Abstract:
:In open-chest pigs during severe myocardial ischemia [K+]e, [Ca2+]e and [H+]e increase, [Na+]e increases transiently reaching control values after 30 min. Extracellular osmolality of the ischemic area increases due to an H2O-shift from the ECS to the ICS. The increase of [Na+]e and [Ca2+]e must b explained by the shrinkage of the ECS due to the H2O-shift. The increase of [Ca2+]e is additionally caused by the decrease of pHe. The increase of [K+]e is mainly caused by the release of K+ from the ICS. The changes of [K+]e and [K+]i cause a decrease of the membrane potential to a range in which slow response potentials and re-entry excitations can occur. The increase of [K+]e therefore seems to be a major factor to cause early post-ischemic arrhythmias.
journal_name
Basic Res Cardioljournal_title
Basic research in cardiologyauthors
Friedrich R,Hirche H,Kebbel U,Zylka V,Bissig Rdoi
10.1007/BF01908341subject
Has Abstractpub_date
1981-07-01 00:00:00pages
453-6issue
4eissn
0300-8428issn
1435-1803journal_volume
76pub_type
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