Myogenic and flow-dependent control mechanisms in the coronary microcirculation.

abstract：:A major limitation in long-term studies of quiescent adult cadiomyocytes in culture has been the decline in contractile properties of the cells over time. Regular contracting cardiomyocyte cultures may represent a more physiological model. The aim of the present study was to investigate the mechanical properties and c...

journal_title：Basic research in cardiology

authors： Holt E,Lunde PK,Sejersted OM,Christensen G

更新日期：1997-10-01 00:00:00

abstract：:A reproducible tourniquet-shock has been produced in hind limbs of dogs by unilateral and bilateral extremity ischemia. The following parameters have been measured for analysing the function of the cardiovascular system: mean aortic pressure, heart rate, cardiac output, intraventricular pressure and left ventricular p...

journal_title：Basic research in cardiology

authors： Stock W,Geppert E,Haase W,Isselhard W

更新日期：1976-03-01 00:00:00

abstract：:Two-weekly echocardiographic examinations were conducted in nine SHHF-Mc-fa(cp) rats in comparison with eight age-matched Wistar rats. In the SHHF-rats, characterized by progressive LV-dilation and decreasing contractile function between 77-87 weeks of age, left ventricular (LV) hypertrophy was most sensitively demons...

journal_title：Basic research in cardiology

authors： Reffelmann T,Kloner RA

更新日期：2003-09-01 00:00:00

abstract：:The effects of a c-myc antisense phosphorothioate DNA oligonucleotide were assessed on the proliferation rate of human arterial smooth muscle cells (HSMCs). Compared to a control oligonucleotide the antisense oligonucleotide suppressed the proliferation of HSMCs in a concentration-dependent manner without a major cyto...

journal_title：Basic research in cardiology

authors： Ebbecke M,Unterberg C,Buchwald A,Stöhr S,Wiegand V

更新日期：1992-11-01 00:00:00

abstract：:Atrial fibrosis is important for the pathogenesis of atrial fibrillation (AF) but the underlying signal transduction is incompletely understood. We therefore studied the role of microRNA-21 (miR-21) and its downstream target Sprouty 1 (Spry1) during atrial fibrillation. Left atria (LA) from patients with AF showed a 2...

journal_title：Basic research in cardiology

authors： Adam O,Löhfelm B,Thum T,Gupta SK,Puhl SL,Schäfers HJ,Böhm M,Laufs U

更新日期：2012-09-01 00:00:00

abstract：:The available data clearly suggest large alterations in myocardial eicosanoid generation during myocardial ischaemia and demonstrate important actions of eicosanoids on myocardial function during ischaemic conditions. These actions include direct effects on the injured myocardium as well as influences on other target ...

journal_title：Basic research in cardiology

authors： Schrör K

更新日期：1987-01-01 00:00:00

abstract：:During long-term treatment with amiodarone, slowing of conduction through the atrioventricular node, a prolongation of the QT-interval, and a prolongation of the atrial and ventricular myocardial refractoriness always developed. During short-term treatment, these effects were not found, except for depression of the AV...

journal_title：Basic research in cardiology

authors： Stark G,Stark U,Windisch M,Vicenzi M,Eggenreich U,Nagl S,Kral K,Pilger E,Tritthart HA

更新日期：1991-03-01 00:00:00

abstract：:The influence of PGI2 and iloprost on the contents of high energy phosphates, cAMP, glycolytic metabolites and on cardiac performance was investigated in open-chest dogs subjected to 3 h of ischaemia, induced by occlusion of the left anterior descending coronary artery. The administration of drugs for 2 h, starting 1 ...

journal_title：Basic research in cardiology

authors： Pissarek M,Goos H,Nöhring J,Graff J,Buller G,Beyerdörfer I,Mest HJ,Lindenau KF,Krause EG

更新日期：1987-11-01 00:00:00

abstract：:Ventricular remodeling following nonfatal myocardial infarction includes an excentric hypertrophy of the surviving myocardium, associated with hemodynamic overload. Disseminated cardiomyocyte apoptosis and phenotype changes of the surviving myocardium, such as a labile calcium homeostasis of the hypertrophied cardiomy...

journal_title：Basic research in cardiology

authors： Holtz J

更新日期：1998-01-01 00:00:00

abstract：:The purpose of this study was to determine the effects of bradykinin (BK), substance P (SP) and histamine on plasma exudation in the skin of conscious dogs with and without pacing-induced heart failure. We also determined the role tissue angiotensin I-converting enzyme (ACE) and neutral endopeptidase (NEP) play in mod...

journal_title：Basic research in cardiology

authors： Rubinstein I,Müns G,Zucker IH

更新日期：1994-09-01 00:00:00

abstract：:Recent studies have demonstrated the presence of autoantibodies against alpha(1)-adrenoceptor (alpha(1)-AAB) in the serum of patients with primary hypertension, and that these autoantibodies exert adrenergic-agonist-like effects. However, their role in the development of hypertension remains unclear. The current study...

journal_title：Basic research in cardiology

authors： Yan L,Xu Y,Yao H,Xue W,Tian J,Ren H,Wu Y,Yang G,Ma XL,Liu H

更新日期：2009-09-01 00:00:00

abstract：:The present study was designed to test the hypothesis that in hypertrophied myocardium of patients with hypertrophic obstructive cardiomyopathy (HOCM) a reduced contractile reserve provided by frequency dependent potentiation of force of contraction contributes to the myocardial dysfunction. Myectomy was performed in ...

journal_title：Basic research in cardiology

authors： Schotten U,Voss S,Wiederin TB,Voss M,Schoendube F,Hanrath P,Schumacher C

更新日期：1999-04-01 00:00:00

abstract：:To determine the effect of magnesium on myocardial function and oxidative metabolism after reperfusion, isolated rat hearts perfused retrogradely with erythrocyte-enriched medium (0.4 mM palmitate bound to 0.4 mM albumin, 11 mM glucose) were subjected to 60 minutes of no-flow ischemia followed by 60 minutes of reperfu...

journal_title：Basic research in cardiology

authors： Tamm C,Papageorgiou I,Tardy I,Mermillod B,Rutishauser W,Lerch R

更新日期：1994-07-01 00:00:00

abstract：:Increased afterload results in 'pathological' cardiac hypertrophy, the most important risk factor for the development of heart failure. Current in vitro models fall short in deciphering the mechanisms of hypertrophy induced by afterload enhancement. The aim of this study was to develop an experimental model that allow...

journal_title：Basic research in cardiology

authors： Hirt MN,Sörensen NA,Bartholdt LM,Boeddinghaus J,Schaaf S,Eder A,Vollert I,Stöhr A,Schulze T,Witten A,Stoll M,Hansen A,Eschenhagen T

更新日期：2012-11-01 00:00:00

abstract：:The ability of the rhesus monkey to form coronary collaterals was tested in ten animals. Ameroid constrictors were implanted on the left circumflex coronary artery and allowed to remain for 12 weeks. One animal died of an acute myocardial infarction nine days after surgery; the remaining animals survived without clini...

journal_title：Basic research in cardiology

authors： Buss DD,Hyde DM,Steffey EP

更新日期：1983-09-01 00:00:00

abstract：:Myocardial ischemia-reperfusion (I/R) injury leads to intensive sympathetic nervous system (SNS) activation and inflammatory reactions. Whether renal sympathetic denervation (RDN) could be a new therapeutic strategy to modulate I/R inflammation and reduce infarct size after myocardial I/R injury needs to be explored. ...

journal_title：Basic research in cardiology

authors： Sun X,Wei Z,Li Y,Wang J,Hu J,Yin Y,Xie J,Xu B

更新日期：2020-01-13 00:00:00

abstract：:Experiments were performed to determine the relative contributions of direct Ca(2+)-entry through the L-type Ca(2+)-current and of Ca(2+)-release from the sarcoplasmic reticulum (s.r.) to the intracellular [Ca2+]i-transient in isolated human atrial and ventricular myocytes from patients with severe heart failure and f...

journal_title：Basic research in cardiology

authors： Beuckelmann DJ

更新日期：1997-01-01 00:00:00

abstract：:We have examined the sodium-calcium exchange stoichiometry in Langendorff-perfused rabbit hearts using gamma-emitting tracers under conditions of sodium pump inhibition. Following a 60-min perfusion with 10(-5) acetylstrophanthidin, and extracellular concentrations [Na]o = 70 mM and [Ca]o = 300 microM, intracellular s...

journal_title：Basic research in cardiology

authors： Axelsen PH,Bassingthwaighte JB

更新日期：1988-05-01 00:00:00

abstract：:In the chronically volume-overloaded canine heart due to AV-block evaluations of cardiac function were performed during the development of hypertrophy and at stable hypertrophy. In an early stage (1 and 2 weeks of AV-block) when no or only a slight increase of cardiac muscle occurred, contractility measured from dP/dt...

journal_title：Basic research in cardiology

authors： Wüsten B,Flameng W,Schaper W

更新日期：1977-03-01 00:00:00

abstract：:It is generally believed that the increased contractility and tachycardia of the hyperthyroid heart are a result of thyroid hormone-induced alterations of the mechanical and electrical properties of the heart, respectively. We compared the contractility (dP/dtmax) and the spontaneous beating rate of hyperthyroid and e...

journal_title：Basic research in cardiology

authors： Wheatley AM,Butkow N,Marcus RH,Lippe IT,Rosendorff C

更新日期：1988-11-01 00:00:00

abstract：:Beta-blockers have been shown to reduce the risk of coronary events and reduce the mortality of patients with hypertension and in those who have had a myocardial infarction. Furthermore, the evidence for long-term benefits in these two patient groups are much more convincing for beta-blockers than for other therapeuti...

journal_title：Basic research in cardiology

authors： Kendall MJ

更新日期：2000-01-01 00:00:00

abstract：:Age-related changes in the myocardial energy metabolism were studied in spontaneously hypertensive (SHR) rats of 5-15 weeks of age. Systolic blood pressure increased rapidly during 5 to 10 weeks of age (developing phase) and attained a plateau level at 10 to 15 weeks (sustained phase). Even during the developing phase...

journal_title：Basic research in cardiology

authors： Shimamoto N,Goto N,Tanabe M,Imamoto T,Fujiwara S,Hirata M

更新日期：1982-07-01 00:00:00

abstract：:It has been investigated whether calcium- and verapamil-dependent sensitivities of carotis baroreceptors also exist in man. To answer this question, we pre- and postoperatively measured changes in heart rate during carotid sinus stimulation before and after intravenous administration of 5 mg verapamil in 23 patients w...

journal_title：Basic research in cardiology

authors： Behrmann C,Runge M,Ringe JD

更新日期：1992-09-01 00:00:00

abstract：:Myocardial stunning, a transient contractile dysfunction that appears following a brief period of ischemia, is at least partly due to the production of oxygen-derived free radicals. The objective of the present study was to determine whether the Ginkgo biloba extract EGb761, which has antioxidant properties in vitro, ...

journal_title：Basic research in cardiology

authors： Rioufol G,Pietri S,Culcasi M,Loufoua J,Staat P,Pop C,Drieu K,Ovize M

更新日期：2003-02-01 00:00:00

abstract：:In an attempt to clarify the mechanism of sarcoplasmic reticulum (SR) dysfunction during the genesis of irreversible damage in the ischemic-reperfused myocardium, the changes in SR Ca2(+)-pumping ATPase (Ca2(+)-activated, Mg2(+)-dependent ATPase; Ca2(+)-ATPase) activity were studied during ischemia and subsequent repe...

journal_title：Basic research in cardiology

authors： Yoshida Y,Shiga T,Imai S

更新日期：1990-09-01 00:00:00

abstract：:Receptor binding studies usually show heterogenic characteristics of the binding isotherm. Scatchard transformation for graphical linearization of the data presentation affects the data inhomogeneously with respect to the experimental error. Thus a non-linear fitting procedure should be preferred for data analysis. Fu...

journal_title：Basic research in cardiology

authors： Wellstein A,Palm D

更新日期：1984-01-01 00:00:00

abstract：:We hypothesized that nandrolone (ND)-abuse induces cardiac hypertrophy, increases myocardial susceptibility to ischemia/reperfusion (I/R) injury, and reduces responsiveness to postconditioning (PostC) cardioprotection. Wistar-rats were ND treated for 2 weeks (short_ND) or 10 weeks (long_ND). Vehicle-treated rats serve...

journal_title：Basic research in cardiology

authors： Penna C,Tullio F,Perrelli MG,Moro F,Abbadessa G,Piccione F,Carriero V,Racca S,Pagliaro P

更新日期：2011-05-01 00:00:00

abstract：:The PKC hypothesis and its variants are attractive but unproved. The chief difficulty is the lack of an objective means to assess whether or not PKC has been activated in hearts preconditioned in vivo with ischemia or in hearts preconditioned by pharmacologic means. The strongest evidence is supporting the PKC hypothe...

journal_title：Basic research in cardiology

authors： Jennings RB

更新日期：1997-01-01 00:00:00

abstract：:In recent years research has shown that muscle is capable of reacting to mechanical stimuli by altering biochemical processes. Myocardium is probably the source of a biochemical factor, or factors which activate myocardial protein synthesis. In experimentally induced cardiac hypertrophy adaptive alterations have been ...

journal_title：Basic research in cardiology

authors： Kölbel F,Schreiber V

更新日期：1983-07-01 00:00:00

abstract：:Toxic peroxides result when oxygen radicals react with various peroxidic precursors in tissue or blood. A colorimetric method based on reactions of malondialdehyde (MDA), a key intermediate in the formation of peroxides, has been described in fresh tissues. The present report adapts this assay to measure MDA levels in...

journal_title：Basic research in cardiology

authors： Liedtke AJ,Mahar CQ,Ytrehus K,Mjøs OD

更新日期：1984-09-01 00:00:00