phosphate compounds and thus, the myocardial energy state (phosphorylation potential) in SHR rats did not differ from those in age-matched normotensive Wistar-Kyoto (WKY) rats. The lactate/pyruvate ratio was significantly lower in SHR rats. On the other hand, during the sustained phase, cardiac hypertrophy progressed only gradually, and myocardial contents of creatine phosphate and ATP were lower, while the lactate content was higher than in WKY rats. The lactate/pyruvate ratio was elevated, while phosphorylation potential was lowered. These findings suggest that the energy state is normal during the developing phase of hypertension despite the presence of cardiac hypertrophy and the increased pressure load, whereas the energy state is at a lower level during the sustained phase of hypertension.
journal_name
Basic Res Cardioljournal_title
Basic research in cardiologyauthors
Shimamoto N,Goto N,Tanabe M,Imamoto T,Fujiwara S,Hirata Mdoi
10.1007/BF02005337subject
Has Abstractpub_date
1982-07-01 00:00:00pages
359-7issue
4eissn
0300-8428issn
1435-1803journal_volume
77pub_type
杂志文章abstract：:Verapamil, at a dose of 1 mg/kg, was given intravenously to anesthetized cats one hour after coronary artery occlusion. Verapamil significantly reduced mean arterial blood pressure, but produced an increase in heart rate, partially offsetting the reduction in myocardial oxygen demand resulting from the reduction in pr...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01907648
更新日期：1979-09-01 00:00:00
abstract：:Hypertension and resulting left ventricular hypertrophy was induced in young male Wistar rats (60 to 70 days old) by narrowing of one renal artery (Goldblatt II). 8 and 24 weeks after operation, myocardial oxygen consumption was measured on a modified in situ heart-lung preparation with nearly isovolumetric left ventr...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01908041
更新日期：1982-05-01 00:00:00
abstract：:The success of therapies targeting myocardial reperfusion injury is limited, while the cardioprotective impact of mitigating ischemia-related damage remains less explored. We have recently shown in a pig model that the intravenous administration of a modified atorvastatin preparation during ischemia attenuates the ris...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/s00395-019-0760-z
更新日期：2019-11-28 00:00:00
abstract：:The influence of decapitation, ketamine and thiopental anesthesia on some properties of rat heart mitochondria was compared. Polarographic analysis were performed, oxygen consumption rates, respiratory control index, ADP : O ratio and oxidation of exogenous NADH were determined. Electronmicroscopic and gasometric exam...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01907952
更新日期：1981-03-01 00:00:00
abstract：:In the control perfused working rat hearts subjected to 25 min global ischemia, reperfusion resulted in a 50% recovery of the hemodynamic functions. A concentration-dependent improvement of this recovery and a reduction of the postischemic lactate dehydrogenase (LDH) release was caused by calmidazolium (CMZ), trifluop...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01906948
更新日期：1989-11-01 00:00:00
abstract：:Mitochondria in largely postmitotic cells (e.g. cardiomyocytes, neurons or skeletal muscle myotubes) have a limited life span of a few weeks. Their replacement during normal turnover requires an intergenomic coordination between the mitochondrial genome (mtDNA, encoding for 13 protein subunits of the respiratory chain...
journal_title：Basic research in cardiology
pub_type： 杂志文章,评审
doi：10.1007/s00395-003-0421-z
更新日期：2003-07-01 00:00:00
abstract：:The aim of this study was to investigate the mechanism of beta-adrenergic preconditioning (BPC). The roles of adenosine and its receptor subtypes, the generation of oxygen free radicals (ROS) and activation of the K(ATP) channels as well as the phosphoinositide-3-kinase (PI(3)K)/PKB/Akt and extracellular signal-regula...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/s00395-012-0281-5
更新日期：2012-09-01 00:00:00
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journal_title：Basic research in cardiology
pub_type： 杂志文章,评审
doi：10.1007/s00395-006-0621-4
更新日期：2006-11-01 00:00:00
abstract：:Patients with insulin resistance and type 2 diabetes have poor cardiac outcomes following myocardial infarction (MI). The mitochondrial uncoupling protein 3 (UCP3) is down-regulated in the heart with insulin resistance. We hypothesized that decreased UCP3 levels contribute to poor cardiac recovery following ischemia/r...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/s00395-018-0707-9
更新日期：2018-10-29 00:00:00
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journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/s00395-015-0494-5
更新日期：2015-01-01 00:00:00
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journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01907227
更新日期：1987-11-01 00:00:00
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journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01907976
更新日期：1989-05-01 00:00:00
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journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01910409
更新日期：1977-09-01 00:00:00
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journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF00794064
更新日期：1997-01-01 00:00:00
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journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/978-3-662-11041-6_12
更新日期：1985-01-01 00:00:00
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journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/s00395-012-0310-4
更新日期：2013-01-01 00:00:00
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journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/s00395-008-0758-4
更新日期：2009-01-01 00:00:00
abstract：:The capillary wall, due to its diffusional resistance, causes concentration differences between the vascular space and the interstitial space for substances which are released or taken up by the heart. Estimation of capillary transfer and interstitial concentration in isolated hearts, however, indicates a variable dif...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：
更新日期：1985-01-01 00:00:00
abstract：:Implicit in attempts to characterize and purify biologically active factors is the premise that the bioassay system employed will show a progressive increase in the response as the concentration of the responsible factor increases. We employed the hamster cheek pouch to assay the neovascularization potential of growth...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01907406
更新日期：1986-05-01 00:00:00
abstract：:A survey was made of vagal afferents whose endings originated in cardiopulmonary areas of the Rhesus monkey. Recordings of action potentials from single fiber preparations of the left cervical vagus were made in both open and closed chest monkeys. A total of 425 receptors were identified in sixteen animals. These cons...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF02023598
更新日期：1977-07-01 00:00:00
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journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/s003950170057
更新日期：2001-05-01 00:00:00
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journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01907365
更新日期：1988-05-01 00:00:00
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journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01910780
更新日期：1976-07-01 00:00:00
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journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/s00395-010-0143-y
更新日期：2011-05-01 00:00:00
abstract：:Dopexamine is a newly developed sympathetic catecholamine which combines dopaminergic (DA-1) and beta 2-adrenergic agonist activity with only minor beta 1-adrenergic action. Thereby, this compound exerts systemic and preferential renal vasodilation, causing afterload reduction, increases in cardiac output, and improve...
journal_title：Basic research in cardiology
pub_type： 杂志文章,评审
doi：10.1007/BF02650357
更新日期：1989-01-01 00:00:00
abstract：:Ventricular and atrial cardiac muscle cells isolated from the adult rat have been cultured and characterized. Once established in culture these myocytes resemble morphologically their in vivo counterparts except that they are flattened on the surface of the culture flask. These cultured cells possess differentiated ul...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：
更新日期：1985-01-01 00:00:00
abstract：:From January 2020, coronavirus disease (COVID-19) originated in China has spread around the world. The disease is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The presence of myocarditis, cardiac arrest, and acute heart failure in COVID-19 patients suggests the existence of a relationshi...
journal_title：Basic research in cardiology
pub_type： 社论
doi：10.1007/s00395-020-0791-5
更新日期：2020-04-09 00:00:00
abstract：:Recent reports indicate that elevating DNA glycosylase/AP lyase repair enzyme activity offers marked cytoprotection in cultured cells and a variety of injury models. In this study, we measured the effect of EndoIII, a fusion protein construct that traffics Endonuclease III, a DNA glycosylase/AP lyase, to the mitochond...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/s00395-014-0459-0
更新日期：2015-03-01 00:00:00
abstract：:To study the signaling mechanisms which mediate ventricular hypertrophy, we utilized the induction of the ANF gene as a marker of the hypertrophic response. The induction of the atrial natriuretic factor gene (ANF) is one of the most conserved features of ventricular hypertrophy, occurring in multiple species (mouse, ...
journal_title：Basic research in cardiology
pub_type： 杂志文章,评审
doi：10.1007/978-3-642-72477-0_5
更新日期：1992-01-01 00:00:00
abstract：:The effects of increased perfusion pressure and epinephrine stimulation on the contractile parameters and glucose transport in the isolated perfused hearts of control and ketotic diabetic rats were studied. An increase in perfusion pressure from 60 mm Hg to 100 mm Hg resulted in increases in coronary flow and peak aor...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01907437
更新日期：1983-05-01 00:00:00
