Abstract:
:In the newborn several situations of hyperinsulinism can be associated with myocardial hypertrophy and increased contractility. Insulin and the insulin-like growth factors (IGF) are derived from a common ancestral molecule. Insulin exerts mainly metabolic action, whereas the IGFs promote cell multiplication and differentiation. Using an assay system of cultured neonatal myocardial cells the stimulatory action of insulin and the insulin-like growth factors I and II on myocardial cell contractility was investigated. Spontaneously beating aggregates of myocardial cells were synchronized by an electric impulse generator. Contractility was measured via the amplitude of contraction by an optoelectronic system. Insulin at a concentration of 6,250 and 12,500 microU/ml increased the contractility by 11 and 18%; IGF-I at a concentration of 12 and 25 ng/ml, and IGF-II at a concentration of 25 and 50 ng/ml increased the contractility by 16 and 22%, and 13 and 18%, respectively. Lower concentrations did not provoke a significant increase in contractility. Insulin only in supraphysiological doses increases the contractility of neonatal myocardial rat cells, whereas both insulin-like growth factors act in physiological concentrations. Therefore, during hyperinsulinism insulin may increase myocardial contractility via the IGF receptor and not via the insulin receptor.
journal_name
Basic Res Cardioljournal_title
Basic research in cardiologyauthors
Vetter U,Kupferschmid C,Lang D,Pentz Sdoi
10.1007/BF01906959subject
Has Abstractpub_date
1988-11-01 00:00:00pages
647-54issue
6eissn
0300-8428issn
1435-1803journal_volume
83pub_type
杂志文章abstract::Increase of Ca2+ concentration to 7.5 mM in the presence of 10 mM or 20 mM caffeine shifted length-tension relationships of 5 rat trabecular muscles and 5 cat papillary muscles to higher tensions. At 1max diastolic tension was enhanced from (formula: see text), for all measured points of stress-strain relationships af...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF01906525
更新日期:1978-09-01 00:00:00
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journal_title:Basic research in cardiology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2000-10-01 00:00:00
abstract::Atrial fibrillation (AF) is the most prevalent cardiac arrhythmia with a strong genetic component. Molecular pathways involving the homeodomain transcription factor Shox2 control the development and function of the cardiac conduction system in mouse and zebrafish. Here we report the analysis of human SHOX2 as a potent...
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journal_title:Basic research in cardiology
pub_type: 杂志文章
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更新日期:2000-04-01 00:00:00
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journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF02005829
更新日期:1988-07-01 00:00:00
abstract::Implicit in attempts to characterize and purify biologically active factors is the premise that the bioassay system employed will show a progressive increase in the response as the concentration of the responsible factor increases. We employed the hamster cheek pouch to assay the neovascularization potential of growth...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF01907406
更新日期:1986-05-01 00:00:00
abstract::The influence of PGI2 and iloprost on the contents of high energy phosphates, cAMP, glycolytic metabolites and on cardiac performance was investigated in open-chest dogs subjected to 3 h of ischaemia, induced by occlusion of the left anterior descending coronary artery. The administration of drugs for 2 h, starting 1 ...
journal_title:Basic research in cardiology
pub_type: 杂志文章
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更新日期:1987-11-01 00:00:00
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journal_title:Basic research in cardiology
pub_type: 杂志文章,评审
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更新日期:2004-03-01 00:00:00
abstract::This paper reviews the recent data concerning the force-frequency relations in experimental animals with heart failure. After a brief overview of the nature of these relations, which are induced by 2 opposite phenomena, the potentiation of force of contraction by heart rate and the restitution process, the paper revie...
journal_title:Basic research in cardiology
pub_type: 杂志文章,评审
doi:10.1007/s003950050212
更新日期:1998-01-01 00:00:00
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journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:
更新日期:1985-01-01 00:00:00
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journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/978-3-662-08390-1_6
更新日期:1987-01-01 00:00:00
abstract::Verapamil alleviates symptoms in patients with hypertrophic cardiomyopathy (HCM), but the underlying mechanism of improvement remains speculative. Baseline and dipyridamole myocardial blood flow (MBF) were measured in 15 HCM patients (14 men, 42 +/- 10 years), before and after 4 weeks of verapamil SR 480 mg daily, usi...
journal_title:Basic research in cardiology
pub_type: 临床试验,杂志文章
doi:10.1007/s003950050126
更新日期:1999-02-01 00:00:00
abstract::32 patients were studied by His-bundle recordings to examine the extent to which frequency and autonomic nervous system influence the conduction velocity in the subdivisions (atrium, AV-node, His-Purkinje system) of the normal PR-interval. The measurements were performed during sinus rhythm and three electrically indu...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:
更新日期:1976-11-01 00:00:00
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journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF01907225
更新日期:1987-11-01 00:00:00
abstract::Hypertension and resulting left ventricular hypertrophy was induced in young male Wistar rats (60 to 70 days old) by narrowing of one renal artery (Goldblatt II). 8 and 24 weeks after operation, myocardial oxygen consumption was measured on a modified in situ heart-lung preparation with nearly isovolumetric left ventr...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF01908041
更新日期:1982-05-01 00:00:00
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journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF01907787
更新日期:1976-01-01 00:00:00
abstract::Because of the close anatomical association between the ventricles, the volume of one ventricle can directly affect the volume and pressure within the other ventricle. To study the mechanical coupling between the ventricles, we modeled the right and left ventricles as a two-compartment model with right wall (Crw), sep...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF01907759
更新日期:1986-09-01 00:00:00
abstract::To understand the effect of transcription regulation in modulating cardiac aging, we sought to study the role of serum response factor (SRF), a key transcription factor in the heart that is normally increased with senescence and also in congestive heart failure. A Tet-Off gene expression system was used for cardiac-sp...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/s00395-006-0634-z
更新日期:2007-05-01 00:00:00
abstract::An increased occurrence of hypertension has been reported among leg-amputees. In order to investigate whether leg amputation is followed by an elevation of sympathetic tone, possibly enhanced by continuous mechanical irritation of the amputation stump by wearing a prosthesis, blood pressure (BP), pulse-rate (PR) and p...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF01907771
更新日期:1981-05-01 00:00:00
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journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF01907862
更新日期:1985-11-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s00395-005-0532-9
更新日期:2005-07-01 00:00:00
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journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/978-3-662-11289-2_26
更新日期:1987-01-01 00:00:00
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journal_title:Basic research in cardiology
pub_type: 杂志文章
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更新日期:2019-11-28 00:00:00
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journal_title:Basic research in cardiology
pub_type: 杂志文章,评审
doi:10.1007/978-3-662-08390-1_8
更新日期:1987-01-01 00:00:00
abstract::Apart from local heterogeneities of myocardial blood flow, the regulation of vascular tone is equally complex. Changes in vascular tone are essential for the adaptation of coronary blood flow to varying metabolic demands. The majority of coronary vascular resistance is found in the microcirculation, that is, in vessel...
journal_title:Basic research in cardiology
pub_type: 杂志文章,评审
doi:10.1007/s003950050114
更新日期:1998-12-01 00:00:00
abstract::In the isometrically contracting rat trabecular muscle strip preparation, contracture tension was induced either by 10 min of hypoxia (low contracture tension) or by 30 min of joint oxygen and glucose withdrawal (severe contracture tension) at optimum length. Using stepwise 0.1 mm releases, length-tension relationship...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF01908059
更新日期:1981-11-01 00:00:00
abstract::We tested the hypothesis that isoproterenol would increase myocardial work and O2 consumption at reduced efficiency and that both left ventricular hypertrophy and chemical sympathectomy would lead to changes in this myocardial efficiency response. Left ventricular hypertrophy was produced by aortic valve plication in ...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF00789303
更新日期:1996-07-01 00:00:00
abstract::The stroke volume at rest of 81 test subjects with no evident cardiac or circulatory dysfunction was determined by impedance cardiography and the measurements were repeated after 11 weeks. In order to attain comparable and reproducible conditions, 44 test subjects were chosen who showed heart rates at rest not higher ...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF01906800
更新日期:1978-11-01 00:00:00
abstract::Cardiac disease is associated with deleterious emission of mitochondrial reactive oxygen species (mito-ROS), as well as enhanced oxidation and activity of the sarcoplasmic reticulum (SR) Ca2+ release channel, the ryanodine receptor (RyR2). The transfer of Ca2+ from the SR via RyR2 to mitochondria is thought to play a ...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/s00395-020-0797-z
更新日期:2020-05-22 00:00:00
abstract::A previous study indicated that 5 mg/kg aspirin can reverse the cardioprotective effects of thromboxane A2 synthetase inhibitors. We determined in the present study if this dose of aspirin can also reverse the protective effects of the thromboxane A2/PGH2 receptor antagonist SQ 30,741 in the same model of coronary occ...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF02190542
更新日期:1991-03-01 00:00:00