Abstract：
:Urapidil (URA) is used to treat acute hypertension in patients with coronary artery disease, but the effect of URA on the performance of ischemic myocardium has not yet been investigated. The present study was intended to assess the function of ischemic myocardium following URA administration. In eight anesthetized (piritramide) open-chest dogs systolic contraction (dL) and end-diastolic length (edL) of myocardium supplied by the left descending (LAD) and circumflex (LCA) coronary arteries were measured by sonomicrometry simultaneously with aortic pressure (AoP), left ventricular end-diastolic pressure (LVedP), heart rate (HR), stroke volume (SV), and LAD-flow (QLAD). QLAD was reduced by LAD stenosis to about 50% of control, decreasing dLLAD by 55%. Concomitantly, edLLAD increased by about 9% and LVedP by 22%, whereas AoP decreased by 5%. Then, URA was given i.v. (0.25 + 0.25 + 0.50 + 1.0 mg/kg) in 15-min intervals. Following URA, the performance of the non-ischemic area was not systematically affected, but dLLAD increased by about 50%. This could neither be related to the significant reduction in afterload (AoP: -8%), nor to an increase in preload (LVedP and edLLAD did not change significantly), nor to an improved oxygen supply via the LAD (QLAD even decreased), although an increased collateral flow the LCA could not be excluded. The increase in systolic shortening correlated very closely to a decrease in heart rate (r = -0.92). It is concluded that the improved function of ischemic myocardium following urapidil resulted from a reduced oxygen demand in consequence to the decrease in heart rate.
journal_name
Basic Res Cardioljournal_title
Basic research in cardiologyauthors
Schad H,Heimisch W,Barankay A,Hesse S,Mendler Ndoi
10.1007/BF01907115subject
Has Abstractpub_date
1990-05-01 00:00:00pages
270-8issue
3eissn
0300-8428issn
1435-1803journal_volume
85pub_type
杂志文章abstract：:Long QT syndrome is a potentially life-threatening disease characterized by delayed repolarization of cardiomyocytes, QT interval prolongation in the electrocardiogram, and a high risk for sudden cardiac death caused by ventricular arrhythmia. The genetic type 3 of this syndrome (LQT3) is caused by gain-of-function mu...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/s00395-016-0530-0
更新日期：2016-03-01 00:00:00
abstract：:It was previously reported that inhibition of carnitine synthesis by 3-(2,2,2-trimethyl-hydrazinium) propionate (MET-88) restores left ventricular (LV) systolic and diastolic function in rats with myocardial infarction (MI). Preservation of the calcium uptake function of sarcoplasmic reticulum Ca2+-ATPase (SERCA2) is ...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/s003950070032
更新日期：2000-10-01 00:00:00
abstract：:In the isometrically contracting rat trabecular muscle strip preparation, contracture tension was induced either by 10 min of hypoxia (low contracture tension) or by 30 min of joint oxygen and glucose withdrawal (severe contracture tension) at optimum length. Using stepwise 0.1 mm releases, length-tension relationship...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01908059
更新日期：1981-11-01 00:00:00
abstract：:The effects of the potassium channel openers (KCO), cromakalim or pinacidil, were evaluated in an anesthetized porcine model of pacing- and ischemia-induced ventricular fibrillation (VF). Hearts were paced at 180 bpm and the left anterior descending coronary artery was occluded until VF was induced. Reproducible times...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF00788735
更新日期：1994-03-01 00:00:00
abstract：:A methodological approach based on Frank's pressure-volume (P-V) diagram and model calculations for analyzing the determinants of stroke volume (SV) under conditions of altered ventricular geometrical configuration is discussed with respect to the underlying geometrical models. The approach is generalized in the sense...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF02190551
更新日期：1991-03-01 00:00:00
abstract：:The authors have retracted this article [1] because of modifications in the control lanes of Figs. 2a and 8a of the COX1 blot obtained for 18-week-old rats (rotation, horizontal flipping and re-use of the control lanes for the 35-week-old rats blot). In light of the concerns raised, the conclusions drawn in this artic...
journal_title：Basic research in cardiology
pub_type： 杂志文章,撤回出版物
doi：10.1007/s00395-018-0680-3
更新日期：2018-04-18 00:00:00
abstract：:The article describes a method for monitoring the total energy output and oxygen uptake of isolated perfused rat hearts with working left ventricles. Twenty-two unpaced hearts (rates 4-4.5 bs-1) were separately investigated inside a flow micro-calorimeter (one minute for 90% thermal response) at 37 degrees C. They pum...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01907920
更新日期：1985-09-01 00:00:00
abstract：:We studied TTX-sensitive Na channels in dissociated single ventricular cells from neonatal rats using the patch clamp method for single channel and whole cell recording. In both cases, slowly inactivating or window currents were observed that decayed in a biexponential fashion. Customary models of Na current kinetics ...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：
更新日期：1985-01-01 00:00:00
abstract：:Atherosclerotic plaque rupture is the key event in the pathogenesis of acute coronary syndromes and it also occurs during coronary interventions. Atherosclerotic plaque rupture does not always result in complete thrombotic occlusion of the epicardial coronary artery with subsequent impending myocardial infarction, but...
journal_title：Basic research in cardiology
pub_type： 杂志文章,评审
doi：10.1007/s00395-006-0616-1
更新日期：2006-09-01 00:00:00
abstract：:Myocardial mechanics and oxygen consumption were studied in right ventricular papillary muscles taken from cats pretreated with cristalline L-thyroxine (1 mg/kg/day, i.p.) 8-18 days prior to the examination. Isotonic afterloaded and isometric contractions were employed. Oxygen consumption was determined polarographica...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01905508
更新日期：1975-05-01 00:00:00
abstract：:Mitochondria in largely postmitotic cells (e.g. cardiomyocytes, neurons or skeletal muscle myotubes) have a limited life span of a few weeks. Their replacement during normal turnover requires an intergenomic coordination between the mitochondrial genome (mtDNA, encoding for 13 protein subunits of the respiratory chain...
journal_title：Basic research in cardiology
pub_type： 杂志文章,评审
doi：10.1007/s00395-003-0421-z
更新日期：2003-07-01 00:00:00
abstract：:A simplified single-plane angiocardiographic method for the measurement of the left ventricular volumes in the reindeer heart has been developed, on the assumption that the left ventricle forms half a revolution ellipsoid. On the basis of a study of 30 ventricular casts the following formulae were constructed for the ...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF02023597
更新日期：1977-07-01 00:00:00
abstract：:The cardiac renin angiotensin system (RAS) is the target for number of therapeutic interventions which proved successful in heart failure. Angiotensin converting enzyme (ACE) inhibitors belong to the most efficient strategies available and angiotensin receptor (ATR) antagonists may be comparably effective. The direct ...
journal_title：Basic research in cardiology
pub_type： 杂志文章,评审
doi：10.1007/s003950050207
更新日期：1998-01-01 00:00:00
abstract：:This paper reviews the recent data concerning the force-frequency relations in experimental animals with heart failure. After a brief overview of the nature of these relations, which are induced by 2 opposite phenomena, the potentiation of force of contraction by heart rate and the restitution process, the paper revie...
journal_title：Basic research in cardiology
pub_type： 杂志文章,评审
doi：10.1007/s003950050212
更新日期：1998-01-01 00:00:00
abstract：:This study was designed to evaluate whether the decreased early survival rate of diabetic rats submitted to acute experimental myocardial infarction can be improved by pretreatment with lidocaine. Male Wistar rats (+/- 210 g) were rendered diabetic with i.v. injection of streptozotocin (50 mg/kg), and only those prese...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01907132
更新日期：1990-07-01 00:00:00
abstract：:Mitochondrial dysfunction is an underlying cause of ischemia-reperfusion injury. In particular, ischemic injury induces dramatic increases in mitochondrial permeability, thereby instigating a chain of events that leads to both apoptotic and necrotic cardiomyocyte death. The mitochondrial permeability transition (MPT) ...
journal_title：Basic research in cardiology
pub_type： 杂志文章,评审
doi：10.1007/s00395-009-0004-8
更新日期：2009-03-01 00:00:00
abstract：:Ischaemic preconditioning is one of the most potent experimental modalities known to decrease infarct size after ischaemia and reperfusion. Much interest has been stimulated by the phenomenon of remote ischaemic conditioning (RIC), in which the preconditioning stimulus is applied to a limb remote from the heart to sti...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/s00395-013-0377-6
更新日期：2013-09-01 00:00:00
abstract：:Pentostatin (2-deoxycoformycin) is a potent inhibitor of adenosine deaminase and has been demonstrated to augment endogenous adenosine levels during regional and global myocardial ischemia. Based on the rationale that increasing endogenous adenosine during ischemia may be cardioprotective, the objective of this study ...
journal_title：Basic research in cardiology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF00789447
更新日期：1995-03-01 00:00:00
abstract：:Sprouty1 (Spry1) is a negative modulator of receptor tyrosine kinase signaling, but its role in cardiomyocyte survival has not been elucidated. The aim of this study was to investigate the potential role of cardiomyocyte Spry1 in cardiac ischemia-reperfusion (I/R) injury. Infarct areas of mouse hearts showed an increa...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/s00395-018-0713-y
更新日期：2019-01-11 00:00:00
abstract：:Phospholamban is a regulatory phosphoprotein which modulates the active transport of Ca2+ by the cardiac sarcoplasmic reticular Ca(2+)-ATPase enzyme (SERCA2) into the lumen of the sarcoplasmic reticulum. Phospholamban, which is a reversible inhibitor of SERCA2, represses the enzyme's activity, and this inhibition is r...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF00794064
更新日期：1997-01-01 00:00:00
abstract：AIMS:Atrial fibrillation (AF) shortens the atrial action potential and the atrial refractory period. These changes promote persistence of AF. Pharmacological prolongation of atrial action potential duration (APD) may therefore help to prevent recurrent AF. In addition to prolonging APD, sodium channel blockers may prev...
journal_title：Basic research in cardiology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00395-005-0513-4
更新日期：2005-03-01 00:00:00
abstract：:There is no doubt that major advances have been made in cardiac electrophysiology using single heart cells. Accurate analysis of rapid inward sodium current and the second inward current carried by calcium has resulted in a major re-examination of the steps involved in excitation-contraction coupling in the heart. Fut...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/978-3-662-11041-6_17
更新日期：1985-01-01 00:00:00
abstract：:The clinical use of positive inotropic agents has been associated with increased mortality, with proarrhythmia speculated to be a contributing factor. This study compares the arrhythmogenic potentials of six positive inotropic agents representing different mechanistic classes: the beta-adrenergic agonist dobutamine, t...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/s003950050181
更新日期：2000-06-01 00:00:00
abstract：:Cardioprotection aims at infarct size reduction and improvement of clinical outcome from myocardial infarction. The translation of cardioprotection from preclinical and promising proof-of-concept studies to clinical benefit for patients has been largely disappointing. Almost all of these studies which did not translat...
journal_title：Basic research in cardiology
pub_type： 杂志文章,评审
doi：10.1007/s00395-019-0756-8
更新日期：2019-10-15 00:00:00
abstract：:Delta-opioid receptors are known to participate in the protection found following ischemic preconditioning (IPC), but the role of kappa-receptors in IPC is currently controversial. Langendorff-perfused rat hearts received 35 min regional ischemia and 2 h reperfusion. PC (2 cycles 5 min global ischemia) substantially r...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/s003950050001
更新日期：2000-02-01 00:00:00
abstract：:The quantitative predominance of free and total cholesterol over the amount of mural calcium is a most significant criterion of healthy human coronary arteries during the whole life span (0-90 years). However, this normal ratio increasingly changes as soon as arteriosclerotic alterations of the coronary walls set in. ...
journal_title：Basic research in cardiology
pub_type： 杂志文章,评审
doi：10.1007/978-3-642-85660-0_15
更新日期：1994-01-01 00:00:00
abstract：:Cardiac alpha- and beta-adrenoceptors and the positive inotropic effects of several adenylate cyclase dependent and independent agents have been measured in papillary muscle strips from patients without, as well as with moderate and severe heart failure. The number of beta-adrenoceptors was found to be decreased depen...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF02650352
更新日期：1989-01-01 00:00:00
abstract：:The influence of decapitation, ketamine and thiopental anesthesia on some properties of rat heart mitochondria was compared. Polarographic analysis were performed, oxygen consumption rates, respiratory control index, ADP : O ratio and oxidation of exogenous NADH were determined. Electronmicroscopic and gasometric exam...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01907952
更新日期：1981-03-01 00:00:00
abstract：:For 219 children between 3 and 15 years with the most frequent congenital and acquired heart failures it was investigated in what way the STI differ consistently from the corresponding standard values. It was found that all the STI of children with cardiovascular diseases can vary from the normal values scaled by hear...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01906520
更新日期：1978-07-01 00:00:00
abstract：:The carnitine system functions in the transport of activated acyl groups over the mitochondrial inner membrane, and is needed for oxidation of long-chain fatty acids by all mitochondria. The rate of cardiac fatty acid oxidation is determined by availability of fatty acids, oxygen and the activity of carnitine palmitoy...
journal_title：Basic research in cardiology
pub_type： 杂志文章,评审
doi：10.1007/978-3-662-08390-1_8
更新日期：1987-01-01 00:00:00
