Barriers in cardiac substrate supply.

abstract：:The effects of the potassium channel openers (KCO), cromakalim or pinacidil, were evaluated in an anesthetized porcine model of pacing- and ischemia-induced ventricular fibrillation (VF). Hearts were paced at 180 bpm and the left anterior descending coronary artery was occluded until VF was induced. Reproducible times...

journal_title：Basic research in cardiology

authors： D'Alonzo AJ,Hess TA,Darbenzio RB,Sewter JC,Conder ML,McCullough JR

更新日期：1994-03-01 00:00:00

abstract：:Diseases accompanied by severe cardiac impairment like sepsis and chronic uremia are frequently linked to an increase in cytokine release. In order to investigate possible toxic effects of the immune mediators on myocardial cells, we studied the contractility of cardiac myocytes and the de novo formation of stress pro...

journal_title：Basic research in cardiology

authors： Löw-Friedrich I,Weisensee D,Mitrou P,Schoeppe W

更新日期：1992-01-01 00:00:00

abstract：:N,N-dimethylsphingosine (DMS) has been documented to be in vitro protective against myocardial ischemia-reperfusion injury (IRI) and can recruit CD4(+)CD25(+)Foxp3(+) regulatory T cells (Tregs), which may participate in the cardioprotection. We hypothesized that when in vivo applied after a myocardial ischemia, DMS ma...

journal_title：Basic research in cardiology

authors： Fang J,Hu F,Ke D,Yan Y,Liao Z,Yuan X,Wu L,Jiang Q,Chen L

更新日期：2016-05-01 00:00:00

abstract：:It has been investigated whether calcium- and verapamil-dependent sensitivities of carotis baroreceptors also exist in man. To answer this question, we pre- and postoperatively measured changes in heart rate during carotid sinus stimulation before and after intravenous administration of 5 mg verapamil in 23 patients w...

journal_title：Basic research in cardiology

authors： Behrmann C,Runge M,Ringe JD

更新日期：1992-09-01 00:00:00

abstract：:A previous study indicated that 5 mg/kg aspirin can reverse the cardioprotective effects of thromboxane A2 synthetase inhibitors. We determined in the present study if this dose of aspirin can also reverse the protective effects of the thromboxane A2/PGH2 receptor antagonist SQ 30,741 in the same model of coronary occ...

journal_title：Basic research in cardiology

authors： Grover GJ,Parham CS,Schumacher WA

更新日期：1991-03-01 00:00:00

abstract：:Enzymes involved in the metabolism nitric oxide (NO) and reactive oxygen species (ROS) may play a role for the decreased availability of NO in atherosclerosis. We, therefore, hypothesized that the pattern of gene expression of these enzymes is altered in atherosclerosis. Myocardial tissue from patients with coronary h...

journal_title：Basic research in cardiology

authors： Chen X,Niroomand F,Liu Z,Zankl A,Katus HA,Jahn L,Tiefenbacher CP

更新日期：2006-07-01 00:00:00

abstract：:Reversibly injured myocardium after short periods of ischemia is characterized by a prolonged depression of contractile function which can, however, be enhanced by inotropic interventions. Thus, a lack of inotropic stimulation due to ischemic damage of cardiac sympathetic nerves has been suggested as a mechanism under...

journal_title：Basic research in cardiology

authors： Schulz R,Frehen D,Heusch G

更新日期：1990-01-01 00:00:00

abstract：:Calcium transport functions of mitochondria and sarcoplasmic reticulum (SR) were studied without prior extraction using isolated rat heart myocytes permeabilized with saponin. Calcium uptake by SR was rapid and its affinity was high in comparison to calcium uptake by mitochondria, which had a higher capacity. The sens...

journal_title：Basic research in cardiology

authors： Kaminishi T,Kako KJ

更新日期：1989-05-01 00:00:00

abstract：:Both the severity and duration of postischemic myocardial dysfunction ("stunned" myocardium) are unpredictable and may vary considerably between subjects that underwent apparently similar ischemic insults. To explain this heterogeneous response of the heart to ischemia and reperfusion, we investigated the determinants...

journal_title：Basic research in cardiology

authors： Wouters PF,Van de Velde M,Van Aken H,Flameng W

更新日期：1996-03-01 00:00:00

abstract：:In the human heart several isoforms of the sodium pump (Na,K-ATPase, the cardiac glycoside receptor) are expressed (alpha1beta1, alpha2beta1, and alpha3beta1). Their expression is regulated in a highly specific manner, so that there are region specific differences in the expression pattern. The isoform expression patt...

journal_title：Basic research in cardiology

authors： Müller-Ehmsen J,McDonough AA,Farley RA,Schwinger RH

更新日期：2002-01-01 00:00:00

abstract：:Transgenic and gene knockout rodent models are primordial to study pathophysiological processes in cardiovascular research. Over time, cardiac MRI has become a gold standard for in vivo evaluation of such models. Technical advances have led to the development of magnets with increasingly high field strength, allowing ...

journal_title：Basic research in cardiology

authors： Vanhoutte L,Gerber BL,Gallez B,Po C,Magat J,Balligand JL,Feron O,Moniotte S

更新日期：2016-07-01 00:00:00

abstract：:Cardiac hypertrophy which occurs during chronic mechanical overload is one of the numerous examples of biological adaptation to environmental requirements. As such, it is obtained at random by trial and error, and adaptation represents the sum of various modifications in gene expression, including the shift in isoform...

journal_title：Basic research in cardiology

authors： Chevalier B,Charlemagne D,Callens-el Amrani F,Carre F,Moalic JM,Delcayre C,Mansier P,Swynghedauw B

更新日期：1992-01-01 00:00:00

abstract：:Since the discovery of a novel mechanism of cell death that differs from traditional necrosis, i.e., apoptosis, there have been numerous studies concluding that increased apoptosis augments myocardial infarction and heart failure and that limiting apoptosis protects the heart. Importantly, the vast majority of cells i...

journal_title：Basic research in cardiology

authors： Jose Corbalan J,Vatner DE,Vatner SF

更新日期：2016-05-01 00:00:00

abstract：:The aim of the present study was to evaluate the expression of hedgehog (Hh) signaling molecules and the chemotactic activity of Sonic hedgehog (Shh) in monocytes from control (CTR) and diabetic patients with or without coronary artery disease (CAD). Previously several studies demonstrated that exogenous administratio...

journal_title：Basic research in cardiology

authors： Dunaeva M,Voo S,van Oosterhoud C,Waltenberger J

更新日期：2010-01-01 00:00:00

abstract：:In recent years research has shown that muscle is capable of reacting to mechanical stimuli by altering biochemical processes. Myocardium is probably the source of a biochemical factor, or factors which activate myocardial protein synthesis. In experimentally induced cardiac hypertrophy adaptive alterations have been ...

journal_title：Basic research in cardiology

authors： Kölbel F,Schreiber V

更新日期：1983-07-01 00:00:00

abstract：:Receptor binding studies usually show heterogenic characteristics of the binding isotherm. Scatchard transformation for graphical linearization of the data presentation affects the data inhomogeneously with respect to the experimental error. Thus a non-linear fitting procedure should be preferred for data analysis. Fu...

journal_title：Basic research in cardiology

authors： Wellstein A,Palm D

更新日期：1984-01-01 00:00:00

abstract：:Isolated rat hearts were perfused by the recirculating Langendorff mode under normoxic conditions for 60 min. The Krebs-Ringer buffer was supplemented with 10 mM glucose + 12 IU/l insulin and either [U-14C]-fructose-1,6-bisphosphate (together with 5 mM cold fructose-1,6-bisphosphate) or [U-14C]-fructose (together with...

journal_title：Basic research in cardiology

authors： Tavazzi B,Starnes JW,Lazzarino G,Di Pierro D,Nuutinen EM,Giardina B

更新日期：1992-05-01 00:00:00

abstract：:To investigate the effect of nifedipine on hypercalcemic electrocardiographical alterations, steadily increasing hypercalcemia was induced in guinea-pigs by continuous calcium gluconate infusion until cardiac arrest occurred. During the experimental time the electrocardiograms were continuously recorded and compared i...

journal_title：Basic research in cardiology

authors： Schäfer W,Schäfer A,Schäfer H

更新日期：1982-01-01 00:00:00

abstract：:Recent attention has focused on the concept that mitochondrial dynamics-that is, the balance between mitochondrial fusion and fission (fragmentation)-may play a pivotal role in determining cell fate in the setting of myocardial ischemia-reperfusion injury. In this regard, there is an emerging consensus that: (1) ische...

journal_title：Basic research in cardiology

authors： Dong Y,Undyala VVR,Przyklenk K

更新日期：2016-09-01 00:00:00

abstract：:An increased occurrence of hypertension has been reported among leg-amputees. In order to investigate whether leg amputation is followed by an elevation of sympathetic tone, possibly enhanced by continuous mechanical irritation of the amputation stump by wearing a prosthesis, blood pressure (BP), pulse-rate (PR) and p...

journal_title：Basic research in cardiology

authors： Grubeck-Loebenstein B,Korn A,Waldhäusl W

更新日期：1981-05-01 00:00:00

abstract：:The clinical use of positive inotropic agents has been associated with increased mortality, with proarrhythmia speculated to be a contributing factor. This study compares the arrhythmogenic potentials of six positive inotropic agents representing different mechanistic classes: the beta-adrenergic agonist dobutamine, t...

journal_title：Basic research in cardiology

authors： Stump GL,Wallace AA,Gilberto DB,Gehret JR,Lynch JJ Jr

更新日期：2000-06-01 00:00:00

abstract：:8 mm long sections of common carotid arteries of conscious, freely moving rabbits were electrically stimulated with DC-impulses by chronically implanted gold-electrodes daily for 1/2 h or two times 1/2 h per day for 4--6 weeks. The electrodes were arranged in such a way that the wall was stimulated transmurally, In th...

journal_title：Basic research in cardiology

authors： Betz E,Schlote W

更新日期：1979-01-01 00:00:00

abstract：:There is a growing need for pharmacological agents to manage cardiovascular disease in the rapidly growing elderly population. Here, we determine if acetaminophen is efficacious in decreasing age-related increases in cardiac reactive oxygen species (ROS) and apoptosis in aging Fischer 344 X Brown Norway rats. Compared...

journal_title：Basic research in cardiology

authors： Kakarla SK,Fannin JC,Keshavarzian S,Katta A,Paturi S,Nalabotu SK,Wu M,Rice KM,Manzoor K,Walker EM Jr,Blough ER

更新日期：2010-07-01 00:00:00

abstract：:Cardiovascular cell therapy offers the first real potential to treat the underlying injuries associated with cardiac and vascular disease. By delivering appropriate exogenous cells to an injury site, the potential exists to mitigate injury or even to begin to reverse damage. Based on their inordinate pre-clinical prom...

journal_title：Basic research in cardiology

authors： Ott HC,McCue J,Taylor DA

更新日期：2005-11-01 00:00:00

abstract：:A method is theoretically described to test the accuracy of various lead system of the ecg. The priniciple of this method consists in the following procedure. The heart position is changed maximally in a proband by varying the position of the body and by deep inspiration and exspiration. If the lead field is parallel,...

journal_title：Basic research in cardiology

authors： Hiltmann WD,Schaefer H

更新日期：1975-01-01 00:00:00

abstract：:In open-chest pigs during severe myocardial ischemia [K+]e, [Ca2+]e and [H+]e increase, [Na+]e increases transiently reaching control values after 30 min. Extracellular osmolality of the ischemic area increases due to an H2O-shift from the ECS to the ICS. The increase of [Na+]e and [Ca2+]e must b explained by the shri...

journal_title：Basic research in cardiology

authors： Friedrich R,Hirche H,Kebbel U,Zylka V,Bissig R

更新日期：1981-07-01 00:00:00

abstract：:It was previously reported that inhibition of carnitine synthesis by 3-(2,2,2-trimethyl-hydrazinium) propionate (MET-88) restores left ventricular (LV) systolic and diastolic function in rats with myocardial infarction (MI). Preservation of the calcium uptake function of sarcoplasmic reticulum Ca2+-ATPase (SERCA2) is ...

journal_title：Basic research in cardiology

authors： Yonekura K,Eto Y,Yokoyama I,Matsumoto A,Sugiura S,Momomura S,Kirimoto T,Hayashi Y,Omata M,Aoyagi T

更新日期：2000-10-01 00:00:00

abstract：:The proximal segments of the left coronary artery are foreshortended in the usual projections. By additional cranio-caudal (half axial) projections the X-ray beam can be directed perpendicular to these segments. In some patients lesions especially of the left main coronary artery or the proximal LAD can be seen or acc...

journal_title：Basic research in cardiology

authors： Rentrop P

更新日期：1976-01-01 00:00:00

abstract：:Because of the close anatomical association between the ventricles, the volume of one ventricle can directly affect the volume and pressure within the other ventricle. To study the mechanical coupling between the ventricles, we modeled the right and left ventricles as a two-compartment model with right wall (Crw), sep...

journal_title：Basic research in cardiology

authors： Santamore WP,Shaffer T,Hughes D

更新日期：1986-09-01 00:00:00

abstract：:Ischemic heart disease is the main cause of death worldwide and is accelerated by increased levels of low-density lipoprotein cholesterol (LDL-C). Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a potent circulating regulator of LDL-C through its ability to induce degradation of the LDL receptor (LDLR) in the...

journal_title：Basic research in cardiology

authors： Glerup S,Schulz R,Laufs U,Schlüter KD

更新日期：2017-05-01 00:00:00