Abstract：
:Transgenic and gene knockout rodent models are primordial to study pathophysiological processes in cardiovascular research. Over time, cardiac MRI has become a gold standard for in vivo evaluation of such models. Technical advances have led to the development of magnets with increasingly high field strength, allowing specific investigation of cardiac anatomy, global and regional function, viability, perfusion or vascular parameters. The aim of this report is to provide a review of the various sequences and techniques available to image mice on 7-11.7 T magnets and relevant to the clinical setting in humans. Specific technical aspects due to the rise of the magnetic field are also discussed.
journal_name
Basic Res Cardioljournal_title
Basic research in cardiologyauthors
Vanhoutte L,Gerber BL,Gallez B,Po C,Magat J,Balligand JL,Feron O,Moniotte Sdoi
10.1007/s00395-016-0565-2subject
Has Abstractpub_date
2016-07-01 00:00:00pages
46issue
4eissn
0300-8428issn
1435-1803pii
10.1007/s00395-016-0565-2journal_volume
111pub_type
杂志文章,评审abstract：:1. Studies on three models of cardiac hypertrophy (aortic constriction, application of isoproterenol, daily administrations of 3,3'5-triiodo-L-thyronine, respectively) reveal that the enhancement of de novo synthesis of adenine nucleotides occurs very early during the development of cardiac hypertorphy and always prec...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01906368
更新日期：1977-03-01 00:00:00
abstract：:We have compared in open-chest dogs the evolution of adenine nucleotides and creatine phosphate to that of regional mechanical function during ischemia and reperfusion. Reperfusion restored normal value of creatine phosphate whereas adenine nucleotide level remained depressed. The percentage of systolic shortening, wh...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01908316
更新日期：1982-11-01 00:00:00
abstract：:For the quantitative evaluation of myocardial damage induced by isoprenaline (ISO) a method based on the uptake of 203Hg-labelled Mercurascan (MSC) in the heart was used. The increase of myocardial uptake of MSC in ISO-treated rats over control values was very rapid and might be directly proportional to the number of ...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01910409
更新日期：1977-09-01 00:00:00
abstract：:A simplified single-plane angiocardiographic method for the measurement of the left ventricular volumes in the reindeer heart has been developed, on the assumption that the left ventricle forms half a revolution ellipsoid. On the basis of a study of 30 ventricular casts the following formulae were constructed for the ...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF02023597
更新日期：1977-07-01 00:00:00
abstract：:The PKC hypothesis and its variants are attractive but unproved. The chief difficulty is the lack of an objective means to assess whether or not PKC has been activated in hearts preconditioned in vivo with ischemia or in hearts preconditioned by pharmacologic means. The strongest evidence is supporting the PKC hypothe...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF00797206
更新日期：1997-01-01 00:00:00
abstract：:Ca2+ overload followed by after-contractions was induced by perfusion of mammalian papillary muscles with O-K0+, high Ca2+ solution. The effect of lipotrophic agents (dexamethasone, indomethacin) or free radical scavengers (alpha-tocopherol, reduced glutathione, synthetic antioxidant) was tested at different stages of...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01908177
更新日期：1985-07-01 00:00:00
abstract：:During long-term treatment with amiodarone, slowing of conduction through the atrioventricular node, a prolongation of the QT-interval, and a prolongation of the atrial and ventricular myocardial refractoriness always developed. During short-term treatment, these effects were not found, except for depression of the AV...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF02190546
更新日期：1991-03-01 00:00:00
abstract：:Epidemiological studies have repeatedly demonstrated a beneficial effect of moderate alcohol consumption on the incidence of coronary heart disease, myocardial infarction and overall mortality. The latter increases with excessive alcohol consumption. Although most epidemiological studies demonstrate a beneficial effec...
journal_title：Basic research in cardiology
pub_type： 杂志文章,评审
doi：10.1007/s003950170062
更新日期：2001-04-01 00:00:00
abstract：:It is commonly thought that the optimal method for intracoronary administration of cells is to stop coronary flow during cell infusion, in order to prolong cell/vascular wall contact, enhance adhesion, and promote extravasation of cells into the interstitial space. However, occlusion of a coronary artery with a balloo...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/s00395-015-0503-8
更新日期：2015-09-01 00:00:00
abstract：:This study was designed to identify mechanisms responsible for coronary vasodilation in response to progressive decreases in hematocrit. Isovolemic hemodilution was produced in open-chest, anesthetized swine via concurrent removal of 500 ml of arterial blood and the addition of 500 ml of 37 °C saline or synthetic plas...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/s00395-017-0654-x
更新日期：2017-09-30 00:00:00
abstract：:For 219 children between 3 and 15 years with the most frequent congenital and acquired heart failures it was investigated in what way the STI differ consistently from the corresponding standard values. It was found that all the STI of children with cardiovascular diseases can vary from the normal values scaled by hear...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01906520
更新日期：1978-07-01 00:00:00
abstract：:Nitroglycerin (GTN) and other organic nitrates are widely used vasodilators. Their side effects are development of nitrate tolerance and endothelial dysfunction. Given the potential of GTN to induce nitro-oxidative stress, we investigated the interaction between nitro-oxidative DNA damage and vascular dysfunction in e...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/s00395-016-0571-4
更新日期：2016-07-01 00:00:00
abstract：:Transformation of structural, functional, metabolic and molecular characteristics is induced by stimulating fast-twitch muscles with the frequency pattern of a motoneuron normally innervating a slow-twitch muscle. These changes correspond to a transition of a "fast-white" into a "slow-red" muscle. Intermittent stimula...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01906369
更新日期：1977-03-01 00:00:00
abstract：:The purpose of this study was to determine the effect of acute and chronic propranolol on heart size and regional O2 supply/consumption variables in thyroxine (T4)-treated rabbit hearts. New Zealand white rabbits were given 0.5 mg/kg T4 for 3 or 16 days with and without concomitant 2 mg/kg propranolol. Another group w...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01907360
更新日期：1988-05-01 00:00:00
abstract：:Conflicting data on the inotropic effect of insulin are present in the literature suggesting a positive inotropic property or no inotropic effect or even a negative influence. To clarify the reason for these diverging findings, dose-response curves of insulin have been performed in isolated working rat and guinea pig ...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/s00395-002-0350-2
更新日期：2002-07-01 00:00:00
abstract：:Receptor for advanced glycation end products (RAGE) is associated with inflammation and the progression of cardiovascular diseases. The current study tested the hypothesis that RAGE is involved in the pathogenesis of aortic valve (AV) calcification. Pioglitazone attenuated AV calcification in experimental hypercholest...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/s00395-012-0306-0
更新日期：2012-11-01 00:00:00
abstract：:Urapidil (URA) is used to treat acute hypertension in patients with coronary artery disease, but the effect of URA on the performance of ischemic myocardium has not yet been investigated. The present study was intended to assess the function of ischemic myocardium following URA administration. In eight anesthetized (p...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01907115
更新日期：1990-05-01 00:00:00
abstract：:A rapid change in length of cat papillary muscle induces two reciprocal diastolic and systolic processes: stretching causes a viscoelastic relaxation of the muscle. The opposite behavior is observed after abrupt releases when - subsequent to an increase in resting tension - diastolic force attains its new equilibrium....
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01910780
更新日期：1976-07-01 00:00:00
abstract：:We investigated whether atrial natriuretic peptide (ANP) given just prior to reperfusion reduces infarction in rabbit hearts and whether protection is related to activation of protein kinase G (PKG). Isolated rabbit hearts were subjected to a 30-min period of regional ischemia; treated hearts received a 20-min infusio...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/s00395-006-0587-2
更新日期：2006-07-01 00:00:00
abstract：:We investigated the force-frequency relationship (0.5-3 Hz) in non-failing human myocardium and in end-stage failing human myocardium due to dilated cardiomyopathy or subacute myocarditis. In non-failing myocardium, force of contraction increased with increasing stimulation frequency. In end-stage heart failure, the f...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/978-3-642-72474-9_17
更新日期：1992-01-01 00:00:00
abstract：:Patients with insulin resistance and type 2 diabetes have poor cardiac outcomes following myocardial infarction (MI). The mitochondrial uncoupling protein 3 (UCP3) is down-regulated in the heart with insulin resistance. We hypothesized that decreased UCP3 levels contribute to poor cardiac recovery following ischemia/r...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/s00395-018-0707-9
更新日期：2018-10-29 00:00:00
abstract：:Reversibly injured myocardium after short periods of ischemia is characterized by a prolonged depression of contractile function which can, however, be enhanced by inotropic interventions. Thus, a lack of inotropic stimulation due to ischemic damage of cardiac sympathetic nerves has been suggested as a mechanism under...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/978-3-662-11038-6_22
更新日期：1990-01-01 00:00:00
abstract：:Cardiac disease is associated with deleterious emission of mitochondrial reactive oxygen species (mito-ROS), as well as enhanced oxidation and activity of the sarcoplasmic reticulum (SR) Ca2+ release channel, the ryanodine receptor (RyR2). The transfer of Ca2+ from the SR via RyR2 to mitochondria is thought to play a ...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/s00395-020-0797-z
更新日期：2020-05-22 00:00:00
abstract：:Transient receptor potential melastatin-7 (TRPM7) channels have been recently reported in human atrial fibroblasts and are believed to mediate fibrogenesis in human atrial fibrillation. The present study investigates whether TRPM7 channels are expressed in human atrial myocytes using whole-cell patch voltage-clamp, RT...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/s00395-012-0282-4
更新日期：2012-09-01 00:00:00
abstract：:Diseases accompanied by severe cardiac impairment like sepsis and chronic uremia are frequently linked to an increase in cytokine release. In order to investigate possible toxic effects of the immune mediators on myocardial cells, we studied the contractility of cardiac myocytes and the de novo formation of stress pro...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF00795385
更新日期：1992-01-01 00:00:00
abstract：:Necrosis is a type of cell death characterized by a gain in cell volume, swelling of organelles, rupture of the plasma membrane and subsequent loss of intracellular contents. For a long time, the process has been considered as a merely accidental and uncontrolled form of cell death, but accumulating evidence suggests ...
journal_title：Basic research in cardiology
pub_type： 杂志文章,评审
doi：10.1007/s00395-011-0192-x
更新日期：2011-09-01 00:00:00
abstract：:Sarcoplasmic reticulum (SR) from left ventricles of rats that developed spontaneous hypertension was studied in vitro. Similar increases of left ventricular mass were found when grouping the animals into mild and severe hypertensives (average systolic arterial pressure of 168 +/- 4 and 202 +/- 6 mmHg, respectively). T...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01907362
更新日期：1988-05-01 00:00:00
abstract：:Previous studies indicated that the increase in protein kinase C (PKC)-mediated myofilament protein phosphorylation observed in failing myocardium might be detrimental for contractile function. This study was designed to reveal and compare the effects of PKCalpha- and PKCepsilon-mediated phosphorylation on myofilament...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/s00395-009-0053-z
更新日期：2010-03-01 00:00:00
abstract：:We have used x-ray microangiography to investigate the influence of EDRF and endothelin-1 on arterial diameters (70-800 microns) at bifurcations in the isolated rabbit ear and the "optimality" of its branching geometry. The median value of the junction exponent x (which is given by d0x = d1x + d2x, where d0, d1 and d2...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/978-3-642-72461-9_10
更新日期：1991-01-01 00:00:00
abstract：:Adult epicardial cells are required for endogenous cardiac repair. After myocardial injury, they are reactivated, undergo epithelial-to-mesenchymal transformation (EMT) and migrate into the injured myocardium where they generate various cell types, including coronary smooth muscle cells and cardiac interstitial fibrob...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/s00395-011-0181-0
更新日期：2011-09-01 00:00:00
