Coronary microembolization.

abstract：:This study aimed to analyze the role of endothelial progenitor cell (EPC)-derived angiogenic factors and chemokines in the multistep process driving angiogenesis with a focus on the recently discovered macrophage migration inhibitory factor (MIF)/chemokine receptor axis. Primary murine and murine embryonic EPCs (eEPCs...

journal_title：Basic research in cardiology

authors： Kanzler I,Tuchscheerer N,Steffens G,Simsekyilmaz S,Konschalla S,Kroh A,Simons D,Asare Y,Schober A,Bucala R,Weber C,Bernhagen J,Liehn EA

更新日期：2013-01-01 00:00:00

abstract：:The concentration of fibroblast growth factor 23 (FGF23) rises progressively in renal failure (RF). High FGF23 concentrations have been consistently associated with adverse cardiovascular outcomes or death, in chronic kidney disease (CKD), heart failure or liver cirrhosis. We identified the mechanisms whereby high con...

journal_title：Basic research in cardiology

authors： Lindner M,Mehel H,David A,Leroy C,Burtin M,Friedlander G,Terzi F,Mika D,Fischmeister R,Prié D

更新日期：2020-07-22 00:00:00

abstract：:The purpose of this study was to determine the effects of bradykinin (BK), substance P (SP) and histamine on plasma exudation in the skin of conscious dogs with and without pacing-induced heart failure. We also determined the role tissue angiotensin I-converting enzyme (ACE) and neutral endopeptidase (NEP) play in mod...

journal_title：Basic research in cardiology

authors： Rubinstein I,Müns G,Zucker IH

更新日期：1994-09-01 00:00:00

abstract：:The effects of the dihydropyridine calcium antagonists, nifedipine, nitrendipine and FR 7534 on the transmural distribution of coronary blood flow (endo/epi) were compared to the structurally unrelated calcium antagonists, verapamil and diltiazem and to the non-calcium antagonist vasodilator drugs, chromonar and dipyr...

journal_title：Basic research in cardiology

authors： Warltier DC,Hardman HF,Brooks HL,Gross GJ

更新日期：1983-11-01 00:00:00

abstract：:The genetic defect in the cardiomyopathic (CM) hamster is a mutation in the glycoprotein-sarcoglycan (a component of the dystrophin-glycoprotein complex). Apoptosis has been identified in skeletal muscle of dystrophin-deficient mice, and therefore the role of myocardial apoptosis in relation to oncosis in causing myoc...

journal_title：Basic research in cardiology

authors： Ryoke T,Gu Y,Ikeda Y,Martone ME,Oh SS,Jeon ES,Knowlton KU,Ross J Jr

更新日期：2002-01-01 00:00:00

abstract：:Impaired nitric oxide (NO)-soluble guanylate cyclase (sGC)-cGMP signaling is involved in the pathogenesis of ischemic heart diseases, yet the impact of long-term sGC activation on progressive cardiac remodeling and heart failure after myocardial infarction (MI) has not been explored. Moreover, it is unknown whether st...

journal_title：Basic research in cardiology

authors： Fraccarollo D,Galuppo P,Motschenbacher S,Ruetten H,Schäfer A,Bauersachs J

更新日期：2014-07-01 00:00:00

abstract：:The hormone-sensitive adenylate cyclase is a multi-component system embedded in the lipid bilayer of the plasma membrane and serves as a signal transduction system for various membrane receptors. The complete system consists of various receptor molecules, which sensitize the external ligands, the effector enzyme adeny...

journal_title：Basic research in cardiology

authors： Jakobs KH,Minuth M,Bauer S,Grandt R,Greiner C,Zubin P

更新日期：1986-01-01 00:00:00

abstract：:Persistent inflammatory responses participate in the pathogenesis of adverse ventricular remodeling after myocardial infarction (MI). We hypothesized that regulatory T (Treg) cells modulate inflammatory responses, attenuate ventricular remodeling and subsequently improve cardiac function after MI. Acute MI was induced...

journal_title：Basic research in cardiology

authors： Tang TT,Yuan J,Zhu ZF,Zhang WC,Xiao H,Xia N,Yan XX,Nie SF,Liu J,Zhou SF,Li JJ,Yao R,Liao MY,Tu X,Liao YH,Cheng X

更新日期：2012-01-01 00:00:00

abstract：:PDE3 cyclic nucleotide phosphodiesterase inhibitors raise cAMP and cGMP content in cardiac and vascular myocytes. Their administration to patients with dilated cardiomyopathy leads to improvements in hemodynamic parameters in the short term but reduces survival with chronic administration. The reasons for this 'biphas...

journal_title：Basic research in cardiology

authors： Movsesian MA

更新日期：2002-01-01 00:00:00

abstract：:The influence of changes in pre- and afterload, heart frequency and inotropic state on the difference between right ventricular dP/dtmax measured isovolumically and auxotonically has been investigated in canine heart-lung preparations. Isovolumic systoles were obtained by occluding the pulmonary artery during diastole...

journal_title：Basic research in cardiology

authors： Hoppe H,Schmidt HD,Seitz E

更新日期：1976-09-01 00:00:00

abstract：:We have examined the sodium-calcium exchange stoichiometry in Langendorff-perfused rabbit hearts using gamma-emitting tracers under conditions of sodium pump inhibition. Following a 60-min perfusion with 10(-5) acetylstrophanthidin, and extracellular concentrations [Na]o = 70 mM and [Ca]o = 300 microM, intracellular s...

journal_title：Basic research in cardiology

authors： Axelsen PH,Bassingthwaighte JB

更新日期：1988-05-01 00:00:00

abstract：:The quantitative predominance of free and total cholesterol over the amount of mural calcium is a most significant criterion of healthy human coronary arteries during the whole life span (0-90 years). However, this normal ratio increasingly changes as soon as arteriosclerotic alterations of the coronary walls set in. ...

journal_title：Basic research in cardiology

authors： Frey M,Just H

更新日期：1994-01-01 00:00:00

abstract：:For 219 children between 3 and 15 years with the most frequent congenital and acquired heart failures it was investigated in what way the STI differ consistently from the corresponding standard values. It was found that all the STI of children with cardiovascular diseases can vary from the normal values scaled by hear...

journal_title：Basic research in cardiology

authors： Braun U,Rautenburg HW

更新日期：1978-07-01 00:00:00

abstract：:The behavior of Ca(2+)-activated K+ channels of large conductance (BKCa) in smooth muscle cells, which were obtained from atherosclerotic plaque material (SMCP) and from media segments (SMCM) of human coronary arteries, were compared using the patch-clamp technique. Voltage-clamp protocols in cell-attached patches rev...

journal_title：Basic research in cardiology

authors： Wiecha J,Schläger B,Voisard R,Hannekum A,Mattfeldt T,Hombach V

更新日期：1997-08-01 00:00:00

abstract：:Ventricular remodeling following nonfatal myocardial infarction includes an excentric hypertrophy of the surviving myocardium, associated with hemodynamic overload. Disseminated cardiomyocyte apoptosis and phenotype changes of the surviving myocardium, such as a labile calcium homeostasis of the hypertrophied cardiomy...

journal_title：Basic research in cardiology

authors： Holtz J

更新日期：1998-01-01 00:00:00

abstract：:During long-term treatment with amiodarone, slowing of conduction through the atrioventricular node, a prolongation of the QT-interval, and a prolongation of the atrial and ventricular myocardial refractoriness always developed. During short-term treatment, these effects were not found, except for depression of the AV...

journal_title：Basic research in cardiology

authors： Stark G,Stark U,Windisch M,Vicenzi M,Eggenreich U,Nagl S,Kral K,Pilger E,Tritthart HA

更新日期：1991-03-01 00:00:00

abstract：:In the isometrically contracting rat trabecular muscle strip preparation, contracture tension was induced either by 10 min of hypoxia (low contracture tension) or by 30 min of joint oxygen and glucose withdrawal (severe contracture tension) at optimum length. Using stepwise 0.1 mm releases, length-tension relationship...

journal_title：Basic research in cardiology

authors： Holubarsch C,Jacob R

更新日期：1981-11-01 00:00:00

abstract：OBJECTIVES:Single electrical field shocks are able to induce ventricular fibrillation (VF) if applied during the vulnerable period. During this period, a shock can either prolong the action potential duration or induce a new action potential. Whether the occurrence of different shock responses contributes to the induct...

journal_title：Basic research in cardiology

authors： Kirchhof PF,Fabritz CL,Behrens S,Franz MR

更新日期：1997-02-01 00:00:00

abstract：:X-ray microanalysis was used to compare chemically untreated cryosections of quick-frozen myocardial tissue in "caffeine contracture" with cryosections of normal muscle. Our goal was to find out if it is possible by means of this method to detect changes in the calcium compartmentalization of the myocardial cell occur...

journal_title：Basic research in cardiology

authors： Wendt-Gallitelli MF,Wolburg H,Schlote W,Schwegler M,Holubarsch C,Jacob R

更新日期：1980-01-01 00:00:00

abstract：:The endothelin (ET) family of peptides have potent vascular, cardiac and renal actions which may be of pathophysiological importance in congestive heart failure (CHF). In vivo studies with selective and non-selective ET receptor antagonists are required to clarify the role of ET in the pathophysiology of CHF and deter...

journal_title：Basic research in cardiology

authors： Love MP,McMurray JJ

更新日期：1996-01-01 00:00:00

abstract：:We tested the hypotheses that myocardial infarction in mice would lead to progressively worsening heart failure 12-18 weeks later and that exercise testing would provide a suitable means to evaluate left ventricular function sequentially. C57BL/6 mice (n = 69) underwent left coronary artery ligation (n = 50) or thorac...

journal_title：Basic research in cardiology

authors： Bayat H,Swaney JS,Ander AN,Dalton N,Kennedy BP,Hammond HK,Roth DM

更新日期：2002-05-01 00:00:00

abstract：:We compared the effects of linagliptin (Lina, a DPP4 inhibitor) and GLP-1 receptor activation by exenatide followed by exendin-4 in an infusion pump (EX) on infarct size (IS), post-infarction activation of the inflammasome and remodeling in wild-type (WT) and db/db diabetic mice. Mice underwent 30 min ischemia followe...

journal_title：Basic research in cardiology

authors： Birnbaum Y,Tran D,Bajaj M,Ye Y

更新日期：2019-08-06 00:00:00

abstract：:The purpose of this study was to obtain more information about the role of the plasma membrane in cellular uptake of tracers used in myocardial scintigraphy (radioactive thallium chloride and palmitic acid). This knowledge is of importance for an adequate interpretation of the results obtained under clinical condition...

journal_title：Basic research in cardiology

authors： Rauch B,Kübler W

更新日期：1985-01-01 00:00:00

abstract：:In open-chest pigs during severe myocardial ischemia [K+]e, [Ca2+]e and [H+]e increase, [Na+]e increases transiently reaching control values after 30 min. Extracellular osmolality of the ischemic area increases due to an H2O-shift from the ECS to the ICS. The increase of [Na+]e and [Ca2+]e must b explained by the shri...

journal_title：Basic research in cardiology

authors： Friedrich R,Hirche H,Kebbel U,Zylka V,Bissig R

更新日期：1981-07-01 00:00:00

abstract：:MicroRNAs (miRNAs) are important regulators of adaptive and maladaptive responses in cardiovascular diseases and hence are considered to be potential therapeutical targets. However, their role as novel biomarkers for the diagnosis of cardiovascular diseases still needs to be systematically evaluated. We assessed here ...

journal_title：Basic research in cardiology

authors： Meder B,Keller A,Vogel B,Haas J,Sedaghat-Hamedani F,Kayvanpour E,Just S,Borries A,Rudloff J,Leidinger P,Meese E,Katus HA,Rottbauer W

更新日期：2011-01-01 00:00:00

abstract：:Apart from local heterogeneities of myocardial blood flow, the regulation of vascular tone is equally complex. Changes in vascular tone are essential for the adaptation of coronary blood flow to varying metabolic demands. The majority of coronary vascular resistance is found in the microcirculation, that is, in vessel...

journal_title：Basic research in cardiology

authors： Tiefenbacher CP,Chilian WM

更新日期：1998-12-01 00:00:00

abstract：:Cardiovascular cell therapy offers the first real potential to treat the underlying injuries associated with cardiac and vascular disease. By delivering appropriate exogenous cells to an injury site, the potential exists to mitigate injury or even to begin to reverse damage. Based on their inordinate pre-clinical prom...

journal_title：Basic research in cardiology

authors： Ott HC,McCue J,Taylor DA

更新日期：2005-11-01 00:00:00

abstract：:The proximal segments of the left coronary artery are foreshortended in the usual projections. By additional cranio-caudal (half axial) projections the X-ray beam can be directed perpendicular to these segments. In some patients lesions especially of the left main coronary artery or the proximal LAD can be seen or acc...

journal_title：Basic research in cardiology

authors： Rentrop P

更新日期：1976-01-01 00:00:00

abstract：:Dopexamine is a newly developed sympathetic catecholamine which combines dopaminergic (DA-1) and beta 2-adrenergic agonist activity with only minor beta 1-adrenergic action. Thereby, this compound exerts systemic and preferential renal vasodilation, causing afterload reduction, increases in cardiac output, and improve...

journal_title：Basic research in cardiology

authors： Meinertz T,Drexler H,Just H

更新日期：1989-01-01 00:00:00

abstract：:32 patients were studied by His-bundle recordings to examine the extent to which frequency and autonomic nervous system influence the conduction velocity in the subdivisions (atrium, AV-node, His-Purkinje system) of the normal PR-interval. The measurements were performed during sinus rhythm and three electrically indu...

journal_title：Basic research in cardiology

authors： Runge M,Luckmann E,Narula OS

更新日期：1976-11-01 00:00:00