Abstract：
:The influence of changes in pre- and afterload, heart frequency and inotropic state on the difference between right ventricular dP/dtmax measured isovolumically and auxotonically has been investigated in canine heart-lung preparations. Isovolumic systoles were obtained by occluding the pulmonary artery during diastole by balloon inflation. The mean difference between isovolumic and auxotonic dP/dtmax is 40 mm Hg/sec (15 to 80 mm Hg/sec) - i.e. about 10% of the value measured auxotonically. Neither hemodynamic (pre- and afterload changes) nor inotropic changes influence this difference. Heart rate increase from 140 to 200/min also has no effect. This corresponds with the unchanged time interval between pulmonary valve opening and right ventricular dP/dtmax under all these conditions. Only heart rates below 100/min seem to enhance the difference between isovolumic and auxotonic dP/dtmax. Since the difference is not altered at various inotropic states, the result of this study leads to the conclusion that the relative changes in contractility could be slightly overestimated by using the auxotonic dP/dtmax for inotropic assessment. Practically, this inexactitude is within the error range of the method. Therefore, the use of dP/dtmax measured auxotonically does not introduce a marked disadvantage related to isovolumic dP/dtmax for assessment of relative inotropic changes of the right ventricle in isolated hearts.
journal_name
Basic Res Cardioljournal_title
Basic research in cardiologyauthors
Hoppe H,Schmidt HD,Seitz Edoi
10.1007/BF01909767keywords:
subject
Has Abstractpub_date
1976-09-01 00:00:00pages
530-41issue
5eissn
0300-8428issn
1435-1803journal_volume
71pub_type
杂志文章abstract：:Protection from postconditioning has been documented in in situ animal models and it has been proposed that it is targeting circulating leukocytes. We therefore tested whether postconditioning can protect leukocyte-free, buffer-perfused rabbit hearts. Infarct size was measured with triphenyltetrazolium staining. In co...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/s00395-004-0498-4
更新日期：2005-01-01 00:00:00
abstract：:Beta-blockers have been shown to reduce the risk of coronary events and reduce the mortality of patients with hypertension and in those who have had a myocardial infarction. Furthermore, the evidence for long-term benefits in these two patient groups are much more convincing for beta-blockers than for other therapeuti...
journal_title：Basic research in cardiology
pub_type： 杂志文章,评审
doi：10.1007/s003950070006
更新日期：2000-01-01 00:00:00
abstract：:The cardiac organ manifestation of arterial hypertension comprises the myocardium itself with left-ventricular hypertrophy, the interstitium with perivascular and interstitial fibrosis, and the coronary circulation with disease of large and small coronary arteries. The consequences of the sum and interactions of these...
journal_title：Basic research in cardiology
pub_type： 杂志文章,评审
doi：10.1007/978-3-662-30769-4_22
更新日期：1991-01-01 00:00:00
abstract：:The aim of this study was to examine the effect of ischemic preconditioning on the releases of cardiac troponin T (TnT) during reperfusion in isolated rat hearts. Experiments were done on 22 rat hearts, which were perfused according to the method of Langendorff and were divided into the control group (n = 14) and the ...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF00795616
更新日期：1994-05-01 00:00:00
abstract：OBJECTIVE:Chemokines control the migration of leukocytes to inflamed tissue, and in particular monocyte chemoattractant protein (MCP)-1 has been implicated in the pathogenesis of several cardiovascular disorders such as chronic heart failure (CHF) and myocarditis. We hypothesised that MCP-1 may directly contribute to a...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/s003950170042
更新日期：2001-07-01 00:00:00
abstract：:The assessment of endothelium-mediated modulation of coronary vasomotor tone in the intact human circulation under physiologic conditions requires very precise determination of both epicardial artery diameters, reflecting effects within the conduit vessels, as well as coronary blood flow, reflecting effects within the...
journal_title：Basic research in cardiology
pub_type： 杂志文章,评审
doi：10.1007/978-3-642-72461-9_18
更新日期：1991-01-01 00:00:00
abstract：:The role of the cardiac current Ik1 in arrhythmogenesis remains highly controversal. To gain further insights into the mechanisms of IK1 involvement in cardiac excitability, we studied the susceptibility of transgenic mice with altered IK1 to arrhythmia during various pharmacological and physiological challenges. Arrh...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/s00395-007-0659-y
更新日期：2007-09-01 00:00:00
abstract：:A reproducible tourniquet-shock has been produced in hind limbs of dogs by unilateral and bilateral extremity ischemia. The following parameters have been measured for analysing the function of the cardiovascular system: mean aortic pressure, heart rate, cardiac output, intraventricular pressure and left ventricular p...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01927866
更新日期：1976-03-01 00:00:00
abstract：:In situ hearts and isolated cardiomyocytes from heterozygous connexin 43-deficient (Cx43+/-) mice cannot be protected by ischemic preconditioning or diazoxide. We have now addressed the role of connexin 43 in ischemic postconditioning (PC). Wild type (WT) and Cx43+/- mice were subjected to 30 min coronary occlusion an...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/s00395-006-0589-0
更新日期：2006-07-01 00:00:00
abstract：:In anaesthetized, artificially respirated mongrel dogs, the intravenous infusion of oxprenolol (0.3 mg and 1 mg/kg over 10 minutes) led to an increase in heart rate and cardiac output. Blood pressure in the pulmonary capillaries and right atrium, and vascular resistance were reduced. The pressure in the aorta was tran...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01906388
更新日期：1975-09-01 00:00:00
abstract：:An ischaemia-like state in cultured heart cells has been obtained by markedly restricting the volume of extracellular medium combined with total deprivation of oxygen (anoxia) and glucose. Cellular injury, as reflected by the release of both cytoplasmic and lysosomal enzymes was significantly greater than during anoxi...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：
更新日期：1985-01-01 00:00:00
abstract：:The clinical use of positive inotropic agents has been associated with increased mortality, with proarrhythmia speculated to be a contributing factor. This study compares the arrhythmogenic potentials of six positive inotropic agents representing different mechanistic classes: the beta-adrenergic agonist dobutamine, t...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/s003950050181
更新日期：2000-06-01 00:00:00
abstract：:The assessment of proarrhythmic risks of drugs remains challenging. To evaluate the suitability of rat engineered heart tissue (EHT) for detecting proarrhythmic effects. We monitored drug effects on spontaneous contractile activity and, in selected cases, on action potentials (sharp microelectrode) and Ca2+ transients...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/s00395-014-0436-7
更新日期：2014-01-01 00:00:00
abstract：:Receptor for advanced glycation end products (RAGE) and connective tissue growth factor (CTGF) play a key role in diabetic myocardial fibrosis, and peroxisome proliferator-activated receptor-gamma (PPAR-gamma) activation has been reported to reduce RAGE and CTGF expression. This study investigated the effects of the P...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/s00395-009-0071-x
更新日期：2010-05-01 00:00:00
abstract：:Nitroglycerin (GTN) and other organic nitrates are widely used vasodilators. Their side effects are development of nitrate tolerance and endothelial dysfunction. Given the potential of GTN to induce nitro-oxidative stress, we investigated the interaction between nitro-oxidative DNA damage and vascular dysfunction in e...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/s00395-016-0571-4
更新日期：2016-07-01 00:00:00
abstract：:The role of miR-92a on vascular remodelling after injury is currently unknown. Thus, the aim of the present study was to evaluate the role of miR-92a on rat endothelial and vascular smooth muscle cells proliferation and migration in vitro as well as after balloon injury or arterial stenting in vivo. MiR-92a was highly...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/s00395-012-0296-y
更新日期：2012-09-01 00:00:00
abstract：:The capillary wall, due to its diffusional resistance, causes concentration differences between the vascular space and the interstitial space for substances which are released or taken up by the heart. Estimation of capillary transfer and interstitial concentration in isolated hearts, however, indicates a variable dif...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：
更新日期：1985-01-01 00:00:00
abstract：:During myocardial ischemia, both the myocardial and serum TNFalpha concentrations are rapidly increased within the area at risk. With prolongation of ischemia and development of cardiomyocyte necrosis, the TNFalpha concentration increases also in the surrounding viable portions of the myocardium. Indeed, in the scenar...
journal_title：Basic research in cardiology
pub_type： 杂志文章,评审
doi：10.1007/s00395-003-0431-x
更新日期：2004-01-01 00:00:00
abstract：:Long QT syndrome is a potentially life-threatening disease characterized by delayed repolarization of cardiomyocytes, QT interval prolongation in the electrocardiogram, and a high risk for sudden cardiac death caused by ventricular arrhythmia. The genetic type 3 of this syndrome (LQT3) is caused by gain-of-function mu...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/s00395-016-0530-0
更新日期：2016-03-01 00:00:00
abstract：:In the human ventricle two isoforms of the phosphorylatable myosin light chain (MPLC) are expressed. These two forms are designated with increasing acidity as LC-2 and LC-2*. In the normal human heart the relation between LC-2/LC-2*-expression is 70/30, suggesting the existence of three different myosin isoenzymes (MP...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/978-3-642-72474-9_11
更新日期：1992-01-01 00:00:00
abstract：:Thyroid hormone (TH) is critical for tissue differentiation at early stages of development, induces physiological hypertrophy and regulates the expression of important contractile proteins such as myosin heavy chain (MHC) isoform and calcium cycling proteins. Furthermore, TH seems to control the response to stress by ...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/s00395-008-0697-0
更新日期：2008-07-01 00:00:00
abstract：:Recent attention has focused on the concept that mitochondrial dynamics-that is, the balance between mitochondrial fusion and fission (fragmentation)-may play a pivotal role in determining cell fate in the setting of myocardial ischemia-reperfusion injury. In this regard, there is an emerging consensus that: (1) ische...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/s00395-016-0578-x
更新日期：2016-09-01 00:00:00
abstract：:Persistent inflammatory responses participate in the pathogenesis of adverse ventricular remodeling after myocardial infarction (MI). We hypothesized that regulatory T (Treg) cells modulate inflammatory responses, attenuate ventricular remodeling and subsequently improve cardiac function after MI. Acute MI was induced...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/s00395-011-0232-6
更新日期：2012-01-01 00:00:00
abstract：:The PKC hypothesis and its variants are attractive but unproved. The chief difficulty is the lack of an objective means to assess whether or not PKC has been activated in hearts preconditioned in vivo with ischemia or in hearts preconditioned by pharmacologic means. The strongest evidence is supporting the PKC hypothe...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF00797206
更新日期：1997-01-01 00:00:00
abstract：:Experiments were performed to determine the relative contributions of direct Ca(2+)-entry through the L-type Ca(2+)-current and of Ca(2+)-release from the sarcoplasmic reticulum (s.r.) to the intracellular [Ca2+]i-transient in isolated human atrial and ventricular myocytes from patients with severe heart failure and f...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF00794074
更新日期：1997-01-01 00:00:00
abstract：:The effects of 3 hours of ischemia and 1 hour of reperfusion on biochemical, physiological and ultrastructural parameters were studied in 12 dogs. In the ischemic subendocardium without reperfusion, mitochondrial losses of adenine (ATP + ADP + AMP) and pyridine (NAD + NADH) nucleotides far exceeded those observed in w...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01908307
更新日期：1984-03-01 00:00:00
abstract：:In dog myocardium, the changes in the levels of creatine phosphate, inorganic phosphate, ATP, ADP, AMP, adenosine and inosine with 8 min of ischemia and subsequent reperfusion for 2, 4, 8, 16 and 32 min have been followed. Creatine phosphate and inorganic phosphate recovered completely within a few minutes as did the ...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01907461
更新日期：1986-07-01 00:00:00
abstract：:In the spontaneously hypertensive rat (SHR) with established hypertension left ventricular mass closely correlated with the proportion of ventricular myosin (VM)-3. A 60% VM-3 content was reached corresponding, under the present housing conditions, to an average age of 40 weeks without any significant change in total ...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/978-3-662-11374-5_15
更新日期：1986-01-01 00:00:00
abstract：:In Langendorff-perfused guinea pig hearts, local myocardial perfusion was evaluated by analysis of FITC-dextran-150 elution kinetics after bolus injection. Locally estimated half-times of the monoexponential elution curves showed good correlation with global undisturbed coronary flow. After ligation of the left anteri...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01935807
更新日期：1984-01-01 00:00:00
abstract：:Successive ischemic episodes are commonly seen in clinical and experimental cardiology. Although prolonged abnormalities of the canine myocardium have been described following a single ischemic episode, it is not known whether myocardial injury is cumulative following multiple ischemic episodes. Dogs were subjected to...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01908148
更新日期：1984-07-01 00:00:00
