Abstract：
:Increasing the frequency of steady state stimulation increases the rate of mechanical restitution in hypothermic (27 degrees C) guinea pig papillary muscles. In this paper we have investigated the influences of the calcium antagonist nifedipine and of reduced extracellular calcium concentration on this phenomenon. We found that nifedipine abolished the frequency dependent increase in the restitution rate, which was also sensitive to extracellular [Ca2+]. These findings suggest that the level of intracellular [Ca2+] can influence the rate of restitution. It is implied that this effect is mediated via ICa, the inward calcium current, which makes a larger than normal contribution to direct contractile activation in hypothermic myocardium.
journal_name
Basic Res Cardioljournal_title
Basic research in cardiologyauthors
Spencer CI,Mörner SE,Noble MI,Seed WAdoi
10.1007/BF00798259subject
Has Abstractpub_date
1993-03-01 00:00:00pages
111-9issue
2eissn
0300-8428issn
1435-1803journal_volume
88pub_type
杂志文章abstract：:We investigated the force-frequency relationship (0.5-3 Hz) in non-failing human myocardium and in end-stage failing human myocardium due to dilated cardiomyopathy or subacute myocarditis. In non-failing myocardium, force of contraction increased with increasing stimulation frequency. In end-stage heart failure, the f...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/978-3-642-72474-9_17
更新日期：1992-01-01 00:00:00
abstract：:Cardioprotection aims at infarct size reduction and improvement of clinical outcome from myocardial infarction. The translation of cardioprotection from preclinical and promising proof-of-concept studies to clinical benefit for patients has been largely disappointing. Almost all of these studies which did not translat...
journal_title：Basic research in cardiology
pub_type： 杂志文章,评审
doi：10.1007/s00395-019-0756-8
更新日期：2019-10-15 00:00:00
abstract：:For 219 children between 3 and 15 years with the most frequent congenital and acquired heart failures it was investigated in what way the STI differ consistently from the corresponding standard values. It was found that all the STI of children with cardiovascular diseases can vary from the normal values scaled by hear...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01906520
更新日期：1978-07-01 00:00:00
abstract：:Age-related changes in the myocardial energy metabolism were studied in spontaneously hypertensive (SHR) rats of 5-15 weeks of age. Systolic blood pressure increased rapidly during 5 to 10 weeks of age (developing phase) and attained a plateau level at 10 to 15 weeks (sustained phase). Even during the developing phase...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF02005337
更新日期：1982-07-01 00:00:00
abstract：:The characterization of various ion transport systems has led to a better understanding of the effects, which seem to take part in the impairment of ischemic and reperfused cardiac tissue. This review discusses the role of the Na+/H+ exchange system in the pathophysiology of ischemia and reperfusion and the beneficial...
journal_title：Basic research in cardiology
pub_type： 杂志文章,评审
doi：10.1007/BF00795411
更新日期：1993-09-01 00:00:00
abstract：:Increase of Ca2+ concentration to 7.5 mM in the presence of 10 mM or 20 mM caffeine shifted length-tension relationships of 5 rat trabecular muscles and 5 cat papillary muscles to higher tensions. At 1max diastolic tension was enhanced from (formula: see text), for all measured points of stress-strain relationships af...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01906525
更新日期：1978-09-01 00:00:00
abstract：:It has been investigated whether calcium- and verapamil-dependent sensitivities of carotis baroreceptors also exist in man. To answer this question, we pre- and postoperatively measured changes in heart rate during carotid sinus stimulation before and after intravenous administration of 5 mg verapamil in 23 patients w...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF00795058
更新日期：1992-09-01 00:00:00
abstract：:Disregarding the influence of thickness on elevated strength of isolated preparations inevitably leads to erroneous tension-frequency relations, especially in the range of high frequencies. Thus, much of the confusion in interpreting the atypical negative staircase phenomenon of the rat heart is due to this. In view o...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/978-3-662-11289-2_25
更新日期：1987-01-01 00:00:00
abstract：:It is commonly thought that the optimal method for intracoronary administration of cells is to stop coronary flow during cell infusion, in order to prolong cell/vascular wall contact, enhance adhesion, and promote extravasation of cells into the interstitial space. However, occlusion of a coronary artery with a balloo...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/s00395-015-0503-8
更新日期：2015-09-01 00:00:00
abstract：:Endothelin-1 elicited a concentration-dependent positive inotropic effect on the isolated rabbit, guinea pig, and rat, but not on the dog ventricular myocardium. The duration of isometric contractions was prolonged by endothelin-1 in a concentration-dependent manner, mainly by prolongation of relaxation time. Phorbol ...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：
更新日期：1991-01-01 00:00:00
abstract：:The mechanism of ergonovine-provoked coronary vasospasm is poorly understood. We tested the effect of ergonovine in perfused hearts from normal and cholesterol-fed (18 weeks, 2% cholesterol diet) rabbits in a constant-flow Langendorff perfusion. Aortic perfusion pressure was monitored to measure coronary vascular resi...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF02070165
更新日期：1983-07-01 00:00:00
abstract：:Heat shock protein 70 (Hsp70) has been shown to have an anti-apoptotic function, but its mechanism is not clear in heart. In this study, we examined the effect of Hsp70 deletion on AIF-induced apoptosis during ischemia/reperfusion (I/R) in vivo. Although Hsp70 KO and WT mice demonstrated similar amounts of AIF release...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/s00395-011-0164-1
更新日期：2011-05-01 00:00:00
abstract：:Atrial fibrosis is important for the pathogenesis of atrial fibrillation (AF) but the underlying signal transduction is incompletely understood. We therefore studied the role of microRNA-21 (miR-21) and its downstream target Sprouty 1 (Spry1) during atrial fibrillation. Left atria (LA) from patients with AF showed a 2...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/s00395-012-0278-0
更新日期：2012-09-01 00:00:00
abstract：:PDE3 cyclic nucleotide phosphodiesterase inhibitors raise cAMP and cGMP content in cardiac and vascular myocytes. Their administration to patients with dilated cardiomyopathy leads to improvements in hemodynamic parameters in the short term but reduces survival with chronic administration. The reasons for this 'biphas...
journal_title：Basic research in cardiology
pub_type： 杂志文章,评审
doi：10.1007/s003950200035
更新日期：2002-01-01 00:00:00
abstract：:Recent studies have demonstrated the presence of autoantibodies against alpha(1)-adrenoceptor (alpha(1)-AAB) in the serum of patients with primary hypertension, and that these autoantibodies exert adrenergic-agonist-like effects. However, their role in the development of hypertension remains unclear. The current study...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/s00395-009-0020-8
更新日期：2009-09-01 00:00:00
abstract：:Mitochondrial dysfunction is an underlying cause of ischemia-reperfusion injury. In particular, ischemic injury induces dramatic increases in mitochondrial permeability, thereby instigating a chain of events that leads to both apoptotic and necrotic cardiomyocyte death. The mitochondrial permeability transition (MPT) ...
journal_title：Basic research in cardiology
pub_type： 杂志文章,评审
doi：10.1007/s00395-009-0004-8
更新日期：2009-03-01 00:00:00
abstract：:Pressure-overloaded cardiac hypertrophy was induced by abdominal aortic constriction in 10-week-old male Wistar rats. 24-26 weeks after aortic constriction, the hearts were excised and a myocardial mechanical study was performed using isolated left ventricular papillary muscles. There was no significant difference in ...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01907024
更新日期：1987-07-01 00:00:00
abstract：AIMS:There is a need for better identification of patients at high risk for malignant arrhythmias who would benefit from implantable cardioverter defibrillators (ICD). The purpose of this study was to assess whether the C825T polymorphism in the G-protein beta3 subunit gene, GNB3, might serve as a genetic marker for re...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/s00395-006-0600-9
更新日期：2006-09-01 00:00:00
abstract：:Myocardial lipoprotein lipase (LPL) activity during ischaemia has not been fully understood, although it plays an important role in regulating myocardial fatty acid metabolism. In this experiment, the effects of ischaemia (Experiment A) and anoxia (Experiment B) on two distinct fractions of LPL, i.e. functional and no...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/978-3-662-08390-1_6
更新日期：1987-01-01 00:00:00
abstract：:MicroRNAs (miRNAs) are important regulators of adaptive and maladaptive responses in cardiovascular diseases and hence are considered to be potential therapeutical targets. However, their role as novel biomarkers for the diagnosis of cardiovascular diseases still needs to be systematically evaluated. We assessed here ...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/s00395-010-0123-2
更新日期：2011-01-01 00:00:00
abstract：:There is a growing need for pharmacological agents to manage cardiovascular disease in the rapidly growing elderly population. Here, we determine if acetaminophen is efficacious in decreasing age-related increases in cardiac reactive oxygen species (ROS) and apoptosis in aging Fischer 344 X Brown Norway rats. Compared...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/s00395-010-0094-3
更新日期：2010-07-01 00:00:00
abstract：:Ex vivo multicellular preparations are essential tools to study tissue physiology. Among them, the recent methodological and technological developments in living myocardial slices (LMS) are attracting increasing interest by the cardiac research field. Despite this, this research model remains poorly perceived and util...
journal_title：Basic research in cardiology
pub_type： 杂志文章,评审
doi：10.1007/s00395-020-00822-y
更新日期：2020-09-10 00:00:00
abstract：:X-ray microanalysis was used to compare chemically untreated cryosections of quick-frozen myocardial tissue in "caffeine contracture" with cryosections of normal muscle. Our goal was to find out if it is possible by means of this method to detect changes in the calcium compartmentalization of the myocardial cell occur...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF02001396
更新日期：1980-01-01 00:00:00
abstract：:The present study was designed to test the hypothesis that in hypertrophied myocardium of patients with hypertrophic obstructive cardiomyopathy (HOCM) a reduced contractile reserve provided by frequency dependent potentiation of force of contraction contributes to the myocardial dysfunction. Myectomy was performed in ...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/s003950050134
更新日期：1999-04-01 00:00:00
abstract：:The capillary wall, due to its diffusional resistance, causes concentration differences between the vascular space and the interstitial space for substances which are released or taken up by the heart. Estimation of capillary transfer and interstitial concentration in isolated hearts, however, indicates a variable dif...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：
更新日期：1985-01-01 00:00:00
abstract：:Nitroglycerin (GTN) and other organic nitrates are widely used vasodilators. Their side effects are development of nitrate tolerance and endothelial dysfunction. Given the potential of GTN to induce nitro-oxidative stress, we investigated the interaction between nitro-oxidative DNA damage and vascular dysfunction in e...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/s00395-016-0571-4
更新日期：2016-07-01 00:00:00
abstract：:We describe diastolic properties of the myocardium in terms of stress-strain relations. In a mathematical analysis, the equation sigma = alpha(e beta.epsilon-1) of the stress-strain curve can be changed by an increase in the exponent beta or the multiplicative constant alpha. It can be experimentally shown that in hyp...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/978-3-662-11289-2_26
更新日期：1987-01-01 00:00:00
abstract：:Although epicardial blood flow can be restored by an early intervention in most cases, a lack of adequate reperfusion at the microvascular level is often a limiting prognostic factor of acute myocardial infarction (AMI). Our group has recently found that paracrine factors secreted from apoptotic peripheral blood monon...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/s00395-012-0292-2
更新日期：2012-09-01 00:00:00
abstract：:The effects of the dihydropyridine calcium antagonists, nifedipine, nitrendipine and FR 7534 on the transmural distribution of coronary blood flow (endo/epi) were compared to the structurally unrelated calcium antagonists, verapamil and diltiazem and to the non-calcium antagonist vasodilator drugs, chromonar and dipyr...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01907211
更新日期：1983-11-01 00:00:00
abstract：:In the human heart several isoforms of the sodium pump (Na,K-ATPase, the cardiac glycoside receptor) are expressed (alpha1beta1, alpha2beta1, and alpha3beta1). Their expression is regulated in a highly specific manner, so that there are region specific differences in the expression pattern. The isoform expression patt...
journal_title：Basic research in cardiology
pub_type： 杂志文章,评审
doi：10.1007/s003950200025
更新日期：2002-01-01 00:00:00
