Theory of ligand-receptor interactions--evidence for more than one site.

Abstract:

:Receptor binding studies usually show heterogenic characteristics of the binding isotherm. Scatchard transformation for graphical linearization of the data presentation affects the data inhomogeneously with respect to the experimental error. Thus a non-linear fitting procedure should be preferred for data analysis. Furthermore this approach allows for reliable weighting of the measurements according to the experimental error.

journal_name

Basic Res Cardiol

authors

Wellstein A,Palm D

doi

10.1007/978-3-642-72376-6_2

subject

Has Abstract

pub_date

1984-01-01 00:00:00

pages

9-15

eissn

0300-8428

issn

1435-1803

journal_volume

79 Suppl

pub_type

杂志文章
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    abstract::Recent reports indicate that elevating DNA glycosylase/AP lyase repair enzyme activity offers marked cytoprotection in cultured cells and a variety of injury models. In this study, we measured the effect of EndoIII, a fusion protein construct that traffics Endonuclease III, a DNA glycosylase/AP lyase, to the mitochond...

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    authors: Yang XM,Cui L,White J,Kuck J,Ruchko MV,Wilson GL,Alexeyev M,Gillespie MN,Downey JM,Cohen MV

    更新日期:2015-03-01 00:00:00

  • The maximal rate of pressure rise in the right ventricle of isolated canine hearts in isovolumic and auxotonic systole under various hemodynamic and inotropic conditions.

    abstract::The influence of changes in pre- and afterload, heart frequency and inotropic state on the difference between right ventricular dP/dtmax measured isovolumically and auxotonically has been investigated in canine heart-lung preparations. Isovolumic systoles were obtained by occluding the pulmonary artery during diastole...

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    pub_type: 杂志文章

    doi:10.1007/BF01909767

    authors: Hoppe H,Schmidt HD,Seitz E

    更新日期:1976-09-01 00:00:00

  • Plasma exudation in conscious dogs with experimental heart failure.

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    pub_type: 杂志文章

    doi:10.1007/BF00788284

    authors: Rubinstein I,Müns G,Zucker IH

    更新日期:1994-09-01 00:00:00

  • The mitochondrial permeability transition pore and ischemia-reperfusion injury.

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    pub_type: 杂志文章,评审

    doi:10.1007/s00395-009-0004-8

    authors: Baines CP

    更新日期:2009-03-01 00:00:00

  • Progressive heart failure after myocardial infarction in mice.

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    更新日期:2002-05-01 00:00:00

  • Cardiac function in the chronically volume-overloaded canine heart.

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    pub_type: 杂志文章

    doi:10.1007/BF01906357

    authors: Wüsten B,Flameng W,Schaper W

    更新日期:1977-03-01 00:00:00

  • Saphenous vein aorto-coronary graft atherosclerosis in patients with chronic kidney disease: more plaque calcification and necrosis, but less vasoconstrictor potential.

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    doi:10.1007/s00395-012-0303-3

    authors: Baars T,Kleinbongard P,Böse D,Konorza T,Möhlenkamp S,Hippler J,Erbel R,Heusch G

    更新日期:2012-11-01 00:00:00

  • Parathyroid hormone-related peptide improves contractile responsiveness of adult rat cardiomyocytes with depressed cell function irrespectively of oxidative inhibition.

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    journal_title:Basic research in cardiology

    pub_type: 杂志文章

    doi:10.1007/s00395-005-0532-9

    authors: Lütteke D,Ross G,Abdallah Y,Schäfer C,Piper HM,Schlüter KD

    更新日期:2005-07-01 00:00:00

  • Alanine, glutamate, and ammonia exchanges in acutely ischemic swine myocardium.

    abstract::Coronary artery disease causes an increase in glutamate uptake and alanine output by the heart. We assessed the effects of acute myocardial ischemia on alanine and glutamate exchange and ammonia production in 10 anesthetized open-chest domestic swine (46.9 +/- 0.7 kg). Coronary blood flow was controlled through an ext...

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    pub_type: 杂志文章

    doi:10.1007/BF00801965

    authors: Hacker TA,Hall JL,Stone CK,Stanley WC

    更新日期:1992-03-01 00:00:00

  • Single channel and whole cell sodium currents in heart cells.

    abstract::We studied TTX-sensitive Na channels in dissociated single ventricular cells from neonatal rats using the patch clamp method for single channel and whole cell recording. In both cases, slowly inactivating or window currents were observed that decayed in a biexponential fashion. Customary models of Na current kinetics ...

    journal_title:Basic research in cardiology

    pub_type: 杂志文章

    doi:

    authors: Wilson DL,Lacerda AE,Kunze DL,Brown AM

    更新日期:1985-01-01 00:00:00

  • Estimates of free-radical production in rat and swine hearts: method and application of measuring malondialdehyde levels in fresh and frozen myocardium.

    abstract::Toxic peroxides result when oxygen radicals react with various peroxidic precursors in tissue or blood. A colorimetric method based on reactions of malondialdehyde (MDA), a key intermediate in the formation of peroxides, has been described in fresh tissues. The present report adapts this assay to measure MDA levels in...

    journal_title:Basic research in cardiology

    pub_type: 杂志文章

    doi:10.1007/BF01910480

    authors: Liedtke AJ,Mahar CQ,Ytrehus K,Mjøs OD

    更新日期:1984-09-01 00:00:00

  • Electrophysiological effects of flecainide and sotalol in the human atrium during persistent atrial fibrillation.

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    journal_title:Basic research in cardiology

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00395-005-0513-4

    authors: Kirchhof P,Engelen M,Franz MR,Ribbing M,Wasmer K,Breithardt G,Haverkamp W,Eckardt L

    更新日期:2005-03-01 00:00:00

  • Mitochondrial damage during myocardial ischemia.

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    pub_type: 杂志文章

    doi:10.1007/BF01908307

    authors: Regitz V,Paulson DJ,Hodach RJ,Little SE,Schaper W,Shug AL

    更新日期:1984-03-01 00:00:00

  • Experimental hyperthyroidism IV. Myocardial muscle mechanics and oxygen consumption in euand hyperthyroidism.

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    journal_title:Basic research in cardiology

    pub_type: 杂志文章

    doi:10.1007/BF01905508

    authors: Strauer BE,Scherpe A

    更新日期:1975-05-01 00:00:00

  • Exogenous fructose-1,6-bisphosphate is a metabolizable substrate for the isolated normoxic rat heart.

    abstract::Isolated rat hearts were perfused by the recirculating Langendorff mode under normoxic conditions for 60 min. The Krebs-Ringer buffer was supplemented with 10 mM glucose + 12 IU/l insulin and either [U-14C]-fructose-1,6-bisphosphate (together with 5 mM cold fructose-1,6-bisphosphate) or [U-14C]-fructose (together with...

    journal_title:Basic research in cardiology

    pub_type: 杂志文章

    doi:10.1007/BF00804337

    authors: Tavazzi B,Starnes JW,Lazzarino G,Di Pierro D,Nuutinen EM,Giardina B

    更新日期:1992-05-01 00:00:00

  • Ginkgo biloba extract EGb 761 attenuates myocardial stunning in the pig heart.

    abstract::Myocardial stunning, a transient contractile dysfunction that appears following a brief period of ischemia, is at least partly due to the production of oxygen-derived free radicals. The objective of the present study was to determine whether the Ginkgo biloba extract EGb761, which has antioxidant properties in vitro, ...

    journal_title:Basic research in cardiology

    pub_type: 杂志文章

    doi:10.1007/s00395-003-0380-4

    authors: Rioufol G,Pietri S,Culcasi M,Loufoua J,Staat P,Pop C,Drieu K,Ovize M

    更新日期:2003-02-01 00:00:00

  • Longer term effects of ouabain on the contractility of rat isolated cardiomyocytes and on the expression of Ca and Na regulating proteins.

    abstract::Cardiac glycosides like ouabain are used in the therapy of heart failure and atrial fibrillation. They exert a positive inotropic effect on cardiomyocytes by inhibiting the plasma membrane sodium pump (Na,K-ATPase), decreasing the Ca-extrusion by the sarcolemmal cardiac sodium/calcium exchanger (NCX) and increasing th...

    journal_title:Basic research in cardiology

    pub_type: 杂志文章

    doi:10.1007/s00395-003-0396-9

    authors: Müller-Ehmsen J,Nickel J,Zobel C,Hirsch I,Bölck B,Brixius K,Schwinger RH

    更新日期:2003-03-01 00:00:00

  • Alterations of pulmonary vascular resistance and pulmonary cyclic nucleotide metabolism in the hypoxic pig.

    abstract::Hypoxia leads to an elevation of the pulmonary vascular resistance (pvR) in pigs. This alteration of the hemodynamic was accompanied by a slight increase of intraparenchymatous concentrations of cyclic GMP (cGMP), while cycle AMP (cAMP) levels were not different from values, measured during normoxia. beta-adrenergic a...

    journal_title:Basic research in cardiology

    pub_type: 杂志文章

    doi:10.1007/BF01910408

    authors: Kaukel E,Beier W,Lanser K,Sill V

    更新日期:1977-09-01 00:00:00

  • Reduced cAMP levels and glycogen phosphorylase activation in isoproterenol perfused SHR myocardium.

    abstract::The effect of isoproterenol perfusion on cAMP levels and phosphorylase activity was investigated in the spontaneously hypertensive rat (SHR) and Kyoto Wistar normotensive control rat (WKY) heart. The basal force of contraction in physiological salt solution perfused hearts was comparable between SHR and WKY. However, ...

    journal_title:Basic research in cardiology

    pub_type: 杂志文章

    doi:10.1007/BF01907217

    authors: Sharma RV,Gupta RC,Ramanadham M,Venema RC,Bhalla RC

    更新日期:1983-11-01 00:00:00

  • The role of adrenergic mechanisms in the blood pressure regulation of leg-amputees.

    abstract::An increased occurrence of hypertension has been reported among leg-amputees. In order to investigate whether leg amputation is followed by an elevation of sympathetic tone, possibly enhanced by continuous mechanical irritation of the amputation stump by wearing a prosthesis, blood pressure (BP), pulse-rate (PR) and p...

    journal_title:Basic research in cardiology

    pub_type: 杂志文章

    doi:10.1007/BF01907771

    authors: Grubeck-Loebenstein B,Korn A,Waldhäusl W

    更新日期:1981-05-01 00:00:00

  • Cell-based cardiovascular repair--the hurdles and the opportunities.

    abstract::Cardiovascular cell therapy offers the first real potential to treat the underlying injuries associated with cardiac and vascular disease. By delivering appropriate exogenous cells to an injury site, the potential exists to mitigate injury or even to begin to reverse damage. Based on their inordinate pre-clinical prom...

    journal_title:Basic research in cardiology

    pub_type: 杂志文章,评审

    doi:10.1007/s00395-004-0558-z

    authors: Ott HC,McCue J,Taylor DA

    更新日期:2005-11-01 00:00:00

  • Alcohol-induced congestive cardiomyopathy in adult turkeys: effects on myocardial antioxidant defence systems.

    abstract::The effects of chronic intake of dietary alcohol upon left ventricular function, activities of myocardial antioxidant enzymes, reduced glutathione (GSH) content and lipoperoxidation (measured as the formation of diene conjugates and lipid-soluble fluorescence) were studied in adult domestic Nicholas turkeys. The non-i...

    journal_title:Basic research in cardiology

    pub_type: 杂志文章

    doi:10.1007/BF01907225

    authors: Edes I,Piros G,Forster T,Csanady M

    更新日期:1987-11-01 00:00:00

  • Hemodynamic changes and renal plasma flow in early heart failure: implications for renin, aldosterone, norepinephrine, atrial natriuretic peptide and prostacyclin.

    abstract::Vasoconstrictory and vasodilatory hormone systems may be important in the regulation of peripheral vascular resistance and renal hemodynamics in the early phase of heart failure. The activity of the renin-angiotensin-aldosterone system (RAAS), the sympathetic nervous activity, and, as possible counterregulating system...

    journal_title:Basic research in cardiology

    pub_type: 杂志文章

    doi:10.1007/BF01907058

    authors: Holmer SR,Riegger AJ,Notheis WF,Kromer EP,Kochsiek K

    更新日期:1987-03-01 00:00:00

  • The platelet-perfused in-vitro heart: an alternative model for studying the role of endogenous prostacyclin and thromboxane in control of coronary perfusion.

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    journal_title:Basic research in cardiology

    pub_type: 杂志文章

    doi:10.1007/BF01908344

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    更新日期:1981-09-01 00:00:00

  • The effect of isolation on myocardial properties.

    abstract::Denervation deprives the heart of its normal adrenergic and cholinergic control via the sympathetic and parasympathetic pathways. In a heart which is blood supplied by a donor animal of the same species, normal contractility is maintained, probably by blood borne catecholamines or possibly by unknown inotropic agents ...

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    pub_type: 杂志文章

    doi:10.1007/BF01907778

    authors: Reichel H

    更新日期:1976-01-01 00:00:00

  • HMG-CoA reductase inhibition reduces the proinflammatory activation of human vascular smooth muscle cells by the terminal complement factor C5b-9.

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    doi:10.1007/BF00795054

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  • Uptake of fatty acids by isolated heart myocytes.

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    doi:

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    更新日期:1985-01-01 00:00:00

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    pub_type: 杂志文章

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