Abstract：
:In situ hearts and isolated cardiomyocytes from heterozygous connexin 43-deficient (Cx43+/-) mice cannot be protected by ischemic preconditioning or diazoxide. We have now addressed the role of connexin 43 in ischemic postconditioning (PC). Wild type (WT) and Cx43+/- mice were subjected to 30 min coronary occlusion and 120 min reperfusion, with and without a PC protocol of three cycles of 10 s coronary occlusion/10 s reperfusion. Infarct size (TTC staining) was reduced by PC from 54+/-5 to 37+/-3% of area at risk in WT. Likewise, infarct size was reduced by PC from 53+/-4 to 34+/-3% of area at risk in Cx43+/-. We conclude that connexin 43 is no prerequisite for PC's protection. To this end, the signal transduction of ischemic preconditioning and postconditioning differs.
journal_name
Basic Res Cardioljournal_title
Basic research in cardiologyauthors
Heusch G,Büchert A,Feldhaus S,Schulz Rdoi
10.1007/s00395-006-0589-0keywords:
subject
Has Abstractpub_date
2006-07-01 00:00:00pages
354-6issue
4eissn
0300-8428issn
1435-1803journal_volume
101pub_type
杂志文章abstract：OBJECTIVE:Ischemic or hypoxic preconditioning has been shown, in multicellular preparations, to reduce post-ischemic injury. In the present study, we attempted to develop a model of preconditioning in isolated rat myocytes in order to facilitate investigation into the mechanism of preconditioning. METHODS:The protecti...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF00788907
更新日期：1996-05-01 00:00:00
abstract：:Protection from postconditioning has been documented in in situ animal models and it has been proposed that it is targeting circulating leukocytes. We therefore tested whether postconditioning can protect leukocyte-free, buffer-perfused rabbit hearts. Infarct size was measured with triphenyltetrazolium staining. In co...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/s00395-004-0498-4
更新日期：2005-01-01 00:00:00
abstract：:Isolated cells obtained from adult myocardium are proving invaluable for a wide range of studies concerned with the mechanisms underlying many important cardiological processes. Although care must always be taken to ensure that the single myocyte is an appropriate model for the particular question to be researched, it...
journal_title：Basic research in cardiology
pub_type： 杂志文章,评审
doi：
更新日期：1985-01-01 00:00:00
abstract：:Perfusion of isoprenaline in the dog may induce left ventricular hypertrophy (LVH), and this effect is suppressed by propranolol. Cultured foetal cardiomyocytes exposed to catecholamines show an increase in protein synthesis and RNA turnover. In spontaneously hypertensive rats (SHR), and perhaps in man, sympatholytic ...
journal_title：Basic research in cardiology
pub_type： 杂志文章,评审
doi：
更新日期：1991-01-01 00:00:00
abstract：:Since the discovery of a novel mechanism of cell death that differs from traditional necrosis, i.e., apoptosis, there have been numerous studies concluding that increased apoptosis augments myocardial infarction and heart failure and that limiting apoptosis protects the heart. Importantly, the vast majority of cells i...
journal_title：Basic research in cardiology
pub_type： 杂志文章,评审
doi：10.1007/s00395-016-0549-2
更新日期：2016-05-01 00:00:00
abstract：:Myocardial ischemia and infarction are the most common substrates for life-threatening ventricular tachyarrhythmias. Experimental and clinical evidence suggests that enhanced activity of the sympathetic nervous system plays an important role in the genesis of ischemia-related arrhythmias. In animal experiments, beta-b...
journal_title：Basic research in cardiology
pub_type： 杂志文章,评审
doi：10.1007/978-3-662-11038-6_24
更新日期：1990-01-01 00:00:00
abstract：:Cardiac glycosides like ouabain are used in the therapy of heart failure and atrial fibrillation. They exert a positive inotropic effect on cardiomyocytes by inhibiting the plasma membrane sodium pump (Na,K-ATPase), decreasing the Ca-extrusion by the sarcolemmal cardiac sodium/calcium exchanger (NCX) and increasing th...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/s00395-003-0396-9
更新日期：2003-03-01 00:00:00
abstract：:We tested the hypothesis that isoproterenol would increase myocardial work and O2 consumption at reduced efficiency and that both left ventricular hypertrophy and chemical sympathectomy would lead to changes in this myocardial efficiency response. Left ventricular hypertrophy was produced by aortic valve plication in ...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF00789303
更新日期：1996-07-01 00:00:00
abstract：:The quantitative predominance of free and total cholesterol over the amount of mural calcium is a most significant criterion of healthy human coronary arteries during the whole life span (0-90 years). However, this normal ratio increasingly changes as soon as arteriosclerotic alterations of the coronary walls set in. ...
journal_title：Basic research in cardiology
pub_type： 杂志文章,评审
doi：10.1007/978-3-642-85660-0_15
更新日期：1994-01-01 00:00:00
abstract：:Mesenchymal stromal cells (MSCs) exhibit antiapoptotic and proangiogenic functions in models of myocardial infarction which may be mediated by secreted small extracellular vesicles (sEVs). However, MSCs have frequently been harvested from aged or diseased patients, while the isolated sEVs often contain high levels of ...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/s00395-020-0785-3
更新日期：2020-03-07 00:00:00
abstract：:Exercise is an efficient strategy for myocardial protection against ischemia-reperfusion (IR) injury. Although endothelial nitric oxide synthase (eNOS) is phosphorylated and activated during exercise, its role in exercise-induced cardioprotection remains unknown. This study investigated whether modulation of eNOS acti...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/s00395-013-0389-2
更新日期：2013-11-01 00:00:00
abstract：:The effects of increased perfusion pressure and epinephrine stimulation on the contractile parameters and glucose transport in the isolated perfused hearts of control and ketotic diabetic rats were studied. An increase in perfusion pressure from 60 mm Hg to 100 mm Hg resulted in increases in coronary flow and peak aor...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01907437
更新日期：1983-05-01 00:00:00
abstract：:The flow pattern and the paths of fluid particles in a saccular aneurysm located at the bifurcation of an intracranial arterial segment are investigated with a numerical method. A normal physiological flow pattern was assumed as input to the studied segment. The theoretical study is carried out for two different Reyno...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01907101
更新日期：1988-01-01 00:00:00
abstract：:Elevation of cardiac troponin I (cTnI) is a well-known complication after percutaneous coronary interventions (PCI). The aims of this study were to quantify the extent of coronary microembolization during elective PCI, to identify predisposing anatomical and procedural factors, and to evaluate its impact on long-term ...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/s00395-012-0289-x
更新日期：2012-09-01 00:00:00
abstract：:Increasing the frequency of steady state stimulation increases the rate of mechanical restitution in hypothermic (27 degrees C) guinea pig papillary muscles. In this paper we have investigated the influences of the calcium antagonist nifedipine and of reduced extracellular calcium concentration on this phenomenon. We ...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF00798259
更新日期：1993-03-01 00:00:00
abstract：:Regional glucose utilization of the developing fetal feline heart was assessed during three stages of gestation and compared with the maternal heart and non-pregnant controls. The specific aims were to determine: 1) if glucose utilization by the whole heart changes from early to late gestation; 2) if there are differe...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF02191527
更新日期：1991-07-01 00:00:00
abstract：:We have recently gained evidence that segmental coronary microvascular diameters, and therefore resistances, are controlled by myogenic and endothelial responses to pressure and flow. Furthermore, intact heart studies are demonstrating that these mechanisms may interact importantly with the metabolic mechanisms primar...
journal_title：Basic research in cardiology
pub_type： 社论
doi：10.1007/BF00788525
更新日期：1993-01-01 00:00:00
abstract：:The hormone-sensitive adenylate cyclase is a multi-component system embedded in the lipid bilayer of the plasma membrane and serves as a signal transduction system for various membrane receptors. The complete system consists of various receptor molecules, which sensitize the external ligands, the effector enzyme adeny...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01907422
更新日期：1986-01-01 00:00:00
abstract：:Six dogs were subjected to an acute stenosis of the left anterior descending coronary artery. The mean aortic pressure was fixed with a windkessel and an occluder on four different levels. A significant decrease of coronary blood flow and poststenotic coronary pressure was closely related to the level of mean aortic ...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01906456
更新日期：1976-05-01 00:00:00
abstract：:To understand the effect of transcription regulation in modulating cardiac aging, we sought to study the role of serum response factor (SRF), a key transcription factor in the heart that is normally increased with senescence and also in congestive heart failure. A Tet-Off gene expression system was used for cardiac-sp...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/s00395-006-0634-z
更新日期：2007-05-01 00:00:00
abstract：OBJECTIVE:Chemokines control the migration of leukocytes to inflamed tissue, and in particular monocyte chemoattractant protein (MCP)-1 has been implicated in the pathogenesis of several cardiovascular disorders such as chronic heart failure (CHF) and myocarditis. We hypothesised that MCP-1 may directly contribute to a...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/s003950170042
更新日期：2001-07-01 00:00:00
abstract：:To investigate the effect of nifedipine on hypercalcemic electrocardiographical alterations, steadily increasing hypercalcemia was induced in guinea-pigs by continuous calcium gluconate infusion until cardiac arrest occurred. During the experimental time the electrocardiograms were continuously recorded and compared i...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01908127
更新日期：1982-01-01 00:00:00
abstract：:A canine model for a standardized induction of collaterals is presented with a fixed external constrictor that is not designed to induce an occlusion of the coronary artery and at least over the timespan of 6 weeks does not impair perfusion under resting conditions in the myocardium-at-risk. The coronary constriction ...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01906671
更新日期：1983-03-01 00:00:00
abstract：:The sympathetic and parasympathetic nervous system play a powerful role in controlling cardiac function by activating adrenergic and muscarinic receptors. In the human heart there exist alpha1-, beta1- and beta2-adrenoceptors and M2-muscarinic receptors and possibly also (prejunctional) alpha2-adrenoceptors. Beta1- an...
journal_title：Basic research in cardiology
pub_type： 杂志文章,评审
doi：10.1007/s003950170003
更新日期：2001-11-01 00:00:00
abstract：:It was previously reported that inhibition of carnitine synthesis by 3-(2,2,2-trimethyl-hydrazinium) propionate (MET-88) restores left ventricular (LV) systolic and diastolic function in rats with myocardial infarction (MI). Preservation of the calcium uptake function of sarcoplasmic reticulum Ca2+-ATPase (SERCA2) is ...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/s003950070032
更新日期：2000-10-01 00:00:00
abstract：:Heart failure has been divided into several different forms depending on etiology, clinical course and pathophysiology of left ventricular (LV) dysfunction. Systolic and diastolic dysfunction are characterized by a reduced cardiac output with normal (= diastolic dysfunction) or depressed (= systolic dysfunction) LV pu...
journal_title：Basic research in cardiology
pub_type： 杂志文章,评审
doi：10.1007/BF00795358
更新日期：1996-01-01 00:00:00
abstract：:It is commonly thought that the optimal method for intracoronary administration of cells is to stop coronary flow during cell infusion, in order to prolong cell/vascular wall contact, enhance adhesion, and promote extravasation of cells into the interstitial space. However, occlusion of a coronary artery with a balloo...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/s00395-015-0503-8
更新日期：2015-09-01 00:00:00
abstract：OBJECTIVE:Cardiac stunning is the consequence of a brief cardiac ischemia. The underlying mechanism is not completely understood. METHODS:Here we induced cardiac transient ischemia in conscious instrumented dogs by means of an occluder in the left anterior descending coronary artery (LAD). Contractile performance, mon...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/s00395-005-0577-9
更新日期：2006-05-01 00:00:00
abstract：:Pentostatin (2-deoxycoformycin) is a potent inhibitor of adenosine deaminase and has been demonstrated to augment endogenous adenosine levels during regional and global myocardial ischemia. Based on the rationale that increasing endogenous adenosine during ischemia may be cardioprotective, the objective of this study ...
journal_title：Basic research in cardiology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF00789447
更新日期：1995-03-01 00:00:00
abstract：:Cardiac disease is associated with deleterious emission of mitochondrial reactive oxygen species (mito-ROS), as well as enhanced oxidation and activity of the sarcoplasmic reticulum (SR) Ca2+ release channel, the ryanodine receptor (RyR2). The transfer of Ca2+ from the SR via RyR2 to mitochondria is thought to play a ...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/s00395-020-0797-z
更新日期：2020-05-22 00:00:00
