Abstract:
:Pressure-overloaded cardiac hypertrophy was induced by abdominal aortic constriction in 10-week-old male Wistar rats. 24-26 weeks after aortic constriction, the hearts were excised and a myocardial mechanical study was performed using isolated left ventricular papillary muscles. There was no significant difference in isometric developed tension (T) between sham-operated control and aortic constriction (AC) rats (control vs AC rats = 2.9 +/- 0.6 vs 2.7 +/- 0.7 g/mm2). dT/dtmax of AC rats, on the other hand, was significantly lower than that of controls (controls vs AC rats = 32.8 +/- 7.5 vs 26.3 +/- 6.1 g/mm2s, p less than 0.05). Myocardial mechanical responses to isoproterenol (10(-7) mol/l) were depressed in the group with aortic constriction compared with the control group (delta T: 18.5 +/- 6.7 vs 12.1 +/- 4.9%, p less than 0.05, delta dT/dt: 25.2 +/- 6.2 vs 17.5 +/- 5.8%, p less than 0.02). Responses of the parameters to dibutyryl cyclic AMP (10(-5) mol/l) were also smaller in the AC group than in the control group (delta T: 18.0 +/- 5.6 vs 13.3 +/- 4.0%, p less than 0.05, delta dT/dt: 20.4 +/- 6.9 vs 14.7 +/- 4.1%, p less than 0.05). Left ventricular myosin isoenzyme pattern, revealed by pyrophosphate gel electrophoresis, shifted towards VM-3 under pressure overload. The present study demonstrates that post-membrane processes may be mainly responsible for the decreased myocardial mechanical catecholamine responsiveness in pressure-overloaded cardiac hypertrophy.
journal_name
Basic Res Cardioljournal_title
Basic research in cardiologyauthors
Takeda N,Ohkubo T,Nakamura I,Suzuki H,Nagano Mdoi
10.1007/BF01907024subject
Has Abstractpub_date
1987-07-01 00:00:00pages
370-4issue
4eissn
0300-8428issn
1435-1803journal_volume
82pub_type
杂志文章abstract::Nitric oxide (NO) exerts several effects on myocardial contraction, including enhancement of relaxation and diastolic function, modulation of beta-adrenergic inotropic responses, and inotropic effects in the absence of agonist pre-stimulation. Different effects have been observed in different species and preparations,...
journal_title:Basic research in cardiology
pub_type: 杂志文章
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journal_title:Basic research in cardiology
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abstract::Receptor for advanced glycation end products (RAGE) and connective tissue growth factor (CTGF) play a key role in diabetic myocardial fibrosis, and peroxisome proliferator-activated receptor-gamma (PPAR-gamma) activation has been reported to reduce RAGE and CTGF expression. This study investigated the effects of the P...
journal_title:Basic research in cardiology
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journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF00795054
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abstract::We tested the hypotheses that myocardial infarction in mice would lead to progressively worsening heart failure 12-18 weeks later and that exercise testing would provide a suitable means to evaluate left ventricular function sequentially. C57BL/6 mice (n = 69) underwent left coronary artery ligation (n = 50) or thorac...
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journal_title:Basic research in cardiology
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journal_title:Basic research in cardiology
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journal_title:Basic research in cardiology
pub_type: 杂志文章
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journal_title:Basic research in cardiology
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doi:10.1007/BF01907942
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journal_title:Basic research in cardiology
pub_type: 杂志文章
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journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/s003950050106
更新日期:1998-10-01 00:00:00
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journal_title:Basic research in cardiology
pub_type: 杂志文章,评审
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更新日期:2001-11-01 00:00:00
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journal_title:Basic research in cardiology
pub_type: 杂志文章
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journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF00788540
更新日期:1995-11-01 00:00:00
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journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF00799686
更新日期:1996-03-01 00:00:00
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journal_title:Basic research in cardiology
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doi:10.1007/s00395-009-0047-x
更新日期:2010-01-01 00:00:00
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journal_title:Basic research in cardiology
pub_type: 临床试验,杂志文章
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更新日期:2002-01-01 00:00:00
abstract::Necrosis is a type of cell death characterized by a gain in cell volume, swelling of organelles, rupture of the plasma membrane and subsequent loss of intracellular contents. For a long time, the process has been considered as a merely accidental and uncontrolled form of cell death, but accumulating evidence suggests ...
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pub_type: 杂志文章,评审
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journal_title:Basic research in cardiology
pub_type: 杂志文章
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journal_title:Basic research in cardiology
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Basic research in cardiology
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journal_title:Basic research in cardiology
pub_type: 杂志文章,评审
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更新日期:2007-09-01 00:00:00
abstract::Light in the near-infrared (NIR) region between 700-900 nm can penetrate deep into living tissue, thereby offering a unique opportunity to use near-infrared fluorescence (NIRF) imaging techniques to detect and visualize fluorescent probes in-vivo. In the past few years, many novel NIR fluorescent probes have been desi...
journal_title:Basic research in cardiology
pub_type: 杂志文章,评审
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更新日期:2008-03-01 00:00:00
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journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/s00395-008-0757-5
更新日期:2009-05-01 00:00:00
abstract::Denervation deprives the heart of its normal adrenergic and cholinergic control via the sympathetic and parasympathetic pathways. In a heart which is blood supplied by a donor animal of the same species, normal contractility is maintained, probably by blood borne catecholamines or possibly by unknown inotropic agents ...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF01907778
更新日期:1976-01-01 00:00:00
abstract::Intermittent, normobaric hypoxia confers robust cardioprotection against ischemia-induced myocardial infarction and lethal ventricular arrhythmias. δ-Opioid receptor (DOR) signaling and reactive oxygen species (ROS) have been implicated in cardioprotective phenomena, but their roles in intermittent hypoxia are unknown...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/s00395-016-0538-5
更新日期:2016-03-01 00:00:00
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journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF01906959
更新日期:1988-11-01 00:00:00
abstract::The effects of the dihydropyridine calcium antagonists, nifedipine, nitrendipine and FR 7534 on the transmural distribution of coronary blood flow (endo/epi) were compared to the structurally unrelated calcium antagonists, verapamil and diltiazem and to the non-calcium antagonist vasodilator drugs, chromonar and dipyr...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF01907211
更新日期:1983-11-01 00:00:00
abstract::Calcium transport functions of mitochondria and sarcoplasmic reticulum (SR) were studied without prior extraction using isolated rat heart myocytes permeabilized with saponin. Calcium uptake by SR was rapid and its affinity was high in comparison to calcium uptake by mitochondria, which had a higher capacity. The sens...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF01907975
更新日期:1989-05-01 00:00:00